scholarly journals Health Risk Assessment of Exposure to 15 Essential and Toxic Elements in Spanish Women of Reproductive Age: A Case Study

2021 ◽  
Vol 18 (24) ◽  
pp. 13012
Author(s):  
Carmen Sáez ◽  
Alfredo Sánchez ◽  
Vicent Yusà ◽  
Pablo Dualde ◽  
Sandra F. Fernández ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Urban Areas ◽  
Toxic Elements ◽  
Essential Elements ◽  
Toxic Element ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Female Population ◽  
Spanish Women

This case study investigates the exposure of 119 Spanish women of reproductive age to 5 essential (Co, Cu, Mn, V, Zn) and 10 toxic (Ba, Be, Cs, Ni, Pb, Pt, Sb, Th, Al, U) elements and assesses their risk. The essential elements (Co, Cu, Mn, V, and Zn) showed average concentrations (GM: geometric mean) of 0.8, 35, 0.5, 0.2, and 347 μg/L, respectively. Five of the toxic elements (Ba, Cs, Ni, Al, U) exhibited detection frequencies of 100%. The GM concentrations of the novel toxic elements were 12 μg/L (Al), 0.01 μg/L (Pt), 0.02 μg/L (U), 0.12 μg/L (Th), 0.009 μg/L (Be) and 4 μg/L (Cs). The urine analysis was combined with a survey to assess any variations between subgroups and potential predictors of exposure to elements in the female population. Significant differences were obtained between the rural and urban areas studied for the toxic element Cs, with higher levels found in mothers living in urban areas. In relation to diet, statistically significantly higher levels of essential (Cu) and toxic (Ba) elements were detected in women with a high consumption of fish, while mothers who consumed a large quantity of legumes presented higher levels of the toxic element Ni (p = 0.0134). In a risk-assessment context, hazard quotients (HQs) greater than 1 were only observed for the essential elements Zn and Cu in P95. No deficiency was found regarding the only essential element for which a biomonitoring equivalent for nutritional deficit is available (Zn). For the less-studied toxic elements (Al, Pt, U, Th, Be, and Cs), HQs were lower than 1, and thus, the health risk due to exposure to these elements is expected to be low for the female population under study.

Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

2021 ◽  
Author(s):  
Clara Coscollà ◽  
Alfredo Sánchez ◽  
Francisca Corpas‐Burgos ◽  
Antonio López ◽  
Rosa Pérez ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Reproductive Age ◽  
Women Of Reproductive Age

scholarly journals Comparison between Different Diagnostic Strategies in Low-Risk Reproductive Age and Pre-Menopausal Women Presenting Abnormal Uterine Bleeding

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 884
Author(s):  
Chiara Belcaro ◽  
Federica Scrimin ◽  
Alessandro Mangogna ◽  
Emanuele Filippo Galati ◽  
Stefania Biffi ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Low Risk ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Female Population ◽  
Diagnostic Strategies ◽  
Study Results

Abnormal uterine bleeding (AUB) is a common symptom in the female population, with an estimated prevalence of 10 to 30% in fertile age and up to 90% in perimenopausal women. In most cases, AUB is due to a benign cause. However, it can also be a symptom of atypical endometrial hyperplasia or endometrial cancer, a more common disease during menopause which can also affect women in their reproductive age. Considering the high prevalence of this symptom an appropriate diagnostic algorithm is needed. Concerns about the risks, pain, and stress associated with an endometrial biopsy and its impact on the healthcare system make the choice of AUB diagnostic strategy extremely relevant. Even if the scientific community agrees on the definition of AUB, International Guidelines show some differences in the management of women of reproductive age with AUB, especially regarding the age cut-off as an independent indication for endometrial biopsy. This study compared different diagnostic strategies to identify a diagnostic pathway with high sensitivity and specificity but low impact on the health system’s resources. The analysis was based on three diagnostic algorithms defined as part of the guidelines of leading scientific societies. Women of reproductive age with AUB (n = 625) and without risk of endometrial cancer were included in the study. Results showed that the best criterion to investigate AUB in women at low risk of endometrial cancer is not age cut-off but the presence or absence of focal endometrial pathology at the ultrasound and the response to the progestin therapy. This approach makes it possible to perform fewer outpatient hysteroscopic biopsies without excluding positive cases from the examination.

