scholarly journals Interactions of Cortisol and Prolactin with Other Selected Menstrual Cycle Hormones Affecting the Chances of Conception in Infertile Women

2020 ◽  
Vol 17 (20) ◽  
pp. 7537
Author(s):  
Artur Wdowiak ◽  
Dorota Raczkiewicz ◽  
Paula Janczyk ◽  
Iwona Bojar ◽  
Marta Makara-Studzińska ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Follicle Stimulating Hormone ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Infertile Women ◽  
The Third ◽  
Potential Factors ◽  
Infertile Group ◽  
Present Understanding ◽  
Stimulating Hormone

One of the major problems of success in infertility treatment could depend on the understanding how the potential factors may affect the conception. The aim of this study was to evaluate present understanding of such factors or hormonal causes that may induce infertility. We studied the interactions between the two menstrual cycle hormones i.e., cortisol (COR) and prolactin (PRL), along with the ultrasonographic ovulation parameters in a group of N = 205 women with diagnosed infertility. The control group consisted of N = 100 women with confirmed fertility. In both groups, follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), thyroid stimulating hormone (TSH), PRL, COR were examined on the third day of the cycle, and estradiol (E2), progesterone (P), and COR were examined during ovulation and 7-days afterwards. In the infertile group, higher levels of PRL and COR were observed than that of in the control group. Cortisol levels at all phases of the menstrual cycle and PRL negatively correlated with E2 secretion during and after ovulation, thus contributed to the attenuation of the ovulatory LH surge. Infertile women who conceived presented with higher levels of E2 during and after ovulation, higher P after ovulation, and thicker endometrium than that of the women who failed to conceive. In conclusion, elevated secretion of COR and PRL in infertile women impairs the menstrual cycle by decreasing the pre-ovulatory LH peak and E2 and postovulatory E2 levels that affect the endometrial growth, and consequently reduce the chances to conceive.

scholarly journals Evaluation the levels of some hormones in women with polycystic ovary syndrome

2019 ◽  
Vol 24 (5) ◽  
pp. 25
Author(s):  
Namareq Ata allah Mohemeed1 ◽  
Firas Shawki Abdul-razzak2
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Control Group ◽  
Age Group ◽  
Ovary Syndrome ◽  
Blood Samples ◽  
Healthy Women ◽  
Stimulating Hormone

This study was conducted on 40 Samples of Patients with polycystic ovary syndrome (PCOS) after their diagnosis, The study aimed to identify the most important  hormonal disorders associated  with  this syndrome . The study begins from Octobar 2017 to March 2018 , the age from(19-45) years .Blood samples were taken during the (2-4( days of menstrual cycle and the selected samples were compared with 20 healthy women as control group ,and the following hormones were evaluated Luteninzing hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin (PRL),Testosterone (Testo) and Oxytocin (OX) ,the study showed a high significant in the concentrations of OX ,Testo and LH (P≤0.01) , a high significant in the PRL concentration (P≤0.05) and a high significant in the FSH concentration (P≤0.05(,the results were distributed to three groups according to BMI ,age and treatment, in term BMI it was divided into three groups, BMI(18.5-24.9)(25.0-29.9) (≥30)kg/m2 the results showed a high significant (P≤0.05)  in the LH and OX concentration in  group BMI (18.5-24.9)kg/m2 and in both PRL and Testo in group BMI(≥30)kg/m2. in term age, it was divided into three groups (19-26) (27-35) (36-45)years, the results showed a high significant (P≤0.05) in LH  and Testo concentration at age group (36-45)years ,compared to other groups, and a high significant (P≤0.05) in both PRL and OX, between three group of age , treatment it was divided  into three groups of metformin, progesterone contraceptive used and non-used of the treatment .the results showed a high significant (P≤0.05) in LH, PRL, OX and Testo concentrations, and a high significant (P≤0.05) of FSH in women treated compared with non-used  .   http://dx.doi.org/10.25130/tjps.24.2019.085

scholarly journals Hormonal evaluation of infertile women in Border Guard Hospital, Peelkhana, Dhaka

2015 ◽  
Vol 10 (1) ◽  
pp. 34-38
Author(s):  
Nahid Reaz Shapla ◽  
Liza Chowdhury ◽  
Rokeya Khan ◽  
Syed Nurun Nabi ◽  
Sharmeen Sultana ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary ◽  
Armed Forces ◽  
Thyroid Stimulating Hormone ◽  
Western World ◽  
Reference Levels ◽  
Free Triiodothyronine ◽  
Infertile Women ◽  
The Mean ◽  
Stimulating Hormone

