scholarly journals Bone Mineral Density and Hemoglobin Levels: Opposite Associations in Younger and Older Women

2021 ◽  
Vol 18 (10) ◽  
pp. 5495
Author(s):  
Tzyy-Ling Chuang ◽  
Malcolm Koo ◽  
Mei-Hua Chuang ◽  
Yuh-Feng Wang
Keyword(s):  
Bone Mineral Density ◽  
Regression Analysis ◽  
Lumbar Spine ◽  
Linear Regression ◽  
Bone Mineral ◽  
Linear Regression Analysis ◽  
Laboratory Data ◽  
Hemoglobin Level ◽  
Adult Women ◽  
Mineral Density

This cross-sectional, retrospective medical record review study aimed to investigate the association between hemoglobin levels and bone mineral density (BMD) in adult women. Medical records obtained from general health examinations conducted from June 2014 to July 2020 at a regional hospital in southern Taiwan were reviewed. Anthropometric and laboratory data were recorded. BMD of the lumbar spine and bilateral femoral neck regions was assessed by dual energy X-ray absorptiometry. Linear regression analysis was used to assess the association between BMD and hemoglobin level with and without adjusting for other anthropometric and laboratory data. The study included 9606 female patients with a mean age of 55.9 years. Of these, 2756 (28.7%) were aged ≤50 years and 6850 (71.3%) were aged >50 years. Results from multiple linear regression analysis showed that hemoglobin and femoral and lumbar spine BMD were significantly correlated. A higher hemoglobin level was significantly associated with a lower BMD level in females aged ≤50 years, but with a higher BMD level in those aged >50 years. Given the relationship between bone metabolism and hematopoiesis, additional research is needed to elucidate the association between hemoglobin and BMD levels in different age groups, particularly in premenopausal and perimenopausal women.

scholarly journals Association Between Bone Mineral Density And Serum Creatinine In People < 46 Years Old

2021 ◽  
Author(s):  
Yanru Guo ◽  
Xianyang Zhu
Keyword(s):  
Bone Mineral Density ◽  
Regression Analysis ◽  
Linear Regression ◽  
Serum Creatinine ◽  
Bone Mineral ◽  
Linear Regression Analysis ◽  
Lumbar Bone Mineral Density ◽  
Multivariate Linear Regression Analysis ◽  
Mineral Density ◽  
The Relationship

Abstract Purpose: To research the relationship between serum creatinine and lumbar bone mineral density in people aged <46 years. Methods: A total of 10,968 subjects from the American Nhanes database were included in this cross-sectional study, including 5,744 males (mean age 26.2 years) and 5224 females (mean age 26.7 years). The exposure factor is the serum creatinine value, and the outcome indicator is the lumbar bone mineral density. This study mainly used multivariate linear regression analysis to test the relationship between lumbar bone mineral density and serum creatinine. Results: In the multivariate linear regression analysis, serum creatinine was positively correlated with lumbar bone mineral density (β = 0.122, 95%CI: 0.047-0.198), but in the subgroup analysis stratified by sex, this positive correlation only exists in the female population (Β = 0.186, 95%CI: 0.070-0.301).Conclusions: Our study found that in women aged <46 years with normal renal function, there is a positive correlation between serum creatinine and lumbar BMD. And in those people, the determination of serum creatinine can provide a sensitive biomarker for the early identification and treatment of Osteopenia or osteoporosis.

scholarly journals P1421SERUM OSTEOPROTEGERIN LEVEL IS NEGATIVELY ASSOCIATED WITH BONE MINERAL DENSITY IN PATIENTS UNDERGOING HEMODIALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Chia-Wen Lu ◽  
Jia-Sian Hou ◽  
Bang-Gee Hsu
Keyword(s):  
Bone Mineral Density ◽  
Body Weight ◽  
Regression Analysis ◽  
Linear Regression ◽  
Bone Mineral ◽  
Linear Regression Analysis ◽  
Hemodialysis Patients ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mineral Density ◽  
Study Results

