Features of metabolic and hormonal abnormalities in women with metabolic syndrome at the stage pregrada

2017 ◽  
pp. 57-61
Author(s):  
O.A. Dyndar ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Reproductive System ◽  
The Body ◽  
Reproductive Age ◽  
High Density Lipoproteins ◽  
Women Of Reproductive Age ◽  
Female Population ◽  
Number Of Components

The problem of obesity and metabolic syndrome among the female population of Ukraine is extremely important, given the current trend toward increasing age of realization of reproductive function,. The prevalence of metabolic syndrome among women of reproductive age is 6–35%, fertility problems are found in 30-35% of women. The objective: to study the characteristics of metabolic disorders and hormonal condition of the reproductive system in women with obesity and the metabolic syndrome on pregravidarity stage depending on the body mass index and severity of metabolic syndrome. Patients and methods. We examined a total of 124 women with obesity and metabolic syndrome that appealed on pregravidar stage and 53 women who had no history of somatic and gynecological pathology. Antropometric studies, determination of blood pressure, examination of carbohydrate and lipid metabolism, evaluation of the endocrine status of the reproductive system, ultrasound examination of small pelvis organs were done. Results. In women of reproductive age, we observed increase of total cholesterol, triglycerides, low-density lipoproteins and decrease high-density lipoproteins, with a predominance of IIb and IV types of dyslipidemia. Insulin resistance was diagnosed in 28.3% of women And 47.4% – II and in 69.7% with III degree of obesity. Metabolic syndrome was diagnosed in 79.2% of patients with obesity of I, in 94.7% – II 100% III. The number of components of metabolic syndrome correlate directly proportional to the severity of obesity. The index of fertility with III degree of obesity increased to 2.7, hypoestrogenia marked with And hyperestrogenia from 50.7% of women in II and III degree of obesity, progesterona failure identified at 66.9%, hyperandrogenism in 58.8%, reduced sex-binding globulin in 83.0% of the observations. Conclusion. Pathological changes of the hormonal status of the female reproductive system on prepregnansy stage is directly proportional to depend on the body mass index number of components of metabolic syndrome and dysmetabolic disorders. Key words: obesity, metabolic syndrome, pregnancy planning.

ETIOPATHOGENETIC ASPECTS, CLINICAL AND DIAGNOSTIC CRITERIA AS WELL AS COMPREHENSIVE APPROACH TO TREATMENT OF METABOLIC SYNDROME IN WOMEN OF REPRODUCTIVE AGE

2020 ◽  
pp. 40-44
Author(s):  
O. V. Dolenko
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Transvaginal Ultrasound ◽  
Combined Treatment ◽  
Clinical Effectiveness ◽  
Comprehensive Approach ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Clinical Efficiency

The development of metabolic syndrome in women of reproductive age is one of the most common causes of anovulatory infertility, miscarriage in early pregnancy. In this pathology treatment in women there is used a comprehensive approach, which aims to restore specific functions, i.e. menstrual, secretory and reproductive ones. Important points are the detection of metabolic disorders in the patients before the formation of polycystic ovaries, normalization of body weight. In order to study the clinical effectiveness of the herbal drug "Glucemedin" in the combined treatment of metabolic syndrome in 40 women of reproductive age, a clinical and laboratory investigation was performed, also transvaginal ultrasound and body mass index were determined. In the first group of patients as the main treatment the metformin was prescribed hydrochloride as monotherapy in a dosage of 500 mg 2 times a day, in the second there was added phytodrug "Glucemedin" in a dosage of 1 capsule 3 times a day. The combined treatment showed a more pronounced dynamics of reduction of total and free cholesterol, low−density lipoprotein, triglycerides, atherogenic factor, decreased body mass index compared with the patients receiving metformin monotherapy. Based on analysis of the results of clinical and laboratory studies a high clinical efficiency of the herbal phytodrug "Glucemedin", which is stipulated with the pronounced effect on lipid spectrum of blood. The presence of natural components being a part of the phytodrug "Glucemedin", their high bioavailability, safety of the drug, no side effects and contraindications indicate its pronounced clinical effectiveness and feasibility of inclusion into the treatment of metabolic syndrome in women of childbearing age. Key words: metabolic syndrome, lipid profile, body mass index, transvaginal ultrasound, Glucemedin, clinical efficiency, combined treatment, women of reproductive age.

scholarly journals Features of social adaptability and autonomic stability of adolescents with metabolic syndrome

2012 ◽  
Vol 93 (4) ◽  
pp. 647-650
Author(s):  
T A Chervinskikh ◽  
M B Kolesnikova ◽  
E S Naymushina ◽  
G V Zhuikova
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Main Group ◽  
The Body ◽  
Social Adaptation ◽  
High Density Lipoproteins ◽  
Hip Circumference ◽  
The Metabolic Syndrome ◽  
Social Adaptability

