scholarly journals Selenium Status, Its Interaction with Selected Essential and Toxic Elements, and a Possible Sex-Dependent Response in Utero, in a South African Birth Cohort

2021 ◽  
Vol 18 (16) ◽  
pp. 8344
Author(s):  
Halina B. Röllin ◽  
Kalavati Channa ◽  
Bukola Olutola ◽  
Jon Øyvind Odland
Keyword(s):  
Birth Outcomes ◽  
Toxic Elements ◽  
Environmental Pollutants ◽  
In Utero ◽  
Maternal Serum ◽  
Complex Interactions ◽  
Total Cohort ◽  
Essential And Toxic Elements ◽  
Positive Correlations ◽  
Se Status

Selenium (Se) is an essential trace element and its deficiency in utero may affect fetus development and birth outcomes. The current study aimed to assess serum Se status at delivery and examine the possible association between Se levels and birth outcomes. The interaction of Se with selected essential and toxic elements as well as possible sex-dependent responses in utero were also evaluated. The negative association between Se levels and head circumference of neonates was evident in the total cohort (β = −0.164; p < 0.001) as well as in the pre-term and full-term cohorts. Significant positive correlations were found between maternal serum Se concentrations and zinc (Zn) and copper (Cu) in the total and regional cohorts. In the total cohort, the toxic elements lead (Pb) and arsenic (As) showed a negative correlation with Se levels, while mercury (Hg), aluminum (Al) and cadmium (Cd) showed a positive correlation. The study found a sex-dependent response in utero for Zn, Cu, Pb, Hg, and Al. The findings of the current study may inform reproductive health policy on Se status in South Africa and highlight the need for sensitive methods to measure Se intake during pregnancy and its complex interactions with other micronutrients and environmental pollutants.

scholarly journals In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

2020 ◽  
Vol 17 (5) ◽  
pp. 1724 ◽  
Author(s):  
Halina B. Röllin ◽  
Kalavati Channa ◽  
Bukola Olutola ◽  
Claudina Nogueira ◽  
Jon Ø. Odland
Keyword(s):  
South African ◽  
Birth Outcomes ◽  
Synergistic Effects ◽  
In Utero ◽  
Maternal Serum ◽  
African Women ◽  
P Value ◽  
In Utero Exposure ◽  
Limited Information ◽  
South African Women

Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities.

scholarly journals Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 328 ◽  
Author(s):  
Rafal Kocylowski ◽  
Mariusz Grzesiak ◽  
Zuzanna Gaj ◽  
Wiktor Lorenc ◽  
Ewa Bakinowska ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Fetal Development ◽  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Maternal Serum ◽  
Growth Disorders ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Spectrometry Technique ◽  
Essential And Toxic Elements

Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic elements on fetal development has not yet been fully investigated, and the results of recent research indicate that these elements may be crucial in the assessment of the risk of malformations in neonates. We determined the association between essential and toxic elements and the level of folate in maternal serum (MS) and amniotic fluid (AF), along with neonatal abnormalities. A total of 258 pregnant Polish women in the age group of 17–42 years participated in this study. AF and MS were collected during vaginal delivery or during cesarean section. An inductively coupled plasma mass spectrometry technique was used to determine the levels of various elements in AF and MS. The results of this exploratory study indicate that the levels of essential and toxic elements are associated with fetal and newborn anatomical abnormalities and growth disorders.

scholarly journals Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

2018 ◽  
Vol 189 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Rafał Kocyłowski ◽  
Mariusz Grzesiak ◽  
Zuzanna Gaj ◽  
Wiktor Lorenc ◽  
Ewa Bakinowska ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Toxic Elements ◽  
Maternal Serum ◽  
Essential And Toxic Elements

scholarly journals Essential and toxic elements in sustainable and underutilized seafood species and derived semi-industrial ready-to-eat products

2021 ◽  
pp. 112331
Author(s):  
Francesca Ferraris ◽  
Francesca Iacoponi ◽  
Andrea Raggi ◽  
Francesca Baldi ◽  
Murielle Fretigny ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Essential And Toxic Elements

Factor analysis of essential and toxic elements in human placentas from deliveries in artic and subarctic areas of Russia and Norway

2001 ◽  
Vol 3 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Jon Øyvind Odland ◽  
Evert Nieboer ◽  
Natalya Romanova ◽  
Yngvar Thomassen ◽  
Dag Hofoss ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Toxic Elements ◽  
Essential And Toxic Elements

Evaluation of the status and the relationship between essential and toxic elements in the hair of occupationally exposed workers

2018 ◽  
Vol 190 (12) ◽  
Author(s):  
Mohamed Anouar Nouioui ◽  
Manel Araoud ◽  
Marie-Laure Milliand ◽  
Frédérique Bessueille-Barbier ◽  
Dorra Amira ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Exposed Workers ◽  
The Status ◽  
Occupationally Exposed ◽  
Essential And Toxic Elements ◽  
The Relationship

scholarly journals In Utero ART Exposure and Birth and Early Growth Outcomes Among HIV-Exposed Uninfected Infants Attending Immunization Services: Results From National PMTCT Surveillance, South Africa

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Vundli Ramokolo ◽  
Ameena E Goga ◽  
Carl Lombard ◽  
Tanya Doherty ◽  
Debra J Jackson ◽  
...  
Keyword(s):  
Birth Outcomes ◽  
Odds Ratio ◽  
In Utero ◽  
Early Growth ◽  
Adverse Birth Outcomes ◽  
Growth Outcomes ◽  
Immunization Services ◽  
Future Policy ◽  
Hiv Exposed ◽  
Exposed Uninfected

Abstract Background Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestational age (SGA), and underweight for age (UFA) at 6 weeks. Methods We surveyed 6179 HIV-unexposed-uninfected (HUU) and 2599 HIV-exposed-uninfected (HEU) infants. HEU infants were stratified into 3 groups: ART, Zidovudine alone, and no antiretrovirals (None). The ART group was further stratified to explore pre- or postconception exposure. Multivariable logistic regression evaluated effects of HIV and ARV exposure on the outcomes. Results We found higher odds of PTD, LBW, SGA, and UFA in HEU than HUU infants. HEU in the None group (adjusted odds ratio [AOR], 1.9; 95% confidence interval [CI], 1.2–3.0) or those whose mothers initiated ART preconception (AOR, 1.7; 95% CI, 1.1–2.5) had almost twice the odds of PTD than infants whose mothers started ART postconception, but no increased odds for other outcomes. Conclusions There was an association between preconception ART and PTD. As ART access increases, pregnancy registers or similar surveillance should be in place to monitor outcomes to inform future policy.

Total determination of essential and toxic elements in milk whey by double focusing ICP-MS

2000 ◽  
Vol 15 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Fidel Angel Rivero Martino ◽  
María Luisa Fernández Sánchez ◽  
Alfredo Sanz Medel
Keyword(s):  
Toxic Elements ◽  
Milk Whey ◽  
Icp Ms ◽  
Essential And Toxic Elements ◽  
Double Focusing
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