scholarly journals Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study

2021 ◽  
Vol 18 (24) ◽  
pp. 13249
Author(s):  
Fábio Santos Lira ◽  
Telmo Pereira ◽  
Luciele Guerra Minuzzi ◽  
Caique Figueiredo ◽  
Tiago Olean-Oliveira ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Body Composition ◽  
Physical Fitness ◽  
Activity Level ◽  
Adult Patients ◽  
Phenotypic Characterization ◽  
Activity Levels ◽  
Vitro Assay ◽  
Physical Activity Levels

Background: This proposal aims to explain some of the gaps in scientific knowledge on the natural history of coronavirus disease (COVID-19), with a specific focus on immune, inflammatory, and metabolic markers, in parallel with temporal assessment of clinical and mental health in patients with COVID-19. The study will explore the temporal modulatory effects of physical activity and body composition on individual trajectories. This approach will provide a better understanding of the survival mechanisms provided by the immunomodulatory role of physical fitness. Methods: We will conduct a prospective observational cohort study including adult patients previously infected with the SARS-CoV-2 virus who have expressed a mild to moderate COVID-19 infection. Procedures will be conducted for all participants at baseline, six weeks after vaccination, and again at 12 months. At each visit, a venous blood sample will be collected for immune phenotypic characterization and biochemistry assays (inflammatory and metabolic parameters). Also, body composition, physical activity level, cardiovascular and pulmonary function, peripheral and respiratory muscle strength, functional exercise capacity, and mental health will be evaluated. Using the baseline information, participants will be grouped based on physical activity levels (sedentary versus active), body composition (normal weight versus overweight or obese), and SARS-CoV-2 status (positive versus negative). A sub-study will provide mechanistic evidence using an in-vitro assay based on well-trained individuals and age-matched sedentary controls who are negative for SARS-CoV-2 infection. Whole blood will be stimulated using recombinant human coronavirus to determine the cytokine profile. Peripheral blood mononuclear cells (PBMCs) from healthy well-trained participants will be collected and treated with homologous serum (from the main study; samples collected before and after the vaccine) and recombinant coronavirus (inactive virus). The metabolism of PBMCs will be analyzed using Respirometry (Seahorse). Data will be analyzed using multilevel repeated-measures ANOVA. Conclusions: The data generated will help us answer three main questions: (1) Does the innate immune system of physically active individuals respond better to viral infections compared with that of sedentary people? (2) which functional and metabolic mechanisms explain the differences in responses in participants with different physical fitness levels? and (3) do these mechanisms have long-term positive modulatory effects on mental and cardiovascular health? Trial registration number: Brazilian Registry of Clinical Trials: RBR-5dqvkv3. Registered on 21 September 2021.

scholarly journals Physical Activity Level and Self-Esteem in Middle-Aged Women

2021 ◽  
Vol 18 (14) ◽  
pp. 7293
Author(s):  
Magdalena Dąbrowska-Galas ◽  
Jolanta Dąbrowska
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Physical Activity Level ◽  
Rating Scale ◽  
Self Esteem ◽  
Activity Level ◽  
Activity Levels ◽  
Middle Aged ◽  
Study Results ◽  
Physical Activity Levels

Background: Physical activity (PA) is a behavioral modality that may help decrease negative symptoms of menopause and enhance some positive aspects of mental health, including self-esteem. Reduced self-esteem may put menopausal women at higher risk of negative outcomes of menopause and result in a more unpleasant and stressful menopausal experience. The objective of this study was to examine the role of physical activity level on self-esteem in middle-aged women. Methods: Women aged 45–60 from Poland took part in this study. The Rosenberg Self-Esteem Scale, the International Physical Activity Questionnaire, the Menopause Rating Scale and Beck Depression Inventory were used in this study. Results: Among the 111 women, the mean age was 51.7 ± 4.7. The most severe symptoms among studied women concerned sexual problems (1.71 ± 1.5), irritability (1.58 ± 1.37) and joint and muscular discomfort (1.56 ± 1.55). Women with higher total PA level had better self-esteem (p = 0.001). Conclusions: The results of this study showed that physical activity levels can be associated with self-esteem. Most middle-aged women reported high physical activity levels. These results have clinical implications for the inclusion of PA in the lives of middle-aged women to improve self-esteem and mental health.

