scholarly journals Long-Term Morbidity and Mortality after First and Recurrent Cardiovascular Events in the ARTPER Cohort

2020 ◽  
Vol 9 (12) ◽  
pp. 4064
Author(s):  
Marina Escofet Peris ◽  
Maria Teresa Alzamora ◽  
Marta Valverde ◽  
Rosa Fores ◽  
Guillem Pera ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cardiovascular Event ◽  
Cardiovascular Events ◽  
Cardiac Event ◽  
Ankle Brachial Index ◽  
Mediterranean Population ◽  
Risk Of Recurrence ◽  
Factors Associated ◽  
Peripheral Arterial ◽  
Low Cardiovascular Risk

Background: Cardiovascular events are a major cause of mortality and morbidity worldwide. The risk of recurrence after a first cardiovascular event has been documented in the international literature, although not as extensively in a Mediterranean population-based cohort with low cardiovascular risk. There is also ample, albeit contradictory, research on the recurrence of stroke and myocardial infarctions (MI) after a first event and the factors associated with such recurrence, including the role of pathological Ankle-Brachial Index (ABI). Methods: The Peripheral Arterial ARTPER study is aimed at deepening our knowledge of patient evolution after a first cardiovascular event in a Mediterranean population with low cardiovascular risk treated at a primary care centre. We study overall recurrence, cardiac and cerebral recurrence. We studied participants in the ARTPER prospective observational cohort, excluding patients without cardiovascular events or with unconfirmed events and patients who presented arterial calcification at baseline or who died. In total, we analyzed 520 people with at least one cardiovascular event, focusing on the presence and type of recurrence, the risk factors associated with recurrence and the behavior of the ankle-brachial index (ABI) as a predictor of risk. Results: Between 2006 and 2017, 46% of patients with a first cardiovascular event experienced a recurrence of some type; most recurrences fell within the same category as the first event. The risk of recurrence after an MI was greater than after a stroke. In our study, recurrence increased with age, the presence of peripheral arterial disease (PAD), diabetes and the use of antiplatelets. Diabetes mellitus was associated with all types of recurrence. Additionally, patients with an ABI < 0.9 presented more recurrences than those with an ABI ≥ 0.9. Conclusions: In short, following a cardiac event, recurrence usually takes the form of another cardiac event. However, after having a stroke, the chance of having another stroke or having a cardiac event is similar. Lastly, ABI < 0.9 may be considered a predictor of recurrence risk.

Adhesion molecules and cardiovascular risk in peripheral arterial disease

2005 ◽  
Vol 93 (03) ◽  
pp. 559-563 ◽  
Author(s):  
Vittorio Schiano ◽  
Francesco Scopacasa ◽  
Massimo Chiariello ◽  
Antonio Silvestro ◽  
Gregorio Brevetti
Keyword(s):  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Adhesion Molecule ◽  
Cardiovascular Event ◽  
Plasma Levels ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Prognostic Impact ◽  
Risk Indicator ◽  
Peripheral Arterial

SummaryAlthough intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) play a relevant role in atherosclerosis, little is known about the prognostic impact of their soluble forms (s) in patients with peripheral arterial disease (PAD). The aim of this prospective study was to verify whether plasma levels of s ICAM-1 and s VCAM-1 predict cardiovascular risk in PAD, and improve the prognostic value of the ankle/brachial index (ABI) alone. Accordingly, plasma levels of sICAM-1 and sVCAM-1, and the ABI were measured in 75 PAD patients who were monitored for a mean of 24±13 months. Twenty-two (29.3%) patients had a cardiovascular event (15 coronary, 3 cerebrovascular and 4 peripheral events). Plasma levels of sVCAM-1 were 618±258 ng/mL in patients with and 496±164 ng/mL in those without an event (p= 0.016). The corresponding sICAM-1 values were 344±239 ng/mL and 275±99 ng/mL (p= 0.079). The cardiovascular event rate was higher in patients with sVCAM-1 levels above the median than in those with sVCAM-1 below the median (p=0.0027 by log rank test). Independent predictors of events were sVCAM-1 levels above the median (p=0.005) and an ABI below the median (p= 0.001). Amongst patients with ABI below the median, the occurrence of sVCAM-1 above the median was associated with a 3.4-fold increase in risk (95% CI 1.308 to 9.573, p= 0.013). In conclusion, increased plasma levels of sVCAM-1 have a negative prognostic impact in PAD and improve the predictive value of ABI, which is currently the most powerful risk indicator in these patients.

