scholarly journals A Low Body Mass Index Is Associated with Unsuccessful Treatment in Patients with Mycobacterium avium Complex Pulmonary Disease

2021 ◽  
Vol 10 (8) ◽  
pp. 1576
Author(s):  
Hironori Sadamatsu ◽  
Koichiro Takahashi ◽  
Hiroki Tashiro ◽  
Koji Kusaba ◽  
Tetsuro Haraguchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Pulmonary Disease ◽  
Body Mass ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Laboratory Data ◽  
Poor Prognostic Factor ◽  
Unsuccessful Treatment ◽  
Low Body Mass Index ◽  
Low Bmi

Background: A low body mass index (BMI) has been reported to be a poor prognostic factor for Mycobacterium avium complex pulmonary disease (MAC-PD). The purpose of this study was to clarify the clinical features of MAC-PD in cases with a low BMI. Methods: This retrospective study analyzed the data of patients diagnosed with MAC-PD at Saga University Hospital between 2008 and 2019. The analyzed patient characteristics included age, gender, BMI, symptoms, laboratory data, chest computed tomography findings, and the treatment courses. We also investigated the factors associated with successful treatment. Results: In total, 144 patients were included in this study. The low-BMI group (BMI < 18.5 kg/m2) had a higher incidence of sputum, Mycobacterium intracellurare infection, and cavitary lesions, in addition to lower blood lymphocyte counts, higher neutrophil–lymphocyte ratios, and a lower prognostic nutritional index (PNI) when compared to the preserved-BMI group (BMI ≥ 18.5 kg/m2). Sixty-six of the 144 patients (45.8%) received treatment. Hemosputum, acid-fast bacillus sputum smear positivity, low lymphocyte counts, a low PNI, and unsuccessful treatment (48.5% vs. 24.2%, p < 0.05) were found to be associated with a low BMI. Conclusions: A low BMI is associated with cavitary lesions, malnutrition, and unsuccessful treatment in MAC-PD.

Low body mass index and lymphocytopenia associate with Mycobacterium avium complex pulmonary disease in patients with rheumatoid arthritis

2018 ◽  
Vol 29 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Wataru Hirose ◽  
Masayoshi Harigai ◽  
Takashi Uchiyama ◽  
Kenji Itoh ◽  
Toshiaki Ishizuka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Pulmonary Disease ◽  
Body Mass ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Low Body Mass Index

Determinants and Detection of Low Body Mass Index in Community-Dwelling Adults With Alzheimer's Disease

2000 ◽  
Vol 12 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Michel Bédard ◽  
D. William Molloy ◽  
Rhonda Bell ◽  
Judy A. Lever
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
At Risk ◽  
Body Mass ◽  
Community Dwelling ◽  
Assessment Protocol ◽  
Geriatric Clinic ◽  
Low Body Mass Index ◽  
Low Bmi

Objective: To determine the proportion of older adults with Alzheimer's disease presenting to a geriatric clinic with low body mass index (BMI), the proportion of these individuals recognized by clinicians as malnourished, and what patients' characteristics and caregivers' and clinicians' impressions are associated with low BMI. Design: Cross-sectional study. Setting: An outpatient geriatric clinic located in a university-affiliated teaching hospital. Participants: 340 patients with Alzheimer's disease, average age 75 years. Measurements: Individuals with a BMI below 21 were considered at risk of malnutrition. Physical examination and medical information were obtained from patients and caregivers by clinicians using a standardized assessment protocol. Clinicians' impression regarding evidence of malnutrition was obtained. Results: Forty-six patients (16%) had a BMI below 21. Clinicians reported evidence of potential malnutrition in 11 patients, 8 of whom had a BMI below 21. Using logistic regression, we found that women were five times more likely to have a BMI below 21 than men, and that individuals with low cognition were twice as likely to have a BMI below 21 than individuals with higher cognition. Conclusion: The proportion of patients with Alzheimer's disease with a BMI below 21 is similar to that encountered in the general population aged 65+. However, clinicians have difficulty identifying persons at risk of malnutrition according to BMI status. Women with low cognition were at increased risk of having a low BMI. Improvement in the detection of malnutrition is desirable. Further exploration of causal links between cognition and malnutrition is required.

scholarly journals Probably the Mycobacterium avium Complex around the Staple Line Exacerbated after Radiation Therapy

