scholarly journals Smart Design Nano-Hybrid Formulations by Machine Learning

Proceedings ◽  
2020 ◽  
Vol 78 (1) ◽  
pp. 5
Author(s):  
Raquel de Melo Barbosa ◽  
Fabio Fonseca de Oliveira ◽  
Gabriel Bezerra Motta Câmara ◽  
Tulio Flavio Accioly de Lima e Moura ◽  
Fernanda Nervo Raffin ◽  
...  
Keyword(s):  
Machine Learning ◽  
Experimental Data ◽  
Water Solubility ◽  
Inorganic Materials ◽  
Fine Tuning ◽  
Support Vector ◽  
Drug Solubility ◽  
Physical Behavior ◽  
Best Fit

Nano-hybrid formulations combine organic and inorganic materials in self-assembled platforms for drug delivery. Laponite is a synthetic clay, biocompatible, and a guest of compounds. Poloxamines are amphiphilic four-armed compounds and have pH-sensitive and thermosensitive properties. The association of Laponite and Poloxamine can be used to improve attachment to drugs and to increase the solubility of β-Lapachone (β-Lap). β-Lap has antiviral, antiparasitic, antitumor, and anti-inflammatory properties. However, the low water solubility of β-Lap limits its clinical and medical applications. All samples were prepared by mixing Tetronic 1304 and LAP in a range of 1–20% (w/w) and 0–3% (w/w), respectively. The β-Lap solubility was analyzed by UV-vis spectrophotometry, and physical behavior was evaluated across a range of temperatures. The analysis of data consisted of response surface methodology (RMS), and two kinds of machine learning (ML): multilayer perceptron (MLP) and support vector machine (SVM). The ML techniques, generated from a training process based on experimental data, obtained the best correlation coefficient adjustment for drug solubility and adequate physical classifications of the systems. The SVM method presented the best fit results of β-Lap solubilization. In silico tools promoted fine-tuning, and near-experimental data show β-Lap solubility and classification of physical behavior to be an excellent strategy for use in developing new nano-hybrid platforms.

scholarly journals NLOS Multipath Classification of GNSS Signal Correlation Output Using Machine Learning

Sensors ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2503
Author(s):  
Taro Suzuki ◽  
Yoshiharu Amano
Keyword(s):  
Machine Learning ◽  
Satellite System ◽  
Training Data ◽  
Support Vector ◽  
Positioning Errors ◽  
Automated Method ◽  
Global Navigation Satellite ◽  
Better Than ◽  
Signal Correlation

This paper proposes a method for detecting non-line-of-sight (NLOS) multipath, which causes large positioning errors in a global navigation satellite system (GNSS). We use GNSS signal correlation output, which is the most primitive GNSS signal processing output, to detect NLOS multipath based on machine learning. The shape of the multi-correlator outputs is distorted due to the NLOS multipath. The features of the shape of the multi-correlator are used to discriminate the NLOS multipath. We implement two supervised learning methods, a support vector machine (SVM) and a neural network (NN), and compare their performance. In addition, we also propose an automated method of collecting training data for LOS and NLOS signals of machine learning. The evaluation of the proposed NLOS detection method in an urban environment confirmed that NN was better than SVM, and 97.7% of NLOS signals were correctly discriminated.

scholarly journals Delineating Smallholder Maize Farms from Sentinel-1 Coupled with Sentinel-2 Data Using Machine Learning

2021 ◽  
Vol 13 (9) ◽  
pp. 4728
Author(s):  
Zinhle Mashaba-Munghemezulu ◽  
George Johannes Chirima ◽  
Cilence Munghemezulu
Keyword(s):  
Machine Learning ◽  
Food Security ◽  
Rural Communities ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Subsistence Agriculture ◽  
Smallholder Farms ◽  
Main Driver ◽  
Sentinel 2

Rural communities rely on smallholder maize farms for subsistence agriculture, the main driver of local economic activity and food security. However, their planted area estimates are unknown in most developing countries. This study explores the use of Sentinel-1 and Sentinel-2 data to map smallholder maize farms. The random forest (RF), support vector (SVM) machine learning algorithms and model stacking (ST) were applied. Results show that the classification of combined Sentinel-1 and Sentinel-2 data improved the RF, SVM and ST algorithms by 24.2%, 8.7%, and 9.1%, respectively, compared to the classification of Sentinel-1 data individually. Similarities in the estimated areas (7001.35 ± 1.2 ha for RF, 7926.03 ± 0.7 ha for SVM and 7099.59 ± 0.8 ha for ST) show that machine learning can estimate smallholder maize areas with high accuracies. The study concludes that the single-date Sentinel-1 data were insufficient to map smallholder maize farms. However, single-date Sentinel-1 combined with Sentinel-2 data were sufficient in mapping smallholder farms. These results can be used to support the generation and validation of national crop statistics, thus contributing to food security.