Aim. To identify the features of social adaptability and autonomic stability of adolescents with metabolic syndrome. Methods. The parameters of social adaptation and autonomic stability of 300 obese adolescents were studied. The main group included 150 adolescents (mean age 14.0±0.12 years) who were diagnosed with metabolic syndrome. The comparison group consisted of 150 adolescents (mean age 13.9±0.14 years) with primary uncomplicated obesity. A two-factor personality questionnaire of M. Gavlinova («society - autonomic nervous system») was used. Anthropometric indices (body weight, body mass index, height, waist circumference, hip circumference, waist/hip circumference ratio) were evaluated, the blood pressure was measured. General and biochemical blood tests and urine tests were performed (determination of the level of glucose, insulin, triglycerides, cholesterol, lipoproteins of high and low density, uric acid), as well as instrumental investigations. Results. In the group of adolescents with metabolic syndrome the mean body mass index 29.21±0.37 was significantly higher (p 0.001) compared to 26.07±0.46 in the group of patients with uncomplicated obesity. The waist/hip circumference ratio was significantly higher in adolescents with metabolic syndrome: 0.89±0.41 vs. 0.80±0.12 in the control group. In 92.71% of adolescents with metabolic syndrome arterial hypertension was diagnosed. In adolescents of the first group found were and laboratory markers of the metabolic syndrome: dyslipidemia in the form of hypertriglyceridemia (2.04±0.08 mmol/l) and decrease of the concentration of high-density lipoproteins (1.1±0.04 mmol/l). The average fasting blood glucose level was 5.78±0.02 mmol/l, the index of the model of homeostasis assessment for insulin resistance was 6.64±0.21. In the group of adolescents with metabolic syndrome the average score on the scale of social adaptation was low (8.48±0.13), whereas in the group without metabolic syndrome it was 13.51±0.22, which was significantly higher than in the main group (p 0.001), and was evidence of normal social adaptation. Low level of social adaptation was observed more frequently in girls than boys in both groups. Established was a correlation between the body mass index and social adaptability (r=-0.358), and with autonomic stability (r=0.378), p 0.05. Conclusion. Social adaptability and autonomic stability of adolescents with metabolic syndrome depend on the severity of clinical and metabolic changes and on the sex, thus this must be taken into account during treatment and rehabilitation.

Association of Obesity with Chronic Idiopathic Urticaria at Birat Medical College and Teaching Hospital

2020 ◽  
Vol 5 (2) ◽  
pp. 1087-1090
Author(s):  
Dilip Choudhary ◽  
Sabrina Yamu Shrestha
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Disease Onset ◽  
Chronic Idiopathic Urticaria ◽  
The Body ◽  
Medical College ◽  
The People ◽  
Obesity And Overweight ◽  
High Incidence

Introduction: A frequent association between metabolic syndrome with chronic idiopathic urticaria has been suggested by many studies but thorough investigations about the influence of obesity and overweight on chronic spontaneous urticaria has not been done.  Objectives: To find out the association of obesity with chronic idiopathic urticaria.  Methodology: Patients with chronic idiopathic urticaria were assessed for the body weight, height, body mass index, age of disease onset and duration of the disease.  Results: A total of 151 patients were enrolled in the study and among them 64 % were females as compared to 26 % males. The age of the patients included ranged from 17 years to 77 years. Among the patients included in study, 69 % of the patients suffering from CIU were found to be overweight and obese. The body mass index of the patient included ranged from 16.7 to 34.2 with mean of 24.3+/-4.3.  Conclusion: There is a relatively high incidence of urticaria among the people who are obese and overweight. 

scholarly journals Demographic, lifestyle, and reproductive determinants of serum anti-Müllerian hormone levels in adult women of reproductive age in Ilorin, North-Central Nigeria

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Oyinkansola Islamiyat Lawal ◽  
Jameelu-deen Omokunmi Yusuff
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cycle Length ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Negative Relationship ◽  
Reproductive Age ◽  
Enzyme Linked Immunosorbent Assay ◽  
Adult Women ◽  
Women Of Reproductive Age

