scholarly journals The Emerging Roles of Antioxidant Enzymes by Dietary Phytochemicals in Vascular Diseases

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 199
Author(s):  
Seung Eun Lee ◽  
Yong Seek Park
Keyword(s):  
Antioxidant Enzymes ◽  
Vascular System ◽  
Inflammatory Diseases ◽  
Vascular Diseases ◽  
Vascular Wall ◽  
Chronic Obstructive ◽  
First Line ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Dietary Phytochemicals

Vascular diseases are major causes of death worldwide, causing pathologies including diabetes, atherosclerosis, and chronic obstructive pulmonary disease (COPD). Exposure of the vascular system to a variety of stressors and inducers has been implicated in the development of various human diseases, including chronic inflammatory diseases. In the vascular wall, antioxidant enzymes form the first line of defense against oxidative stress. Recently, extensive research into the beneficial effects of phytochemicals has been conducted; phytochemicals are found in commonly used spices, fruits, and herbs, and are used to prevent various pathologic conditions, including vascular diseases. The present review aims to highlight the effects of dietary phytochemicals role on antioxidant enzymes in vascular diseases.

scholarly journals Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Audray St-Jean ◽  
Dan Chateau ◽  
Matthew Dahl ◽  
Pierre Ernst ◽  
Nick Daneman ◽  
...  
Keyword(s):  
Nova Scotia ◽  
Antibiotic Stewardship ◽  
Outpatient Setting ◽  
Utilization Review ◽  
Chronic Obstructive ◽  
First Line ◽  
Obstructive Pulmonary Disease ◽  
Fluoroquinolone Antibiotics ◽  
Acute Bacterial Sinusitis ◽  
Drug Regulatory Agencies

Abstract Background Serious adverse effects of fluoroquinolone antibiotics have been described for more than decade. Recently, several drug regulatory agencies have advised restricting their use in milder infections for which other treatments are available, given the potential for disabling and possibly persistent side effects. We aimed to describe variations in fluoroquinolone use for initial treatment of urinary tract infection (UTI), acute bacterial sinusitis (ABS), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in the outpatient setting across Canada. Methods Using administrative health data from six provinces, we identified ambulatory visits with a diagnosis of uncomplicated UTI, uncomplicated AECOPD or ABS. Antibiotic exposure was determined by the first antibiotic dispensed within 5 days of the visit. Results We identified 4,303,144 uncomplicated UTI events among 2,170,027 women; the proportion of events treated with fluoroquinolones, mostly ciprofloxacin, varied across provinces, ranging from 18.6% (Saskatchewan) to 51.6% (Alberta). Among 3,467,678 ABS events (2,087,934 patients), between 2.2% (Nova Scotia) and 11.2% (Ontario) were dispensed a fluoroquinolone. For 1,319,128 AECOPD events among 598,347 patients, fluoroquinolones, mostly levofloxacin and moxifloxacin, ranged from 5.8% (Nova Scotia) to 35.6% (Ontario). The proportion of uncomplicated UTI and ABS events treated with fluoroquinolones declined over time, whereas it remained relatively stable for AECOPD. Conclusions Fluoroquinolones were commonly used as first-line therapies for uncomplicated UTI and AECOPD. However, their use varied widely across provinces. Drug insurance formulary criteria and enforcement may be a key to facilitating better antibiotic stewardship and limiting potentially inappropriate first-line use of fluoroquinolones.

scholarly journals Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases

2020 ◽  
Vol 21 (1) ◽  
pp. 307 ◽  
Author(s):  
Sara Ottolenghi ◽  
Aida Zulueta ◽  
Anna Caretti
Keyword(s):  
High Altitude ◽  
Inflammatory Diseases ◽  
Physiological Adaptation ◽  
Adaptation To Hypoxia ◽  
Chronic Obstructive ◽  
Compensatory Response ◽  
Obstructive Pulmonary Disease ◽  
Pathological Conditions ◽  
High Altitude Pulmonary Edema ◽  
Sphingosine 1 Phosphate

Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological conditions (respiratory diseases). In this narrative review, we introduce high altitude pulmonary edema (HAPE), acute respiratory distress syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD), and Cystic Fibrosis (CF) as examples of maladaptation to hypoxia, and highlight some of the potential mechanisms influencing the prognosis of the affected patients. Among the specific pathways modulated in response to hypoxia, iron metabolism has been widely explored in recent years. Recent evidence emphasizes hepcidin as highly involved in the compensatory response to hypoxia in healthy subjects. A less investigated field in the adaptation to hypoxia is the sphingolipid (SPL) metabolism, especially through Ceramide and sphingosine 1 phosphate. Both individually and in concert, iron and SPL are active players of the (mal)adaptation to physiological hypoxia, which can result in the pathological HAPE. Our aim is to identify some pathways and/or markers involved in the physiological adaptation to low atmospheric pressures (high altitudes) that could be involved in pathological adaptation to hypoxia as it occurs in pulmonary inflammatory diseases. Hepcidin, Cer, S1P, and their interplay in hypoxia are raising growing interest both as prognostic factors and therapeutical targets.

scholarly journals Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hyojung Lee ◽  
Youngeun Kim ◽  
Hye Jin Kim ◽  
Soojin Park ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Murine Model ◽  
Lung Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Chronic Obstructive ◽  
Herbal Formula ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-αand IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.

scholarly journals Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 123 ◽  
Author(s):  
Kui Wang ◽  
Yi Chen ◽  
Pengju Zhang ◽  
Ping Lin ◽  
Na Xie ◽  
...  
Keyword(s):  
Pulmonary Infection ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Autophagy Pathway ◽  
Pulmonary Arterial ◽  
Cellular Components ◽  
Cellular Stressors

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of cellular components, including protein aggregates, damaged organelles (such as mitochondria, endoplasmic reticulum, and others), as well as various pathogens. Thus, the autophagy pathway represents a major adaptive response for the maintenance of cellular and tissue homeostasis in response to numerous cellular stressors. A growing body of evidence suggests that autophagy is closely associated with diverse human diseases. Specifically, acute lung injury (ALI) and inflammatory responses caused by bacterial infection or xenobiotic inhalation (e.g., chlorine and cigarette smoke) have been reported to involve a spectrum of alterations in autophagy phenotypes. The role of autophagy in pulmonary infection and inflammatory diseases could be protective or harmful dependent on the conditions. In this review, we describe recent advances regarding the protective features of autophagy in pulmonary diseases, with a focus on ALI, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), tuberculosis, pulmonary arterial hypertension (PAH) and cystic fibrosis.

scholarly journals The emerging role of C/EBPs in glucocorticoid signaling: lessons from the lung

2011 ◽  
Vol 212 (3) ◽  
pp. 291-305 ◽  
Author(s):  
Abraham B Roos ◽  
Magnus Nord
Keyword(s):  
Transcription Factors ◽  
Potential Role ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Steroid Resistance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Glucocorticoid Signaling ◽  
Enhancer Binding Protein

Glucocorticoids (GCs) have been successfully used in the treatment of inflammatory diseases for decades. However, there is a relative GC resistance in several inflammatory lung disorders, such as chronic obstructive pulmonary disease (COPD), but still the mechanism(s) behind this unresponsiveness remains unknown. Interaction between transcription factors and the GC receptor contribute to GC effects but may also provide mechanisms explaining steroid resistance. CCAAT/enhancer-binding protein (C/EBP) transcription factors are important regulators of pulmonary gene expression and have been implicated in inflammatory lung diseases such as asthma, pulmonary fibrosis, cystic fibrosis, sarcoidosis, and COPD. In addition, several studies have indicated a role for C/EBPs in mediating GC effects. In this review, we discuss the different mechanisms of GC action as well as the function of the lung-enriched members of the C/EBP transcription factor family. We also summarize the current knowledge of the role of C/EBP transcription factors in mediating the effects of GCs, with emphasis on pulmonary effects, and their potential role in mediating GC resistance.

scholarly journals Vagotomy and Parkinson disease

Neurology ◽  
2017 ◽  
Vol 88 (21) ◽  
pp. 1996-2002 ◽  
Author(s):  
Bojing Liu ◽  
Fang Fang ◽  
Nancy L. Pedersen ◽  
Annika Tillander ◽  
Jonas F. Ludvigsson ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Vascular Diseases ◽  
Truncal Vagotomy ◽  
Chronic Obstructive ◽  
Cox Models ◽  
Obstructive Pulmonary Disease ◽  
Selective Vagotomy ◽  
Hazard Ratios ◽  
Comorbidity Index ◽  
Using Data