scholarly journals Breast Cancer Type Classification Using Machine Learning

2021 ◽  
Vol 11 (2) ◽  
pp. 61
Author(s):  
Jiande Wu ◽  
Chindo Hicks
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Machine Learning ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Genomic Research ◽  
Support Vector ◽  
Cancer Type ◽  
Classification Models

Background: Breast cancer is a heterogeneous disease defined by molecular types and subtypes. Advances in genomic research have enabled use of precision medicine in clinical management of breast cancer. A critical unmet medical need is distinguishing triple negative breast cancer, the most aggressive and lethal form of breast cancer, from non-triple negative breast cancer. Here we propose use of a machine learning (ML) approach for classification of triple negative breast cancer and non-triple negative breast cancer patients using gene expression data. Methods: We performed analysis of RNA-Sequence data from 110 triple negative and 992 non-triple negative breast cancer tumor samples from The Cancer Genome Atlas to select the features (genes) used in the development and validation of the classification models. We evaluated four different classification models including Support Vector Machines, K-nearest neighbor, Naïve Bayes and Decision tree using features selected at different threshold levels to train the models for classifying the two types of breast cancer. For performance evaluation and validation, the proposed methods were applied to independent gene expression datasets. Results: Among the four ML algorithms evaluated, the Support Vector Machine algorithm was able to classify breast cancer more accurately into triple negative and non-triple negative breast cancer and had less misclassification errors than the other three algorithms evaluated. Conclusions: The prediction results show that ML algorithms are efficient and can be used for classification of breast cancer into triple negative and non-triple negative breast cancer types.

Classification of Diffusion Tensor Metrics for the Diagnosis of a Myelopathic Cord Using Machine Learning

2018 ◽  
Vol 28 (02) ◽  
pp. 1750036 ◽  
Author(s):  
Shuqiang Wang ◽  
Yong Hu ◽  
Yanyan Shen ◽  
Hanxiong Li
Keyword(s):  
Machine Learning ◽  
Surgical Planning ◽  
Diffusion Tensor ◽  
Mean Value ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Svm Classifier ◽  
Control Groups ◽  
Diffusion Tensor Imaging Dti

In this study, we propose an automated framework that combines diffusion tensor imaging (DTI) metrics with machine learning algorithms to accurately classify control groups and groups with cervical spondylotic myelopathy (CSM) in the spinal cord. The comparison between selected voxel-based classification and mean value-based classification were performed. A support vector machine (SVM) classifier using a selected voxel-based dataset produced an accuracy of 95.73%, sensitivity of 93.41% and specificity of 98.64%. The efficacy of each index of diffusion for classification was also evaluated. Using the proposed approach, myelopathic areas in CSM are detected to provide an accurate reference to assist spine surgeons in surgical planning in complicated cases.

scholarly journals KDClassifier: Urinary Proteomic Spectra Analysis Based on Machine Learning for Classification of Kidney Diseases

2020 ◽  
Author(s):  
Wanjun Zhao ◽  
Yong Zhang ◽  
Xinming Li ◽  
Yonghong Mao ◽  
Changwei Wu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Mass Spectrum ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Training Dataset ◽  
Validation Dataset ◽  
Support Vector ◽  
Urinary Proteomics ◽  
Diagnosis Model

