scholarly journals Female Gender Is Associated with Higher Susceptibility of Weight Induced Arterial Stiffening and Rise in Blood Pressure

2021 ◽  
Vol 10 (16) ◽  
pp. 3479
Author(s):  
Junli Zuo ◽  
Huijuan Chao ◽  
Biwen Tang ◽  
Alberto P. Avolio ◽  
Markus P. Schlaich ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Systolic Pressure ◽  
Female Gender ◽  
Arterial Stiffening ◽  
Hemodynamic Forces ◽  
Traditional Risk Factors ◽  
Gender Based ◽  
Male Subjects ◽  
The Brain

Arterial stiffness is an important predictor of cardiovascular events, independent of traditional risk factors. Stiffening of arteries, though an adaptive process to hemodynamic load, results in substantial increase in the pulsatile hemodynamic forces that detrimentally affects the microcirculation perfusing the vital organs such as the brain, heart and kidneys. Studies have proposed that arterial stiffness precedes and may contribute to the development of hypertension in individuals with obesity. Our study sought to determine the gender-based effects on arterial stiffening in obesity which may predispose to the development of hypertension. We found female sex is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure in obesity. Women had significantly higher carotid-femoral pulse wave velocity (CF-PWV) with higher body mass index (BMI) status (normal: 7.9 ± 2 m/s; overweight: 9.1 ± 2 m/s; obese: 9 ± 2 m/s, p < 0.001), whereas it was similar in males across all BMI categories. The linear association between arterial stiffness and BMI following adjustment for age and brachial systolic and diastolic blood pressure (BP), remained significant in females (β = 0.06; 95% CI 0.01 to 0.1; p < 0.05) but not in males (β = 0.04; 95% CI −0.01 to 0.1; p > 0.05). The mean CF-PWV values increased by 0.1 m/s for every 1 kg/m2 increase in BMI in the female subjects in the age adjusted linear model, while such effect was not seen in the male subjects. In line with arterial stiffening, the overweight and obese females demonstrated significantly higher systolic brachial BP. (BP difference: ΔBP 9−11 mmHg, p < 0.01) and central systolic pressure (ΔBP 8−10 mmHg, p < 0.05) compared to their lean counterparts, unlike the male subjects. Our results suggest that female gender is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure.

IC-P-018: Arterial stiffness is associated with amyloid deposition in the brain independent of blood pressure

2013 ◽  
Vol 9 ◽  
pp. P19-P20 ◽  
Author(s):  
Timothy Hughes ◽  
Lewis Kuller ◽  
Emma Barinas-Mitchell ◽  
Eric McDade ◽  
Rachel Mackey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Amyloid Deposition ◽  
The Brain

P5466Exaggerated exercise blood pressure response is accompanied by increased sympathetic activity and arterial stiffness in subjects with high normal blood pressure

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Kalos ◽  
C Tsioufis ◽  
K Dimitriadis ◽  
N Vogiatzakis ◽  
A Kasiakogias ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Arterial Stiffness ◽  
Sympathetic Nerve ◽  
Muscle Sympathetic Nerve Activity ◽  
Left Ventricular ◽  
Normal Blood ◽  
Peak Exercise ◽  
Normal Blood Pressure ◽  
Arterial Stiffening

