scholarly journals Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

2021 ◽  
Vol 22 (9) ◽  
pp. 4338
Author(s):  
Rita Caparica ◽  
Ana Júlio ◽  
Filipe Fernandes ◽  
Maria Eduarda M. Araújo ◽  
João Guilherme Costa ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Poorly Soluble Drugs ◽  
Versatile Tool ◽  
Poorly Soluble ◽  
And Performance ◽  
The Stability ◽  
Drug Incorporation ◽  
Toxic Concentrations ◽  
The Impact

Numerous studies are continuously being carried out in pursuit of formulations with higher performance. Problems such as poor drug solubility, which hinders drug incorporation into delivery systems and bioavailability, or limitations concerning the stability and performance of the formulations may cause difficulties, since solving all these drawbacks at once is a huge challenge. Ionic liquids (ILs), due to their tunable nature, may hypothetically be synthesized for a particular application. Therefore, predicting the impact of a particular combination of ions within an IL in drug delivery could be a useful strategy. Eight ILs, two choline amino acid ILs, two imidazole halogenated ILs, and four imidazole amino acid ILs, were prepared. Their applicability at non-toxic concentrations, for improving solubility and the incorporation of the poorly soluble, ferulic, caffeic, and p-coumaric acids, as well as rutin, into topical emulsions, was assessed. Next, the impact of the ILs on the performance of the formulations was investigated. Our study showed that choosing the appropriate IL leads to a clear upgrade of a topical emulsion, by optimizing multiple features of its performance, such as improving the delivery of poorly soluble drugs, altering the viscosity, which may lead to better sensorial features, and increasing the stability over time.

Map Width Enhancement Technique for a Turbocharger Compressor

2013 ◽  
Vol 136 (6) ◽  
Author(s):  
Subenuka Sivagnanasundaram ◽  
Stephen Spence ◽  
Juliana Early
Keyword(s):  
Performance Improvement ◽  
Peak Pressure ◽  
Pressure Ratio ◽  
Comparison Study ◽  
Heavy Duty ◽  
Recirculating Flow ◽  
Heavy Duty Diesel ◽  
And Performance ◽  
The Stability ◽  
The Impact

This paper presents an investigation of map width enhancement and the performance improvement of a turbocharger compressor using a series of static vanes in the annular cavity of a classical bleed slot system. The investigation has been carried out using both experimental and numerical analysis. The compressor stage used for this study is from a turbocharger unit used in heavy duty diesel engines of approximately 300 kW. Two types of vanes were designed and added to the annular cavity of the baseline classical bleed slot system. The purpose of the annular cavity vane technique is to remove some of the swirl that can be carried through the bleed slot system, which would influence the pressure ratio. In addition to this, the series of cavity vanes provides a better guidance to the slot recirculating flow before it mixes with the impeller main inlet flow. Better guidance of the flow improves the mixing at the inducer inlet in the circumferential direction. As a consequence, the stability of the compressor is improved at lower flow rates and a wider map can be achieved. The impact of two cavity vane designs on the map width and performance of the compressor was highlighted through a detailed analysis of the impeller flow field. The numerical and experimental study revealed that an effective vane design can improve the map width and pressure ratio characteristic without an efficiency penalty compared to the classical bleed slot system without vanes. The comparison study between the cavity vane and noncavity vane configurations presented in this paper showed that the map width was improved by 14.3% due to a significant reduction in surge flow and the peak pressure ratio was improved by 2.25% with the addition of a series of cavity vanes in the annular cavity of the bleed slot system.

A Predictive Energy Landscape Model of Metamorphic Protein Conformational Specificity

2021 ◽  
Author(s):  
James O. Wrabl ◽  
Keila Voortman-Sheetz ◽  
Vincent J. Hilser
Keyword(s):  
Amino Acid ◽  
Structure Prediction ◽  
Large Scale ◽  
Energy Landscape ◽  
Thermodynamic Approach ◽  
High Identity ◽  
Denatured State ◽  
Metamorphic Protein ◽  
The Stability ◽  
The Impact

'Metamorphic' proteins challenge state-of-the-art structure prediction methods reliant on amino acid similarity. Unfortunately, this obviates a more effective thermodynamic approach necessary to properly evaluate the impact of amino acid changes on the stability of two different folds. A vital capability of such a thermodynamic approach would be the quantification of the free energy differences between 1) the energy landscape minima of each native fold, and 2) each fold and the denatured state. Here we develop an energetic framework for conformational specificity, based on an ensemble description of protein thermodynamics. This energetic framework was able to successfully recapitulate the structures of high-identity engineered sequences experimentally shown to adopt either Streptococcus protein GA or GB folds, demonstrating that this approach indeed reflected the energetic determinants of fold. Residue-level decomposition of the conformational specificity suggested several testable hypotheses, notably among them that fold-switching could be affected by local de-stabilization of the populated fold at positions sensitive to equilibrium perturbation. Since this ensemble-based compatibility framework is applicable to any structure and any sequence, it may be practically useful for the future targeted design, or large-scale proteomic detection, of novel metamorphic proteins.

