scholarly journals Electrochemical Sensors for Detection of Markers on Tumor Cells

2021 ◽  
Vol 22 (15) ◽  
pp. 8184
Author(s):  
Han Zhou ◽  
Xin Du ◽  
Zhenguo Zhang
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Protein Detection ◽  
High Sensitivity ◽  
Immunological Methods ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
Incidence And Mortality

In recent years, the increasing incidence and mortality of cancer have inspired the development of accurate and rapid early diagnosis methods in order to successfully cure cancer; however, conventional methods used for detecting tumor cells, including histopathological and immunological methods, often involve complex operation processes, high analytical costs, and high false positive rates, in addition to requiring experienced personnel. With the rapid emergence of sensing techniques, electrochemical cytosensors have attracted wide attention in the field of tumor cell detection because of their advantages, such as their high sensitivity, simple equipment, and low cost. These cytosensors are not only able to differentiate tumor cells from normal cells, but can also allow targeted protein detection of tumor cells. In this review, the research achievements of various electrochemical cytosensors for tumor cell detection reported in the past five years are reviewed, including the structures, detection ranges, and detection limits of the cytosensors. Certain trends and prospects related to the electrochemical cytosensors are also discussed.

Circulating tumor cell detection using a parallel flow micro-aperture chip system

Lab on a Chip ◽  
2015 ◽  
Vol 15 (7) ◽  
pp. 1677-1688 ◽  
Author(s):  
Chun-Li Chang ◽  
Wanfeng Huang ◽  
Shadia I. Jalal ◽  
Bin-Da Chan ◽  
Aamer Mahmood ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Circulating Tumor Cell ◽  
Parallel Flow ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
System P

A parallel flow micro-aperture chip system for detection of circulating tumor cells.

scholarly journals Role of 99mTc-(V)DMSA in Detecting Tumor Cell Proliferation

2007 ◽  
Vol 2 ◽  
pp. 117739010700200 ◽  
Author(s):  
Fatma Al-Saeedi
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Dimercaptosuccinic Acid ◽  
Cell Detection ◽  
Tumor Cell Proliferation ◽  
Technetium 99M ◽  
Tumor Cell Detection ◽  
Technetium 99M Dimercaptosuccinic Acid

Pentavalent technetium-99m dimercaptosuccinic acid (99mTc-(V)DMSA) is a tumor-seeking agent which was introduced to evaluate, image, and manage many types of cancers. In this review, the beginning of, and the most recent applications of using this agent was appraised. The relation with tumor cell detection and proliferation was reported and several mechanisms of uptake of 99mTc-(V)DMSA in tumor cells are described.

Electrokinetic Analysis of Cell Translocation in Low-Cost Microfluidic Cytometry for Tumor Cell Detection and Enumeration

2013 ◽  
Vol 60 (12) ◽  
pp. 3269-3275 ◽  
Author(s):  
Jinhong Guo ◽  
Tze Sian Pui ◽  
Yong-Ling Ban ◽  
Abdur Rub Abdur Rahman ◽  
Yuejun Kang
Keyword(s):  
Tumor Cell ◽  
Low Cost ◽  
Cell Detection ◽  
Tumor Cell Detection

A light-up fluorescence assay for tumor cell detection based on bifunctional split aptamers

The Analyst ◽  
2018 ◽  
Vol 143 (15) ◽  
pp. 3579-3585 ◽  
Author(s):  
Yuqiong Sun ◽  
Baoyin Yuan ◽  
Meitao Deng ◽  
Qing Wang ◽  
Jin Huang ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Fluorescence Detection ◽  
Fluorescence Assay ◽  
Cell Detection ◽  
Label Free ◽  
Tumor Cell Detection ◽  
One Step

Truncating, splitting and fusing of two aptamers for label-free and one-step fluorescence detection of tumor cells.

Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis.