Abstract Background and Aims Osteoprotegerin, a potent osteoclast activation inhibitor, decreases bone resorption and positively affects bone mineral density (BMD). Our aim was to evaluate the relationship between BMD and fasting serum osteoprotegerin concentration in hemodialysis patients. Method Fasting blood samples were obtained from 75 chronic hemodialysis patients. BMD was measured by dual energy X-ray absorptiometry in lumbar vertebrae (L2-L4). Serum osteoprotegerin levels were measured using a commercial enzyme-linked immunosorbent assay. Results A total of 7 patients (9.3%) had osteoporosis and 20 patients (26.7%) had osteopenia in hemodialysis patients. Older age (p = 0.023), increased serum osteoprotegerin (p &lt; 0.001), urea reduction rate (URR, p = 0.021), Kt/V (p = 0.027), while decreased height (p &lt; 0.001), body weight (p &lt; 0.001), body mass index (BMI; p &lt; 0.001), and logarithmically transformed triglyceride (log-triglyceride, p = 0.020) was significantly correlated with low lumbar T-score cut-off points between groups (normal, osteopenia, and osteoporosis) in hemodialysis patients. Female patients had lower lumbar BMD than male hemodialysis patients (p = 0.002). Univariate linear regression analysis indicated lumbar BMD were positively correlated with height (p &lt; 0.001), body weight (p &lt; 0.001), BMI (p &lt; 0.001), log-triglyceride (p = 0.004), creatinine (p = 0.016), while negatively correlated with age (p = 0.001), alkaline phosphatase (p = 0.016), URR (p = 0.012), Kt/V (p = 0.013), and osteoprotegerin (p &lt; 0.001) among the hemodialysis patients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that female hemodialysis patient (adjusted R2 change = 0.040; p = 0.003), body weight (adjusted R2 change = 0.126; p = 0.001), kt/V (adjusted R2 change = 0.024; p = 0.034) and osteoprotegerin (adjusted R2 change = 0.332; p &lt; 0.001) were the independent predictors of lumbar BMD values in the hemodialysis patients. Conclusion Our study results revealed that increased serum osteoprotegerin levels were independently associated with decreased BMD in the lumbar spine, and with increased risk of osteoporosis in hemodialysis patients.

scholarly journals Anti-Inflammatory Effects of Low-Dose Glucocorticoids Compensate for Their Detrimental Effects on Bone Mineral Density in Patients with Rheumatoid Arthritis

2021 ◽  
Vol 10 (13) ◽  
pp. 2944
Author(s):  
Ji-Won Kim ◽  
Ju-Yang Jung ◽  
Hyoun-Ah Kim ◽  
Chang-Hee Suh
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Low Dose ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Annual Rate ◽  
Mineral Density

Objectives: This study aimed to provide reliable information on the impact of low-dose glucocorticoids (GCs) on the bone mineral density (BMD) of patients with rheumatoid arthritis (RA). Methods: This retrospective study enrolled 933 patients with RA who continued the consumption of GCs (GC group) and 100 patients who had discontinued consumption for >1 year (no-GC group). The BMD values were measured at baseline and follow-up, and the annual rate of change in BMD between the groups was compared using dual-energy X-ray absorptiometry. We used multiple linear regression analysis to identify the factors associated with changes in BMD. Results: The demographic characteristics and use of medical treatments affecting bone metabolism were similar between the two groups. Furthermore, there were no significant differences in the annual rate of changes in BMD and incidence of newly developed osteoporosis and incidental fractures between the two groups. Multiple linear regression analysis revealed that the disease activity score for 28 joints with erythrocyte sedimentation rate was the only factor affecting the annual rate of changes in BMD, and it was inversely proportional to changes in BMD. Conclusion: The benefits of GC therapy in attenuating inflammation compensate for the risk of osteoporosis if adequate measures to prevent bone loss are implemented in patients with RA.

scholarly journals Predictors of Bone Mineral Density Improvement after Parathyroidectomy for Secondary Hyperparathyroidism: A Retrospective Single-Center Analysis

2021 ◽  
Author(s):  
Manabu Okada ◽  
Yoshihiro Tominaga ◽  
Toshihide Tomosugi ◽  
Takahisa Hiramitsu ◽  
Toshihiro Ichimori ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Lumbar Spine ◽  
Secondary Hyperparathyroidism ◽  
Bone Mineral ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Mineral Density

