Drug Discovery in Liver Disease Using Kinome Profiling

The liver is one of the most important organs, playing critical roles in maintaining biochemical homeostasis. Accordingly, disease of the liver is often debilitating and responsible for untold human misery. As biochemical nexus, with kinases being master regulators of cellular biochemistry, targeting kinase enzymes is an obvious avenue for treating liver disease. Development of such therapy, however, is hampered by the technical difficulty of obtaining comprehensive insight into hepatic kinase activity, a problem further compounded by the often unique aspects of hepatic kinase activities, which makes extrapolations from other systems difficult. This consideration prompted us to review the current state of the art with respect to kinome profiling approaches towards the hepatic kinome. We observe that currently four different approaches are available, all showing significant promise. Hence we postulate that insight into the hepatic kinome will quickly increase, leading to rational kinase-targeted therapy for different liver diseases.

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Spectrum of liver diseases occurring solely in pregnancies carrying male fetuses: A case series

10.52768/jjgastro/1010 ◽

2021 ◽

Vol 1 (2) ◽

Author(s):

Eva koulaymi ◽

◽

Mayssaloun khairallah ◽

Zeinab Haroun ◽

Jihad Al Hassan ◽

...

Keyword(s):

Liver Disease ◽

Mortality Rate ◽

High Mortality ◽

Liver Diseases ◽

Case Series ◽

Specific Effect ◽

Related Liver Disease ◽

Insight Into

Liver disease affects nearly 3% of pregnancies. It is a challenging topic for obstetricians as it can be fatal for both, the mother and the fetus. They carry a high mortality rate reaching 25%. Sex-specific effect on the expression of pregnancy-related liver diseases is largely unknown. We present several cases of familial pregnancy-related liver diseases that were expressed solely when the mothers had male fetuses, ending with deleterious outcomes. Liver disease was not expressed when they had female fetuses. These cases provide a novel insight into the diversity of pregnancy-related liver disease complications expression among sex.

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Enhancing Language Learning in Study Abroad

Annual Review of Applied Linguistics ◽

10.1017/s0267190511000031 ◽

2011 ◽

Vol 31 ◽

pp. 58-73 ◽

Cited By ~ 64

Author(s):

Celeste Kinginger

Keyword(s):

Study Abroad ◽

Language Learning ◽

Language Learners ◽

State Of The Art ◽

Positive Impact ◽

Study Abroad Programs ◽

Language Competence ◽

Communicative Practices ◽

Current State ◽

Insight Into

Research demonstrates that study abroad can have a positive impact on every domain of language competence, and that it is particularly helpful for the development of abilities related to social interaction. However, some results suggest that study abroad intensifies individual differences in achievement: Certain students thrive while others founder. Qualitative studies provide insight into the sources of these differences both in the stances that students adopt toward their host communities and in the ways in which they are received. Overall, the research points to a need for language learners’ broader engagement in local communicative practices, for mindfulness of their situation as peripheral participants, and for more nuanced awareness of language itself. This article offers a rationale, based on the current state of the art in research, for including the expertise of language educators in the choice and design of study abroad programs. Students will benefit from programs specifically designed to foster language learning through observation, participation, and reflection.

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State-of-the-Art of Artificial Intelligence

Journal of Mobile Multimedia ◽

10.13052/jmm1550-4646.171322 ◽

2021 ◽

Author(s):

Ramjee Prasad ◽

Purva Choudhary

Keyword(s):

Artificial Intelligence ◽

Big Data ◽

State Of The Art ◽

Turing Test ◽

Rapid Progress ◽

Current State ◽

Recent Developments ◽

Historical Developments ◽

Insight Into ◽

Made In

Artificial Intelligence (AI) as a technology has existed for less than a century. In spite of this, it has managed to achieve great strides. The rapid progress made in this field has aroused the curiosity of many technologists around the globe and many companies across various domains are curious to explore its potential. For a field that has achieved so much in such a short duration, it is imperative that people who aim to work in Artificial Intelligence, study its origins, recent developments, and future possibilities of expansion to gain a better insight into the field. This paper encapsulates the notable progress made in Artificial Intelligence starting from its conceptualization to its current state and future possibilities, in various fields. It covers concepts like a Turing machine, Turing test, historical developments in Artificial Intelligence, expert systems, big data, robotics, current developments in Artificial Intelligence across various fields, and future possibilities of exploration.

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Ambulatory Monitoring of Daily Voice Use

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd21.2.56 ◽

2011 ◽

Vol 21 (2) ◽

pp. 56-61 ◽

Cited By ~ 11

Author(s):

Robert E. Hillman ◽

Daryush D. Mehta

Keyword(s):

State Of The Art ◽

Ambulatory Monitoring ◽

Vocal Behavior ◽

Future Directions ◽

Vocal Function ◽

Current State ◽

Voice Use ◽

Insight Into

Many common voice disorders are chronic or recurring conditions likely to result from faulty and/or abusive patterns of vocal behavior. Such behaviorally based disorders can be difficult to assess accurately in the clinical setting and potentially could be much better characterized by long-term ambulatory monitoring of vocal function as individuals engage in their typical daily activities. Ambulatory monitoring also could provide new insight into the actual role of voice use in common disorders and missing quantitative data on what constitutes normal levels of daily voice use for different groups of individuals, activities, and occupations. This report describes the motivation, previous development efforts, current state-of-the-art technology, and future directions in ambulatory monitoring of voice use.

