scholarly journals Presentation of Acrodermatitis Chronica Atrophicans Rashes on Lyme Disease Patients in Canada

Healthcare ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 157
Author(s):  
John D. Scott
Keyword(s):  
Lyme Disease ◽  
Clinical Manifestations ◽  
Geographic Area ◽  
The Body ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Acrodermatitis Chronica Atrophicans ◽  
Different Types ◽  
Age Range ◽  
First Time ◽  
Body Case

Lyme disease (Lyme borreliosis) is a complex multisystem illness with varying clinical manifestations. This tick-borne zoonosis is caused by the spirochetal bacterium, Borrelia burgdorferi sensu lato (Bbsl) and, worldwide, presents with at least 20 different types of rashes. Certain cutaneous rashes are inherently interconnected to various stages of Lyme disease. In this study, five Canadian Lyme disease patients from a multi-age range presented various phases of the acrodermatitis chronica atrophicans (ACA) rash. In each case of ACA, the underlying etiological pathogen was the Lyme disease spirochete. Although ACA rashes are normally found on the lower extremities, this study illustrates that ACA rashes are not directly correlated with a tick bite, geographic area, age, Bbsl genospecies, exercise, or any given surface area of the body. Case 4 provides confirmation for an ACA rash and gestational Lyme disease. One patient (Case 5) puts forth a Bbsl and Bartonella sp. co-infection with a complex ACA rash. This study documents ACA rashes on Lyme disease patients for the first time in Canada.

scholarly journals THE HISTORY OF ANTIBIOTICS IN SURGERY

2015 ◽  
Vol 2 (4) ◽  
pp. 210-213
Author(s):  
Gina Lupașcu ◽  
Georgiana Radu ◽  
Cristina Veronica Andreescu ◽  
Alexandra Bolocan
Keyword(s):  
Natural Compounds ◽  
The Body ◽  
Different Types ◽  
History Of ◽  
First Time ◽  
Positive Results

Selman Waksman is an important name that introduced for the first time the idea of some natural compounds with visible effects in treatment of diseases called- antibiotics. Its continuous and irrational utilization has been proven to make the body resistant to a future need of the antibiotic administered. This aspect did not stop the studies to shown the importance of this biosynthesized medicines in prophylaxis of surgery. During the years there were identified a lot of these natural compounds with positive results in different types of surgery. The purpose of this article is to bring to attention the evolution of antibiotics during the years, especially in surgery field, how its usage influenced the prophylaxis and which are the main principles to be respected in administration of antibiotics.

Detection of a large linear plasmid inBorrelia spielmaniiisolate

2011 ◽  
Vol 57 (4) ◽  
pp. 343-346
Author(s):  
Daniela Handžáková Lenčáková ◽  
Ulrike Schulte-Spechtel ◽  
Volker Fingerle ◽  
Branislav Pet’ko ◽  
Bettina Wilske
Keyword(s):  
Lyme Disease ◽  
Gel Electrophoresis ◽  
Previous History ◽  
Pulsed Field Gel Electrophoresis ◽  
Linear Plasmid ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Large Plasmid ◽  
Linear Plasmids ◽  
History Of ◽  
First Time

Borrelia spielmanii belongs to human pathogenic species within the Borrelia burgdorferi sensu lato complex in Europe, which is a causative agent of Lyme disease. So far, the human disease caused by B. spielmanii has been associated with skin manifestations. The aim of the study was to analyze 4 human B. spielmanii isolates by pulsed-field gel electrophoresis and to localize genes of 3 important Borrelia proteins: OspA, DbpA, and VlsE. The analysis revealed variation within linear plasmid profiles among the strains; isolate PSigII contained a large plasmid of 100 kb compared with a 50 kb plasmid present in the 3 other B. spielmanii isolates, all carried the genes ospA and dbpA. Differences in the size of linear plasmids among the Borrelia strains may be a result of host–pathogen interactions, as the PSigII strain was the only strain of the 4 tested strains to be isolated from a patient with a previous history of Lyme disease, whereas 3 other patients were diagnosed with this disease for the first time.

Molecular Interactions During Borrelia burgdorferi Migration from the Vector to the Mammalian Nervous System

2020 ◽  
Vol 21 (5) ◽  
pp. 517-526
Author(s):  
Manzama-Esso Abi ◽  
Zhenhua Ji ◽  
Miaomiao Jian ◽  
Xiting Dai ◽  
Ruolan Bai ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Nervous System ◽  
Lyme Disease ◽  
Host Defense ◽  
Molecular Interactions ◽  
Clinical Symptoms ◽  
The Body ◽  
Mammalian Host ◽  
Different Types ◽  
In The Beginning