Abstract Background Parathyroidectomy (PTx) reportedly increases bone mineral density (BMD) in patients with severe secondary hyperparathyroidism (SHPT). To date, however, there has not been sufficient evidence on predictors of BMD improvement post-PTx for SHPT, an issue the present retrospective cohort study aimed to address. Methods A total of 173 SHPT patients who underwent total PTx with forearm autograft between 2009 and 2017 were included in the present study. Demographic information, perioperative laboratory data and pre- and post-PTx BMD values (measured by dual-energy X-ray absorptiometry) were collected from their medical records. The change in BMD post-PTx in the lumbar spine was evaluated as the primary outcome. Then, a multivariate logistic regression analysis was performed for a ≥ 10% increase in BMD post-PTx. Results Overall, the median BMD in the lumbar spine was increased by 8.7% post-PTx. The multivariate logistic regression analysis revealed that age ≥ 70 years (P = 0.005; odds ratio [OR], 0.138; 95% confidence interval [CI]: 0.034–0.555), serum Ca level (P = 0.017; OR, 0.598; 95% CI: 0.392–0.911) and pre-PTx BMD in the lumbar spine (P = 0.003; OR, 0.013; 95% CI: 0.001–0.229) were negatively associated with a ≥ 10% increase in BMD post-PTx. Conclusion Our study demonstrated that presurgical age, serum Ca levels and BMD values could better predict an improvement in BMD post-PTx in SHPT patients.

Short-term, high-dose glucocorticoid treatment does not contribute to reduced bone mineral density in patients with multiple sclerosis

2015 ◽  
Vol 21 (12) ◽  
pp. 1557-1565 ◽  
Author(s):  
A Olsson ◽  
DB Oturai ◽  
PS Sørensen ◽  
PS Oturai ◽  
AB Oturai
Keyword(s):  
Multiple Sclerosis ◽  
Bone Mineral Density ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
High Dose ◽  
Mineral Density ◽  
Short Term

Background: Patients with multiple sclerosis (MS) are at increased risk of reduced bone mineral density (BMD). A contributing factor might be treatment with high-dose glucocorticoids (GCs). Objectives: The objective of this paper is to assess bone mass in patients with MS and evaluate the importance of short-term, high-dose GC treatment and other risk factors that affect BMD in patients with MS. Methods: A total of 260 patients with MS received short-term high-dose GC treatment and had their BMD measured by dual x-ray absorptiometry. BMD was compared to a healthy age-matched reference population ( Z-scores). Data regarding GCs, age, body mass index (BMI), serum 25(OH)D, disease duration and severity were collected retrospectively and analysed in a multiple linear regression analysis to evaluate the association between each risk factor and BMD. Results: Osteopenia was present in 38% and osteoporosis in 7% of the study population. Mean Z-score was significantly below zero, indicating a decreased BMD in our MS patients. Multiple linear regression analysis showed no significant association between GCs and BMD. In contrast, age, BMI and disease severity were independently associated with both lumbar and femoral BMD. Conclusion: Reduced BMD was prevalent in patients with MS. GC treatment appears not to be the primary underlying cause of secondary osteoporosis in MS patients.

scholarly journals AB0252 ASSOCIATION OF FAT MASS AND ITS DISTRIBUTION WITH BONE MINERAL DENSITY FOR RHEUMATOID ARTHRITIS PATIENTS.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1425.3-1426
Author(s):  
O. Lamkhanat ◽  
H. Azzouzi ◽  
B. Touil ◽  
I. Linda
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Linear Regression ◽  
Body Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Lean Mass ◽  
Body Fat Mass ◽  
Mineral Density

Background:Bone mineral density (BMD) and body mass are closely associated. lean mass(LM) and fat mass(FM) account for approximately 95% of body mass[1].Objectives:We aimed to study the association between body fat mass and its distribution with femoral and lumbar bone mineral density in rheumatoid arthritis (RA) patients.Methods:The present RA population-based cross sectionnel study done on 2019 was part of our rhumatology departement. Clinical data, femoral and lumbar BMD, body fat mass (BFM), android fat mass(AFM), gynoid fat mass (GFM), visceral fat mass (VFM) measured with dual energy X-ray absorptiometry (DXA: Hologic®) and results of laboratory tests were collected. Our statistical analysis was based on descriptive study and linear regression with SPSS20.Results:We included 73 RA patients witch mean age of 52.7+/-11.7, their mean of body mass index was 26.6+/5.8, mean of disease activity score was 2.6+/-0.94 and the mean health assessment questionnaire was 1.14+/0.78. In univariable linear regression, we found a significant association between femoral BMD and (BFM) (p=0.001, béta=0.36, IC:[0.000003-0.00001]), (AFM) (p=0.01, béta=0.29, IC:[0.00001, 0.00008]) and (GFM) (p=0.001, béta= 0.38, IC=[0.000005-0.000088]). There wasn’t any association between (VFM) and femoral BMD. Also we have found a significant association between lumbar spine BMD and BFM (p=0.0002, béta=0.41, IC[0.000003-0.000011]), AFM(p=0.001, béta=0.38, IC[0.000025-0.000094]), GFM(p=0.000018, béta=0.47, IC[0.00003-0.00007] and VFM (p=0.01, béta=0.28, IC[0.000027, 0.000251]). Adjusted on BFM, GFM, AFM and VFM in multiple regression analysis, it seems that the association between GFM, femoral BMD (p=0.02, béta= 0.38, IC[0.000005, 0.000088]. and lumbar spine BMD(p=0.01, béta=0.85, IC[0.000022, 0.000168]), was more significant.Conclusion:The finding of this study confirmed previous studies partly, that genoid fat mass has a positive effect of lumbar and femoral BMD.References:[1]S. Yang et al.Association between fat mass, lean mass, and bone loss: the Dubbo osteoporosis epidemiology study. International Osteoporosis Foundation and National Osteoporosis Foundation 2014, osteoporosis int. 2015; 26(4): 1381-6.Disclosure of Interests:None declared