Abstract Background Anti-Müllerian hormone is a dimeric glycoprotein produced by the granulosa cells of preantral and small antral follicles of the ovaries. It is a reliable biomarker of ovarian reserve, ageing, and response in the management of women with infertility. However, there are few studies on the determinants of serum anti-Müllerian hormone in Nigerian women. This study aimed to investigate determinants of serum anti-Müllerian hormone among adult women of reproductive age. The study was a hospital-based cross-sectional study involving 161 women of reproductive age attending the gynaecology clinic and immunisation clinic of a Nigerian tertiary hospital. Baseline characteristics were collected using a semi-structured questionnaire. Serum anti-Müllerian hormone was quantified using enzyme-linked immunosorbent assay. Results In univariate analysis, age (B = − 0.035, P = 0.000), parity (B = − 0.080, P = 0.001), and infertility duration (B = − 0.050, P = 0.011) had a negative relationship with serum anti-Müllerian hormone, while ethnicity (B = 0.180, P = 0.040), body mass index (B = 0.015, P = 0.010), and cycle length (B = 0.042, P = 0.000) had a positive relationship with serum anti-Müllerian hormone. In multivariable analysis, all relationships except infertility duration persisted. Conclusion We found that age, ethnicity, parity, infertility duration, body mass index, and cycle length were associated with serum anti-Müllerian hormone. A large prospective population-based study is required to better understand factors that are associated with serum anti-Müllerian hormone in an ethnically diverse country like Nigeria.

scholarly journals Pattern of Body Mass Index and Common Health Problems in Women of Reproductive Age Group in a Private Clinic in Kathmandu

2017 ◽  
Vol 56 (207) ◽  
pp. 352-356 ◽  
Author(s):  
Saraswati M Padhye
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Health Problems ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Reproductive Age Group ◽  
Genitourinary Infection

Introduction: High Body Mass Index is one of the risk factors for many chronic diseases and adverse health outcomes. It is associated with an increased risk of coronary heart disease, ischemic stroke, high blood pressure and type 2 diabetes mellitus. It also have many adverse effect on reproductive health of the women like sub fertility, polycystic ovarian disease, menstrual abnormality etc. The purpose of this study is to find Basal Metabolic Rate and the diseases pattern of reproductive age woman in Nepal. Methods: This is a descriptive study of women of reproductive age (15 to 49 years) attending a private gynaecology clinic in Kathmandu Valley from October 2016 to June 2017. Six hundred and eight women of current reproductive age group participated in this study. Women’s particulars and complaints were noted down. Detailed history was taken. Height, weight and blood pressure were recorded and general examination was done. BMI was calculated as BMI is weight in kilogram divided by height in meter square, and it was interpreted as per WHO guidelines. Results: Out of the total 608 participants, 243 (40%) were overweight, 96 (15.8%) were obese. Regarding the common health problems, 154 (25.3%) have sub fertility and 199 (32%) had genitourinary infection. Similarly, 90 (14.8%) had menstrual problems. Conclusions: Prevalence of overweight and obesity has risen significantly comparing to the study done decade ago in same setting. Similarly, sub fertility rate has also risen whereas the prevalence of genitourinary infections has decreased. Keywords: BMI; genitourinary infection; Nepal-reproductive age women; sub fertility.

scholarly journals Normal uterine size in women of reproductive age in northern Islamic Republic of Iran

2004 ◽  
Vol 10 (3) ◽  
pp. 437-441
Author(s):  
S. Esmaelzadeh ◽  
N. Rezaei ◽  
M. Hajiahmadi
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Reproductive Age ◽  
Islamic Republic ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Nulliparous Women ◽  
Multiparous Women ◽  
Islamic Republic Of Iran ◽  
Ultrasonographic Assessment

Todetermine the efficacy of ultrasonographic assessment of uterus size in women of reproductive age, we conducted a cross-sectional analytic study of 231 women aged 15-45 years in Babol, northern Islamic Republic of Iran. Mean uterus size was 86.6 mm x 49.6 mm x 40.6 mm overall, 72.8 mm x 42.8 mm x 32.4 mm for nulliparous women and 90.8 mm x 51.7 mm x 43.0 mm for multiparous women. Mean age was 31.7 +/- 9.6 years and mean body mass index [BMI] was 24.7 +/- 4.0 kg/m2. Uterus size was significantly associated with parity and age; but not with BMI. Our findings show a greater mean uterus size than reported by others. Ultrasonographic measurement of uterus size is valuable for predicting pathologies associated with abnormal uterine size

Therapeutic non-contraceptive properties of the drug containing ethinylestradiol 0.03 mg and drospirenone 3 mg

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (5) ◽  
pp. 65-68
Author(s):  
Natalia V Artymuk ◽  
Olga A Tachkova
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Randomized Study ◽  
Clinical Effectiveness ◽  
The Body ◽  
Reproductive Age ◽  
Anthropometric Parameters ◽  
To Receive ◽  
Prescribing Information