The Relationship Among Television Watching, Physical Activity, and Body Composition of Young Children

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 449-455
Author(s):  
Robert H. DuRant ◽  
Tom Baranowski ◽  
Maribeth Johnson ◽  
William O. Thompson
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Rating Scale ◽  
Interobserver Reliability ◽  
Activity Level ◽  
Self Report ◽  
Activity Levels ◽  
Television Watching ◽  
Physical Activity Levels ◽  
The Relationship

Purpose. Television watching has been reported to be associated with obesity, resting energy expenditure, and lower daily physical activity among both children and adolescents. However, most of these studies were based on self report or data collected in laboratory settings. This study examined the relationship among observed time of television watching, observed physical activity level and body composition among 3- or 4-year-old children. Methods. African-American (41.4%), Mexican-American (23%), and Anglo-American (35.6%) children (N = 191, males = 90) from the Texas site of the Studies of Child Activity and Nutrition program were observed from 6 to 12 hours per day up to 4 days over 1 year. Activity level each minute of the day was measured with the Children's Activity Rating Scale (interobserver reliability = .84 ± .001). The interobserver reliability of time of television watching was .96 ± .08. Results. The median of the longest number of consecutive minutes of television watching was 15 (range = 1 to 79). The median percent of minutes of television watching of total observed minutes was 14.8% (0% to 58%) and the median percent of minutes of inside minutes was 17.9% (0% to 80.9%). There were no gender or ethnic differences in time watching television or physical activity during television watching. Physical activity during television watching was lowest during the longest bout of television watching (\l=x_\ = 1.48 ± .28) compared to outside minutes (\l=x_\ = 2.38 ± .21), inside non-television minutes (\l=x_\ = 1.96 ± .13) and inside television minutes (\l=x_\ = 1.65 ± .18). The level of physical activity during television-watching times was highest (P <.0031) during October and November and lowest during March, April, June, and July. Longest bout of television watching and percent of minutes watching television to total observed minutes were inversely associated with mean physical activity, percent of minutes of physical activity levels 3, 4, or 5, and percent of physical activity levels 4 or 5. Percent of television watching to inside minutes was negatively correlated with physical activity levels 4 or 5. Television-watching behavior was not associated with body composition. Conclusions. Television watching was weakly negatively correlated with physical activity levels, and physical activity was lower during television-watching than non-television-watching time in this sample of children. Television viewing behavior was not associated with body composition.

scholarly journals Choroidal Thickness and Volume Modifications Induced by Aerobic Exercise in Healthy Young Adults

2020 ◽  
Author(s):  
Gema Insa-Sánchez ◽  
Lorena Fuentes-Broto ◽  
Alberto Cobos ◽  
Elvira Orduna Hospital ◽  
Francisco Segura ◽  
...  
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Physical Exercise ◽  
Choroidal Thickness ◽  
Activity Level ◽  
Enhanced Depth Imaging ◽  
Activity Levels ◽  
Imaging Protocol ◽  
Post Exercise ◽  
Physical Activity Levels

<b><i>Introduction:</i></b> Our aim was to evaluate the changes in choroidal thickness (CT) and volume (CV) following aerobic physical exercise in healthy young adults. <b><i>Methods:</i></b> This study included 72 eyes from healthy volunteers between 22 and 37 years old. Using the International Physical Activity Questionnaire, total physical activity was computed. Measurements using an autorefractometer, ocular biometry, and spectral-domain optical coherence tomography using the Enhanced Depth Imaging protocol were taken. OCT was performed as a baseline measurement and after performing 10 min of dynamic physical exercise (3 and 10 min post-exercise). The choroidal layer was manually segmented, and the CT and CV in different areas from the Early Treatment Diabetic Retinopathy Study grid were obtained. <b><i>Results:</i></b> In healthy adults, at 3 min post-exercise, CT was higher in the subfoveal, the 3-mm nasal, and the 6-mm superior areas. Between 3 and 10 min post-exercise, the CT was reduced in all areas, and in some areas, the values were even smaller than the baseline measurements. The CV values showed changes after exercise similar to those of thickness. The total CV recovery after exercise was related to sex and physical activity level. <b><i>Conclusion:</i></b> Individuals with higher physical activity habits had greater CV at rest than those with lower physical activity levels. During exercise, healthy young people adjust CT and CV. At 3 min post-exercise, CT and CV increase. Women and individuals with greater physical activity levels reduce their total CV more than others during recovery.

scholarly journals Cancer-Related Fatigue and Muscle Quality in Hodgkin’s Lymphoma Survivors

2017 ◽  
Vol 17 (2) ◽  
pp. 299-305 ◽  
Author(s):  
Filipe Dinato de Lima ◽  
Martim Bottaro ◽  
Ritielli de Oliveira Valeriano ◽  
Lorena Cruz ◽  
Claudio L. Battaglini ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Hodgkin’S Lymphoma ◽  
Muscle Thickness ◽  
Peak Torque ◽  
Hodgkin's Lymphoma ◽  
Muscle Quality ◽  
Activity Levels ◽  
Physical Activity Levels ◽  
Lymphoma Survivors

