scholarly journals Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1

2016 ◽  
Vol 95 (6) ◽  
Author(s):  
Teddy G. Goetz ◽  
Ramanaiah Mamillapalli ◽  
Hugh S. Taylor
Keyword(s):  
Gene Expression ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Expression Levels ◽  
Endometrial Cells ◽  
Low Body Mass Index ◽  
Low Bmi ◽  
Six Genes

Abstract The gynecological disease endometriosis is characterized by the deposition and proliferation of endometrial cells outside the uterus and clinically is linked to low body mass index (BMI). Gene expression in the liver of these women has not been reported. We hypothesized that endometriosis may impact hepatic gene expression, promoting a low BMI. To determine the effect of endometriosis on liver gene expression, we induced endometriosis in female mice by suturing donor mouse endometrium into the peritoneal cavity and measuring the weight of these mice. Dual-energy X-ray absorptiometry (DEXA) scanning of these mice showed lower body weight and lower total body fat than controls. Microarray analysis identified 26 genes differentially regulated in the livers of mice with endometriosis. Six of 26 genes were involved in metabolism. Four of six genes were upregulated and were related to weight loss, whereas two genes were downregulated and linked to obesity. Expression levels of Cyp2r1, Fabp4, Mrc1, and Rock2 were increased, whereas Igfbp1 and Mmd2 expression levels were decreased. Lep and Pparg, key metabolic genes in the pathways of the six genes identified from the microarray, were also upregulated. This dysregulation was specific to metabolic pathways. Here we demonstrate that endometriosis causes reduced body weight and body fat and disrupts expression of liver genes. We suggest that altered metabolism mediated by the liver contributes to the clinically observed low BMI that is characteristic of women with endometriosis. These findings reveal the systemic and multiorgan nature of endometriosis.

scholarly journals The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

2019 ◽  
Vol 29 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Soo-Hyun Park ◽  
Su-Jin Jung ◽  
Eun-Kyung Choi ◽  
Ki-Chan Ha ◽  
Hyang-Im Baek ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Ethanolic Extract ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Fat Loss

Abstract Steamed ginger ethanolic extract (SGE) is a product with a high 6-shogaol contents and is thought to be more potent than other ginger products. We conducted a 12-week, randomized, double-blind, placebo-controlled clinical trial to determine the effects of SGE on weight and body fat loss. Eighty healthy obese participants were recruited and randomly divided into the SGE and placebo groups. The outcome measures comprised indicators of efficacy (body weight, body mass index, body composition, and blood markers) and safety. Following the supplementation period, mean body weight, body mass index, and body fat level were significantly lower in the SGE group than in the placebo group. No clinically significant changes were observed for any safety parameter. These results suggest that SGE is a potent anti-obesity agent that does not cause significant side effects. Therefore, SGE supplementation combined with lifestyle modification could be effective in the management of body weight and fat mass.

Determinants and Detection of Low Body Mass Index in Community-Dwelling Adults With Alzheimer's Disease

2000 ◽  
Vol 12 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Michel Bédard ◽  
D. William Molloy ◽  
Rhonda Bell ◽  
Judy A. Lever
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
At Risk ◽  
Body Mass ◽  
Community Dwelling ◽  
Assessment Protocol ◽  
Geriatric Clinic ◽  
Low Body Mass Index ◽  
Low Bmi

Objective: To determine the proportion of older adults with Alzheimer's disease presenting to a geriatric clinic with low body mass index (BMI), the proportion of these individuals recognized by clinicians as malnourished, and what patients' characteristics and caregivers' and clinicians' impressions are associated with low BMI. Design: Cross-sectional study. Setting: An outpatient geriatric clinic located in a university-affiliated teaching hospital. Participants: 340 patients with Alzheimer's disease, average age 75 years. Measurements: Individuals with a BMI below 21 were considered at risk of malnutrition. Physical examination and medical information were obtained from patients and caregivers by clinicians using a standardized assessment protocol. Clinicians' impression regarding evidence of malnutrition was obtained. Results: Forty-six patients (16%) had a BMI below 21. Clinicians reported evidence of potential malnutrition in 11 patients, 8 of whom had a BMI below 21. Using logistic regression, we found that women were five times more likely to have a BMI below 21 than men, and that individuals with low cognition were twice as likely to have a BMI below 21 than individuals with higher cognition. Conclusion: The proportion of patients with Alzheimer's disease with a BMI below 21 is similar to that encountered in the general population aged 65+. However, clinicians have difficulty identifying persons at risk of malnutrition according to BMI status. Women with low cognition were at increased risk of having a low BMI. Improvement in the detection of malnutrition is desirable. Further exploration of causal links between cognition and malnutrition is required.

