Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique

The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO2 matrix, we embedded different weight percentages of polyethylene glycol (PEG6, 12, 24 wt%) and ferrous citrate (Fe(II)C5, 10, 15 wt%) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe2+ released was detected by Ultraviolet–Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, E. coli and P. aeruginosa, were investigated.

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Antibacterial Activity and Iron Release of Organic-Inorganic Hybrid Biomaterials Synthesized via the Sol-Gel Route

Applied Sciences ◽

10.3390/app11199311 ◽

2021 ◽

Vol 11 (19) ◽

pp. 9311

Author(s):

Michelina Catauro ◽

Ylenia D’Errico ◽

Antonio D’Angelo ◽

Ronald J. Clarke ◽

Ignazio Blanco

Keyword(s):

Hybrid Materials ◽

Release Kinetics ◽

Sol Gel ◽

Antibacterial Properties ◽

Iron Release ◽

Biological Characterization ◽

Visible Spectroscopy ◽

E Coli ◽

Hybrid Biomaterials ◽

Kinetics Of

The aim of this work was the synthesis of hybrid materials of iron (II)-based therapeutic systems via the sol-gel method. Increasing amounts of polyethylene glycol (PEG 6, 12, 24, 50 wt%) were added to SiO2/Fe20 wt% to modulate the release kinetics of the drug from the systems. Fourier-transform infrared (FTIR) spectroscopy was used to study the interactions between different components in the hybrid materials. The release kinetics in a simulated body fluid (SBF) were investigated, and the amount of Fe2+ released was detected via ultraviolet-visible spectroscopy (UV-Vis) after reaction with ortho-phenanthroline. Furthermore, biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated via the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using spectroscopy. Finally, the potential antibacterial properties of seven different materials against two different bacteria—E. coli and S. aureus—were investigated.

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Synthesis, Structural, Morphological and Thermal Characterization of Five Different Silica-Polyethylene Glycol-Chlorogenic Acid Hybrid Materials

Polymers ◽

10.3390/polym13101586 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1586

Author(s):

Michelina Catauro ◽

Pavel Šiler ◽

Jiří Másilko ◽

Roberta Risoluti ◽

Stefano Vecchio Ciprioti

Keyword(s):

Polyethylene Glycol ◽

Chlorogenic Acid ◽

Hybrid Materials ◽

Sol Gel ◽

Antibacterial Properties ◽

Silica Matrix ◽

Sem Images ◽

Fixed Amount ◽

Organic Components ◽

Free Material

The present study investigated the structure, morphology, thermal behavior, and bacterial growth analysis of novel three-component hybrid materials synthesized by the sol-gel method. The inorganic silica matrix was weakly bonded to the network of two organic components: a well-known polymer such as polyethylene glycol (PEG, average molar mass of about 4000 g/mol), and an antioxidant constituted by chlorogenic acid (CGA). In particular, a first series was made by a 50 wt% PEG-based (CGA-free) silica hybrid along with two 50 wt% PEG-based hybrids containing 10 and 20 wt% of CGA (denoted as SP50, SP50C10 and SP50C20, respectively). A second series contained a fixed amount of CGA (20 wt%) in silica-based hybrids: one was the PEG-free material (SC20) and the other two contained 12 and 50 wt% of PEG, respectively (SP12C20 and SP50C20, respectively), being the latter already included in the first series. The X-ray diffraction (XRD) patterns and scanning electron microscope (SEM) images of freshly prepared materials confirmed that all the materials were amorphous and homogeneous regardless of the content of PEG or CGA. The thermogravimetric (TG) analysis revealed a higher water content was adsorbed into the two component hybrids (SP50 and SC20) because of the availability of a larger number of H-bonds to be formed with water with respect to those of silica/PEG/CGA (SPC), where silica matrix was involved in these bonds with both organic components. Conversely, the PEG-rich materials (SP50C10 and SP50C20, both with 50 wt% of the polymer) retained a lower content of water. Decomposition of PEG and CGA occurred in almost the same temperature interval regardless of the content of each organic component. The antibacterial properties of the SiO2/PEG/CGA hybrid materials were studied in pellets using either Escherichia coli and Enterococcus faecalis, respectively. Excellent antibacterial activity was found against both bacteria regardless of the amount of polymer in the hybrids.