The purpose of this study was to compare fatigue, strength, body composition, muscle thickness, and muscle quality between Hodgkin’s lymphoma survivors (HLS) and apparently healthy subjects matched by age, gender, and physical activity levels (CON). Twelve HLS (32.16 ± 8.06) and 36 CON (32.42 ± 7.64) were enrolled in the study. Fatigue was assessed using the 20-item Multidimensional Fatigue Inventory, muscle strength using an isokinetic dynamometer, body composition using dual-energy X-ray absorptiometry, and thickness and muscle quality using B-mode ultrasound. Differences between HLS and CON were analyzed using independent samples t tests. No significant differences were observed between groups for any demographic characteristics: age ( P = .922), weight ( P = .943), height ( P = .511), body mass index ( P = .796), fat mass ( P = .688), fat-free mass ( P = .520), and percent body fat ( P = .446). No significant differences were observed for strength (peak torque; P = .552), relative peak torque ( P = .200), muscle thickness ( P > .05) and muscle quality ( P > .05). However, self-perceived fatigue was significantly higher in HLS than in CON ( P = .009). It appears that when HLS are matched by age and physical activity levels to CON, no significant difference in body composition, muscle thickness, muscle quality, or strength is observed. Self-perceived fatigue, as predicted, is higher in HLS, which may have implications and should be considered when prescribing exercise training to this cancer population.

scholarly journals Reduced level of physical activity during COVID-19 pandemic is associated with depression and anxiety levels: an internet-based survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Paulo José Puccinelli ◽  
Taline Santos da Costa ◽  
Aldo Seffrin ◽  
Claudio Andre Barbosa de Lira ◽  
Rodrigo Luiz Vancini ◽  
...  
Keyword(s):  
Physical Activity ◽  
Mood Disorders ◽  
Physical Activity Level ◽  
Negative Impact ◽  
Mood State ◽  
Activity Level ◽  
Activity Levels ◽  
Depression And Anxiety ◽  
Social Distancing ◽  
Physical Activity Levels

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has resulted in a strong negative impact on economic and social life worldwide. It has also negatively influenced people’s general health and quality of life. The aim of the present study was to study the impact of social distancing on physical activity level, and the association between mood state (depression and anxiety level) or sex with actual physical activity levels, the change in physical activity caused by social distancing period, the adhesion level to social distancing, the adoption time of social distancing, family income and age. Methods A self-administered questionnaire with personal, quarantine, physical activity, and mood state disorders information’s was answered by 2140 Brazilians of both sex who were recruited through online advertising. Results The physical activity level adopted during the period of social distancing (3.5 ± 0.8) was lower than that the adopted prior to the pandemic period (2.9 ± 1.1, p < 0.001). Thirty percent of the participants presented symptoms of moderate/severe depression and 23.3% displayed moderate/severe anxiety symptoms. A greater presence of symptoms related to anxiety and depression were associated with low physical activity levels, low family monthly income, and younger age. A higher percentage of men who had no mood disorders was observed among those who were very active than among those less active. Conclusion The COVID-19 pandemic has a negative impact on physical activity. Those who reduced their level of physical activity had the highest levels of mood disorders. Therefore, physical activity programs should be encouraged, while respecting the necessary social distancing to prevent the spread of Severe Acute Respiratory Syndrome Coronavirus 2.

Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention

Gerontology ◽  
2018 ◽  
Vol 65 (3) ◽  
pp. 229-239 ◽  
Author(s):  
Haritz Arrieta ◽  
Gotzone Hervás ◽  
Chloe Rezola-Pardo ◽  
Fátima Ruiz-Litago ◽  
Miren Iturburu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Nursing Home ◽  
Physical Fitness ◽  
Physical Activity Level ◽  
Exercise Intervention ◽  
Nursing Home Residents ◽  
Exercise Program ◽  
Activity Level

Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels. Methods: We obtained study data on 112 participants from long-term nursing homes. Participants were randomly assigned to a control or an intervention group and performed a 6-month multicomponent exercise program. Serum myostatin levels were analyzed by ELISA. Assessments also included body composition (anthropometry and bioelectrical impedance), physical fitness (Senior Fitness Test), physical activity level (accelerometry), and frailty (Fried frailty criteria, Clinical Frailty Scale, and Tilburg frailty indicator). Results: The concentration of myostatin at baseline was positively correlated with: a leaner body composition (p < 0.05), and a higher number of steps per day and light and moderate-vigorous physical activity in women (p < 0.005); greater upper and lower limb strength, endurance, and poorer flexibility (p < 0.05) in men; and better performance (less time) in the 8-ft timed up-and-go test in both women (p < 0.01) and men (p < 0.005). We observed higher concentrations of serum myostatin in non-frail than in frail participants (p < 0.05). Additionally, we found that the implemented physical exercise intervention, which was effective to improve physical fitness, increased myostatin concentration in men (p < 0.05) but not in women. The improvements in physical condition were related with increases in serum myostatin only in men (p < 0.05–0.01). Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.

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