Lyme disease (LD) is an infectious disease caused by the spirochetes of genus borrelia, which are transmitted by the ticks of the genus ixodes. LD is transmitted by the spirochete B. burgdorferi sensu lato. Once in contact with the host through a tick bite, the pathogen comes into contact with the host defense, and must escape this machinery to establish LD, thus using a large number of mechanisms involving the vector of the pathogen, the pathogen itself and also the host. The initial diagnosis of the disease can be made based on the clinical symptoms of LD and the disease can be treated and cured with antibiotics if the diagnosis is made early in the beginning of the disease. Contrariwise, if LD is left untreated, the pathogen disseminates throughout the tissues and organs of the body, where it establishes different types of disease manifestations. In the nervous system, the inflammation caused by B. burgdorferi is known as Lyme neuroborreliosis (LNB). LNB is one of the principal manifestations of LD. In this review, we systematically describe the different molecular interactions among B. burgdorferi, the vector (tick) and the mammalian host.

scholarly journals Clinical Features of 705Borrelia burgdorferiSeropositive Patients in an Endemic Area of Northern Italy

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Giuseppe Stinco ◽  
Maurizio Ruscio ◽  
Serena Bergamo ◽  
Davide Trotter ◽  
Pasquale Patrone
Keyword(s):  
Borrelia Burgdorferi ◽  
Clinical Features ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Geographic Area ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Neurological Involvement ◽  
Clinical Feature ◽  
Cutaneous Manifestations ◽  
Acrodermatitis Chronica Atrophicans

Background. Lyme Borreliosis is a multisystemic infection caused by spirochetes ofBorrelia burgdorferi sensu latocomplex. The features of Lyme Borreliosis may differ in the various geographical areas, primarily between the manifestations found in America and those found in Europe and Asia.Objective. to describe the clinical features of Lyme Borreliosis in an endemic geographic area such as Friuli-Venezia Giulia in the Northeastern part of Italy.Methods. The medical records of patients resulted seropositive forBorrelia burgdorferihave been retrospectively recorded and analyzed.Results. Seven hundred and five patients met the inclusion criteria, 363 males and 342 females. Erythema migrans was the most common manifestation, detected in 437 patients. Other classical cutaneous manifestations included 58 cases of multiple erythema migrans, 7 lymphadenosis benigna cutis, and 18 acrodermatitis chronica atrophicans. The musculoskeletal system was involved in 511 patients. Four hundred and sixty patients presented a neurological involvement. Flu-like symptoms preceded or accompanied or were the only clinical feature in 119 patients.Comments. The manifestations of Lyme borreliosis recorded in this study are similar to the ones of other endemic areas in Europe, even if there are some peculiar features which are different from those reported in Northern Europe and in the USA.

scholarly journals  Cardiac manifestations of borreliosis in a dog: a case report

2011 ◽  
Vol 56 (No. 2) ◽  
pp. 85-92 ◽  
Author(s):  
CF Agudelo ◽  
P. Schanilec ◽  
K. Kybicova ◽  
P. Kohout
Keyword(s):  
Nervous System ◽  
Heart Disease ◽  
Case Report ◽  
Lyme Disease ◽  
Clinical Manifestations ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Lyme Carditis ◽  
Cardiac Manifestations ◽  
Antibody Dynamics ◽  
Echocardiographic Findings

In Europe Lyme disease is caused by the spirochete Borrelia burgdorferi sensu lato. It presents with a variety of clinical manifestations including heart disease and problems of the nervous system, skin and joints. Lyme carditis occurs in 4–10% of infected humans and is characterized by a plethora of cardiovascular syndromes such as arrhythmia, myocarditis, and pericarditis among others. This article is a case report of a serologically positive (B. burgdorferi s.l.) dog, in which the antibody dynamics correlated with clinical, electrocardiographic, and echocardiographic findings of heart disease resembling human Lyme-induced dilated cardiomyopathy (DCM).

REPORT OF SUBCOMMITTEE ON ACCIDENTAL POISONING

PEDIATRICS ◽  
1961 ◽  
Vol 27 (4) ◽  
pp. 676-680
Author(s):  
Keyword(s):  
Public Health ◽  
Urban Areas ◽  
Health Surveys ◽  
Clinical Manifestations ◽  
The Body ◽  
Lead Intoxication ◽  
Accidental Poisoning ◽  
History Of ◽  
Ready Access ◽  
Age Range

LEAD INTOXICATION occurs most frequently in children between 1 and 3 years of age. (In the various series of cases reported in the literature approximately 85% of the cases were first diagnosed in the children in this age range.) For reasons not completely understood approximately 80% of symptomatic cases occur during the summer months. With rare exceptions children exhibiting clinical lead intoxication reside in the older sections of urban areas where they may have ready access to crumbling, peeling or easily chipped paint. Lead pigment paints were widely used for indoor painting until approximately 25 years ago. Lead pigments are still found in exterior paints, particularly those specified as mildew suppressants. Since the absorption of lead from the intestine proceeds slowly a child must nibble upon these flakes for several months before a quantity of lead sufficient to produce toxic manifestations is absorbed into the body. The child need ingest only a few chips each week; but if he continues this practice for longer than 3 to 6 months the clinical manifestations of lead intoxication to be described may occur thereafter, especially during the summer months. Although a history of pica may be a valuable question to ask in public health surveys, one must not overlook the possibility of pica even when it is denied. It is important for the clinician to realize that mothers may or may not observe their children eating a paint chip now and then. Even when they do see it they may not attribute much importance to the ingestion of the paint. If the clinician strongly suspects the possibility of lead poisoning he should proceed with the necessary laboratory diagnostic steps.

