scholarly journals Acute Toxicity Evaluation of Non-Innocent Oxidovanadium(V) Schiff Base Complex

Inorganics ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 42
Author(s):  
Lidiane M. A. Lima ◽  
Heide Murakami ◽  
D. Jackson Gaebler ◽  
Wagner E. Silva ◽  
Mônica F. Belian ◽  
...  
Keyword(s):  
Schiff Base ◽  
Acute Toxicity ◽  
Anticancer Agents ◽  
Large Scale ◽  
Hydrolytic Stability ◽  
Scale Up ◽  
Free Ligand ◽  
Schiff Base Complex ◽  
The Body ◽  
Vanadium Complex

The vanadium(V) complexes have been investigated as potential anticancer agents which makes it essential to evaluate their toxicity for safe use in the clinic. The large-scale synthesis and the acute oral toxicity in mice of the oxidovanadium(V) Schiff base catecholate complex, abbreviated as [VO(HSHED)dtb] containing a redox-active ligand with tridentate Schiff base (HSHED = N-(salicylideneaminato)-N’-(2-hydroxyethyl)-1,2-ethylenediamine) and dtb = 3,5-di-(t-butyl)catechol ligands were carried out. The body weight, food consumption, water intake as well biomarkers of liver and kidney toxicity of the [VO(HSHED)dtb] were compared to the precursors, sodium orthovanadate, and free ligand. The 10-fold scale-up synthesis of the oxidovanadium(V) complex resulting in the preparation of material in improved yield leading to 2–3 g (79%) material suitable for investigating the toxicity of vanadium complex. No evidence of toxicity was observed in animals when acutely exposed to a single dose of 300 mg/kg for 14 days. The toxicological results obtained with biochemical and hematological analyses did not show significant changes in kidney and liver parameters when compared with reference values. The low oral acute toxicity of the [VO(HSHED)dtb] is attributed to redox chemistry taking place under biological conditions combined with the hydrolytic stability of the oxidovanadium(V) complex. These results document the design of oxidovanadium(V) complexes that have low toxicity but still are antioxidant and anticancer agents.

scholarly journals Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting

Micromachines ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 765 ◽  
Author(s):  
Shenglong Li ◽  
Xiaohong Tian ◽  
Jun Fan ◽  
Hao Tong ◽  
Qiang Ao ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Biomedical Applications ◽  
Large Scale ◽  
Scale Up ◽  
Three Dimensional ◽  
The Body ◽  
3D Bioprinting ◽  
Chemically Modified ◽  
Excellent Candidate ◽  
Complex Organ

Chitosan is a unique natural resourced polysaccharide derived from chitin with special biocompatibility, biodegradability, and antimicrobial activity. During the past three decades, chitosan has gradually become an excellent candidate for various biomedical applications with prominent characteristics. Chitosan molecules can be chemically modified, adapting to all kinds of cells in the body, and endowed with specific biochemical and physiological functions. In this review, the intrinsic/extrinsic properties of chitosan molecules in skin, bone, cartilage, liver tissue repair, and organ three-dimensional (3D) bioprinting have been outlined. Several successful models for large scale-up vascularized and innervated organ 3D bioprinting have been demonstrated. Challenges and perspectives in future complex organ 3D bioprinting areas have been analyzed.

A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents

2018 ◽  
Vol 54 (68) ◽  
pp. 9533-9536 ◽  
Author(s):  
Pavel Štarha ◽  
Zdeněk Trávníček ◽  
Zdeněk Dvořák
Keyword(s):  
Schiff Base ◽  
Anticancer Agents ◽  
Schiff Base Complex ◽  
Sandwich Complex ◽  
Base Complex ◽  
Half Sandwich

The new and pharmacologically promising electroneutral half-sandwich Ta(v)-dichlorido Schiff-base complex was described.

Synthesis and Fluorescence Property of Novel Zn2+ Schiff Base Complex

2012 ◽  
Vol 535-537 ◽  
pp. 1237-1240
Author(s):  
Li Hua Wang ◽  
Yong Li Wang ◽  
Zhan Zhong Hou ◽  
Yan Zhu Liu
Keyword(s):  
Schiff Base ◽  
Infrared Spectroscopy ◽  
Solid State ◽  
Zinc Chloride ◽  
Free Ligand ◽  
Schiff Base Complex ◽  
Blue Fluorescence ◽  
Peak Wavelength ◽  
Solid Fluorescence ◽  
Chloride Hydrate

The complex of ZnL2Cl4 was synthesized by using zinc chloride hydrate and ligand 2-[(4-Methylpiperazin-1-yl)iminomethyl]phenol(L) under reflux conditions and anhydrous ethanol as solvent. The complex was characterized by elemental analysis, Infrared spectroscopy, solid fluorescence. Experimental results showed that the free ligand was thermally stable, and emitted intensive blue fluorescence at the peak wavelength of 493 nm. Compared with the fluorescent emission of free ligand, the complex of ZnL2Cl4 is blue-shifted to 448 nm in solid-state and exhibiting stronger blue fluorescence.

scholarly journals PILOT PLANT SCALE-UP STUDIES FOR PARENTERAL - A REVIEW

2021 ◽  
Vol 12 (8) ◽  
pp. 58-63
Author(s):  
V. Manikandan
Keyword(s):  
Pilot Plant ◽  
Large Scale ◽  
Scale Up ◽  
Therapeutic Index ◽  
The Body ◽  
Plant Production ◽  
Scale Production ◽  
Large Scale Production ◽  
Production Techniques ◽  
Pilot Plant Scale

