scholarly journals The Association between Neighborhood Disorder and Health: Exploring the Moderating Role of Genotype and Marriage

Author(s):  
Man-Kit Lei ◽  
Ronald L. Simons

The present study extends prior research on the link between neighborhood disorder and health by testing an integrated model that combines various social and biological factors. Hypotheses were tested using a sample of 325 African American women from the Family and Community Health Study (FACHS). As expected, inflammatory burden was the biophysiological mechanism that mediated much of the association between neighborhood physical disorder and perceived physical health. This finding provided additional support for the view that global self-ratings of health are powerful predictors of morbidity because, in large measure, they are indicators of chronic, systemic inflammation. Further, both genetic variation and marital status served to moderate the association between neighborhood disorder and health. Finally, being married largely eliminated the probability that neighborhood disorder would combine with genetic vulnerability to increase inflammatory burden and perceived illness. Overall, the findings demonstrate the value of constructing integrated models that specify various biophysiological mechanisms that link social conditions to physical health.

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Dr. Anuradha Wats

Background: Addictive behavior could be defined as any activity, substances, object or behavior that has become the major focus of a person’s life to the exclusion of other activities or that has begun to harm individually, physically, mentally or socially. These behaviors increase the risks of diseases associated with personal and social problems. They are often experienced subjectively as loss of control, meaning the behavior continues to occur despite volitional attempts to abstain it. Material and Methods: In the present study 560 representative samples out of which 280 were substance-dependent & 280 Non-dependent drawn from the general population, drug addiction institute & rehabilitation centre selected from Chhattisgarh. The study was concentrated on male substance dependent & non-dependent between, the age group ranged between 18-50 years and involved in different type of profession, individuals having history of any neurological disorder, mental disorder, physical disorder and psychological before starting the drug were excluded from the study. Conclusion: Family history of addiction plays a significant role for substance intake. Alcohol intake was more among police and Businessman whereas cannabis intake was more among Teachers and Doctors. Addiction affects psycho-physical health.


Author(s):  
John Deigh

This essay is a study of the nature of moral judgment. Its main thesis is that moral judgment is a type of judgment defined by its content and not its psychological profile. The essay arrives at this thesis through a critical examination of Hume’s sentimentalism and the role of empathy in its account of moral judgment. The main objection to Hume’s account is its exclusion of people whom one can describe as making moral judgments though they have no motivation to act on them. Consideration of such people, particularly those with a psychopathic personality, argues for a distinction between different types of moral judgment in keeping with the essay’s main thesis. Additional support for the main thesis is then drawn from Piaget’s theory of moral judgment in children.


2021 ◽  
pp. 016402752110187
Author(s):  
Weiyu Mao ◽  
Bei Wu ◽  
Iris Chi ◽  
Wei Yang ◽  
XinQi Dong

Objectives: To investigate the relationship between acculturation and subsequent oral health problems in older Chinese Americans and to further test the moderating role of neighborhood disorder in such a relationship. Methods: The working sample included 2,706 foreign-born community-dwelling older Chinese Americans aged 60 years or older who participated in the Population Study of Chinese Elderly in Chicago at baseline between 2011 and 2013 and the 2-year follow-up between 2013 and 2015. Stepwise Poisson regressions with lagged dependent variable were conducted. Results: Behavioral acculturation was protective against subsequent oral health problems, and the protective role was stronger among individuals reporting lower levels of neighborhood disorder. Residence in Chinatown was associated with an increase in the risk of subsequent oral health problems. Discussion: To reduce oral health symptoms and related burdens, it is important to consider, in practice and policy, the role of acculturation and the neighborhood on subsequent oral health outcomes.


2021 ◽  
Vol 19 (2) ◽  
pp. 115-122
Author(s):  
A. Hartley ◽  
C. L. Gregson ◽  
L. Paternoster ◽  
J. H. Tobias

Abstract Purpose of Review This paper reviews how bone genetics has contributed to our understanding of the pathogenesis of osteoarthritis. As well as identifying specific genetic mechanisms involved in osteoporosis which also contribute to osteoarthritis, we review whether bone mineral density (BMD) plays a causal role in OA development. Recent Findings We examined whether those genetically predisposed to elevated BMD are at increased risk of developing OA, using our high bone mass (HBM) cohort. HBM individuals were found to have a greater prevalence of OA compared with family controls and greater development of radiographic features of OA over 8 years, with predominantly osteophytic OA. Initial Mendelian randomisation analysis provided additional support for a causal effect of increased BMD on increased OA risk. In contrast, more recent investigation estimates this relationship to be bi-directional. However, both these findings could be explained instead by shared biological pathways. Summary Pathways which contribute to BMD appear to play an important role in OA development, likely reflecting shared common mechanisms as opposed to a causal effect of raised BMD on OA. Studies in HBM individuals suggest this reflects an important role of mechanisms involved in bone formation in OA development; however further work is required to establish whether the same applies to more common forms of OA within the general population.


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