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

scholarly journals SAT0477 A TWO-YEAR LONGITUDINAL STUDY COMPLETION, LONGITUNEAL STUDY, THE DIFFERENCE IN BONE LOSS IN PATIENTS WITH EROSIVE AND NON-EROSIVE HAND OSTEOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1195.2-1195
Author(s):  
K. Pavelka ◽  
L. Šenolt ◽  
O. Sleglova ◽  
J. Baloun ◽  
O. Růžičková
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Bone Mineral ◽  
Hand Osteoarthritis ◽  
Mineral Density ◽  
Erosive Disease ◽  
Femur Neck ◽  
American College Of Rheumatology

Background:Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain and morbidity. Some metabolic factors were suggested to be implicated in erosive disease. Few studies investigated differences in systemic bone loss between erosive and non-erosive hand OA.Objectives:To compare the change of bone mineral density (BMD) between patients with erosive and non-erosive hand OA in a two-year longitudinal study.Methods:Consecutive patients with symptomatic HOA fulfilling the American College of Rheumatology (ACR) criteria were included in this study. Erosive hand OA was defined by at least one erosive interphalangeal joint. All patients underwent clinical assessments of joint swelling and radiographs of both hands. DEXA examination of lumbar spine, total femur and femur neck was performed at the baseline and after two years.Results:Altogether, 141patients (15 male) with symptomatic nodal HOA were included in this study and followed between April 2012 and January 2019. Out of these patients, 80 had erosive disease after two years. The disease duration (p<0.01) was significantly higher in patients with erosive compared with non-erosive disease at baseline.Osteoporosis (T-score <-2.5 SD) was diagnosed in 12.5% (9/72) of patients with erosive hand OA and in 8.06% (5/57) of patients with non-erosive hand OA at baseline. BMD was significantly lowered in patients with erosive compared with non-erosive disease at baseline (lumbar spine: 1.05g/cm2 vs. 1.13 g/cm2, p<0.05, total femur: 0.90 g/cm2 vs. 0.97 g/cm2, p<0.01 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05). T-scores of lumbar spine (-0.96 vs. -0.41 SD, p<0.05), total femur (-0.69 vs. -0.33 SD, p<0.05) and femur neck (-1.14 vs. -0.88 SD, p<0.05) were also significantly lowered in patients with erosive compared with non-erosive disease.Two years, the BMD remained also significantly lowered in patients with erosive compared with non-erosive disease (lumbar spine: 1.05g/cm2 vs. 1.14 g/cm2, p<0.05, total femur: 0.92 g/cm2 vs. 0.97 g/cm2, p<0.05 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05), which was in agreement with the finding for T-scores of lumbar spine (-1.05 vs. -0.39 SD, p<0.05), total femur (-0.74 vs. -0.34 SD, p<0.01) and femur neck (-1.07 vs. -0.72 SD, p<0.01).Conclusion:These results suggest that patients with erosive hand OA are at higher risk for the development of general bone loss. Over two years patients with erosive disease had significant lower bone mineral density at all measured sites.References:[1]This work was supported by the project AZV no. 18-00542 and MHCR No. 023728.Acknowledgments:Project AZV no. 18-00542 and MHCR No. 023728Disclosure of Interests:Karel Pavelka Consultant of: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Speakers bureau: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Ladislav Šenolt: None declared, Olga Sleglova: None declared, Jiří Baloun: None declared, Olga Růžičková: None declared

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