scholarly journals Coupled SPH–FEM Modeling of Tsunami-Borne Large Debris Flow and Impact on Coastal Structures

2021 ◽  
Vol 9 (10) ◽  
pp. 1068
Author(s):  
Anis Hasanpour ◽  
Denis Istrati ◽  
Ian Buckle
Keyword(s):  
Turbulent Flows ◽  
Large Scale ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Fem Modeling ◽  
Vertical Column ◽  
Initial Water ◽  
Modeling Approach ◽  
Non Linear ◽  
The Impact

Field surveys in recent tsunami events document the catastrophic effects of large waterborne debris on coastal infrastructure. Despite the availability of experimental studies, numerical studies investigating these effects are very limited due to the need to simulate different domains (fluid, solid), complex turbulent flows and multi-physics interactions. This study presents a coupled SPH–FEM modeling approach that simulates the fluid with particles, and the flume, the debris and the structure with mesh-based finite elements. The interaction between the fluid and solid bodies is captured via node-to-solid contacts, while the interaction of the debris with the flume and the structure is defined via a two-way segment-based contact. The modeling approach is validated using available large-scale experiments in the literature, in which a restrained shipping container is transported by a tsunami bore inland until it impacts a vertical column. Comparison of the experimental data with the two-dimensional numerical simulations reveals that the SPH–FEM models can predict (i) the non-linear transformation of the tsunami wave as it propagates towards the coast, (ii) the debris–fluid interaction and (iii) the impact on a coastal structure, with reasonable accuracy. Following the validation of the models, a limited investigation was conducted, which demonstrated the generation of significant debris pitching that led to a non-normal impact on the column with a reduced contact area and impact force. While the exact level of debris pitching is highly dependent on the tsunami characteristics and the initial water depth, it could potentially result in a non-linear force–velocity trend that has not been considered to date, highlighting the need for further investigation preferably with three-dimensional models.

scholarly journals 3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome

2020 ◽  
Vol 49 (D1) ◽  
pp. D38-D46
Author(s):  
Kyukwang Kim ◽  
Insu Jang ◽  
Mooyoung Kim ◽  
Jinhyuk Choi ◽  
Min-Seo Kim ◽  
...  
Keyword(s):  
Cell Line ◽  
Large Scale ◽  
Three Dimensional ◽  
Cancer Cell Line ◽  
Cancer Genome ◽  
Structural Variations ◽  
3D Genome ◽  
Tightly Coupled ◽  
Regulatory Effects ◽  
The Impact

Abstract Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene expression. However, unraveling the pathogenicity of the 3D cancer genome remains a challenge since closer examinations have been greatly limited due to the lack of appropriate tools specialized for disorganized higher-order chromatin structure. Here, we updated a 3D-genome Interaction Viewer and database named 3DIV by uniformly processing ∼230 billion raw Hi-C reads to expand our contents to the 3D cancer genome. The updates of 3DIV are listed as follows: (i) the collection of 401 samples including 220 cancer cell line/tumor Hi-C data, 153 normal cell line/tissue Hi-C data, and 28 promoter capture Hi-C data, (ii) the live interactive manipulation of the 3D cancer genome to simulate the impact of structural variations and (iii) the reconstruction of Hi-C contact maps by user-defined chromosome order to investigate the 3D genome of the complex genomic rearrangement. In summary, the updated 3DIV will be the most comprehensive resource to explore the gene regulatory effects of both the normal and cancer 3D genome. ‘3DIV’ is freely available at http://3div.kr.

Investigation on Mechanical Properties of Fibreglass Reinforced Flexible Pipes Under Torsion

2018 ◽  
Author(s):  
Pan Fang ◽  
Yuxin Xu ◽  
Shuai Yuan ◽  
Yong Bai ◽  
Peng Cheng
Keyword(s):  
Mechanical Behavior ◽  
Torsion Angle ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Load Condition ◽  
Element Model ◽  
Flexible Pipe ◽  
Torsional Load ◽  
Flexible Pipes ◽  
The Impact