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Combined and individual doxorubicin/vancomycin drug loading, release kinetics and apatite formation for the CaO–CuO–P2O5–SiO2–B2O3 mesoporous glasses

RSC Advances ◽

10.1039/c6ra06829d ◽

2016 ◽

Vol 6 (56) ◽

pp. 51046-51056 ◽

Cited By ~ 20

Author(s):

Gurbinder Kaur ◽

O. P. Pandey ◽

K. Singh ◽

Bhupendra Chudasama ◽

V. Kumar

Keyword(s):

Release Kinetics ◽

Drug Loading ◽

Sol Gel ◽

Apatite Formation ◽

The Novel ◽

Gel Technique ◽

Glass Series

The novel mesoporous glass series based on (25 − x)CaO–xCuO–10P2O5–5B2O3–60SiO2 (x = 2.5, 5, 7.5, 10) has been prepared using the sol–gel technique.

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Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties

Molecules ◽

10.3390/molecules25204717 ◽

2020 ◽

Vol 25 (20) ◽

pp. 4717 ◽

Cited By ~ 1

Author(s):

Jelena Pajnik ◽

Ivana Lukić ◽

Jelena Dikić ◽

Jelena Asanin ◽

Milan Gordic ◽

...

Keyword(s):

Release Kinetics ◽

Antibacterial Properties ◽

Water Vapor Permeability ◽

Weibull Model ◽

Vapor Permeability ◽

E Coli ◽

Supercritical Solvent ◽

Composite Polymers ◽

Before And After ◽

Impregnation Time

In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material. Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent. Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4–24 h. The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively. The addition of natural zeolite (15–60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7–27.3%. FTIR and SEM analyses were applied for the characterization of the films. Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well. Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model. SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).

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Antibacterial Shoe Insole-Coated CuO-ZnO Nanocomposite Synthesized by the Sol-Gel Technique

Journal of Nanomaterials ◽

10.1155/2020/8825567 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13

Author(s):

Nguyen Lam Uyen Vo ◽

Thi Thuy Van Nguyen ◽

Tri Nguyen ◽

Phung Anh Nguyen ◽

Van Minh Nguyen ◽

...

Keyword(s):

Inhibitory Concentration ◽

Antibacterial Effect ◽

Sol Gel ◽

Average Particle Size ◽

Point Of Zero Charge ◽

Average Particle ◽

E Coli ◽

High Antibacterial Activity ◽

Gel Technique ◽

Shoe Insoles

In this study, CuO-ZnO composite was synthesized via the sol-gel method using oxalic acid to form the medium complex and its applications in antibacterial have been conducted with B. cereus, E. coli, S. aureus, Salmonella, and P. aeruginosa. Then, nanopowder of CuO-ZnO was coated on shoe insoles and their antibacterial effect with S. aureus was tested. The nanocomposite products were characterized by XRD, XPS, SEM, TEM, and UV-Vis. The results showed that the CuO-ZnO composite has the average particle size in a range of 20-50 nm, the point of zero charge of 7.8, and the bandgap of 1.7 eV. XPS result shows the composite structure with Cu2+ in the product. The minimum inhibitory concentration (MIC) of CuO-ZnO nanocomposite was 0.313 mg·mL-1 for S. aureus and Samonella, 0.625 mg·mL-1 for E. coli, and 5 mg·mL-1 for B. cereus and P. aeruginosa. The shoe insoles coated with 0.35 wt.% of CuO-ZnO nanocomposite also had high antibacterial activity against S. aureus, and this antibacterial nanocomposite was implanted durably on the surface of the shoe insoles.

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Antibacterial Properties of Zn Doped Hydrophobic SiO2 Coatings Produced by Sol-Gel Method

Coatings ◽

10.3390/coatings9060362 ◽

2019 ◽

Vol 9 (6) ◽

pp. 362

Author(s):

Bożena Pietrzyk ◽

Katarzyna Porębska ◽

Witold Jakubowski ◽

Sebastian Miszczak

Keyword(s):

Sol Gel ◽

Antibacterial Properties ◽

Zinc Nitrate ◽

Surface Wettability ◽

Gel Method ◽

Sol Gel Method ◽

E Coli ◽

Source Of Infection ◽

Bacteria Adhesion ◽

Hydrophobic Sio2

Bacteria existing on the surfaces of various materials can be both a source of infection and an obstacle to the proper functioning of structures. Increased resistance to colonization by microorganisms can be obtained by applying antibacterial coatings. This paper describes the influence of surface wettability and amount of antibacterial additive (Zn) on bacteria settlement on modified SiO2-based coatings. The coatings were made by sol-gel method. The sols were prepared on the basis of tetraethoxysilane (TEOS), modified with methyltrimethoxysilane (MTMS), hexamethyldisilazane (HMDS) and the addition of zinc nitrate or zinc acetate. Roughness and surface wettability tests, as well as study of the chemical structure of the coatings were carried out. The antibacterial properties of the coatings were checked by examining their susceptibility to colonization by Escherichia coli. It was found that the addition of zinc compound reduced the susceptibility to colonization by E. coli, while in the studied range, roughness and hydrophobicity did not affect the level of bacteria adhesion to the coatings.

