The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study

Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of −0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially.

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The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

10.20944/preprints202103.0637.v1 ◽

2021 ◽

Author(s):

Caitriona Murphy ◽

Jennifer Byrne ◽

Jennifer B Keogh ◽

Michelle L Headland ◽

Peter M. Clifton

Keyword(s):

Significant Interaction ◽

Acute Effect ◽

Control Group ◽

Early Event ◽

Magnesium Supplementation ◽

Over The Counter ◽

Men And Women ◽

Supplement Group ◽

Flow Mediated Dilatation ◽

The Difference

Magnesium (Mg) deficiency may be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim was to determine the acute effect of an oral Mg supplement compared to control on endothelieal function assessed by flow-mediated-dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9kg/m2) completed this randomised cross-over study. Blood pressure (BP) and FMD were measured and blood samples taken before participants drank 200ml water with or without an over the counter Mg supplement (450mg and 300mg for men and women). Measurements were repeated at 60 and 120 minutes. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = .037). A difference of -0.085mm in FMD was observed 60 minutes post drink in the control group compared to baseline FMD, and no difference was observed in the supplement group compared to baseline. Despite the non-significant interaction between treatment and time on FMD, the difference seen in the control group and the lack of change in the supplement group at 60 minutes post-drink suggests that Mg may attenuate the reduction in FMD post-prandially.

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Acute Effect of Mini-Trampoline Jumping on Vertical Jump and Balance Performance

International Journal of Kinesiology and Sports Science ◽

10.7575/aiac.ijkss.v.7n.2p.1 ◽

2019 ◽

Vol 7 (2) ◽

pp. 1

Author(s):

Nada Rhouni ◽

Nicole C. Dabbs ◽

Trevor Gillum ◽

Jared W. Coburn

Keyword(s):

Significant Interaction ◽

Peak Power ◽

Dynamic Balance ◽

Vertical Jump ◽

Rest Period ◽

Acute Effect ◽

Control Group ◽

Balance Performance ◽

Jump Performance ◽

Warm Up

Jumping and balance are necessary skills for most athletes, and mini-trampoline training has been shown to improve them. Little is known about the acute effect of mini-trampoline jumping on jump performance and dynamic balance. Objectives: The purpose of this study is to investigate the effect of 6 maximal jumps on a mini-trampoline on countermovement vertical jump (CMVJ) variables and on balance parameters. Methods: Twenty one recreationally trained individuals participated in three testing sessions and were either allocated to a control group (N=10) or a trampoline group (N=11). All the participants performed a dynamic warm up prior to their assessments. Baseline CMVJ and balance assessments were measured. For the jump performance tests, the control group rested for 30s, and the trampoline group performed 6 maximal CMVJs on a mini-trampoline. Immediately following the trampoline jumps or the rest period, participants performed three jump trials. The jumping protocol was repeated every minute up to 5 minutes and balance was reassessed immediately after only. Results: There was no significant interaction of time by group and no group effects in all the jumping parameters, however, there was a significant increase in jump height (p <0.001) post-condition, and a significant decrease in peak power (p= 0.01) at the 4th minute for both groups. There was no significant interaction of time by condition, no time effect and no group effect (p>0.05) on the balance variables. Conclusion: These results do not support our hypothesis and show that trampoline jumping does not improve jump and balance performance acutely.

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Study of endothelial function in pregnant women with gestational diabetes mellitus by flow mediated dilation of brachial artery

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202315 ◽

2020 ◽

Vol 9 (6) ◽

pp. 2377

Author(s):

Nidhi Pandey ◽

Poonam Goel ◽

Anita Malhotra ◽

Reeti Mehra ◽

Navjot Kaur

Keyword(s):