Aim. To compare effects of the drug containing ethinylestradiol (EE) 0.03 mg and drospirenone (DRSP) 3 mg and the drug containing EE 0.02 mg and DRSP 3 mg on the skin and anthropometric parameters. Materials and methods. A prospective comparative randomized study included 40 women of reproductive age who didn’t have contraindications to use of combined oral contraceptive (COCs). The first group consisted of 20 women who were administrated EE 0.03 mg and DRSP 3 mg in the 21/7 regimen according to a prescribing information; the 2nd group included 20 patients who were administrated EE 0.02 mg and DRSP 3 mg in the 24/4 regimen according to a prescribing information. The study protocol included 8 visits: at the 0th visit, the inclusion and exclusion criteria were evaluated, at the 1st visit patient were randomized (envelope method) to receive one or another drug, at the 2nd - 7th visits (once a month) blood pressure was measured, anthropometric parameters were determined including body weight, height, waist, hips as well as body mass index, a degree of hirsutism (with Ferriman-Gallwey scale), skin and hair skin oiliness, acne (with a 10-point visual scale) were evaluated. Results. The use of EE 0.03 mg and DRSP 3 mg for 6 months did not significantly affect the body weight and body mass index, waist and hips. In the 6th month, the use of EE 0.03 mg and DRSP 3 mg lead to a statistically significant decrease in skin oiliness, severity of acne and hirsutism, which was comparable to a clinical effectiveness of EE 0.02 mg and DRSP 3 mg. Conclusions. EE 0.03 mg and DRSP 3 mg has a similar effect on skin oiliness, severity of acne and hirsutism with EE 0.02 mg and DRSP 3 mg, without significantly affecting the main anthropometric parameters. It is likely that the effect of DRSP-containing COCs on androgen levels and adipose tissue is due precisely to the effect of DRSP, and not to the dose of EE.

scholarly journals Disturbed balance of steroid hormones in men under 40 years of age presenting with obesity and metabolic syndrome

2011 ◽  
Vol 57 (4) ◽  
pp. 7-12
Author(s):  
G V Katsiia ◽  
N P Goncharov ◽  
N A Chagina
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Steroid Hormone ◽  
Young Men ◽  
The Body ◽  
Normal Body Mass Index ◽  
Aldosterone Level ◽  
The Relationship ◽  
Consistent Tendency

We have studied steroid hormone profiles in young men with normal body mass index suffering obesity and metabolic syndrome. They showed a consistent tendency toward a shift in blood aldosterone level to the upper normal level and beyond. It was higher in patients with metabolic syndrome than with obesity. The testosterone levels displayed the downward trend from normal through obesity to metabolic syndrome values. The main predictors of testosterone dynamics in the course of development of obesity and metabolic syndrome were insulin concentration and BMI. Dynamics of dehydroepiandrosterone levels followed that of testosterone. It significantly decreased in men with metabolic syndrome compared with health subjects. Young men presenting with obesity and metabolic syndrome did not experience changes in morning and evening cortisol levels in peripheral blood. The study revealed the relationship between aldosterone levels and the development of metabolic syndrome mediated through the body mass index and the direct relationship between metabolic syndrome and testosterone dynamics.

Body mass index of women in Bangladesh: comparing Multiple Linear Regression and Quantile Regression

2020 ◽  
pp. 1-19 ◽  
Author(s):  
Sorif Hossain ◽  
Raaj Kishore Biswas ◽  
Md Amir Hossain
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Quantile Regression ◽  
Multiple Linear Regression ◽  
Body Mass ◽  
Demographic Factors ◽  
Educational Status ◽  
The Body ◽  
Reproductive Age ◽  
Socio Demographic Factors

Abstract This study explored the association between socio-demographic factors and the body mass index (BMI) of women of reproductive age (15–49 years) in Bangladesh. Data from the 2014 Bangladesh Demographic and Health Survey (BDHS-14) were analysed using Multiple Linear Regression (MLR) and Quantile Regression (QR) analyses. The study sample comprised 15,636 non-pregnant women aged 15–49. The mean BMI of the women was 22.35±4.12 kg/m2. Over half (56.75%) had a BMI in the normal range (18<BMI<25 kg/m2), and 18.50%, 20.00% and 4.75% were underweight (BMI≤18 kg/m2), overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2), respectively. The results of the MLR found that age, wealth index, urban/rural place of residence, geographical division, womenʼs educational status, husbandʼs educational status, womenʼs working status and total number of children ever born were significantly (p<0.001) associated with respondents’ mean BMI. The QR results showed different associations between socio-demographic factors and mean BMI, as well as a different conditional distribution of mean BMI. Overall, the results indicated that women with uneducated husbands, with little or no education and from less-affluent households from rural areas tended to be more underweight compared with women in other groups. The inter-relationship between the study womenʼs mean BMI and associated socio-demographic factors was assessed using QR analysis to identify the most vulnerable cohorts of women in Bangladesh.

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