AbstractBackgroundBy extracting the spectrum features from urinary proteomics based on an advanced mass spectrometer and machine learning algorithms, more accurate reporting results can be achieved for disease classification. We attempted to establish a novel diagnosis model of kidney diseases by combining machine learning with an extreme gradient boosting (XGBoost) algorithm with complete mass spectrum information from the urinary proteomics.MethodsWe enrolled 134 patients (including those with IgA nephropathy, membranous nephropathy, and diabetic kidney disease) and 68 healthy participants as a control, and for training and validation of the diagnostic model, applied a total of 610,102 mass spectra from their urinary proteomics produced using high-resolution mass spectrometry. We divided the mass spectrum data into a training dataset (80%) and a validation dataset (20%). The training dataset was directly used to create a diagnosis model using XGBoost, random forest (RF), a support vector machine (SVM), and artificial neural networks (ANNs). The diagnostic accuracy was evaluated using a confusion matrix. We also constructed the receiver operating-characteristic, Lorenz, and gain curves to evaluate the diagnosis model.ResultsCompared with RF, the SVM, and ANNs, the modified XGBoost model, called a Kidney Disease Classifier (KDClassifier), showed the best performance. The accuracy of the diagnostic XGBoost model was 96.03% (CI = 95.17%-96.77%; Kapa = 0.943; McNemar’s Test, P value = 0.00027). The area under the curve of the XGBoost model was 0.952 (CI = 0.9307-0.9733). The Kolmogorov-Smirnov (KS) value of the Lorenz curve was 0.8514. The Lorenz and gain curves showed the strong robustness of the developed model.ConclusionsThis study presents the first XGBoost diagnosis model, i.e., the KDClassifier, combined with complete mass spectrum information from the urinary proteomics for distinguishing different kidney diseases. KDClassifier achieves a high accuracy and robustness, providing a potential tool for the classification of all types of kidney diseases.

scholarly journals Phybrata Sensors and Machine Learning for Enhanced Neurophysiological Diagnosis and Treatment

Sensors ◽  
2021 ◽  
Vol 21 (21) ◽  
pp. 7417
Author(s):  
Alex J. Hope ◽  
Utkarsh Vashisth ◽  
Matthew J. Parker ◽  
Andreas B. Ralston ◽  
Joshua M. Roper ◽  
...  
Keyword(s):  
Machine Learning ◽  
Time Series ◽  
Random Forest ◽  
Binary Classification ◽  
Classification Performance ◽  
Support Vector ◽  
Use Case ◽  
Signal Features ◽  
Test Population

Concussion injuries remain a significant public health challenge. A significant unmet clinical need remains for tools that allow related physiological impairments and longer-term health risks to be identified earlier, better quantified, and more easily monitored over time. We address this challenge by combining a head-mounted wearable inertial motion unit (IMU)-based physiological vibration acceleration (“phybrata”) sensor and several candidate machine learning (ML) models. The performance of this solution is assessed for both binary classification of concussion patients and multiclass predictions of specific concussion-related neurophysiological impairments. Results are compared with previously reported approaches to ML-based concussion diagnostics. Using phybrata data from a previously reported concussion study population, four different machine learning models (Support Vector Machine, Random Forest Classifier, Extreme Gradient Boost, and Convolutional Neural Network) are first investigated for binary classification of the test population as healthy vs. concussion (Use Case 1). Results are compared for two different data preprocessing pipelines, Time-Series Averaging (TSA) and Non-Time-Series Feature Extraction (NTS). Next, the three best-performing NTS models are compared in terms of their multiclass prediction performance for specific concussion-related impairments: vestibular, neurological, both (Use Case 2). For Use Case 1, the NTS model approach outperformed the TSA approach, with the two best algorithms achieving an F1 score of 0.94. For Use Case 2, the NTS Random Forest model achieved the best performance in the testing set, with an F1 score of 0.90, and identified a wider range of relevant phybrata signal features that contributed to impairment classification compared with manual feature inspection and statistical data analysis. The overall classification performance achieved in the present work exceeds previously reported approaches to ML-based concussion diagnostics using other data sources and ML models. This study also demonstrates the first combination of a wearable IMU-based sensor and ML model that enables both binary classification of concussion patients and multiclass predictions of specific concussion-related neurophysiological impairments.

scholarly journals Support Vector Machines in Big Data Classification: A Systematic Literature Review

2021 ◽  
Author(s):  
Mohammad Hassan Almaspoor ◽  
Ali Safaei ◽  
Afshin Salajegheh ◽  
Behrouz Minaei-Bidgoli
Keyword(s):  
Machine Learning ◽  
Big Data ◽  
Large Scale ◽  
Support Vector ◽  
Research Areas ◽  
Large Scale Data ◽  
Training Samples ◽  
Big Data Classification ◽  
Scale Data

Abstract Classification is one of the most important and widely used issues in machine learning, the purpose of which is to create a rule for grouping data to sets of pre-existing categories is based on a set of training sets. Employed successfully in many scientific and engineering areas, the Support Vector Machine (SVM) is among the most promising methods of classification in machine learning. With the advent of big data, many of the machine learning methods have been challenged by big data characteristics. The standard SVM has been proposed for batch learning in which all data are available at the same time. The SVM has a high time complexity, i.e., increasing the number of training samples will intensify the need for computational resources and memory. Hence, many attempts have been made at SVM compatibility with online learning conditions and use of large-scale data. This paper focuses on the analysis, identification, and classification of existing methods for SVM compatibility with online conditions and large-scale data. These methods might be employed to classify big data and propose research areas for future studies. Considering its advantages, the SVM can be among the first options for compatibility with big data and classification of big data. For this purpose, appropriate techniques should be developed for data preprocessing in order to covert data into an appropriate form for learning. The existing frameworks should also be employed for parallel and distributed processes so that SVMs can be made scalable and properly online to be able to handle big data.