Fibreglass reinforced flexible pipe (FRFP) is regarded as a great alternative to many bonded flexible pipes in the field of oil or gas transportation in shallow water. This paper describes an analysis of the mechanical behavior of FRFP under torsion. The mechanical behavior of FRFP subjected to pure torsion was investigated by experimental, analytical and numerical methods. Firstly, this paper presents experimental studies of three 10-layer FRFP subjected to torsional load. Torque-torsion angle relations were recorded during this test. Then, a theoretical model based on three-dimensional (3D) anisotropic elasticity theory was proposed to study the mechanical behavior of FRFP. In addition, a finite element model (FEM) including reinforced layers and PE layers was used to simulate the torsional load condition in ABAQUS. Torque-torsion angle relations obtained from these three methods agree well with each other, which illustrates the accuracy and reliability of the analytical model and FEM. The impact of fibreglass winding angle, thickness of reinforced layers and radius-thickness ratio were also studied. Conclusions obtained from this research may be of great practicality to manufacturing engineers.

scholarly journals Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Seongil Kang ◽  
Sangyeol Song ◽  
Joosang Lee ◽  
Hyekyung Chang ◽  
Sanghun Lee
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Weight Control ◽  
Large Scale ◽  
Total Cholesterol Level ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
Citrus Unshiu ◽  
The Impact

Objectives. Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods. For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results. Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p < 0.01) decrease in BMI from 27.47±2.24 to 27.27±2.22 was observed in all subjects after CUPP treatment and 65.3% (N = 77) of them lost 1.03±0.83 kg of weight after 4 weeks of treatment. Total cholesterol level was significantly (p < 0.01) decreased from 204.0±37.4 mg/dL to 193.5±36.5 mg/dL. Significant (p < 0.05) decreases in levels of low-density lipoprotein, cholesterol, and triglyceride were also observed. Conclusions. These results suggest that CUPP in practice could help weight control and improve total cholesterol level. Findings of this study provide clinical foundation for future large-scale trials to establish clinical benefits of CUPP.

Numerical study of asymmetric and axisymmetric thermal jet with entropy generation concept

2021 ◽  
Vol 15 (1) ◽  
pp. 7628-7636
Author(s):  
D. Belakhal ◽  
Kouider Rahmani ◽  
Amel Elkaroui Elkaroui ◽  
Syrine Ben Haj Ayech ◽  
Nejla Mahjoub Saïd ◽  
...  
Keyword(s):  
Entropy Generation ◽  
Numerical Study ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Variable Density ◽  
Current Investigation ◽  
Numerical Resolution ◽  
Different Temperatures ◽  
Density Ratios ◽  
The Impact

In the current investigation, numerical study of a thermal jet of asymmetric (rectangular and elliptical) and axisymmetric (circular) geometry was investigated with variable density to verify the impact of the ratio of density and geometry on the generation of entropy. The central jet was brought to different temperatures (194, 293 and 2110 K) to obtain density ratios (0.66, 1 and 7.2) identical to a mixture jet ((Air-CO2), (Air-Air) and (Air-He)), respectively. Solving the three-dimensional numerical resolution of the Navier Stocks for turbulent flow permanent enclosed on the turbulence model K-εstandard was made. The results acquired are compared with that carried out in previous experimental studies, where it was concluded that, the axisymmetric (circular) geometry increases the entropy generation.

Experimental Indirect Determination of Wind Turbine Performance and Blade Element Theory Parameters in Controlled Conditions

2012 ◽  
Vol 36 (6) ◽  
pp. 717-737 ◽  
Author(s):  
David A. Johnson ◽  
Ahmed Abdelrahman ◽  
Drew Gertz
Keyword(s):  
Large Scale ◽  
Radial Direction ◽  
Turbine Blades ◽  
Model Development ◽  
Experimental Studies ◽  
Indirect Determination ◽  
Controlled Conditions ◽  
Power Measurements ◽  
The Impact ◽  
Blade Element

The performance of a three bladed 3.3 m diameter turbine was measured unobtrusively in a large scale, controlled wind, open jet facility. Due to the scale of the facility blockage was very low in comparison to previous studies. The turbine blades utilized NREL S83X airfoils appropriate for the flow conditions and Reynolds number present in the facility. Airfoils were blended along the radial direction in a varying chord, varying twist blade design with a design coefficient of power ( Cp) peak at λ = 5.4. Simultaneous three component velocity measurements were obtained using a purpose built traverse at specific radial locations (segments) upstream and immediately downstream of the rotor plane. These velocities were utilized to determine blade element momentum (BEM) parameters and to predict the performance of the rotor. Comparisons are made to the limited number of experimental studies reported in the literature and with parameters derived from CFD numerical simulations. Measured radial velocities upstream of the rotor were near zero and uniform in the radial direction and were uniform and slightly larger downstream of the rotor indicating the BEM assumption of limited radial interaction between segments was acceptable and that the wake was expanding. Axial induction was most uniform in the radial direction at the design and peak Cp condition and area averaged values approached 1/3 but did not exceed this value. Tangential measured velocities, tangential induction and circulation show the impact of the nacelle and blade root location and the tip. An evaluation of the local angle of attack and two dimensional airfoil data at one radial location gave a reasonable comparison with other measured torque values. Rotor performance determined with this method was compared with electrical power measurements and previous BEM model predictions. The power derived from the BEM method outlined here closely followed electrical turbine power measurements although the method overpredicted the power likely due to the segment discretization in the tip region. The detail of these results should be useful to further understand the flow immediately downstream of a rotor in controlled conditions and provide detailed data for BEM model enhancement and future model development.