scholarly journals Aerobic exercise-induced changes in body composition and blood lipids in young women

Medicina ◽  
2010 ◽  
Vol 46 (2) ◽  
pp. 129 ◽  
Author(s):  
Arvydas Stasiulis ◽  
Asta Mockienė ◽  
Daiva Vizbaraitė ◽  
Pranas Mockus
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Blood Lipids ◽  
Density Lipoprotein ◽  
Body Fat Mass ◽  
Cycling Training

The objective of the study was to assess changes in body composition, blood lipid and lipoprotein concentrations in 18–24-year-old women during the period of two-month aerobic cycling training. Material and methods. Young, healthy, nonsmoking women (n=19) volunteered to participate in this study. They were divided in two groups: experimental (E, n=10) and control (C, n=9). The subjects of group E exercised 3 times a week with intensity of the first ventilatory threshold and duration of 60 min. The group C did not exercise regularly over a two-month period of the experiment. The subjects of group E were tested before and after 2, 4, 6 and 8 weeks of the experiment. The participants of group C were tested twice with an eight-week interval. Results. Body weight, body mass index, body fat mass, and triacylglycerol (TAG) concentration decreased and high-density lipoprotein cholesterol (HDL-ch) concentration increased after the 8-week training program in the experimental group (P<0.05). Blood total cholesterol (Tch) and low-density lipoprotein cholesterol (LDL-ch) concentrations did not change significantly. Body weight and body mass index started to decrease after 2 weeks of the experiment, but significant changes were observed only after 6 and 8 weeks. Body fat mass was significantly decreased after 2 and 8 weeks of aerobic training. A significant increase in HDL-ch concentration was observed after 4, 6, and 8 weeks. A significant decrease in TAG concentration was observed after 2-week training. No significant changes in all the parameters except TAG (it was slightly increased) were seen in the control group. Conclusions. The two-month aerobic cycling training (within VT1, 60-min duration, three times a week) may induce significant changes in the parameters of body composition – body weight, body mass index, body fat mass, and blood lipids – in young women. The following significant changes were observed: TAG level decreased after 2 weeks, body mass and body mass index decreased after 6 weeks, body fat mass decreased and HDL-ch level increased after 8 weeks. Peak oxygen uptake increased after 4 weeks.

scholarly journals The Relationship Between Body Mass Index with Body Fat Percentage of Participants EXPO 2021 Universitas Teuku Umar

2021 ◽  
Vol 2 (1) ◽  
pp. 19
Author(s):  
Suci Eka Putri ◽  
Adelina Irmayani Lubis
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Nutritional Status ◽  
Body Mass ◽  
Body Fat ◽  
Body Height ◽  
The Body ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
The Relationship

Body mass index (BMI) is to monitor nutritional status adults, especially those related to deficiency and overweight. Body fat percentage can describe the risk of degenerative diseases.This study was conducted to measure the relationship between BMI and body fat percentage. Methods An analytical study was conducted to 41 male and 51 female participant from Universitas Teuku Umar. The body weight was measured using scales, whereas the body height was measured using microtoise. The body fat percentage was measured using Karada Scan. The BMI was calculated by dividing the body weight in kilogram divided by body height in meter square. Data was collected from 16-18th February 2021 and analyzed by Pearson’s correlation test. The results showed BMI underweight, normal, and overweight were 10,9, 57,6, and 31,5. High body fat percentage in men were 75,6% and in women were 35,5%. There is a relationship between the nutritional status of the women group and the body fat percentage with p-value is obtained = 0.021. Furthermore, for men, there is no relationship between nutritional status in the men group and the body fat percentage. There is a relationship between nutritional status and body fat percentage in women. Among this population, BMI can still be used to determine body fat percentage

scholarly journals Effect of L-citrulline, L-leucine, and multicomponent exercises on body compositions, physical activity, and amino acid concentrations in older Japanese women with low body mass index: A randomized double-blind placebo-controlled study

2021 ◽  
Author(s):  
Mijin Kim ◽  
Hiroko Isoda ◽  
Tomohiro Okura
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Composition ◽  
Body Weight ◽  
Amino Acid ◽  
Bone Mass ◽  
Older Women ◽  
Body Mass ◽  
Low Body Mass Index ◽  
Amino Acid Concentrations