The dosage form of parenteral is sterile and gives a quick beginning of activity and gives an immediate action to accomplishing the medication impact inside the body. The route of parenteral administration is the most well-known and productive route for the conveyance of dynamic medication substances with poor bioavailability and medications with a tight therapeutic index. The principal objective of the technique was to endeavour to talk about the different procedures needed for the pilot plant production considers. The pilot plant is the term that is normally more modest than large-scale production plants yet it is the underlying scope of sizes. It is planned for learning, and making the definitions on a limited scale to accomplish the relationship with the enormous scope production, and they are normally more adaptable perhaps to the detriment of the economy. Most of the pilot plants are implicit in the maker's own research centres of the manufacturer utilizing stock lab hardware. These pilot plant studies are performed by using a technology transfer (TT) documentation report which is made by the research and development department for product development. Hence, this process would meet product quality, safety, and efficacy and further this production techniques will transfer to large-scale production for parenteral preparation.

scholarly journals Development and Implementation of Liposomal Encapsulated Micronutrient Fortified Body Oil Intervention for Infant Massage: An Innovative Concept to Prevent Micronutrient Deficiencies in Children

2021 ◽  
Vol 8 ◽  
Author(s):  
Aditi Apte ◽  
Himangi Lubree ◽  
Mudra Kapoor ◽  
Sanjay Juvekar ◽  
Rinti Banerjee ◽  
...  
Keyword(s):  
Motor Development ◽  
Large Scale ◽  
Scale Up ◽  
Cultural Practice ◽  
The Body ◽  
Community Level ◽  
Theory Of Change ◽  
Controlled Study ◽  
Implementation Phase ◽  
Novel Technologies

Indian communities have the ancient cultural practice of gentle oil massage for infants which has been shown to play a beneficial role in neuro-motor development. The concept of incorporating nanosized liposomes of micronutrients (i.e., iron, folate, vitamin B12, and vitamin D) in the body oil leverages this practice for transdermal supplementation of essential micro-nutrients. This paper describes the experience of developing an intervention in the form of body oil containing nanosized liposomes of iron and micro-nutrients built on the social context of infant oil massage using a theory of change approach. The process of development of the intervention has been covered into stages such as design, decide and implement. The design phase describes how the idea of nanosized liposomal encapsulated micronutrient fortified (LMF) body oil was conceptualized and how its feasibility was assessed through initial formative work in the community. The decide phase describes steps involved while scaling up technology from laboratory to community level. The implementation phase describes processes while implementing the intervention of LMF oil in a community-based randomized controlled study. Overall, the theory of change approach helps to outline the various intermediate steps and challenges while translating novel technologies for transdermal nutrient fortification to community level. In our experience, adaptation in the technology for large scale up, formative work and pilot testing of innovation at community level were important processes that helped in shaping the innovation. Meticulous mapping of these processes and experiences can be a useful guide for translating similar innovations.

scholarly journals Synthesis, characterization, and biological studies of some biometal complexes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vinay Kumar Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Anticancer Agents ◽  
Anthranilic Acid ◽  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Binding Studies ◽  
Metal Acetate ◽  
Biological Studies

Abstract Background Metal complexes Cu[C13H8O4N]22, Ni[Cl3H8O4N]23, and Co[C13H8O4N]24 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi. Results Results indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes. Conclusion The octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies. Graphical abstract

PHARMACOGNOSTIC, ANTIOXIDANT AND ACUTE TOXICITY STUDY OF Ficus sycomorus (Linn) (Moraceae) ROOT AND STEM BARK

2020 ◽  
Vol 4 (2) ◽  
pp. 605-614
Author(s):  
Murtala M. Namadina ◽  
H. Haruna ◽  
U. Sanusi
Keyword(s):  
Acute Toxicity ◽  
Radical Scavenging ◽  
Stem Bark ◽  
The Body ◽  
Toxicity Study ◽  
Bark Extract ◽  
Root Extract ◽  
Acute Toxicity Study ◽  
Radical Scavenging Ability ◽  
Phytochemical Components

Most of biochemical reactions in the body generates Reactive Oxygen Species (ROS), which are involved in the pathogenesis of oxidative stress-related disorders like diabetes, nephrotoxicity, cancer, cardiovascular disorders, inflammation and neurological disorders when they attack biochemical molecules like proteins, lipids and nucleic acid. Antioxidants are used to protect the cells or tissues against potential attack by ROS. Most medicinal plants possess a rich source of antioxidants such as flavonoids, phenols, tannins, alkaloids among others. These phytochemicals are currently pursued as an alternative and complimentary drug. In this study, phytochemical components, antioxidant and acute toxicity study of the methanol extract of stem bark and root of F. sycomorus were carried out using standard methods. Findings from this study revealed the presence of some diagnostic microscopical features such as calcium oxalate, starch, gum/mucilage, lignin, Aleurone grain, suberized/Cuticular cell wall and inulin but calcium carbonate was absent in stem bark but present in the powdered root. Quantitative physical constants include moisture contents (6.40% and 7.82%), ash value (7.20% and 9.30 %) in stem bark and root respectively. Carbohydrates, alkaloid, flavonoids, saponins, tannins, glycoside, steroid, triterpenes and phenols were present in all the extracts. They were found to exhibit potent 1,1,-diphenyl 2-picryl hydrazyl (DPPH) free scavenging activity. The DPPH radical scavenging ability of the extracts showed the following trend Ascorbic acid < stem bark extract˃ root extract. The LD50 of the methanolic stem bark and root extracts were found to be greater than 5000 mg /kg and is considered safe for use. Nonetheless, further

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