Gestational Diabetes ◽

Endothelial Function ◽

Pregnant Women ◽

Brachial Artery ◽

Vascular Function ◽

Post Partum ◽

Control Group ◽

Flow Mediated Dilation ◽

The Mean ◽

The Difference

Background: The objective of the study was to assess vascular function in normal pregnant women and women with gestational diabetes and to study its temporal relationship with gestational age at 24-28-week POG and at 36-38-week POG and changes in FMD in postpartum period.Methods: Assessment of vascular function was done at 24-28-week POG, 36-38-week POG and at 6-12-week postpartum by flow mediated dilation of brachial artery in 37 healthy pregnant women and 37 pregnant women with GDM.Results: In GDM group mean FMD at 24-28 weeks of POG, at 36-38 weeks POG was lower as compared to the control group (11.225±6.20,8.464±6.09 versus 14.49±5.21, 10.898±4.12) although the difference in mean FMD in two groups was not statistically significant. It was found that the decrease in FMD at 36-38-week POG as compared to 24-28 weeks POG was statistically significant in both the groups (p<0.001).Conclusions: This study revealed that when endothelial function as assessed by FMD was compared at different period of gestation, the mean decrease in FMD at 36-38-week POG as compared to 24-28-week POG and 6-week post-partum was statistically significant in patients with GDM and as well as the control group, however this trend of change was same in both the groups and was not statistically significant when compared between the two group (GDM versus control). A negative correlation of FMD was found with BMI, and HBA1c, that was stronger in GDM group.

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Effect of sacubitril valsartan on cardiac function and endothelial function in patients with chronic heart failure with reduced ejection fraction

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-201032 ◽

2020 ◽

pp. 1-9

Author(s):

Bao-Hua Li ◽

Kuai-Fa Fang ◽

Pei-Huan Lin ◽

Yi-Hui Zhang ◽

Yong-Xiang Huang ◽

...

Keyword(s):

Ejection Fraction ◽

Endothelial Function ◽

Cardiac Function ◽

Conventional Treatment ◽

Left Ventricular ◽

Control Group ◽

Observation Group ◽

Ang Ii ◽

Reduced Ejection Fraction ◽

The Difference

OBJECTIVE: The aim of the present study was to observe the effect of sacubitril valsartan on cardiac function and vascular endothelial function in patients with chronic heart failure with reduced ejection fraction (HFrEF). METHODS: A total of 80 patients with HFrEF were randomly divided into an observation group and a control group, with 40 patients in each group. Sacubitril valsartan was added to the conventional treatment in the observation group, and perindopril was added to the conventional treatment in the control group. Both groups were treated continuously for 12 weeks. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), flow-mediated vasodilatory function (FMD) of the brachial artery, and levels of plasma Ang II, endothelin 1 (ET-1), and calcitonin gene-related peptide (CGRP), together with the serum nitric oxide (NO) and NO synthase (NOS) were compared before and after treatment in the groups. RESULTS: Before the treatment, the levels of LVEF, LVEDD, FMD, Ang II, ET-1, CGRP, NO, and NOS in the observation group were not significantly different from those in the control group (P > 0.05). However, the levels of LVEF, FMD, CGRP, NO, and NOS in both groups were significantly higher after the treatment than those before the treatment (P < 0.05) and significantly higher in the observation group than those in the control group. The difference was statistically significant (P < 0.05). Meanwhile, the levels of LVEDD, Ang II, and ET-1 in both groups decreased significantly after the treatment (P < 0.05) and were significantly lower in the observation group than those in the control group. The difference was statistically significant (P < 0.05). CONCLUSION: Sacubitril valsartan might improve endothelial function while increasing cardiac function in HFrEF patients.

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The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158169 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8169

Author(s):

Jennifer Byrne ◽

Caitríona Murphy ◽

Jennifer B. Keogh ◽

Peter M. Clifton

Keyword(s):