scholarly journals AB1365-HPR FREQUENCY OF JOINT DAMAGE IN PATIENTS WITH ULCERATIVE COLITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1969.1-1969
Author(s):  
D. Tarasova ◽  
L. Shilova ◽  
E. Lutaya ◽  
E. Korenskaya ◽  
M. Koroleva ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Joint Damage ◽  
The Body ◽  
Systemic Autoimmune Disease ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Mechanisms Of Development ◽  
First Time

Background:Ulcerative colitis (UC) is considered as a systemic autoimmune disease with lesions of the colon mucosa. The current of UC is often accompanied by different extra-intestinal manifestations. Their frequency, according to various studies, varies widely – from 25 to 60 %. It is a serious problem that affects the quality of life and the effectiveness of therapy [1, 2]. Rheumatological manifestations, in particular, damage to the joints and spine, are one of the extra-intestinal manifestations and they are of particular importance. To date, the relationship between UC and joint damage has not been fully studied. These diseases can occur independently in the body or have a common autoimmune or inflammatory nature. It is believed that having common pathogenetic mechanisms of development, UC and joint damage can be different clinical forms of the same disease.Objectives:To evaluate the frequency of clinical manifestations of joint damage in patients with ulcerative colitis.Methods:The study was conducted at the gastroenterological Department of the Hospital №25 (Russia, Volgograd). Archived data from the case histories of 69 patients with a confirmed diagnosis of ulcerative colitis were analyzed, including 58 men (30.4%) with an average age of 33.4 years, and 38 women (69.5%) with an average age of 37.6 years.Results:Among 48 patients with UC, extra-intestinal manifestations were detected in 40 (41.6%) patients. A total lesion of the large intestine was found in 20 patients (20.8%), left-sided colitis in 14 (14, 6%), proctosigmoiditis in 6 (6.25%). The diagnosis was made for the first time in 4 patients (4.16%), 36 patients (37.5%) were admitted to the hospital again due to an exacerbation of the disease. Among the extra-intestinal manifestations, joint lesions prevailed: 20 patients (20.8%) showed clinical signs of peripheral arthritis, spondyloarthritis was detected in 8 patients (8.3 %), and 6 patients (6.25 %) had symptoms of unilateral sacroiliitis. 4 (4.16%) patients were diagnosed with nodular erythema. Primary sclerosing cholangitis was detected in two patients (2.08%).Conclusion:The development of extra-intestinal manifestations in UC is largely determined by the course of the disease and the length of the inflammatory process in the colon. More than a third of patients with UC revealed extra-intestinal manifestations, among which the most common signs of joint damage were present, which necessitates timely diagnosis of extra-intestinal manifestations and involvement of a rheumatologist in the management of this category of patients.References:[1]Knyazev O. V. et al. Epidemiologi of inflammatory bowel disease. Yesterdey, today, tomorrow. Eksperimental’naya i Klinicheskaya Gastroenterologiya 2017; 139 (3): 4–12 (In Russ.)[2]Sadygova G.G. Extraintestinal manifestations of inflammatory bowel diseases: arthropathy and arthritis. Ross z gastroenterol gepatol koloproktol 2016; 26(6):101-5 (In Russ.)Disclosure of Interests:None declared

scholarly journals Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

2021 ◽  
Vol 22 (17) ◽  
pp. 9543
Author(s):  
Nika Kučuk ◽  
Mateja Primožič ◽  
Željko Knez ◽  
Maja Leitgeb
Keyword(s):  
Therapeutic Agents ◽  
The Body ◽  
Therapeutic Applications ◽  
Administration Routes ◽  
Advantages And Disadvantages ◽  
Different Types ◽  
Global Companies ◽  
Delivery Vehicles ◽  
First Time ◽  
Therapy Delivery

Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety of therapeutic applications due to their unique characteristics, especially due to the ineffectiveness and cytotoxicity of some existing therapies and synthetic therapeutic nanocarriers. They are highly promising as carriers of drugs, genes, and other therapeutic agents that can be incorporated into their interior or onto their surface through various modification techniques to improve their targeting abilities. In addition, they are biocompatible, safe, and stable. The review focuses on different types of exosomes and methods of their preparation, including the incorporation of different kinds of cargo, especially for drug delivery purposes. In particular, their importance and effectiveness as delivery vehicles of various therapeutic agents for a variety of therapeutic applications, including different diseases and disorders such as cancer treatment, cardiovascular and neurodegenerative diseases, are emphasized. Administration routes of exosomes into the body are also included. A novelty in the article is the emphasis on global companies that are already successfully developing and testing such therapeutic biomaterials, with a focus on the most influential ones. Moreover, a comparison of the advantages and disadvantages of the various methods of exosome production is summarized for the first time.

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

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