EPEGENTIC TOXICOLOGY: PERSPECTIVES OF THE DEVELOPMENT

2018 ◽  
pp. 2-7
Author(s):  
G. A. Sofronov ◽  
E. L. Patkin
Keyword(s):  
Public Health ◽  
Life Cycle ◽  
Human Health ◽  
Chronic Exposure ◽  
Environmental Pollutants ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Mechanism Of Formation ◽  
Health Disorders ◽  
Time Periods

One of the complex problems of modern experimental toxicology remains the molecular mechanism of formation of human health disorders separated at different time periods from acute or chronic exposure to toxic environmental pollutants (ecotoxicants). Identifying and understanding what epigenetic changes are induced by the environment, and how they can lead to unfavorable outcome, are vital for protecting public health. Therefore, we consider it important a modern understanding of epigenetic mechanisms involved in the life cycle of mammals and assess available data on the environmentally caused epigenetic toxicity and, accordingly fledging epigenenomic (epigenetic) regulatory toxicology.

scholarly journals Human Health, Economic and Environmental Assessment of Onsite Non-Potable Water Reuse Systems for a Large, Mixed-Use Urban Building

2020 ◽  
Vol 12 (13) ◽  
pp. 5459
Author(s):  
Sam Arden ◽  
Ben Morelli ◽  
Mary Schoen ◽  
Sarah Cashman ◽  
Michael Jahne ◽  
...  
Keyword(s):  
Public Health ◽  
Life Cycle ◽  
Human Health ◽  
Life Cycle Cost ◽  
Water Reuse ◽  
Energy Demand ◽  
Membrane Bioreactor ◽  
Thermal Recovery ◽  
Hot Water ◽  
Quantitative Microbial Risk Assessment

Onsite non-potable reuse (NPR) is being increasingly considered as a viable option to address water scarcity and infrastructure challenges, particularly at the building scale. However, there are a range of possible treatment technologies, source water options, and treatment system sizes, each with its unique costs and benefits. While demonstration projects are proving that these systems can be technologically feasible and protective of public health, little guidance exists for identifying systems that balance public health protection with environmental and economic performance. This study uses quantitative microbial risk assessment, life cycle assessment and life cycle cost analysis to characterize the human health, environmental and economic aspects of onsite NPR systems. Treatment trains for both mixed wastewater and source-separated graywater were modeled using a core biological process—an aerobic membrane bioreactor (AeMBR), an anaerobic membrane bioreactor (AnMBR) or recirculating vertical flow wetland (RVFW)—and additional treatment and disinfection unit processes sufficient to meet current health-based NPR guidelines. Results show that the graywater AeMBR system designed to provide 100% of onsite non-potable demand results in the lowest impacts across most environmental and human health metrics considered but costs more than the mixed-wastewater version due to the need for a separate collection system. The use of multiple metrics also allows for identification of weaknesses in systems that lead to burden shifting. For example, although the RVFW process requires less energy than the AeMBR process, the RVFW system is more environmentally impactful and costly when considering the additional unit processes required to protect human health. Similarly, we show that incorporation of thermal recovery units to reduce hot water energy consumption can offset some environmental impacts but result in increases to others, including cumulative energy demand. Results demonstrate the need for additional data on the pathogen treatment performance of NPR systems to inform NPR health guidance.

Chronic exposure to inorganic mercury induces biochemical and morphological changes in the salivary glands of rats

Metallomics ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 1271-1278 ◽  
Author(s):  
W. A. B. Aragão ◽  
N. M. M. da Costa ◽  
N. C. F. Fagundes ◽  
M. C. F. Silva ◽  
S. M. Alves-Junior ◽  
...  
Keyword(s):  
Public Health ◽  
Salivary Glands ◽  
Human Health ◽  
Health Problem ◽  
Chronic Exposure ◽  
Morphological Changes ◽  
Inorganic Mercury ◽  
Public Health Problem ◽  
Mercury Exposure ◽  
Toxic Effects

Mercury exposure is considered to be a public health problem due to the generation of toxic effects on human health as a result of environmental and occupational conditions.

Epigenetics, Nutrition, Disease and Drug Development

2019 ◽  
Vol 16 (4) ◽  
pp. 386-391 ◽  
Author(s):  
Kenneth Lundstrom
Keyword(s):  
Dna Methylation ◽  
Drug Discovery ◽  
Rna Interference ◽  
Nutritional Requirements ◽  
Signal Pathways ◽  
Disease Development ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Health And Disease ◽  
Novel Drug

Epigenetic mechanisms comprising of DNA methylation, histone modifications and gene silencing by RNA interference have been strongly linked to the development and progression of various diseases. These findings have triggered research on epigenetic functions and signal pathways as targets for novel drug discovery. Dietary intake has also presented significant influence on human health and disease development and nutritional modifications have proven important in prevention, but also the treatment of disease. Moreover, a strong link between nutrition and epigenetic changes has been established. Therefore, in attempts to develop novel safer and more efficacious drugs, both nutritional requirements and epigenetic mechanisms need to be addressed.