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Synthesis and Characterization of Nonwoven Cotton-Reinforced Cellulose Hydrogel for Wound Dressings

Polymers ◽

10.3390/polym13234098 ◽

2021 ◽

Vol 13 (23) ◽

pp. 4098

Author(s):

Faheem Ahmad ◽

Bushra Mushtaq ◽

Faaz Ahmed Butt ◽

Muhammad Sohail Zafar ◽

Sheraz Ahmad ◽

...

Keyword(s):

Sol Gel ◽

Antibacterial Properties ◽

Wound Dressings ◽

Original Form ◽

Wound Exudate ◽

Moisture Management ◽

Cellulose Hydrogel ◽

Gel Technique ◽

The Fourier Transform

Hydrogels wound dressings have enormous advantages due to their ability to absorb high wound exudate, capacity to load drugs, and provide quick pain relief. The use of hydrogels as wound dressings in their original form is a considerable challenge, as these are difficult to apply on wounds without support. Therefore, the incorporation of polymeric hydrogels with a certain substrate is an emerging field of interest. The present study fabricated cellulose hydrogel using the sol–gel technique and reinforced it with nonwoven cotton for sustainable wound dressing application. The nonwoven cotton was immersed inside the prepared solution of cellulose and heated at 50 °C for 2 h to form cellulose hydrogel–nonwoven cotton composites and characterized for a range of properties. In addition, the prepared hydrogel composite was also loaded with titania particles to attain antibacterial properties. The Fourier transform infrared spectroscopy and scanning electron microscopy confirmed the formation of cellulose hydrogel layers inside the nonwoven cotton structure. The fabricated composite hydrogels showed good moisture management and air permeability, which are essential for comfortable wound healing. The wound exudate testing revealed that the fluid absorptive capacity of cellulose hydrogel nonwoven cotton composite was improved significantly in comparison to pure nonwoven cotton. The results reveal the successful hydrogel formation, having excellent absorbing, antimicrobial, and sustainable properties.

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Bacteriostatic Activity of LLDPE Nanocomposite Embedded with Sol–Gel Synthesized TiO2/ZnO Coupled Oxides at Various Ratios

Polymers ◽

10.3390/polym10080878 ◽

2018 ◽

Vol 10 (8) ◽

pp. 878 ◽

Cited By ~ 11

Author(s):

Khairul Saharudin ◽

Srimala Sreekantan ◽

Norfatehah Basiron ◽

Yong Khor ◽

Nor Harun ◽

...

Keyword(s):

Metal Oxide ◽

Structural Characteristics ◽

Sol Gel ◽

Antibacterial Properties ◽

Polymer Nanocomposite ◽

Zinc Ion ◽

Active Species ◽

Ion Release ◽

E Coli ◽

Bactericidal Effects

Metal oxide-polymer nanocomposite has been proven to have selective bactericidal effects against the main and common pathogens (Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli)) that can cause harmful infectious diseases. As such, this study looked into the prospect of using TiO2/ZnO with linear low-density polyethylene (LLDPE) to inactivate S. aureus and E. coli. The physical, structural, chemical, mechanical, and antibacterial properties of the nanocomposite were investigated in detail in this paper. The production of reactive species, such as hydroxyl radicals (•OH), holes (h+), superoxide anion radicals (O2•¯), and zinc ion (Zn2+), released from the nanocomposite were quantified to elucidate the underlying antibacterial mechanisms. LLDPE/25T75Z with TiO2/ZnO (1:3) nanocomposite displayed the best performance that inactivated S. aureus and E. coli by 95% and 100%, respectively. The dominant reactive active species and the zinc ion release toward the superior antibacterial effect of nanocomposite are discussed. This work does not only offer depiction of the effective element required for antimicrobial biomedical appliances, but also the essential structural characteristics to enhance water uptake to expedite photocatalytic activity of LLDPE/metal oxide nanocomposite for long term application.

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