A Comparison of Machine Learning Algorithms for the Segmentation and Classification of Snow Micro Penetrometer Profiles on Arctic Sea Ice

2021 ◽  
Author(s):  
Julia Kaltenborn ◽  
Viviane Clay ◽  
Amy R. Macfarlane ◽  
Joshua Michael Lloyd King ◽  
Martin Schneebeli
Keyword(s):  
Machine Learning ◽  
Sea Ice ◽  
Arctic Sea Ice ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
Support Vector ◽  
Snow Layer ◽  
Arctic Sea ◽  
Execution Speed

<p>Snow-layer classification is an essential diagnostic task for a wide variety of cryospheric science and climate research applications. Traditionally, these measurements are made in snow pits, requiring trained operators and a substantial time commitment. The SnowMicroPen (SMP), a portable high-resolution snow penetrometer, has been demonstrated as a capable tool for rapid snow grain classification and layer type segmentation through statistical inversion of its mechanical signal. The manual classification of the SMP profiles requires time and training and becomes infeasible for large datasets.</p><p>Here, we introduce a novel set of SMP measurements collected during the MOSAiC expedition and apply Machine Learning (ML) algorithms to automatically classify and segment SMP profiles of snow on Arctic sea ice. To this end, different supervised and unsupervised ML methods, including Random Forests, Support Vector Machines, Artificial Neural Networks, and k-means Clustering, are compared. A subsequent segmentation of the classified data results in distinct layers and snow grain markers for the SMP profiles. The models are trained with the dataset by King et al. (2020) and the MOSAiC SMP dataset. The MOSAiC dataset is a unique and extensive dataset characterizing seasonal and spatial variation of snow on the central Arctic sea-ice.</p><p>We will test and compare the different algorithms and evaluate the algorithms’ effectiveness based on the need for initial dataset labeling, execution speed, and ease of implementation. In particular, we will compare supervised to unsupervised methods, which are distinguished by their need for labeled training data.</p><p>The implementation of different ML algorithms for SMP profile classification could provide a fast and automatic grain type classification and snow layer segmentation. Based on the gained knowledge from the algorithms’ comparison, a tool can be built to provide scientists from different fields with an immediate SMP profile classification and segmentation. </p><p> </p><p>King, J., Howell, S., Brady, M., Toose, P., Derksen, C., Haas, C., & Beckers, J. (2020). Local-scale variability of snow density on Arctic sea ice. <em>The Cryosphere</em>, <em>14</em>(12), 4323-4339, https://doi.org/10.5194/tc-14-4323-2020.</p>

Using Remote Monitoring and Machine Learning to Classify Slam Events of Wave Piercing Catamarans

2021 ◽  
Vol 163 (A3) ◽  
Author(s):  
B Shabani ◽  
J Ali-Lavroff ◽  
D S Holloway ◽  
S Penev ◽  
D Dessi ◽  
...  
Keyword(s):  
Machine Learning ◽  
Monitoring System ◽  
Probability Distributions ◽  
Feature Space ◽  
Support Vector ◽  
Acceleration Threshold ◽  
Vector Machines ◽  
Structural Responses ◽  
As Stress

An onboard monitoring system can measure features such as stress cycles counts and provide warnings due to slamming. Considering current technology trends there is the opportunity of incorporating machine learning methods into monitoring systems. A hull monitoring system has been developed and installed on a 111 m wave piercing catamaran (Hull 091) to remotely monitor the ship kinematics and hull structural responses. Parallel to that, an existing dataset of a similar vessel (Hull 061) was analysed using unsupervised and supervised learning models; these were found to be beneficial for the classification of bow entry events according to key kinematic parameters. A comparison of different algorithms including linear support vector machines, naïve Bayes and decision tree for the bow entry classification were conducted. In addition, using empirical probability distributions, the likelihood of wet-deck slamming was estimated given a vertical bow acceleration threshold of 1  in head seas, clustering the feature space with the approximate probabilities of 0.001, 0.030 and 0.25.

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