Effects of Circumferential Inlet Distortion on the Performance of a Transonic Fan Together With the Impact of Tip Injection

2016 ◽  
Author(s):  
Hossein Khaleghi ◽  
Reza Jalaly
Keyword(s):  
Flow Field ◽  
Axial Flow ◽  
Test Case ◽  
Inlet Distortion ◽  
Distorted Region ◽  
And Performance ◽  
Tip Injection ◽  
The Stability ◽  
Transonic Fan ◽  
The Impact

Half-annulus unsteady numerical simulations have been conducted with a 60-deg total pressure circumferential distortion in a transonic axial-flow fan. The effects of inlet distortion on the performance, stability and flow field of the test case are investigated and analyzed. Results show that the incidence angles are reduced when the blades are entering into the distorted region. Conversely, distortion increases the incidence angles onto the blades when they are leaving the distorted section. Results further reveal that the time-averaged flow field at the tip of the blade is similar with and without distortion. However, the distortion applied is found to have detrimental effects on both the stability and performance. The impacts of both annular and discrete tip injection on the endwall flow field are further studied in the current work. It is shown that endwall injection reduces the incidence angles onto the blades. Consequently, the passage shock and the leakage flow are pushed rearward, which postpones stall initiation.

scholarly journals Self-Recirculating Casing Treatment Concept for Enhanced Compressor Performance

2002 ◽  
Author(s):  
Michael D. Hathaway
Keyword(s):  
High Speed ◽  
Flow Characteristics ◽  
Treatment Concept ◽  
Casing Treatment ◽  
Compressor Performance ◽  
And Performance ◽  
The Stability ◽  
The Impact ◽  
Compressor Efficiency ◽  
Transonic Rotor

A state-of-the-art CFD code (APNASA) was employed in a computationally based investigation of the impact of casing bleed and injection on the stability and performance of a moderate speed fan rotor wherein the stalling mass flow is controlled by tip flow field breakdown. The investigation was guided by observed trends in endwall flow characteristics (e.g., increasing endwall aerodynamic blockage) as stall is approached, and based on the hypothesis that application of bleed or injection can mitigate these trends. The “best” bleed and injection configurations were then combined to yield a self-recirculating casing treatment concept. The results of this investigation yielded: 1) identification of the fluid mechanisms which precipitate stall of tip critical blade rows, and 2) an approach to recirculated casing treatment which results in increased compressor stall range with minimal or no loss in efficiency. Subsequent application of this approach to a high speed transonic rotor successfully yielded significant improvements in stall range with no loss in compressor efficiency.

Map Width Enhancement Technique for a Turbocharger Compressor

2012 ◽  
Author(s):  
Subenuka Sivagnanasundaram ◽  
Stephen Spence ◽  
Juliana Early
Keyword(s):  
Performance Improvement ◽  
Peak Pressure ◽  
Pressure Ratio ◽  
Comparison Study ◽  
Heavy Duty ◽  
Recirculating Flow ◽  
Heavy Duty Diesel ◽  
And Performance ◽  
The Stability ◽  
The Impact

This paper presents an investigation of map width enhancement and the performance improvement of a turbocharger compressor using a series of static vanes in the annular cavity of a classical bleed slot system. The investigation has been carried out using both experimental and numerical analysis. The compressor stage used for this study is from a turbocharger unit used in heavy duty diesel engines of approximately 300 kW. Two types of vanes have been designed and added to the annular cavity of the baseline classical bleed slot system. The purpose of the annular cavity vane technique is to remove some of the swirl that can be carried through the bleed slot system, which would influence the pressure ratio. In addition to this, the series of cavity vanes provides a better guidance to the slot recirculating flow before it mixes with the impeller main inlet flow. Better guidance of the flow improves the mixing at the inducer inlet in the circumferential direction. As a consequence, the stability of the compressor is improved at lower flow rates and a wider map can be achieved. The impact of two cavity vane designs on the map width and performance of the compressor has been highlighted through a detailed analysis of the impeller flow field. The numerical and experimental study revealed that an effective vane design can improve the map width and pressure ratio characteristic without an efficiency penalty compared to the classical bleed slot system without vanes. The comparison study between the cavity vane and non-cavity vane configurations presented in this paper showed that the map width was improved by 14.3% due to a significant reduction in surge flow and the peak pressure ratio was improved by 2.25% with the addition of a series of cavity vanes in the annular cavity of the bleed slot system.

