scholarly journals Toxicity of Thallium at Low Doses: A Review

2019 ◽  
Vol 16 (23) ◽  
pp. 4732 ◽  
Author(s):  
Beatrice Campanella ◽  
Laura Colombaioni ◽  
Edoardo Benedetti ◽  
Agostino Di Ciaula ◽  
Lisa Ghezzi ◽  
...  
Keyword(s):  
Human Health ◽  
Cell Cultures ◽  
Chronic Exposure ◽  
Biological Effects ◽  
Contaminated Water ◽  
Severe Toxicity ◽  
Low Doses ◽  
Regulatory Issues ◽  
Scientific Opinion

A mini review of the toxicity of Thallium (Tl) at low doses is herein presented. Thallium has severe toxicity. Although its acute biological effects have been widely investigated and are well known, its biological effects on human health and in cell cultures at low doses (<100 μg/L) due, for example, to Tl chronic exposure via consumption of contaminated water or foods, have often been overlooked or underestimated. Relatively few papers have been published on this topic and are herein reviewed to provide a focused scientific opinion in the light of current worldwide regulatory issues.

EPEGENTIC TOXICOLOGY: PERSPECTIVES OF THE DEVELOPMENT

2018 ◽  
pp. 2-7
Author(s):  
G. A. Sofronov ◽  
E. L. Patkin
Keyword(s):  
Public Health ◽  
Life Cycle ◽  
Human Health ◽  
Chronic Exposure ◽  
Environmental Pollutants ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Mechanism Of Formation ◽  
Health Disorders ◽  
Time Periods

One of the complex problems of modern experimental toxicology remains the molecular mechanism of formation of human health disorders separated at different time periods from acute or chronic exposure to toxic environmental pollutants (ecotoxicants). Identifying and understanding what epigenetic changes are induced by the environment, and how they can lead to unfavorable outcome, are vital for protecting public health. Therefore, we consider it important a modern understanding of epigenetic mechanisms involved in the life cycle of mammals and assess available data on the environmentally caused epigenetic toxicity and, accordingly fledging epigenenomic (epigenetic) regulatory toxicology.

Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock

2012 ◽  
Vol 38 (8) ◽  
pp. 1306-1314 ◽  
Author(s):  
Bruno Laviolle ◽  
Djillali Annane ◽  
Claire Fougerou ◽  
Eric Bellissant
Keyword(s):  
Septic Shock ◽  
Day Treatment ◽  
Biological Effects ◽  
Low Doses

scholarly journals Dietary Isoflavones: Biological Effects and Relevance to Human Health

1999 ◽  
Vol 129 (3) ◽  
pp. 758S-767S ◽  
Author(s):  
Kenneth D. R. Setchell ◽  
Aedin Cassidy
Keyword(s):  
Human Health ◽  
Biological Effects

Bupivacaine and levobupivacaine induce apoptosis in rat chondrocyte cell cultures at ultra-low doses

2013 ◽  
Vol 24 (3) ◽  
pp. 291-295 ◽  
Author(s):  
Irfan Gungor ◽  
Akin Yilmaz ◽  
Akif Muhtar Ozturk ◽  
Mehmet Ali Ergun ◽  
Sevda Menevse ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Low Doses

Technological Interventions in Management of Hg Contaminated Water

2018 ◽  
pp. 126-140
Author(s):  
Vidushi Abrol ◽  
Sharada Mallubhotla ◽  
Sundeep Jaglan
Keyword(s):  
Human Health ◽  
Cost Effective ◽  
Industrial Wastes ◽  
Mercury Contamination ◽  
Contaminated Water ◽  
Treatment Techniques ◽  
Innovative Methods ◽  
Technological Interventions ◽  
Treatment Technologies ◽  
Ancient Times

Rising cases of environmental mercury hazards has led to a need for cost-effective mercury treatment techniques. Extensive use of mercury from ancient times has resulted in water contamination that may require remediation. Mercury contamination is tedious to treat and may pose a risk to human health and the environment. To deal with this threat of mercury contamination, industrial wastes and wastewaters containing mercury requires treatment for its removal and immobilization. This chapter provides a synopsis of the availability, performance, and technologies for management of mercury in water. It covers the innovative methods to treat the mercury contamination like biosorption. In this chapter, the technological aspects available for the mercury treatment technologies are reviewed. It describes the theory, design, and operation of the technologies; provides information on commercial availability and use; and includes data on performance, where available.

Early Indicators of Nitrate Stress; Effects to Ecosystems of Chronic Exposure to Low Doses of Bioavailable Nitrogen

2002 ◽  
Vol 2002 (8) ◽  
pp. 859-888 ◽  
Author(s):  
Eric E. Jorgensen ◽  
Paul M. Mayer ◽  
Ann E. West ◽  
Mary E. Gonsoulin ◽  
Susan J. Tunnell ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Low Doses ◽  
Stress Effects ◽  
Early Indicators

scholarly journals A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafish

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sophia Murat El Houdigui ◽  
Christelle Adam-Guillermin ◽  
Giovanna Loro ◽  
Caroline Arcanjo ◽  
Sandrine Frelon ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Nuclear Power ◽  
Muscle Development ◽  
Low Dose ◽  
Neuromuscular Junctions ◽  
Biological Effects ◽  
Cardiac Activity ◽  
Developmental Defects ◽  
Dose Rates ◽  
Larval Behaviour

AbstractContamination of the environment after the Chernobyl and Fukushima Daiichi nuclear power plant (NPP) disasters led to the exposure of a large number of humans and wild animals to radioactive substances. However, the sub-lethal consequences induced by these absorbed radiological doses remain understudied and the long-term biological impacts largely unknown. We assessed the biological effects of chronic exposure to ionizing radiation (IR) on embryonic development by exposing zebrafish embryo from fertilization and up to 120 hours post-fertilization (hpf) at dose rates of 0.5 mGy/h, 5 mGy/h and 50 mGy/h, thereby encompassing the field of low dose rates defined at 6 mGy/h. Chronic exposure to IR altered larval behaviour in a light-dark locomotor test and affected cardiac activity at a dose rate as low as 0.5 mGy/h. The multi-omics analysis of transcriptome, proteome and transcription factor binding sites in the promoters of the deregulated genes, collectively points towards perturbations of neurogenesis, muscle development, and retinoic acid (RA) signaling after chronic exposure to IR. Whole-mount RNA in situ hybridization confirmed the impaired expression of the transcription factors her4.4 in the central nervous system and myogenin in the developing muscles of exposed embryos. At the organ level, the assessment of muscle histology by transmission electron microscopy (TEM) demonstrated myofibers disruption and altered neuromuscular junctions in exposed larvae at 5 mGy/h and 50 mGy/h. The integration of these multi-level data demonstrates that chronic exposure to low dose rates of IR has an impact on neuronal and muscle progenitor cells, that could lead to motility defects in free swimming larvae at 120 hpf. The mechanistic understanding of these effects allows us to propose a model where deregulation of RA signaling by chronic exposure to IR has pleiotropic effects on neurogenesis and muscle development.

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