Assessing young learners’ foreign language abilities

2020 ◽  
Vol 54 (1) ◽  
pp. 1-37 ◽  
Author(s):  
Marianne Nikolov ◽  
Veronika Timpe-Laughlin
Keyword(s):  
Foreign Language ◽  
Language Learning ◽  
Language Proficiency ◽  
Large Scale ◽  
Experimental Studies ◽  
Language Abilities ◽  
Language Programs ◽  
Young Learners ◽  
Foreign Language Programs ◽  
The Impact

AbstractGiven the exponential growth in the popularity of early foreign language programs, coupled with an emphasis of evidence-based instruction, assessing young learners’ (YLs) foreign language abilities has moved to center stage. This article canvasses how the field of assessing young learners of foreign languages has evolved over the past two decades. The review offers insights into how and why the field has developed, how constructs have been defined and operationalized, what language proficiency frameworks have been used, why children were assessed, what aspects of their foreign language proficiency have been assessed, who was involved in the assessment, and how the results have been used. By surveying trends in foreign language (FL) and content-based language learning programs involving children between the ages of 3 and 14, the article highlights research into assessment of and for learning, and critically discusses areas such as large-scale assessments and proficiency examinations, comparative and experimental studies, the impact of assessment, teachers’ beliefs and assessment practices, young learners’ test-taking strategies, age-appropriate tasks, alternative and technology-mediated assessment, as well as game-based assessments. The final section of the article highlights where more research is needed, thus outlining potential future directions for the field.

Can the Deforestation Breeze Change the Rainfall in Amazonia? A Case Study for the BR-163 Highway Region

2010 ◽  
Vol 14 (18) ◽  
pp. 1-25 ◽  
Author(s):  
Sandra I. Saad ◽  
Humberto R. da Rocha ◽  
Maria A. F. Silva Dias ◽  
Rafael Rosolem
Keyword(s):  
Boundary Layer ◽  
Large Scale ◽  
Three Dimensional ◽  
Atmospheric Modeling ◽  
Thermal Cell ◽  
Soil Wetness ◽  
Soil Dryness ◽  
Regional Atmospheric Modeling ◽  
The Impact

Abstract The authors simulated the effects of Amazonian mesoscale deforestation in the boundary layer and in rainfall with the Brazilian Regional Atmospheric Modeling System (BRAMS) model. They found that both the area and shape (with respect to wind incidence) of deforestation and the soil moisture status contributed to the state of the atmosphere during the time scale of several weeks, with distinguishable patterns of temperature, humidity, and rainfall. Deforestation resulted in the development of a three-dimensional thermal cell, the so-called deforestation breeze, slightly shifted downwind to large-scale circulation. The boundary layer was warmer and drier above 1000-m height and was slightly wetter up to 2000-m height. Soil wetness affected the circulation energetics proportionally to the soil dryness (for soil wetness below ∼0.6). The shape of the deforestation controlled the impact on rainfall. The horizontal strips lined up with the prevailing wind showed a dominant increase in rainfall, significant up to about 60 000 km2. On the other hand, in the patches aligned in the opposite direction (north–south), there was both increase and decrease in precipitation in two distinct regions, as a result of clearly separated upward and downward branches, which caused the precipitation to increase for patches up to 15 000 km2. The authors’ estimates for the size of deforestation impacting the rainfall contributed to fill up the low spatial resolution in other previous studies.