Abstract Background: The intake of citrulline (CIT) and leucine (LEU) can stimulate protein synthesis. However, the efficacy of the combined intervention of CIT and LEU intake with exercise on body composition and physical activity (PA) remains unclear. This study aimed to investigate the combined effect of CIT and LEU intake and weight-bearing exercises (WBE) and square stepping exercise (SSE) for 20 weeks on body composition, PA, and amino acid concentration in older women with low body mass index (BMI) (16 to 21 kg/m 2 ). Methods: A total of 23 participants practiced WBE and SSE once a week for 75 minutes and were administered supplement (Ex + CIT·LEU group: CIT 0.8 g and LEU 1.6 g; Ex + Placebo group: 3.5 g carbohydrate) twice a day for 20 weeks. Body composition was measured using dual-energy X-ray absorptiometry. PA, including leisure-time, household, and occupational PA, was assessed using the Physical Activity Scale for the Elderly. Amino acid concentrations in the blood were analyzed by high-performance liquid chromatography.Results: Significant interactions were observed in the body weight, BMI, lean mass, body mass, household and total PA, tyrosine, and phenylalanine. The within-group analysis showed that tyrosine of post-intervention measurement (Post) significantly in both groups ( p < 0.05). Body weight, BMI, lean mass, body mass, household PA, total PA, and phenylalanine of Post increased significantly in the Ex + CIT·LEU group ( p < 0.05). Additionally, significant positive correlations were observed between the intake rate of supplements and bone mass ( r = 0.80) and between the practice rate of WBE at home and bone mineral density ( r = 0.66) in the Ex + CIT·LEU group. Conclusion: Our findings suggest that the intake of CIT and LEU, with the practice of WBE and SSE, could improve body weight, muscle mass, bone mass, and PA in older women with low BMI, which may prevent sarcopenia and frailty.Trial registration: UMIN000022385. Registered 20 May 2016, https://upload.umin.ac.jp/cgi-open-39 bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000025797&type=summary&language=J

scholarly journals Evaluation of body weight, body mass index, and body fat percentage changes in early stages of fixed orthodontic therapy

2016 ◽  
Vol 6 (4) ◽  
pp. 349 ◽  
Author(s):  
GowriSankar Singaraju ◽  
KSai Sandeep ◽  
VKarunakar Reddy ◽  
Prasad Mandava ◽  
VenkataN Bhavikati ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Orthodontic Therapy ◽  
Early Stages

scholarly journals Do body mass index and fat volume influence vocal quality, phonatory range, and aerodynamics in females?

CoDAS ◽  
2013 ◽  
Vol 25 (4) ◽  
pp. 310-318 ◽  
Author(s):  
Ben Barsties ◽  
Rudi Verfaillie ◽  
Nelson Roy ◽  
Youri Maryn
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Fat ◽  
Voice Quality ◽  
Normal Weight ◽  
P Values ◽  
Range Profile ◽  
Vocal Quality ◽  
Fat Volume

PURPOSE: To analyze the impact of body weight and body fat volume on selected parameters of vocal quality, phonatory range, and aerodynamics in females. METHODS: Based on measurements of body mass index in combination with body fat volume, 29 normophonic female subjects were classified as normal weight, underweight, and obese. Voice quality was investigated via auditory-perceptual ratings of breathiness, roughness, and overall dysphonia severity, via various acoustic measures and a multiparametric index. Phonatory range performance was examined using selected measures of the voice range profile and speech range profile. Measures of vocally relevant aerodynamics included vital capacity (i.e., VC), expected VC, phonation quotient, and maximum phonation time (i.e., MPT). RESULTS: Significant differences between the three weight groups were found across several measures of intensity, VC, MPT, and shimmer. As compared to the other groups, significantly higher values of maximum and minimum intensity levels, as well as sound pressure level during habitual running speech were observed for the obese group (all p-values<0.05); whereas, the underweight group had significantly lower values for VC and ratio of expected to measured VC (p-values<0.01). Furthermore, underweight subjects differed significantly as compared to normal weight subjects with lower MPT (p=0.025) and higher lowest-F0 (p=0.035). Finally the obese group showed significantly lower shimmer values than the normal weight subjects (p<0.05). CONCLUSION: Body weight and body fat volume appear to influence select objective measures of voice quality, vocal aerodynamics, and phonatory range performance.

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