Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells
2019 ◽
Vol 20
(11)
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pp. 2836
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Keyword(s):
A Cell
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Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine secretion, and cytolytic function. Although a great deal is known about PD-1 mediated regulation of CD4+ and CD8+ T cells, its expression and function in innate lymphoid cells (ILCs) are yet to be fully deciphered. This review summarizes the role of PD-1 in (1) modulating ILC development, (2) ILC function, and (3) PD-1 signaling in ILC. Finally, we explore how PD-1 based immunotherapies may be beneficial in boosting ILC responses in cancer, infections, and other immune-related disorders.
2018 ◽
Vol 25
(8)
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pp. 2484-2491
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2009 ◽
Vol 50
(10)
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pp. 4941
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2019 ◽
Vol 19
(4)
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pp. 277
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1996 ◽
Vol 184
(6)
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pp. 2361-2370
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Keyword(s):