COVID-19 Epigenetics and Implications for Public Health

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Verda Tunalıgil ◽  
Gülsen Meral ◽  
Ahmet Katı ◽  
Dhrubajyoti Chattopadhyay ◽  
Amit Kumar Mandal
Keyword(s):  
Chronic Conditions ◽  
Empirical Investigation ◽  
Age Groups ◽  
Infectious Agent ◽  
Well Being ◽  
Epigenetic Mechanisms ◽  
Age Group ◽  
Epigenetic Changes ◽  
Patient Groups ◽  
Epigenetic Processes

Abstract:: Epigenetic changes in COVID-19 host, a pandemic-causing infectious agent that globally incapacitated communities in varying complexities and capacities are discussed, proposing an analogy that epigenetic processes contribute to disease severity and elevate the risk for death from infection. Percentages of hospitalization, with and without intensive care, in the presence of diseases with increased ACE2 expression, were compared, based on the best available data. Further analysis compared two different age groups, 19-64 and ≥65 years of age. The COVID-19 disease is observed to be the most severe in the 65-and-higher-age group with preexisting chronic conditions. This observational study is a non-experimental empirical investigation of the outcomes of COVID-19 in different patient groups. Results are promising for conducting clinical trials with intervention groups. To ultimately succeed in disease prevention, researchers and clinicians must integrate epigenetic mechanisms to generate valid prescriptions for global well-being.

EU Health Law & Policy

2019 ◽  
Author(s):  
Anniek de Ruijter
Keyword(s):  
Public Health ◽  
Health Care ◽  
Human Health ◽  
Fundamental Rights ◽  
The European Union ◽  
Health Issues ◽  
Division Of Powers ◽  
Legal Principle ◽  
Legal Competence ◽  
The Eu

This book describes the expansion of EU power in health care and public health and analyses the implications of this expansion on EU health values and rights. The main conclusion of the book is that the EU is de facto balancing fundamental rights and values relating to health, implicitly taking on obligations for safeguarding fundamental rights in the field of health and affecting individuals’ rights sometimes without an explicit legal competence to do so. This brings to light instances where EU health policy has implications for fundamental rights and values without the possibility to challenge the exercise of power of the EU in human health. This begs the question of whether subsidiarity is still the most relevant legal principle for the division of powers and tasks among the Member States, particularly when EU policy and law involves the politically sensitive areas of health care and public health. This question draws out the parameter for continuing the debate on the role of the European Union in promoting its own values and the wellbeing of its peoples, in light of its ever-growing role in human health issues.

scholarly journals Biodiversity and Health in the Urban Environment

2021 ◽  
Author(s):  
Melissa R. Marselle ◽  
Sarah J. Lindley ◽  
Penny A. Cook ◽  
Aletta Bonn
Keyword(s):  
Public Health ◽  
Human Health ◽  
Urban Policy ◽  
Policy Research ◽  
Well Being ◽  
Ecosystem Functions ◽  
Natural Environments ◽  
Positive Health ◽  
Causal Pathways ◽  
Health And Well Being

Abstract Purpose of review Biodiversity underpins urban ecosystem functions that are essential for human health and well-being. Understanding how biodiversity relates to human health is a developing frontier for science, policy and practice. This article describes the beneficial, as well as harmful, aspects of biodiversity to human health in urban environments. Recent findings Recent research shows that contact with biodiversity of natural environments within towns and cities can be both positive and negative to human physical, mental and social health and well-being. For example, while viruses or pollen can be seriously harmful to human health, biodiverse ecosystems can promote positive health and well-being. On balance, these influences are positive. As biodiversity is declining at an unprecedented rate, research suggests that its loss could threaten the quality of life of all humans. Summary A key research gap is to understand—and evidence—the specific causal pathways through which biodiversity affects human health. A mechanistic understanding of pathways linking biodiversity to human health can facilitate the application of nature-based solutions in public health and influence policy. Research integration as well as cross-sector urban policy and planning development should harness opportunities to better identify linkages between biodiversity, climate and human health. Given its importance for human health, urban biodiversity conservation should be considered as public health investment.

