scholarly journals Special Issue: DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 356
Author(s):  
Robert M. Brosh
Keyword(s):  
Nucleic Acid ◽  
Biological Pathways ◽  
Special Issue ◽  
Genome Maintenance ◽  
Metabolizing Enzymes ◽  
Cellular Homeostasis ◽  
Dna Helicases ◽  
Disease Relevance

DNA helicases have emerged as a prominent class of nucleic acid-metabolizing enzymes that play important roles in genome maintenance and cellular homeostasis [...]

scholarly journals Nucleic Acids Chemistry and Engineering: Special Issue on Nucleic Acid Conjugates for Biotechnological Applications

2021 ◽  
Vol 11 (8) ◽  
pp. 3594
Author(s):  
Tamaki Endoh ◽  
Eriks Rozners ◽  
Takashi Ohtsuki
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Genetic Information ◽  
Biotechnological Applications ◽  
Biological Functions ◽  
Primary Sequence ◽  
Special Issue

Nucleic acids not only store genetic information in their primary sequence but also exhibit biological functions through the formation of their unique structures [...]

scholarly journals Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

2009 ◽  
Vol 186 (5) ◽  
pp. 655-663 ◽  
Author(s):  
Kasper Fugger ◽  
Martin Mistrik ◽  
Jannie Rendtlew Danielsen ◽  
Christoffel Dinant ◽  
Jacob Falck ◽  
...  
Keyword(s):  
Small Interfering Rna ◽  
Ectopic Expression ◽  
Dna Lesions ◽  
Premature Aging ◽  
Genome Integrity ◽  
Helicase Activity ◽  
Genome Maintenance ◽  
Dna Helicases ◽  
Replication Block ◽  
Interfering Rna

Homologous recombination (HR) is essential for faithful repair of DNA lesions yet must be kept in check, as unrestrained HR may compromise genome integrity and lead to premature aging or cancer. To limit unscheduled HR, cells possess DNA helicases capable of preventing excessive recombination. In this study, we show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box. hFbh1 interacted with single-stranded DNA (ssDNA), the formation of which was required for hFbh1 recruitment to DNA lesions. Conversely, depletion of endogenous Fbh1 or ectopic expression of helicase-deficient hFbh1 attenuated ssDNA production after replication block. Although elevated levels of hFbh1 impaired Rad51 recruitment to ssDNA and suppressed HR, its small interfering RNA–mediated depletion increased the levels of chromatin-associated Rad51 and caused unscheduled sister chromatid exchange. Thus, by possessing both pro- and anti-recombinogenic potential, hFbh1 may cooperate with other DNA helicases in tightly controlling cellular HR activity.

Superfamily I helicases as modular components of DNA-processing machines

2011 ◽  
Vol 39 (2) ◽  
pp. 413-423 ◽  
Author(s):  
Mark S. Dillingham
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Molecular Mechanisms ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism ◽  
Cellular Functions ◽  
Dna Helicases ◽  
Wide Range ◽  
Look Back ◽  
Partner Proteins

Helicases are a ubiquitous and abundant group of motor proteins that couple NTP binding and hydrolysis to processive unwinding of nucleic acids. By targeting this activity to a wide range of specific substrates, and by coupling it with other catalytic functionality, helicases fulfil diverse roles in virtually all aspects of nucleic acid metabolism. The present review takes a look back at our efforts to elucidate the molecular mechanisms of UvrD-like DNA helicases. Using these well-studied enzymes as examples, we also discuss how helicases are programmed by interactions with partner proteins to participate in specific cellular functions.

scholarly journals Editorial for the Special Issue on “Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials”

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 951 ◽  
Author(s):  
Justin R. Halman ◽  
Kirill A. Afonin
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Special Issue ◽  
Rna And Dna ◽  
Multifunctional Platform

The use of nucleic acids (RNA and DNA) offers a unique and multifunctional platform for numerous applications including therapeutics, diagnostics, nanodevices, and materials [...]

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