An Impact Assessment of GPS Radio Occultation Data on Prediction of a Rapidly Developing Cyclone over the Southern Ocean*

2014 ◽  
Vol 142 (11) ◽  
pp. 4187-4206 ◽  
Author(s):  
Shu-Ya Chen ◽  
Tae-Kwon Wee ◽  
Ying-Hwa Kuo ◽  
David H. Bromwich
Keyword(s):  
Data Assimilation ◽  
Southern Ocean ◽  
Large Scale ◽  
Radio Occultation ◽  
Three Dimensional ◽  
Wrf Model ◽  
The Other ◽  
Gps Radio Occultation ◽  
The Antarctic ◽  
The Impact

Abstract The impact of global positioning system (GPS) radio occultation (RO) data on an intense synoptic-scale storm that occurred over the Southern Ocean in December 2007 is evaluated, and a synoptic explanation of the assessed impact is offered. The impact is assessed by using the three-dimensional variational data assimilation scheme (3DVAR) of the Weather Research and Forecasting (WRF) Model Data Assimilation system (WRFDA), and by comparing two experiments: one with and the other without assimilating the refractivity data from four different RO missions. Verifications indicate significant positive impacts of the RO data in various measures and parameters as well as in the track and intensity of the Antarctic cyclone. The analysis of the atmospheric processes underlying the impact shows that the assimilation of the RO data yields substantial improvements in the large-scale circulations that in turn control the development of the Antarctic storm. For instance, the RO data enhanced the strength of a 500-hPa trough over the Southern Ocean and prevented the katabatic flow near the coast of East Antarctica from an overintensification. This greatly influenced two low pressure systems of a comparable intensity, which later merged together and evolved into the major storm. The dominance of one low over the other in the merger dramatically changed the track, intensity, and structure of the merged storm. The assimilation of GPS RO data swapped the dominant low, leading to a remarkable improvement in the subsequent storm’s prediction.

scholarly journals Integrating Transposable Elements in the 3D Genome

2019 ◽  
Author(s):  
Alexandros Bousios ◽  
Hans-Wilhelm Nuetzmann ◽  
Dorothy Buck ◽  
Davide Michieletto
Keyword(s):  
Transposable Elements ◽  
Cell Fate ◽  
Large Scale ◽  
Spatial Information ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Predictive Modelling ◽  
Polymer Physics ◽  
Modelling Framework ◽  
Polymer Folding

Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still only rarely integrated in experimental studies or accounted for in modelling. Here, we propose a new predictive modelling framework for the study of the integration patterns of TEs based on extensions of widely employed polymer models for genome organisation. Whilst polymer physics is recognised as an important tool to understand the mechanisms of genome folding, we now show that it can also offer orthogonal and generic insights into the integration and distribution profiles (or “topography”) of TEs across organisms. Here, we present polymer physics arguments and molecular dynamics simulations on TEs inserting into heterogeneously flexible polymers and show with a simple model that polymer folding and local flexibility affects TE integration patterns. The preliminary discussion presented herein lay the foundations for a large-scale analysis of TE integration dynamics and topography as a function of the three-dimensional host genome.

scholarly journals Using AlphaFold to predict the impact of single mutations on protein stability and function

2021 ◽  
Author(s):  
Marina A Pak ◽  
Karina A Markhieva ◽  
Mariia S Novikova ◽  
Dmitry S Petrov ◽  
Ilya S Vorobyev ◽  
...  
Keyword(s):  
Protein Folding ◽  
Protein Stability ◽  
Structure Prediction ◽  
Large Scale ◽  
3D Structure ◽  
Three Dimensional ◽  
Single Mutation ◽  
Before And After ◽  
And Function ◽  
The Impact

AlphaFold changed the field of structural biology by achieving three-dimensional (3D) structure prediction from protein sequence at experimental quality. The astounding success even led to claims that the protein folding problem is "solved". However, protein folding problem is more than just structure prediction from sequence. Presently, it is unknown if the AlphaFold-triggered revolution could help to solve other problems related to protein folding. Here we assay the ability of AlphaFold to predict the impact of single mutations on protein stability (ΔΔG) and function. To study the question we extracted metrics from AlphaFold predictions before and after single mutation in a protein and correlated the predicted change with the experimentally known ΔΔG values. Additionally, we correlated the AlphaFold predictions on the impact of a single mutation on structure with a large scale dataset of single mutations in GFP with the experimentally assayed levels of fluorescence. We found a very weak or no correlation between AlphaFold output metrics and change of protein stability or fluorescence. Our results imply that AlphaFold cannot be immediately applied to other problems or applications in protein folding.

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