Introduction: Infertility is very often observed in women. It is the failure to conceive after one year of regular unprotected coitus. Data from population based studies suggest that 10-15% couples in the western world experience infertility. Infertility can be caused by a number of factors. Hormonal problems are amongst the important factors contributing to female infertility. Aim: The aim of this study was to ascertain the FSH(Follicle Stimulating Hormone), LH(Leuteinizing Hormone), Prolactin, Testosterone, FT3(Free Triiodothyronine), FT4(Free Thyroxine), TSH(Thyroid Stimulating Hormone) and Oestradiol levels in infertile women. Methods: This observational study was carried out over a period of 1 year from June 2012 to May 2013 on 110 infertile women who reported to Gynae OPD(Out-Patient Department) in Border Guard Hospital, Dhaka. Blood samples of the subjects were taken on 2nd day of menstruation of regular menstrual cycle and on first visit of women having irregular menstrual cycle. Different hormonal studies were done by IMMULITE immunoassay. Semen analyses of their husbands were found to be normal. The results obtained were compared with the reference levels. Results: Among 110 infertile women, 86.37% cases were of primary infertility and 13.63% were 34 JAFMC Bangladesh. Vol 10, No 1 (June) 2014 of secondary infertility. In this study on infertile women majority (34.54%) of the cases of infertility were having PCODs(Polycystic Ovary Disease), others were of hypothyroidism (23.6%) and hyperprolactinaemia was found in 19.09% cases. Both PCODs and hypothyroidism were found in 6.36% cases and no abnormality was detected in 16.36% cases. The Mean ± SD of different hormonal levels were: FSH 2.58±1.63, LH 10.20±4.36, prolactin 61.17±1158 and testosterone 140±34.22 respectively. The mean ± SD of measured hormone levels were compared with reference levels of different hormones by using student t test. In case of FSH, LH, TSH, prolactin, testosterone, FT4 and Oestradiol the difference were statistically significant (P<0.01) but for FT3 was not statistically significant. Conclusion: In this study, PCOD was found to be the most common cause of infertility and other causes found were hyperprolactinaemia and hypothyroidism. DOI: http://dx.doi.org/10.3329/jafmc.v10i1.22902 Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014

Combined study on the single nucleotide polymorphisms in the follicle-stimulating hormone receptor (Ser680Asn) and anti-Müllerian hormone receptor type II (−482A>G) as genetic markers in assisted reproduction

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Ioannis G. Papanikolaou ◽  
Polina Giannelou ◽  
Elli Anagnostou ◽  
Despoina Mavrogianni ◽  
Petros Drakakis ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Gene Polymorphisms ◽  
Follicle Stimulating Hormone ◽  
Average Concentration ◽  
In Vitro Fertilisation ◽  
Control Group ◽  
Type Ii ◽  
Infertile Women ◽  
Stimulating Hormone

Abstract Background Infertile women may have underlying genetic abnormalities. There is, at present, a significant number of studies on the relation between the follicle stimulating hormone receptor (FSHR) or anti-Müllerian hormone type II receptor (AMHRII) polymorphisms and response to in-vitro fertilisation (IVF) treatment. However, it is not yet clear which genotype or combination of genotypes is favourable towards a better ovarian stimulation and pregnancy outcome. Materials and methods In this study we assessed the distribution of the genotypes of FSHR Ser680Asn and of AMHRII −482A>G gene polymorphisms in a group of 126 infertile women and a control group of 100 fertile women by using real-time polymerase chain reaction (RT-PCR). Results Statistical analysis showed that the frequency of the genotypes is similar in both control and IVF/ intracytoplasmic sperm injection (ICSI) groups. Further investigation of the frequency of the nine possible combinations of these polymorphisms in the groups revealed no correlation between infertility and combination of the polymorphisms. Women with one polymorphism have on average 5.5 units higher levels of AMH compared to women carrying no polymorphism. In women with no polymorphisms, for each unit of FSH increase, the average concentration of blood AMH is expected to be 72% lower. Conclusion The distribution of the FSHR Ser680Asn and of the AMHRII −482A>G gene polymorphisms, in the Greek population is similar in fertile and infertile women. The study showed that FSH and AMH correlated levels in certain cases could be used to estimate a patient’s ovarian reserve.

scholarly journals Significance of hyperprolactinemia for cytomorphologic features of breast secretions

2010 ◽  
Vol 67 (1) ◽  
pp. 42-47
Author(s):  
Danijela Radojkovic ◽  
Slobodan Antic ◽  
Milica Pesic ◽  
Milan Radojkovic ◽  
Dijana Basic ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Nipple Discharge ◽  
Thyroid Stimulating Hormone ◽  
Serum Prolactin ◽  
Control Group ◽  
Clinical Group ◽  
Group I ◽  
Stimulating Hormone