Pilot Study ◽

Endothelial Function ◽

Saturated Fat ◽

Significant Negative Correlation ◽

Healthy Population ◽

Over The Counter ◽

Baseline Serum ◽

Low Magnesium ◽

Flow Mediated Dilatation ◽

Usual Diet

Evidence supports an association between low magnesium (Mg) intake and coronary heart disease and between Mg intake and endothelial function. The aim of this study was to assess the effect of one week of Mg supplementation on endothelial function, assessed by flow mediated dilatation (FMD). Nineteen healthy men and women completed this cross-over pilot study in which participants were randomised to take an over-the-counter magnesium supplement for one week or to follow their usual diet. Weight, FMD and blood pressure (BP) were taken on completion of each intervention and 24 h urine collections and blood samples were taken to assess compliance. Baseline serum Mg was within normal range for all participants. Urinary Mg and urinary magnesium-creatinine ratio (Mg/Cr) significantly increased between interventions, (p = 0.03, p = 0.005, respectively). No significant differences in FMD or BP were found between the interventions. A significant negative correlation was seen between age and FMD (r = −0.496, p = 0.031). When adjusted for age, saturated fat was negatively associated with FMD (p = 0.045). One week of Mg supplementation did not improve FMD in a healthy population.

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Effect of coffee on endothelial function in healthy subjects: the role of caffeine

Clinical Science ◽

10.1042/cs20040358 ◽

2005 ◽

Vol 109 (1) ◽

pp. 55-60 ◽

Cited By ~ 88

Author(s):

Chris M. PAPAMICHAEL ◽

Konstantinos A. AZNAOURIDIS ◽

Emmanouil N. KARATZIS ◽

Kalliopi N. KARATZI ◽

Kimon S. STAMATELOPOULOS ◽

...

Keyword(s):

Endothelial Function ◽

Acute Effect ◽

Composite Effect ◽

Unfavourable Effect ◽

Flow Mediated Dilatation ◽

Decaffeinated Coffee ◽

Caffeinated Coffee ◽

Pharmacologically Active ◽

Single Blind

Coffee is one of the most widely used pharmacologically active beverages. The present study was designed to evaluate the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery before and 30, 60, 90 and 120 min after ingestion of a cup of caffeinated coffee (80 mg of caffeine) or the corresponding decaffeinated beverage (<2 mg of caffeine) in two separate sessions, following a randomized single-blind cross-over design. There was no difference in baseline FMD values between the two sessions [7.78 compared with 7.07% after caffeinated and decaffeinated coffee respectively; P=NS (not significant)]. Caffeinated coffee led to a decline of FMD (7.78, 2.86, 2.12, 4.44 and 4.57% at baseline, 30, 60, 90 and 120 min respectively; P<0.001). This adverse effect was focused at 30 (P=0.004) and 60 min (P<0.001). No significant effect on FMD was found with the decaffeinated coffee session (7.07, 6.24, 5.21, 7.41 and 5.20%; P=NS). The composite effect of the type of coffee consumed over time on FMD was significantly different (P=0.021). In conclusion, coffee exerts an acute unfavourable effect on the endothelial function in healthy adults, lasting for at least 1 h after intake. This effect might be attributed to caffeine, given that decaffeinated coffee was not associated with any change in the endothelial performance.

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Assessment of Endothelial Dysfunction With Flow-Mediated Dilatation in Myeloproliferative Disorders

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029618766260 ◽

2018 ◽

Vol 24 (7) ◽

pp. 1102-1108 ◽

Cited By ~ 2

Author(s):

Abdulkerim Yildiz ◽

Melike Güryildirim ◽

Mehmet Sezgin Pepeler ◽

Merve Yazol ◽

Suna Özhan Oktar ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Endothelial Function ◽

Polycythemia Vera ◽

Primary Myelofibrosis ◽

Myeloproliferative Disorders ◽

Cardiovascular Complication ◽

Control Group ◽

Essential Thrombocytosis ◽

Flow Mediated Dilatation ◽

Disease Subtypes

Background: Thrombosis is the most important cardiovascular complication of classical myeloproliferative disorders (MPDs). Endothelial dysfunction (ED) is known to play a major role in the mechanism of thrombophilia in MPDs. Methods: Endothelial dysfunction and its associations with other parameters were investigated. A total of 18 patients with polycythemia vera (PV), 24 with essential thrombocytosis (ET), 7 with primary myelofibrosis (PMF), and 30 healthy patients as a control group were included in the study. To assess the ED, flow-mediated dilatation (FMD) measurements were used. Results: The FMD (%) result showing ED was determined as 9.9 (0.0-21.6) in the patients with PV, 7.3 (0.0-30.5) in patients with ET, 7.5 (0.0-18.0) in patients with PMF, and 13.9 (6.2-26.7) in the control group. The FMD (%) was markedly impaired in all patients with MPD compared to the control patients (7.8 [0.0-30.5] vs 13.9 [6.15-26.8], P = .02). According to the disease subtypes, FMD (%) was significantly lower in the ET group than in the control group ( P = .01). Conclusion: Endothelial function was assessed in patients with MPD having FMD and was determined to demonstrate ED. Lower FMD was associated with older age, leukocytosis, thrombocytosis, and thrombosis history.