Objective:To examine whether vagotomy decreases the risk of Parkinson disease (PD).Methods:Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year of birth with a 40:1 ratio. Participants were followed up from the date of vagotomy until PD diagnosis, death, emigration out of Sweden, or December 31, 2010, whichever occurred first. Vagotomy and PD were identified from the Swedish Patient Register. We estimated hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox models stratified by matching variables, adjusting for country of birth, chronic obstructive pulmonary disease, diabetes mellitus, vascular diseases, rheumatologic disease, osteoarthritis, and comorbidity index.Results:A total of 4,930 cases of incident PD were identified during 7.3 million person-years of follow-up. PD incidence (per 100,000 person-years) was 61.8 among vagotomized patients (80.4 for truncal and 55.1 for selective) and 67.5 among reference individuals. Overall, vagotomy was not associated with PD risk (HR 0.96, 95% CI 0.78–1.17). However, there was a suggestion of lower risk among patients with truncal vagotomy (HR 0.78, 95% CI 0.55–1.09), which may be driven by truncal vagotomy at least 5 years before PD diagnosis (HR 0.59, 95% CI 0.37–0.93). Selective vagotomy was not related to PD risk in any analyses.Conclusions:Although overall vagotomy was not associated the risk of PD, we found suggestive evidence for a potential protective effect of truncal, but not selective, vagotomy against PD development.

scholarly journals Рhysiotherapy in Patients with Chronic Obstructive Pulmonary Disease

2017 ◽  
Vol 5 (6) ◽  
pp. 720-723 ◽  
Author(s):  
Antoaneta Dimitrova ◽  
Nikolay Izov ◽  
Ivan Maznev ◽  
Danche Vasileva ◽  
Milena Nikolova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Inflammatory Diseases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Therapy Program ◽  
Group A ◽  
Severity Of The Disease ◽  
Group B ◽  
Positive Effect

BACKGROUND: Physiotherapy is an essential for the treatment of patients with chronic respiratory non-inflammatory diseases especially for chronic obstructive pulmonary disease (COPD).AIM: To assess the effect of six months physiotherapy (PT) program on functional status in patients with COPD.МАTERIAL AND METHODS: The patients were divided into two groups according to the severity of the disease. Group A included 33 patients (mean age 68.6 ± 7.3; GOLD II – III stages). Group B included 32 patients (mean age 71.7 ± 6.9; GOLD I –II). They were referred to supervised PT program performed three times weekly for a half a year. All the patients were on standard medical care. At entry and after PT, six minutes walking test (6 MWT), Borg scale and modified Medical Research Council (mMRC) scale were assessed.RESULTS: Significant changes in 6 MWT (р < 0.001) and mMRC scale (р < 0.001) were found after applied physical therapy program in patients of group A. Exertional dyspnoea decreased significantly in patients with group A (р < 0.001). Positive changes were found in physical tolerance in the patients of group B (р < 0.001).CONCLUSIONS: The present study revealed the positive effect of six months physiotherapy in physical tolerance and dyspnoea in patients with COPD at different stages of the disease.

scholarly journals Kinesiotherapeutic interventions in diaphragmatic mobility of patients with chronic obstructive lung disease: systematic review

2020 ◽  
Vol 19 (2) ◽  
pp. 141
Author(s):  
Gilson Rosa De Jesus ◽  
Milena Santos Peixoto ◽  
Sidney De Souza Oliveira
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive Lung Disease ◽  
Intervention Programs ◽  
Chronic Obstructive ◽  
Diaphragmatic Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects ◽  
Risk Of Mortality ◽  
Respiratory Rehabilitation

This study analyzed the pathophysiological impacts of Chronic Obstructive Pulmonary Disease (COPD) on the respiratory system and the benefits of kinesiotherapeutic interventions on diaphragmatic mobility in patients affected by COPD. Systematic literature review carried out in the Scielo, Medline, VHL, Lilacs and PEDro databases, using the following keywords: Chronic Obstructive Pulmonary Disease, Respiratory Rehabilitation, Kinesitherapeutic Interventions and Diaphragmatic Dysfunction. Only original articles published between 2009 and 2019, about the benefits of different respiratory physical therapy intervention programs were included. Two examiners analyzed the qualities and evidence of the articles using the PEDro scale. Twelve manuscripts make up the discussion of this work. The present study confirms the beneficial effects of different Kinesiotherapy Intervention programs on physical health and quality of life, reduction of respiratory symptoms and risk of mortality, increased mobility of the rib cage, diaphragmatic functionality, functional capacity and respiratory muscle strength of patients affected by COPD.Keywords: chronic obstructive pulmonary disease, respiratory rehabilitation, kinesiotherapeutic interventions, diaphragmatic dysfunction.

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