Background/Aim. Nipple discharge syndrome is a clinical entity capable of presenting various disorders such is mammary infection (nonpuerperal and puerperal mastitis), intraductal papillomas, fibrodenoma, breast cancer and hyperprolactinemia syndrome. The aim of the study was to determine differencies in cytological features of mammary secretion in patients with hyperprolactinemia and those with normal serum prolactin levels and to define the role of growth hormone, follicle-stimulating hormone, luteinizing hormone and thyroid-stimulating hormone in creating cellular profile of breast secretion. Methods. The study included 50 patients with nipple discharge syndrome. The patients were devided into the clinical group (27 patients with hyperprolactinemia and nipple discharge) and the control group I (23 patients with normal serum prolactin and nipple discharge). The control group II included the patients of the clinical group achiving normalised serum prolactin levels after the treatment of hyperprolactinemia. Serum prolactin, follicle-stimulating hormone and luteinizing hormone levels were assessed by RIA using commercial kits IRMA hPRL, hLH and hFSH, (INEP, Zemun, Serbia) while serum growth hormone and thyroid-stimulating hormone levels were assessed by RIA using commercial kits LKB-wallac. Cytologic evaluation of samples, taken from all the patients with mammary secretion, was done using standard techniques of staining Haemathoxilin-eozine and May- Gr?nwald/Giemsa. Results. Our results showed a significantly higher presence of lipid and protein material in clinical group, in comparison with the control group I (p < 0.01). Also, our data demonstrated significantly higher number of ductal epithelial cells (p < 0.05) and ductal histiocities (p < 0.001) in the clinical group, compared with the control group I. Macrophagies frequency was proportionally higher in clinical group (44.44%) compared the control group I (17.39%). Erythrocites were significantly lower in the clinical group (p < 0.001) than in the control group I. Significantly decreased mammary secretion (p < 0.01), lower lipid (p < 0.01) and protein synthesis (p < 0.01), and less presence of all cellular categories (p < 0.01) were obtained after normalization of serum prolactin levels. Conclusion. Growth hormone, follicle-stimulating hormone, luteinizing hormone and thyroid-stimulating hormone did not show significant influence on creating cytological features of mammary secretion. The most expressive role, hyperprolactinemia demonstrated in the domain of mammary ductal secretory activity, making mammary secretion reach in lipid and protein material and simultaneously increasing number of ductal epithelial cells, ductal histiocytes and 'foam cells'- macrophages. These cytological findings indicate that hyperprolactinemia promote periductal and intraductal steril inflammation which withdraws after serum prolactin normalization.

Influence of Hormones on Sjögren’s Syndrome

2019 ◽  
Vol 24 (35) ◽  
pp. 4167-4176 ◽  
Author(s):  
Liu Yang ◽  
Wei Wei ◽  
Xi He ◽  
Yu Xie ◽  
Mohammad A. Kamal ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Adrenocorticotropic Hormone ◽  
Sjögren's Syndrome ◽  
Follicle Stimulating Hormone ◽  
Hormone Treatment ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Thyroid Stimulating Hormone ◽  
Sjögren‘S Syndrome ◽  
Stimulating Hormone

Sjögren’s syndrome (SS) is an immune system oral disorder that is characterized generally by dry mouth and eyes. In this review, SS classification, presentation and pathogenesis are briefly discussed. Moreover, the epidemiology of SS regarding sex, age and association with other complications are also presented. This review also addresses the interactions between endocrine axes and SS, and the important findings up to regarding hormone treatment of this syndrome. The main hormones discussed in this review includes Adrenocorticotropic hormone (ACTH), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Thyroid-stimulating hormone (TSH), and prolactin.

scholarly journals Effects of l-Carnitine on the Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Testicular Tissue Oxidative Stress Levels in Streptozotocin-Induced Diabetic Rats

2018 ◽  
Vol 23 ◽  
pp. 2515690X1879605 ◽  
Author(s):  
Nourollah Rezaei ◽  
Tahereh Mardanshahi ◽  
Majid Malekzadeh Shafaroudi ◽  
Saeed Abedian ◽  
Hamid Mohammadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Group Vi ◽  
Group I ◽  
Stimulating Hormone

The present study was designed to investigate the antioxidant property of l-carnitine (LC) on serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TH) and testis oxidative stress in streptozotocin (STZ)-induced diabetic rats. The rats were divided into the following groups: group I, control; group II, LC 100 mg/kg/d; group III, diabetic; and groups IV to VI, diabetic rats treated with 50, 100, and 200 mg/kg/d of LC, respectively. Daily injections were given intraperitoneally for 7 weeks. At the end of experimental period, after sacrificing the rats, FSH, LH, TH, total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), mitochondrial function (MTT), protein carbonyl (PC), and reactive oxygen species (ROS) levels were measured. STZ caused an elevation of MDA, ROS, and PC ( P < .001) with reduction of GSH, CAT, TAC, and MTT ( P < .001) in the serum levels. Group VI had significantly increased FSH, LH, and TH levels versus the untreated diabetic group ( P < .001). Although groups V and VI significantly decreased MDA ( P < .001), PC ( P < .01), and ROS ( P < .01) compared with the untreated diabetic group; only in group VI, the activity of GSH ( P < .001), CAT ( P < .01), TAC ( P < .001), and MTT ( P < .001) significantly increased. The results of the present study suggest that LC decreased diabetes-induced oxidative stress complications and also improved serum level of FSH, LH, and TH by reducing levels of lipid peroxidation and increasing antioxidant enzymes.

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