Decreased prevalence and age-specific risk factors for Toxoplasma gondii IgG antibodies in The Netherlands between 1995/1996 and 2006/2007

2010 ◽  
Vol 139 (4) ◽  
pp. 530-538 ◽  
Author(s):  
A. HOFHUIS ◽  
W. VAN PELT ◽  
Y. T. H. P. VAN DUYNHOVEN ◽  
C. D. M. NIJHUIS ◽  
L. MOLLEMA ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
The Netherlands ◽  
Urban Areas ◽  
Marked Decrease ◽  
Congenital Toxoplasmosis ◽  
Reproductive Age ◽  
Igg Antibodies ◽  
Women Of Reproductive Age ◽  
Occupational Contact

SUMMARYTo estimate the change in the seroprevalence and risk factors for toxoplasmosis in The Netherlands, a study was conducted in the general population in 2006/2007, similarly designed as a previous study in 1995/1996. Testing 5541 sera for IgG antibodies against Toxoplasma gondii showed a marked decrease of the overall seroprevalence to 26·0% [95% confidence interval (CI) 24·0–28·0], compared to 40·5% (95% CI 37·5–43·4) in 1995/1996. In women of reproductive age the seroprevalence decreased from 35·2% (95% CI 32·9–38·6) in 1995/1996 to 18·5% (95% CI 16·2–20·7) in 2006/2007, leaving the majority of pregnant women susceptible to primary infection with T. gondii and their babies to congenital toxoplasmosis. In participants aged ⩾20 years, Toxoplasma seropositivity was associated with living in the Northwest, living in urban areas, low educational level, consumption of raw pork, keeping a cat, and not having occupational contact with clients or patients. For younger participants, risk factors were keeping sheep or cattle, consumption of raw unwashed vegetables and putting sand in the mouth.

scholarly journals Cause of death by verbal autopsy among women of reproductive age in Rajasthan, India

2015 ◽  
Vol 1 (1) ◽  
pp. 56 ◽  
Author(s):  
Bal Kishan Gulati ◽  
Anil Kumar ◽  
Arvind Pandey
Keyword(s):  
Cause Of Death ◽  
Verbal Autopsy ◽  
Urban Areas ◽  
International Classification Of Diseases ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Laboratory Findings ◽  
Maternal Deaths ◽  
Mortality And Morbidity ◽  
Rural And Urban Areas

<p class="abstract"><strong><span lang="EN-US">Background: </span></strong>Reliable data on mortality and morbidity among women of reproductive age are scarce in India. The present study is the Rajasthan component of a large multi-centric study on cause of death by verbal autopsy conducted in five states of India. The data pertaining to deaths among women of reproductive age are presented.  </p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>House-to-house surveys of a representative population from rural and urban areas in six districts of Rajasthan were undertaken by Probability of Proportion to Size (PPS) sampling. Information on death was obtained from the relatives of the deceased and cause of death was assigned using the standardized algorithm prepared for the purpose. International Classification of Diseases - ICD-10 was used to code the assigned cause of death.  </p><p class="abstract"><strong><span lang="EN-US">Results: </span></strong>A total of 231 deaths of women of reproductive age were investigated, of which 36 (16%) were maternal deaths while 195 (84%) were non-maternal deaths. Nine out of ten maternal deaths were in rural area.</p><p class="abstract"><strong><span lang="EN-US">Conclusions: </span></strong>Certain infectious and parasitic diseases; pregnancy, childbirth and the puerpurium; injury, poisoning and other consequences of external causes; and symptoms, signs and abnormal clinical and laboratory findings not elsewhere classified were found to be the major killers among the women of reproductive age. A comprehensive approach that includes in addition to reproductive health interventions, interventions addressing underlying illiteracy among women and social reforms needs to be undertaken. </p><p class="keywords"><strong><span lang="EN-US">Keywords: </span></strong>Maternal deaths, Non-maternal deaths, Women of reproductive age, Verbal autopsy</p>