Abstract Background/Introduction The clinical importance of a hypertensive response to exercise (HRE) in subjects with high normal blood pressure (BP) is not fully elucidated, while sympathetic overactivity and arterial stiffening are linked with adverse cardiovascular prognosis. Purpose The aim of this study was to assess the relation of HRE with sympathetic drive as assessed by muscle sympathetic nerve activity (MSNA) and arterial stiffness in subjects with high normal BP. Methods 42 subjects with high normal office BP [defined as office systolic BP=130–139 mmHg and office diastolic BP=85–89 mmHg (age: 53±9 years, 29 males, office BP: 134/84 mmHg, 24-hour BP: 114/72 mmHg)] with a negative treadmill exercise test (Bruce protocol) were divided into those with HRE (n=12) (peak exercise systolic BP ≥210mmHg in men and ≥190 mmHg in women) and those without HRE (n=30). Arterial stiffness was evaluated on the basis of carotid to femoral pulse wave velocity (PWV) values. In all participants sympathetic drive was assessed by MSNA estimations based on established methodology (microneurography). Results Subjects with a HRE compared to those without exhibited higher waist circumference (108.2±5.3 vs 94.7±9.2 cm, p=0.001) and were characterized by greater levels of carotid to femoral PWV (8.5±0.8 vs 7.0±0.9 m/sec, p<0.001) and sympathetic nerve traffic as reflected by MSNA levels (41.1±1.5 vs 32.1±1.9 bursts per 100 heart beats, p<0.001), while did not differ regarding metabolic profile and left ventricular mass index (p=NS). In the total population, peak exercise systolic BP was related to 24-h systolic BP (r=0.229, p<0.05), PWV (r=0.218, p=0.002), and MSNA (r=0.214, p<0.05). Moreover, MSNA was related to waist circumference (r=0.33, p=0.004) and office systolic BP levels (r=0.31, p<0.05) but there was no association with PWV values (p=NS). Conclusion In subjects with high normal BP, a HRE identifies a state of arterial stiffening and sympathetic overdrive, as reflected by increased PWV and MSNA levels respectively. These finding suggest that exercise testing provides additional clinical information regarding the vascular status and modulation of sympathetic tone in this setting.

Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis

Rheumatology ◽  
2021 ◽  
Author(s):  
Yuanyuan Wang ◽  
Tao Meng ◽  
Guangfeng Ruan ◽  
Shuang Zheng ◽  
Jimin Zhu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Augmentation Index ◽  
Systolic Pressure ◽  
Cartilage Volume ◽  
Knee Cartilage ◽  
Knee Oa ◽  
Femoral Cartilage ◽  
Symptomatic Knee

Abstract Objective To describe the associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee OA. Methods A secondary analysis was performed on the data from participants in a randomized controlled trial that identified the effects of vitamin D supplementation on knee structures and symptoms among patients with symptomatic knee OA. Brachial and central blood pressure, arterial stiffness indicators and knee cartilage volume were measured at baseline and the 2 year follow-up. Associations were assessed using generalized estimating equations. Results Among 231 participants (average age 63.2 years), 48.9% were females. Higher supine systolic and diastolic pressures were significantly associated with lower tibial cartilage volume (systolic: lateral β −6.23, medial β −5.14, total β −11.35 mm3/mmHg; diastolic: lateral β −10.25, medial β −11.29, total β −21.50 mm3/mmHg). Higher supine systolic pressure was associated with lower femoral cartilage volume (lateral β −17.35, total β −28.31 mm3/mmHg). Central systolic pressure and arterial stiffness indicators (including pulse wave velocity, central pulse pressure and peripheral pulse pressure) were largely not associated with knee cartilage volume; however, higher augmentation index was associated with lower tibial and femoral cartilage volume (tibial: medial β −8.24, total β −19.13 mm3/%; femoral: lateral β −23.70, medial β −26.42, total β −50.12 mm3/%). Conclusions Blood pressure and arterial stiffness are associated with knee cartilage volume at several sites in knee OA patients. This supports that blood pressure and arterial stiffness may involve in the progression of knee OA.

Abstract 12973: Atrial Fibrillation is Associated With Increased Central Blood Pressure and Arterial Stiffness

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Priit Pauklin ◽  
Jaan Eha ◽  
Kaspar Tootsi ◽  
Rein Kolk ◽  
Rain Paju ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Pressure ◽  
Augmentation Index ◽  
Systolic Pressure ◽  
Applanation Tonometry ◽  
Central Blood Pressure ◽  
Control Group ◽  
Lack Of Information