A comparative study of the effects of the Hofmeister series anions of the ionic salts and ionic liquids on the stability of α-chymotrypsin

2015 ◽  
Vol 39 (2) ◽  
pp. 938-952 ◽  
Author(s):  
Awanish Kumar ◽  
Anjeeta Rani ◽  
Pannuru Venkatesu
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Comparative Study ◽  
Hofmeister Series ◽  
Amino Acid Residues ◽  
Ionic Salts ◽  
The Stability ◽  
Catalytic Amino Acid

Direct interactions between the anion and the catalytic amino acid residues lead to denaturation of CT.

The impact of polymeric excipients on the particle size of poorly soluble drugs after pH-induced precipitation

2016 ◽  
Vol 95 ◽  
pp. 138-144 ◽  
Author(s):  
Kateřina Punčochová ◽  
Marie Prajzlerová ◽  
Josef Beránek ◽  
František Štěpánek
Keyword(s):  
Particle Size ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
The Impact

scholarly journals Organic-Inorganic Fertilization Built Higher Stability of Soil And Root Microbial Networks Than Exclusive Mineral Or Organic Fertilization

2021 ◽  
Author(s):  
Luhua Yang ◽  
Renhua Sun ◽  
Jungai Li ◽  
Limei Zhai ◽  
Huiling Cui ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Organic Fertilizer ◽  
Soil Microbiome ◽  
Microbial Network ◽  
Long Term Experiment ◽  
And Performance ◽  
The Stability ◽  
The Impact ◽  
Root Microbiome

Abstract BackgroundRoot microbiome is critical for plant health and performance. Many studies have assessed the impact of agricultural management on soil microbiome. But a comprehensive understanding of how root microbiota is affected by soil types and fertilization is still lacking. It is clear yet whether the stability of root microbiome is affected by fertilization regimes, and whether in the same patterns as soil microbiome. MethodsWe conducted a long-term experiment and investigated the impact of soil type, plant type and fertilization regimes on soil and root bacterial communities using high-throughput sequencing and network analysis.ResultsOur results indicated that microbial network under combined organic-inorganic fertilization had higher stability than exclusive inorganic or organic fertilizer. In addition, fertilization exhibited stronger effects on root microbiome than on soil microbiome. While total nitrogen mainly contributes to the variance of root microbiome, pH and soil organic matter were responsible for the differences of soil microbiome. Bacteroidetes and Firmicutes appeared as important drivers in soil and root microbiome amended with organic fertilizer, whereas Actinobacteria was enriched in the soil microbiome under inorganic fertilizer. ConclusionsOur results clearly indicated the responsive shifts of soil and root microbiome to different fertilization regimes, and gave hints for developing better fertilization practices and establishing healthy root associated microbiota.

scholarly journals TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 7
Author(s):  
Ana Júlio ◽  
João Guilherme Costa ◽  
Catarina Pereira-Leite ◽  
Tânia Santos de Almeida
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Colloidal Stability ◽  
Storage Stability ◽  
Pharmaceutical Formulations ◽  
Controlled Delivery ◽  
New Class ◽  
Improved Performance ◽  
And Performance ◽  
The Impact

Ionic liquids (ILs) have increasingly been studied as key materials to upgrade the performance of many pharmaceutical formulations. In controlled delivery systems, ILs have improved multiple physicochemical properties, showing the relevance of continuing to study their incorporation into these formulations. Transfersomes are biocompatible nanovesicular systems, quite useful in controlled delivery. They have promising characteristics, such as elasticity and deformability, making them suitable for cutaneous delivery. Nonetheless, their overall properties and performance may still be improved. Herein, new TransfersomILs systems to load rutin were developed and the physicochemical properties of the formulations were assessed. These systems were prepared based on an optimized formulation obtained from a Box–Behnken factorial design (BBD). The impact of imidazole-based ILs, cholinium-based ILs, and their combinations on the cell viability of HaCaT cells and on the solubility of rutin was initially assessed. The newly developed TransfersomILs containing rutin presented a smaller size and, in general, a higher association efficiency, loading capacity, and total amount of drug release compared to the formulation without IL. The ILs also promoted the colloidal stability of the vesicles, upgrading storage stability. Thus, ILs were a bridge to develop new TransfersomILs systems with an overall improved performance.

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