The concentration and risk assessment of potentially toxic elements (PTEs) in unrefined salt: a case study of Aran and Bidgol Lake, Iran

2020 ◽  
pp. 1-13 ◽  
Author(s):  
Gholamreza Reza Mostafaii ◽  
Alireza Moravveji ◽  
Bahareh Hajirostamloo ◽  
Mohsen Hesami Arani ◽  
Masoud Dehghani ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Toxic Elements ◽  
Potentially Toxic Elements

Management of Putraghni Yonivyapada by Uttarbasti: A case study

2020 ◽  
Vol 8 (01) ◽  
Author(s):  
Jayamala Shirke
Keyword(s):  
Spontaneous Abortion ◽  
Healthy Child ◽  
Recurrent Miscarriage ◽  
Reproductive Age ◽  
Recurrent Abortion ◽  
Women Of Reproductive Age ◽  
Mode Of Administration ◽  
Alternative System ◽  
Hormonal Balance

Recurrent miscarriage is defined as a sequence of three or more consecutive spontaneous abortion before 20 weeks. This distressing problem is affecting approximately 1% of all women of reproductive age. In Ayurvedic literature, recurrent abortion may be correlated as Putraghni yonivyapad mentioned in Charak samhita, Sushruta samhita and Ashtanga Hridaya. To overcome this disconcerting problem; Ayurveda- an alternative system of medicine may be procured. According to Ashtanga Hridaya (one of the Brihattrayi), Uttarbasti (mode of  administration of drug by urethral or genital route) is indicated in treatment of all types of Yoni vyapad (gynaecological disorders). In this particular case of recurrent miscarriage, we used Phalghrita Uttarbasti and Dashamula qwath niruha basti along with internal medications such as Shatavari- Ashwagandha siddha kshirapaka and Vrishya vati. Uttarbasti removes strotorodha and maintains hormonal balance in uterus and ovaries. Patient was conceived after 6 month course of treatment. She was further treated with Garbhini Paricharya and resulted into normal labour with healthy child.

Features of metabolic and hormonal abnormalities in women with metabolic syndrome at the stage pregrada

2017 ◽  
pp. 57-61
Author(s):  
O.A. Dyndar ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Reproductive System ◽  
The Body ◽  
Reproductive Age ◽  
High Density Lipoproteins ◽  
Women Of Reproductive Age ◽  
Female Population ◽  
Number Of Components

The problem of obesity and metabolic syndrome among the female population of Ukraine is extremely important, given the current trend toward increasing age of realization of reproductive function,. The prevalence of metabolic syndrome among women of reproductive age is 6–35%, fertility problems are found in 30-35% of women. The objective: to study the characteristics of metabolic disorders and hormonal condition of the reproductive system in women with obesity and the metabolic syndrome on pregravidarity stage depending on the body mass index and severity of metabolic syndrome. Patients and methods. We examined a total of 124 women with obesity and metabolic syndrome that appealed on pregravidar stage and 53 women who had no history of somatic and gynecological pathology. Antropometric studies, determination of blood pressure, examination of carbohydrate and lipid metabolism, evaluation of the endocrine status of the reproductive system, ultrasound examination of small pelvis organs were done. Results. In women of reproductive age, we observed increase of total cholesterol, triglycerides, low-density lipoproteins and decrease high-density lipoproteins, with a predominance of IIb and IV types of dyslipidemia. Insulin resistance was diagnosed in 28.3% of women And 47.4% – II and in 69.7% with III degree of obesity. Metabolic syndrome was diagnosed in 79.2% of patients with obesity of I, in 94.7% – II 100% III. The number of components of metabolic syndrome correlate directly proportional to the severity of obesity. The index of fertility with III degree of obesity increased to 2.7, hypoestrogenia marked with And hyperestrogenia from 50.7% of women in II and III degree of obesity, progesterona failure identified at 66.9%, hyperandrogenism in 58.8%, reduced sex-binding globulin in 83.0% of the observations. Conclusion. Pathological changes of the hormonal status of the female reproductive system on prepregnansy stage is directly proportional to depend on the body mass index number of components of metabolic syndrome and dysmetabolic disorders. Key words: obesity, metabolic syndrome, pregnancy planning.

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