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice, yet there is a lack of information about the hemodynamic profile and arterial stiffness of these patients. Purpose: The purpose of this study is to describe the differences in arterial stiffness and central blood pressures in patients with paroxysmal/persistent AF compared to a healthy control group. Methods: We included 76 patients with paroxysmal and persistent AF who underwent electrical cardioversion or pulmonary vein isolation (PVI) for AF. Carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx) and central blood pressure (cBP) were measured by applanation tonometry. All measurements were done in sinus rhythm (SR). We compared the results with 75 healthy age matched individuals. Results: Patients with a history of AF had higher cfPWV compared to the control group (8,0 m/s vs 7,2 m/s, p<0,001). AF patients also had higher central systolic blood pressure (cSBP) (118 mmHg vs 114 mmHg, p=0,03) and central pulse pressure (cPP) (39 mmHg vs 37 mmHg, p=0,03), without differences in peripheral systolic pressure (pSBP) (127 mmHg vs 123 mmHg, p=0,13), peripheral diastolic blood pressure (pDPB) (78 mmHg vs 76 mmHg, p=0,14) and peripheral pulse pressure (pPP) (48 mmHg vs 47 mmHg, p=0,37). There was no difference in heart rate (HR) (58 vs 61 bpm, p=0,08) (Table 1). In a multiple regression analysis (adjusted R 2 = 0,37) where cfPWV was set as the dependent variable and adjusting for age, sex, HR, weight, mean central arterial pressure (cMAP), estimated glomerular filtration rate (eGFR), the AF group remained to be an independent predictor for cfPWV (p=0,016). Conclusions: Patients with atrial fibrillation have a higher cSBP, cPP and cfPWV compared to healthy subjects without differences in peripheral blood pressure and HR. These findings support the hypothesis that arterial stiffness may play an important role in the development of atrial fibrillation.

Abstract P285: Aging In Male Mice Is Characterized By Arterial Stiffening And Diastolic Dysfunction

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Benard O Ogola ◽  
Bruna Visniauskas ◽  
Isabella Kilanowski-doroh ◽  
Caleb M Abshire ◽  
Alec Horton ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Cardiac Function ◽  
Vascular Function ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Male Mice ◽  
Middle Aged ◽  
Mature Adult ◽  
Arterial Stiffening

Aging is a nonmodifiable risk factor for cardiovascular mortality and is associated with arterial stiffening and cardiac dysfunction. In this study, we hypothesized that aging would decrease vascular compliance and cardiac function in male mice. Tail-cuff plethysmography was used to measure blood pressure, pulse wave velocity (PWV) for arterial stiffness, echocardiography for systolic and diastolic cardiac function, and wire myography for vessel reactivity in mature adult (25 weeks) and middle-aged (57 weeks) C57Bl/6 mice. Data was analyzed by t-test or 2-way ANOVA, and P<0.05 was considered significant. While there was no difference in blood pressure, PWV was higher in middle-aged male mice (1.8 ± 0.04 m/s vs. 1.2 ± 0.05 m/s; P<0.001) and associated with increased left ventricular (LV) posterior wall thickness (1.4 ± 0.07 mm vs. 1.1 ± 0.13 mm; P=0.03), and LV mass (172 ± 8 mg vs. 158 ± 20 mg; P=0.04). The ratio of early to late filling velocities, a measure of diastolic function, was lower in middle-age (1.6 ± 0.07 vs. 2.7 ± 0.37; P<0.001). Carotid artery histological analysis indicated that middle-aged mice had a greater collagen-to-elastin ratio along with decreased amounts of smooth muscle and thin collagen (P<0.05). Mesenteric artery contraction to PGF2α (446 ± 15% vs. 378 ± 14%; P=0.02) as well as relaxation to sodium nitroprusside (55 ± 7% vs. 31 ± 7%; P<0.01) were both blunted in the middle-aged group. The current study demonstrates that aging in male mice increases arterial stiffening and LV remodeling while decreasing diastolic and vascular function, independent of increased blood pressure. Future studies will investigate whether strategies that counteract arterial stiffness in the absence of changes in blood pressure can protect from cardiovascular aging.

scholarly journals Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: role of arterial stiffness