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Rhaponticin as an anti-inflammatory component of rhubarb: a minireview of the current state of the art and prospects for future research

Phytochemistry Reviews ◽

10.1007/s11101-019-09652-w ◽

2019 ◽

Vol 18 (5) ◽

pp. 1375-1386 ◽

Cited By ~ 2

Author(s):

Joanna Kolodziejczyk-Czepas ◽

Jan Czepas

Keyword(s):

State Of The Art ◽

Active Form ◽

Biologically Active ◽

Future Research ◽

Human Diet ◽

Comprehensive Review ◽

Current State ◽

Anti Inflammatory ◽

Insight Into ◽

Inflammatory Component

Abstract Rhaponticin (3,3′,5-trihydroxy-4′-methoxystilbene 3-O-β-d-glucoside; synonym–rhapontin), is a stilbene compound, mainly found in various species of rhubarb (Rheum L.). The aglycone, rhapontigenin, is thought to be the biologically active form of rhaponticin. As a component of rhubarb, rhaponticin may be present in the human diet both in foods and dietary supplements. Although promising reports have been published on the various activities of rhaponticin (see: antioxidant, estrogenic, antithrombotic, anticancer and anti-inflammatory actions), no comprehensive review exists of its anti-inflammatory properties. Therefore, the aim of the present work is to summarize the existing evidence of the anti-inflammatory properties of rhaponticin and provide a prospective insight into research on this stilbenoid.

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Current state of the art in rapid diagnostics for antimicrobial resistance

Lab on a Chip ◽

10.1039/d0lc00034e ◽

2020 ◽

Vol 20 (15) ◽

pp. 2607-2625 ◽

Cited By ~ 1

Author(s):

Rathina Kumar Shanmugakani ◽

Balaji Srinivasan ◽

Marshall J. Glesby ◽

Lars F. Westblade ◽

Washington B. Cárdenas ◽

...

Keyword(s):

Antimicrobial Resistance ◽

State Of The Art ◽

Rapid Diagnostics ◽

Technical Aspects ◽

Current State ◽

Insight Into

This review provides an insight into current rapid diagnostics for antimicrobial resistance, their technical aspects and benefits/limitations on their application.

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Surgery for Lone Atrial Fibrillation: Present State-of-the-Art

Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery ◽

10.1097/imi.0b013e3181bb370f ◽

2009 ◽

Vol 4 (5) ◽

pp. 248-255 ◽

Cited By ~ 9

Author(s):

Jeanne Shen ◽

Marci Bailey ◽

Ralph J. Damiano

Keyword(s):

Atrial Fibrillation ◽

Surgical Treatment ◽

State Of The Art ◽

Technical Difficulty ◽

Lone Atrial Fibrillation ◽

Future Directions ◽

The Past ◽

Current State ◽

Preoperative Diagnostic ◽

Diagnostic Technologies

For 2 decades, the cut-and-sew Cox-Maze III procedure was the gold standard for the surgical treatment of atrial fibrillation (AF) and proved to be effective at curing lone AF and preventing its most dreaded complication, stroke. However, this procedure was not widely adopted because of its complexity and technical difficulty. During the past 5 to 10 years, the introduction of new ablation technology has led to the development of the Cox-Maze IV procedure, as well as, more limited lesion sets, with the ultimate goal of performing a minimally invasive lesion set on the beating heart, without the need for cardiopulmonary bypass. This review summarizes the current state of the art and future directions in the surgical treatment of lone AF. The hope is that as we learn more about the mechanisms of AF and develop preoperative diagnostic technologies capable of precisely locating the areas responsible for AF, it will become possible to tailor specific lesion sets and ablation modalities to individual patients, making the surgical treatment of lone AF available to a larger population of patients.

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Behavioral Genetics: Concepts for Research and Practice in Language Development and Disorders

Journal of Speech Language and Hearing Research ◽

10.1044/jshr.3805.1126 ◽

1995 ◽

Vol 38 (5) ◽

pp. 1126-1142 ◽

Cited By ~ 14

Author(s):

Jeffrey W. Gilger

Keyword(s):

Language Development ◽

Behavioral Genetics ◽

State Of The Art ◽

Genetic Research ◽

Great Promise ◽

Behavioral Genetic ◽

Fine Grained ◽

Future Goals ◽

Current State ◽

Research Designs

This paper is an introduction to behavioral genetics for researchers and practioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done—including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

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