scholarly journals Potential of Fumagillin and Agaricus blazei Mushroom Extract to Reduce Nosema ceranae in Honey Bees

Insects ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 282
Author(s):  
Uros Glavinic ◽  
Jevrosima Stevanovic ◽  
Marko Ristanic ◽  
Milan Rajkovic ◽  
Dajana Davitkov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Nosema Ceranae ◽  
Agaricus Blazei ◽  
Infection Level ◽  
Immunostimulatory Activity ◽  
Negative Effect ◽  
Immune Related Genes ◽  
Bee Colonies ◽  
And Oxidative Stress

Depending on the infection level and colony strength, Nosema ceranae, a microsporidian endoparasite of the honey bee may have significant consequences on the health, reproduction and productivity of bee colonies. Despite exerting some side effects, fumagillin is most often used for Nosema control. In this study, in a cage experiment, N. ceranae infected bees were treated with fumagillin or the extract of Agaricus blazei mushroom, a possible alternative for Nosema control. Bee survival, Nosema spore loads, the expression levels of immune-related genes and parameters of oxidative stress were observed. Fumagillin treatment showed a negative effect on monitored parameters when applied preventively to non-infected bees, while a noticeable anti-Nosema effect and protection from Nosema-induced immunosuppression and oxidative stress were proven in Nosema-infected bees. However, a protective effect of the natural A. blazei extract was detected, without any side effects but with immunostimulatory activity in the preventive application. The results of this research suggest the potential of A. blazei extract for Nosema control, which needs to be further investigated.

The mechanisms involved in obesity-induced male infertility

2020 ◽  
Vol 16 ◽  
Author(s):  
Hamed Heydari ◽  
Rafighe Ghiasi ◽  
Saber Ghaderpour ◽  
Rana Keyhanmanesh
Keyword(s):  
Oxidative Stress ◽  
Metabolic Disease ◽  
Male Infertility ◽  
Male Fertility ◽  
Reproductive Function ◽  
Disease Development ◽  
Significant Evidence ◽  
Male Reproductive Function ◽  
Negative Effect ◽  
And Oxidative Stress

Introduction: Obesity resulted by imbalance between the intake of energy and energy consumption can lead to growth and metabolic disease development in people. Both in obese men and animal models, several studies indicate that obesity leads to male infertility. Objective: This review has discussed some mechanisms involved in obesity-induced male infertility. Method: Online documents were searched through Science Direct, Pubmed, Scopus, and Google Scholar websites dating from 1959 to recognize studies on obesity, kisspeptin, leptin, and infertility. Results: Obesity induced elevated inflammatory cytokines and oxidative stress can affect male reproductive functions including spermatogenesis disorders, reduced male fertility power and hormones involved in hypothalamus-pituitarygonadal axis. Conclusion: There is significant evidence that obesity resulted in male infertility. obesity has negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress.

scholarly journals Haloperidol-loaded polysorbate-coated polymeric nanocapsules decrease its adverse motor side effects and oxidative stress markers in rats

2012 ◽  
Vol 61 (5) ◽  
pp. 623-631 ◽  
Author(s):  
Dalila Moter Benvegnú ◽  
Raquel Cristine Silva Barcelos ◽  
Nardeli Boufleur ◽  
Camila Simonetti Pase ◽  
Patrícia Reckziegel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Polymeric Nanocapsules ◽  
And Oxidative Stress

scholarly journals THE LIFESPAN AND OXIDATIVE STRESS BETWEEN FERAL AND MANAGED HONEY BEE COLONIES

2021 ◽  
Author(s):  
Kilea Ward ◽  
Hongmei Li-Byarlay
Keyword(s):  
Oxidative Stress ◽  
Honey Bee ◽  
Stress Resistance ◽  
Honey Bees ◽  
Term Survival ◽  
Oxidative Stress Resistance ◽  
Honey Bee Health ◽  
The Impact ◽  
Bee Colonies ◽  
And Oxidative Stress

Molecular damage caused by oxidative stress may lead to organismal aging and resulted in acute mortality in organisms. Oxidative stress resistance and longevity are closely linked. Honey bees are the most important managed pollinator in agriculture but the long-term survival of honey bees is seriously threatened. Feral honey bee colonies displayed persistence to Varroa mites. However, it is unknown whether feral honey bees are stress-resistant or survive longer than managed bee populations. More work is needed to determine the impact of oxidative stress on honey bee health and survival. We used the paired colony design to determine the lifespan and levels of oxidative stress on worker bees from either a feral or a managed colony. Each pair of colonies shared similar foraging resources. Results exhibit longer survival time and lifespans of foragers in feral colonies than the managed colonies. The levels of oxidative stress from the lipid damage of feral colonies are higher than the managed colonies, indicating a tolerant mechanism not a repair mechanism to survive. Our study provided new insights into colony difference of physiology and oxidative stress resistance between feral honey bees and commercial stocks.

scholarly journals Protective Effects of Kinetin Against Pesticide Induced Toxicity

2020 ◽  
Vol 2 (1) ◽  
pp. 73
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Side Effects ◽  
Cell Lines ◽  
Fibroblast Cell ◽  
Live Cells ◽  
Protective Effects ◽  
Negative Effect ◽  
Cancerous Cells ◽  
Made In

India, as a nation, is primarily dependent on agriculture not only as a means to feed its people but also the sector, which contributes almost 80% of the country’s GDP. That being said, pesticides and fertilizers are enormously used to curb the pest attack against crops and to boost plant growth. It can be said that the negligent use of these chemicals may have side effects on the plants. We wanted to check the level of such side effects caused by acephate and also to find out whether such side effects can be neutralized by an organic and plant safe compound such as kinetin. Thus, in our project, we focused on checking the effects caused by the application of acephate, when sprayed (foliar) on to fenugreek plants. We performed three tests to study the oxidative stress, from which we can conclude that acephate by and of itself caused more oxidative stress whereas when applied in combination with Kinetin (lower acephate concentration and a comparatively higher concentration of Kinetin) the oxidative stress was comparatively low. Further studies were made in an animal model and cell lines. In the animal model, there was no significant result as both acephate and kinetin were inhibiting AChE activity. In Blood, the hemolysis percentage was calculated, and from the results, we could conclude that the combination of kinetin and acephate showed reduced hemolysis. When checked in cell lines, in fibroblast cells, the application of acephate increased the percentage of dead cells, whereas in combination with kinetin even-though there were initially some dead cells, the live cells that were remaining proliferated which can be viewed as the effect of kinetin. Whereas the cancerous cells of the sarcoma also had similar results, but the proliferation of the live cancerous sarcoma was more robust compared to the fibroblast cell, which could be inferred as a negative effect as it promotes cancerous growth. Thus, we can conclude that kinetin could be used as an ameliorative compound against pesticides by doing a few more extensive studies on various plant species and against various pesticides.

scholarly journals Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 176 ◽  
Author(s):  
Lourdes Alvarez-Arellano ◽  
Nadia González-García ◽  
Marcela Salazar-García ◽  
Juan Carlos Corona
Keyword(s):  
Oxidative Stress ◽  
Attention Deficit Hyperactivity Disorder ◽  
Substance Use ◽  
Side Effects ◽  
Adjuvant Therapy ◽  
Attention Deficit ◽  
Antioxidant Treatment ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
And Oxidative Stress

Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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