2001 ◽  
Vol 38 (2) ◽  
pp. 506-513 ◽  
Author(s):  
Douglas R Seals ◽  
Hirofumi Tanaka ◽  
Christopher M Clevenger ◽  
Kevin D Monahan ◽  
Mary Jo Reiling ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Postmenopausal Women ◽  
Systolic Pressure ◽  
Sodium Restriction

Abstract 2961: Ventricular Stiffness Contributes to Hypertension in Patients with Clinical Science Repaired Coarctation of the Aorta

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Hideaki Senzaki ◽  
Hirotaka Ishido ◽  
Satoshi Masutani
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Systolic Pressure ◽  
Regulatory System ◽  
Left Ventricular Pressure ◽  
Coarctation Of The Aorta ◽  
Left Ventricular ◽  
Pressure Area ◽  
The Mean ◽  
Preload Reduction

Background Despite successful repair, patients with coarctation of the aorta (CoA) often show persistent hypertension at rest and/or during exercise. Previous studies indicated that this phenomenon is mainly due to abnormality in arterial bed and its regulatory system. However, blood pressure is determined not only by the state of arterial bed but also by cardiac function to which the blood vessels are coupled. We hypothesized that ventricular stiffness contributes to the hypertensive state in patients with repaired CoA, in addition to increased vascular stiffness. Methods and Results The left ventricular pressure-area relationship was measured invasively in 37 patients (2–14 years of age) with successfully repaired CoA (defined as 0 mmHg pressure gradient) and compared with that of 41 age-matched control subjects who had small ventricular septal defect with an estimated shunt ratio <5%. Data recorded at rest and during transient preload reduction by inferior vena caval obstruction yielded left ventricular chamber stiffness (Ees) and effective arterial stiffness (Ea). The mean systolic blood pressure (SBP) was significantly higher in CoA patients (118±24 mmHg) than in the control (98±9 mmHg, p<0.01). Ees (45±19 mmHg/mlm 2 ) and Ea (36±19 mmHg/mlm 2 ) of CoA patients were significantly higher than those of the controls (18±7 and 20±7 mmHg/mlm 2 , respectively, P<0.001). To quantify the contribution of increased ventricular stiffness to the high SBP in CoA patients, SBP was estimated by assuming that Ees of CoA patients was equal to the mean Ees value of the control. The results showed a significant decrease in blood pressure by 12±5 mmHg, indicating that ventricular stiffness accounts for about 60% of the elevated blood pressure in CoA patients. Conclusions Increased ventricular stiffness greatly contributes to elevated systolic pressure in patients with repaired CoA. Thus, in addition to the recognized arterial stiffness, abnormal neurohumoral activity and autonomic dysfunction, ventricular stiffness could be a viable target for reduction of blood pressure and improvement of prognosis of patients with this disease.

scholarly journals Assessment of Arterial Stiffness, Brachial Haemodynamics, and Central Haemodynamics in Diabetic Hypertensives: A Pulse Wave Analysis-Based Case-Control Study from an Urban Area of West India

Pulse ◽  
2021 ◽  
pp. 1-10
Author(s):  
Jayesh Dalpatbhai Solanki ◽  
Sunil J. Panjwani ◽  
Ravi Kanubhai Patel ◽  
Devanshi Nishantbhai Bhatt ◽  
Param Jagdeep Kakadia ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Glycaemic Control ◽  
Arterial Stiffness ◽  
Pulse Wave ◽  
Case Control Study ◽  
Female Gender ◽  
Case Control ◽  
Wave Analysis ◽  
Control Study