Chronic Exposure to Air Pollution and Risk of Mental Health Disorders Complicating Pregnancy

2021 ◽  
pp. 110937
Author(s):  
Jenna Kanner ◽  
Anna Z. Pollack ◽  
Shamika Ranasinghe ◽  
Danielle R. Stevens ◽  
Carrie Nobles ◽  
...  
Keyword(s):  
Mental Health ◽  
Air Pollution ◽  
Chronic Exposure ◽  
Mental Health Disorders ◽  
Health Disorders

scholarly journals Climate Change and Health Preparedness in Africa: Analysing Trends in Six African Countries

2021 ◽  
Vol 18 (9) ◽  
pp. 4672
Author(s):  
Samuel Kwasi Opoku ◽  
Walter Leal Filho ◽  
Fudjumdjum Hubert ◽  
Oluwabunmi Adejumo
Keyword(s):  
Public Health ◽  
Climate Change ◽  
South Africa ◽  
Human Health ◽  
Health Systems ◽  
Health Professionals ◽  
Health Problems ◽  
Sub Saharan Africa ◽  
Basic Knowledge ◽  
African Countries

Climate change is a global problem, which affects the various geographical regions at different levels. It is also associated with a wide range of human health problems, which pose a burden to health systems, especially in regions such as Africa. Indeed, across the African continent public health systems are under severe pressure, partly due to their fragile socioeconomic conditions. This paper reports on a cross-sectional study in six African countries (Ghana, Nigeria, South Africa, Namibia, Ethiopia, and Kenya) aimed at assessing their vulnerabilities to climate change, focusing on its impacts on human health. The study evaluated the levels of information, knowledge, and perceptions of public health professionals. It also examined the health systems’ preparedness to cope with these health hazards, the available resources, and those needed to build resilience to the country’s vulnerable population, as perceived by health professionals. The results revealed that 63.1% of the total respondents reported that climate change had been extensively experienced in the past years, while 32% claimed that the sampled countries had experienced them to some extent. Nigerian respondents recorded the highest levels (67.7%), followed by Kenya with 66.6%. South Africa had the lowest level of impact as perceived by the respondents (50.0%) when compared with the other sampled countries. All respondents from Ghana and Namibia reported that health problems caused by climate change are common in the two countries. As perceived by the health professionals, the inadequate resources reiterate the need for infrastructural resources, medical equipment, emergency response resources, and technical support. The study’s recommendations include the need to improve current policies at all levels (i.e., national, regional, and local) on climate change and public health and to strengthen health professionals’ skills. Improving the basic knowledge of health institutions to better respond to a changing climate is also recommended. The study provides valuable insights which may be helpful to other nations in Sub-Saharan Africa.

scholarly journals Exploring sustainability potentials in vineyards through LCA? Evidence from farming practices in South Africa

2021 ◽  
Author(s):  
V. Russo ◽  
A. E. Strever ◽  
H. J. Ponstein
Keyword(s):  
South Africa ◽  
Life Cycle Assessment ◽  
Life Cycle ◽  
Human Health ◽  
South African ◽  
Wine Grape ◽  
Impact Categories ◽  
Farming Practices ◽  
Manual Labour ◽  
The Impact

Abstract Purpose Following the urgency to curb environmental impacts across all sectors globally, this is the first life cycle assessment of different wine grape farming practices suitable for commercial conventional production in South Africa, aiming at better understanding the potentials to reduce adverse effects on the environment and on human health. Methods An attributional life cycle assessment was conducted on eight different scenarios that reduce the inputs of herbicides and insecticides compared against a business as usual (BAU) scenario. We assess several impact categories based on ReCiPe, namely global warming potential, terrestrial acidification, freshwater eutrophication, terrestrial toxicity, freshwater toxicity, marine toxicity, human carcinogenic toxicity and human non-carcinogenic toxicity, human health and ecosystems. A water footprint assessment based on the AWARE method accounts for potential impacts within the watershed. Results and discussion Results show that in our impact assessment, more sustainable farming practices do not always outperform the BAU scenario, which relies on synthetic fertiliser and agrochemicals. As a main trend, most of the impact categories were dominated by energy requirements of wine grape production in an irrigated vineyard, namely the usage of electricity for irrigation pumps and diesel for agricultural machinery. The most favourable scenario across the impact categories provided a low diesel usage, strongly reduced herbicides and the absence of insecticides as it applied cover crops and an integrated pest management. Pesticides and heavy metals contained in agrochemicals are the main contributors to emissions to soil that affected the toxicity categories and impose a risk on human health, which is particularly relevant for the manual labour-intensive South African wine sector. However, we suggest that impacts of agrochemicals on human health and the environment are undervalued in the assessment. The 70% reduction of toxic agrochemicals such as Glyphosate and Paraquat and the 100% reduction of Chlorpyriphos in vineyards hardly affected the model results for human and ecotoxicity. Our concerns are magnified by the fact that manual labour plays a substantial role in South African vineyards, increasing the exposure of humans to these toxic chemicals at their workplace. Conclusions A more sustainable wine grape production is possible when shifting to integrated grape production practices that reduce the inputs of agrochemicals. Further, improved water and related electricity management through drip irrigation, deficit irrigation and photovoltaic-powered irrigation is recommendable, relieving stress on local water bodies, enhancing drought-preparedness planning and curbing CO2 emissions embodied in products.

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