2022 ◽  
Vol 2022 ◽  
pp. 1-4
Author(s):  
Masashi Ito ◽  
Akihiro Yoshii ◽  
Takashi Osaki ◽  
Tomohito Kuwako ◽  
Ei Yamaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Staple Line ◽  
Laboratory Data ◽  
Radiologic Findings ◽  
Effects Of Radiation ◽  
Pulmonary Granulomas

The space around the staple line after lung surgery is at high risk of nontuberculosis Mycobacterium pulmonary disease (NTM-PD). Solitary nodules of NTM-PD around the staple line are difficult to distinguish from lung cancer. There is no clear identification from laboratory data and radiologic findings without histological examination. In the present case, we misdiagnosed the pulmonary granulomas with Mycobacterium avium complex pulmonary disease (MAC-PD) as a recurrence of lung cancer. We conducted radiation therapy. The pulmonary granulomas with MAC-PD were exacerbated by irradiation. The effects of radiation therapy for MAC-PD are unknown. When radiation therapy is performed for the patient coexistence with MAC-PD, we should pay attention to exacerbation of MAC-PD.

Training Depletes Muscle Glutathione in Patients with Chronic Obstructive Pulmonary Disease and Low Body Mass Index

Respiration ◽  
2006 ◽  
Vol 73 (6) ◽  
pp. 757-761 ◽  
Author(s):  
Roberto A. Rabinovich ◽  
Esther Ardite ◽  
Ana Maria Mayer ◽  
Maite Figueras Polo ◽  
Jordi Vilaró ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Pulmonary Disease ◽  
Body Mass ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Low Body Mass Index

scholarly journals Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1

2016 ◽  
Vol 95 (6) ◽  
Author(s):  
Teddy G. Goetz ◽  
Ramanaiah Mamillapalli ◽  
Hugh S. Taylor
Keyword(s):  
Gene Expression ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Expression Levels ◽  
Endometrial Cells ◽  
Low Body Mass Index ◽  
Low Bmi ◽  
Six Genes

Abstract The gynecological disease endometriosis is characterized by the deposition and proliferation of endometrial cells outside the uterus and clinically is linked to low body mass index (BMI). Gene expression in the liver of these women has not been reported. We hypothesized that endometriosis may impact hepatic gene expression, promoting a low BMI. To determine the effect of endometriosis on liver gene expression, we induced endometriosis in female mice by suturing donor mouse endometrium into the peritoneal cavity and measuring the weight of these mice. Dual-energy X-ray absorptiometry (DEXA) scanning of these mice showed lower body weight and lower total body fat than controls. Microarray analysis identified 26 genes differentially regulated in the livers of mice with endometriosis. Six of 26 genes were involved in metabolism. Four of six genes were upregulated and were related to weight loss, whereas two genes were downregulated and linked to obesity. Expression levels of Cyp2r1, Fabp4, Mrc1, and Rock2 were increased, whereas Igfbp1 and Mmd2 expression levels were decreased. Lep and Pparg, key metabolic genes in the pathways of the six genes identified from the microarray, were also upregulated. This dysregulation was specific to metabolic pathways. Here we demonstrate that endometriosis causes reduced body weight and body fat and disrupts expression of liver genes. We suggest that altered metabolism mediated by the liver contributes to the clinically observed low BMI that is characteristic of women with endometriosis. These findings reveal the systemic and multiorgan nature of endometriosis.

scholarly journals Spontaneous contralateral pneumothorax in a patient with low Body Mass Index

Open Medicine ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. 733-735
Author(s):  
Kensuke Nakazawa ◽  
Gen Ohara ◽  
Katsunori Kagohashi ◽  
Koichi Kurishima ◽  
Atsushi Ishibashi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Young Adults ◽  
Body Mass ◽  
Spontaneous Pneumothorax ◽  
Adolescents And Young Adults ◽  
Increased Risk ◽  
Low Body Mass Index ◽  
Low Bmi

AbstractSpontaneous pneumothorax is most common in adolescents and young adults. Some of them develop contralateral pneumothorax. In this paper, we report the case of a patient with spontaneous contralateral pneumothorax, whose body mass index (BMI) was 18.8 kg/m2. For either chest physicians or thoracic surgeons, follow up with recognition of increased risk of the contralateral pneumothorax is important especially in patients with contralateral bullous lesions and low BMI.

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