scholarly journals Cardiovascular Risk Factors Associated With Peripheral Arterial Disease in a Mediterranean Population

2019 ◽  
Vol 58 (6) ◽  
pp. e827-e828
Author(s):  
Gabriela Goncalves Martins ◽  
Daniel Gil Sala ◽  
Cristina Tello Diaz ◽  
Xavier Tenezaca Sari ◽  
Carlos Marrero Eligio de la puente ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Cardiovascular Risk Factors ◽  
Arterial Disease ◽  
Mediterranean Population ◽  
Factors Associated ◽  
Peripheral Arterial

scholarly journals Factors Associated with Cardiovascular Risk in High School Students of a Public School in the City of Santiago de Cali, Colombia

2020 ◽  
Vol 18 (1) ◽  
pp. 24 ◽  
Author(s):  
Carmelina Zorrilla-López ◽  
Juan David Ceballos-Santacruz ◽  
Christian Daniel Ramírez-Giraldo ◽  
Brayan Esneider Patiño-Palma ◽  
Pedro Calero-Saa
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Alcohol Consumption ◽  
Body Mass ◽  
Educational Institution ◽  
Factors Associated ◽  
The City ◽  
Low Cardiovascular Risk

Introduction: Cardiovascular diseases are the leading cause of death worldwide, and they have become a problem of interest of public health, both for developed and developing countries. In this regard, the decrease in time devoted to physical activity and the increase of sedentary activities stand out, thus making physical inactivity one of the many risk factors for Cardiovascular diseases. The objective was to determine the factors associated with cardiovascular risk in students of an educational institution in the city of Cali, Colombia. Materials and Methods: It is an observational and analytical epidemiological study with a sample of 227 randomly selected students, with 95 % reliability. To determine the level of physical activity in schoolchildren, researchers applied the international IPAQ physical activity questionnaire, and took anthropometric measures such as weight, height, and waist and hip circumference. Results: 96 % of the participants presented low cardiovascular risk. Likewise, the variables that showed a statistically significant association with cardiovascular risk were alcohol consumption and body mass index, which predict 81 % of the possibility of being at risk. Conclusions: The low cardiovascular risk and the high level of physical activity prevailed in the evaluated schoolchildren, significant differences regarding gender were observed, finding that men have higher values in weight, height, and waist/hip ratio compared to females. Finally, it was established that the factors associated with cardiovascular risk are body mass index and alcohol consumption.

scholarly journals The prognostic value of various markers of lower limb atherosclerotic lesions in patients with high and very high cardiovascular risk

2019 ◽  
pp. 14-19
Author(s):  
V. V. Genkel ◽  
I. I. Shaposhnik
Keyword(s):  
Cardiovascular Risk ◽  
Lower Limb ◽  
Predictive Value ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Coronary Revascularization ◽  
Prognostic Significance ◽  
Ankle Brachial Index ◽  
High Cardiovascular Risk ◽  
Very High

Aim. To study the prognostic significance of various markers of atherosclerosis of lower limb arteries (LLA) in patients at high and very high cardiovascular risk (CVR).Methods. The study included 108 patients at high and very high CVR, the median age of which was 62.0 (55.7; 67.0) years. All patients underwent duplex scanning of the LLA, as well as measurement of the ankle-brachial index (ABI) by the Doppler method. The combined end point was cardiovascular death, nonfatal myocardial infarction or unstable angina, requiring hospitalization, nonfatal stroke, coronary revascularization.Results. Atherosclerotic plaques in LLA were detected in 69.4% of cases, while a decrease in ABI was detected in 22.2% of patients, and LLA stenosis more than 50% in 36.1%. The follow-up duration was 25.0 (14.5; 35.5) months. The adverse cardiovascular events occurred in 41 (37.9%) patients. According to the Cox regression results, the following indicators had an independent predictive value in relation to the development of adverse cardiovascular events: a decrease in ABI ≤0.9 (RR 2.23; 95% CI 1.01-4.94; p=0.048), LLA stenosis ≥40% (RR 3.17; 95% CI 1.27–7.92; p=0.013) and the presence of plaque in the popliteal arteries (RR 2.49; 95% CI 1.27–7.92; p=0.013).Conclusion. In the group of patients at high and very high CVR, among ultrasonographic markers of lower limb arteriosclerosis, independent predictive value regarding the development of adverse cardiovascular events had a decrease in ABI ≤0.9, the presence of plaque in the popliteal arteries and LLA stenosis more than 40%.

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