1992 ◽  
Vol 10 (10) ◽  
pp. 1534-1539 ◽  
Author(s):  
I J Diel ◽  
M Kaufmann ◽  
R Goerner ◽  
S D Costa ◽  
S Kaul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Distant Metastasis ◽  
Primary Breast Cancer ◽  
Nodal Status ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
Human Breast Carcinomas

PURPOSE At the time of primary surgery, approximately 90% of all patients with breast cancer are free of metastases, but in the next 5 years almost 50% of them will relapse. We evaluated the significance of the presence of tumor cells in bone marrow of patients with primary breast cancer to investigate their predictive value for relapse. PATIENTS AND METHODS Two hundred sixty patients with primary breast cancer were examined for tumor cells in bone marrow aspirates taken from six sites of the skeleton. After density centrifugation, cells in interphase were smeared and stained. For the immunocytologic reaction, we used a new monoclonal antibody (2E11) that was reactive with the core protein of the tumor-associated glycoprotein TAG12. TAG12 is secreted by nearly all human breast carcinomas. RESULTS A significant correlation was found between tumor-cell detection and tumor stage (P < .0001), nodal status (P < .0001), and tumor grading (P = .002). A good relation to progesterone receptor (PR; P = .008) was found, but there was no correlation to estrogen receptor (ER) and menopausal status. Follow-up examinations showed distant metastases in 26 of 211 patients (15%). Twenty-two relapses occurred among the 81 patients with 2E11-positive cells in bone marrow, but only four occurred among the 130 patients without tumor-cell detection. CONCLUSIONS This study suggests that tumor-cell detection in bone marrow of patients with primary breast carcinoma is a good predictor for all distant relapses (P < .0005, Cox multiple regression analysis) and provides additional information in regard to other prognostic factors. The highest predicting value for distant metastasis results from the combination of nodal status, negative PR, and tumor-cell presence in bone marrow.

Covalent Organic Frameworks for Electrochemical Sensors: Recent Research and Future Prospects

2021 ◽  
Vol 17 ◽  
Author(s):  
Linyu Wang ◽  
Shasha Hong ◽  
Yuxi Yang ◽  
Yonghai Song ◽  
Li Wang
Keyword(s):  
Specific Surface ◽  
Electrochemical Sensors ◽  
Gas Adsorption ◽  
Low Cost ◽  
High Sensitivity ◽  
Crystalline Polymer ◽  
Synthesis Methods ◽  
High Porosity ◽  
Covalent Organic Frameworks ◽  
Covalent Bonds

Background: In recent years, electrochemical sensors are widely preferred because of their high sensitivity, rapid response, low cost and easy miniaturization. Covalent organic frameworks (COFs), a porous crystalline polymer formed by organic units connected by covalent bonds, have been widely used in gas adsorption and separation, drug transportation, energy storage, photoelectric catalysis, electrochemistry and other aspects due to their large specific surface, excellent stability, high inherent porosity, good crystallinity as well as structural and functional controllability. The topological structure of COFs can be designed in advance, the structural units and linkage are diversified, and the structure is easy to be functionalized, which are all beneficial to their application in electrochemical sensors. Methods: The types, synthesis methods, properties of covalent organic frameworks and some examples of using covalent organic frameworks in electrochemical sensors are reviewed. Results: Due to their characteristics of a large specific surface, high porosity, orderly channel and periodically arranged π electron cloud, COFs are often used to immobilize metal nanoparticles, aptamers or other materials to achieve the purpose of building electrochemical sensors with high sensitivity and good stability. Since the structure of COFs can be predicted, different organic units can build COFs with different structures and properties. Therefore, organic units with certain functional groups can be selected to build COFs with certain properties and used directly for electrochemical sensors. Conclusion: COFs have a good application prospect in electrochemical sensors.

Tumor cell detection method using complement-mediated cytolytic reaction and imaging sensor system

1987 ◽  
Vol 15 (3) ◽  
pp. 191-200 ◽  
Author(s):  
Masayasu Suzuki ◽  
Nobuyuki Watamabe ◽  
Eiichi Tamiya ◽  
Tetsuro Kataoka ◽  
Tohru Tokunaga ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Detection Method ◽  
Sensor System ◽  
Cell Detection ◽  
Tumor Cell Detection ◽  
Imaging Sensor
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