<b><i>Introduction:</i></b> Hypertension (HTN) and diabetes frequently coexist, imposing significant cardiovascular risk that is normally studied in terms of brachial blood pressure (bBP). Direct and superior parameters like central haemodynamics and arterial stiffness are studied scarcely. Pulse wave analysis (PWA) offers a non-invasive measurement of the same that we studied in diabetic hypertensives. <b><i>Materials and Methods:</i></b> We conducted a case-control study on 333 treated diabetic hypertensive cases and 333 euglycaemic normotensive controls. Oscillometric PWA was performed by Mobil-o-Graph (IEM, Aachen, Germany). Parameters were further analysed in relation to gender, physical activity, body mass index (BMI), glycaemic control, blood pressure control, and disease duration (cut-off 5 years). Multiple linear regressions were done to find significant associations. <b><i>Results:</i></b> Cases had significantly higher brachial haemodynamics (blood pressure, heart rate (HR), and rate pressure product); arterial stiffness measures (augmentation pressure, augmentation index, pulse wave velocity, total arterial stiffness, and pulse pressure amplification), and central haemodynamics (central blood pressure, cardiac output, stroke work) than controls. In the case group, female gender, BMI ≥23, and uncontrolled blood pressures were significant factors that affected the results while other factors such as glycaemic control, physical activity, and duration did not. HR was significantly associated with study parameters. Brachial pressures were not significantly associated with corresponding aortic pressures. <b><i>Conclusion:</i></b> Diabetic hypertensives had adverse profile of cardiovascular parameters beyond bBP, related to female gender, and HTN and its control, more than that of diabetes. This baseline work suggests further study on these potential parameters.

Arterial stiffness and progression to hypertension in Japanese male subjects with high normal blood pressure

2007 ◽  
Vol 25 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Minoru Yambe ◽  
Hirofumi Tomiyama ◽  
Jiko Yamada ◽  
Yutaka Koji ◽  
Kohki Motobe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Japanese Male ◽  
Japanese Male Subjects ◽  
Male Subjects

scholarly journals Gender Difference of the Relationship between Arterial Stiffness and Blood Pressure Variability in Participants in Prehypertension

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Yang Lan ◽  
Huan Liu ◽  
Jinbo Liu ◽  
Hongwei Zhao ◽  
Hongyu Wang
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Blood Pressure Variability ◽  
Total Population ◽  
Vascular System ◽  
Blood Pressure Monitoring ◽  
Linear Regression Analysis ◽  
Multivariable Linear Regression Analysis ◽  
Female Body Mass ◽  
Traditional Risk Factors

Aim. The association of pressure load with elasticity in vascular system has not been studied fully. We proposed a hypothesis whether gender could modify the association of blood pressure variability (BPV) and arterial stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) in prehypertensive patients. Methods. 24h ambulatory blood pressure monitoring (24h-ABPM) and CF-PWV were measured in 723 participants with prehypertension. Univariate and multivariate regression analyses of these clinical and biological parameters were performed in total population, male and female. Results. A total of 723 participants (mean age 59.76 ± 12.37years, male 329 and female 394) were enrolled into the study. Compared with female, body mass index (BMI), fasting plasma glucose (FPG), uric acid (UA), and homocysteine (HCY) were significantly higher (all p < 0.05). Arterial stiffness (CF-PWV, male versus female, 10.89 ± 2.50 versus 10.33 ± 2.13 m/s, p=0.004) and BPVs (male versus female, 24 h SBPV 13.2 ± 5.11 versus 13.03 ± 5.20; 24 h DBPV 10.34 ± 3.87 versus 9.64 ± 3.59; N SBPV 11.90 ± 6.60 versus 10.94 ± 4.79; N DBPV 9.64 ± 5.87 versus 8.20 ± 4.48, all p<0.05) were higher in male. Multivariable linear regression analysis showed that 24 h BPV were linearly and positively related to CF-PWV in total population (24h SBPV, B=0.033; 24 h DBPV, B=0.035, both P<0.05) and female (24h SBPV, B=0.041; 24h DBPV, B=0.067, both P<0.05) independent of traditional risk factors and medications. Conclusion. BPV was independently associated with arterial stiffness in total population and the relation was modified by gender. 24 h BPVs in prehypertensive patients were useful to identify the early arterial stiffness. Clinical Trials Registration. This trial was registered with Clinical Trials.gov Identifier: NCT02569268.

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