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The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

10.20944/preprints202105.0640.v1 ◽

2021 ◽

Author(s):

Jennifer Byrne ◽

Caitriona Murphy ◽

Jennifer B. Keogh ◽

Peter M. Clifton

Keyword(s):

Pilot Study ◽

Endothelial Function ◽

Saturated Fat ◽

Significant Negative Correlation ◽

Healthy Population ◽

Over The Counter ◽

Baseline Serum ◽

Low Magnesium ◽

Flow Mediated Dilatation ◽

Usual Diet

Evidence supports an association between low magnesium (Mg) intake and coronary heart disease and between Mg intake and endothelial function. The aim of this study was to assess the effect of one week of Mg supplementation on endothelial function, assessed by flow mediated dilatation (FMD). Nineteen healthy men and women completed this cross-over pilot study in which participants were randomised to take an over-the-counter magnesium supplement for one week or to follow their usual diet. Weight, FMD and blood pressure (BP) were taken on completion of each intervention and 24hour urine collections and blood samples were taken to assess compliance. Baseline serum Mg was within normal range for all participants. Urinary Mg and urinary magnesium-creatinine ratio (Mg/Cr) significantly increased between interventions, (p = 0.03, p = 0.005 respectively). No significant differences in FMD or BP were found between the interventions. A significant negative correlation was seen between age and FMD (r = -0.496, p = 0.031). When adjusted for age, saturated fat was negatively associated with FMD (p = 0.045). One week of Mg supplementation did not improve FMD in a healthy population.

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The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

10.20944/preprints202103.0729.v1 ◽

2021 ◽

Author(s):

Byrne Byrne ◽

Caitriona Murphy ◽

Jennifer B. Keogh ◽

Peter M. Clifton

Keyword(s):

Pilot Study ◽

Endothelial Function ◽

Saturated Fat ◽

Significant Negative Correlation ◽

Healthy Population ◽

Over The Counter ◽

Baseline Serum ◽

Low Magnesium ◽

Flow Mediated Dilatation ◽

Usual Diet

Evidence supports an association between low magnesium (Mg) intake and coronary heart disease and between Mg intake and endothelial function. The aim of this study was to assess the effect of one week of Mg supplementation on endothelial function, assessed by flow mediated dilatation (FMD). Nineteen healthy men and women completed this cross-over pilot study in which participants were randomised to take an over-the-counter magnesium supplement for one week or to follow their usual diet. Weight, FMD and blood pressure (BP) were taken on completion of each intervention and 24hour urine collections and blood samples were taken to assess compliance. Baseline serum Mg was within normal range for all participants. Urinary Mg and urinary magnesium-creatinine ratio (Mg/Cr) significantly increased between interventions, (p = 0.03, p = 0.005 respectively). No significant differences in FMD or BP were found between the interventions. A significant negative correlation was seen between age and FMD (r = -0.496, p = 0.031). When adjusted for age, saturated fat was negatively associated with FMD (p = 0.045). One week of Mg supplementation did not improve FMD in a healthy population.

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Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100127906 ◽

1987 ◽

Vol 45 ◽

pp. 718-719

Author(s):

G.A. Miranda ◽

M.A. Arroyo ◽

C.A. Lucio ◽

M. Mongeotti ◽

S.S. Poolsawat

Keyword(s):

Low Dose ◽

Fetal Liver ◽

Late Pregnancy ◽

Toxic Chemicals ◽

Control Group ◽

High Dose ◽

Over The Counter ◽

Liver And Kidney ◽

Neonatal Liver ◽

Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

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