scholarly journals Enzymatically Crosslinked In Situ Synthesized Silk/Gelatin/Calcium Phosphate Hydrogels for Drug Delivery

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7191
Author(s):  
Andra Grava ◽  
Karina Egle ◽  
Arita Dubnika
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Natural Protein ◽  
Natural Bone ◽  
Ph Values ◽  
Sustained Drug Delivery ◽  
Dexamethasone Phosphate ◽  
Horseradish Peroxide

Our research focuses on combining the valuable properties of silk fibroin (SF) and calcium phosphate (CaP). SF is a natural protein with an easily modifiable structure; CaP is a mineral found in the human body. Most of the new age biocomposites lack interaction between organic/inorganic phase, thus SF/CaP composite could not only mimic the natural bone, but could also be used to make drug delivery systems as well, which can ensure both healing and regeneration. CaP was synthesized in situ in SF at different pH values, and then crosslinked with gelatin (G), horseradish peroxide (HRP), and hydrogen peroxide (H2O2). In addition, dexamethasone phosphate (DEX) was incorporated in the hydrogel and drug delivery kinetics was studied. Hydrogel made at pH 10.0 was found to have the highest gel fraction 110.24%, swelling degree 956.32%, and sustained drug delivery for 72 h. The highest cell viability was observed for the hydrogel, which contained brushite (pH 6)—512.43%.

scholarly journals Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA–PEG–PLGA

2012 ◽  
Vol 13 (2) ◽  
pp. 590-600 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farnaz Sadat Mirzazadeh Tekie ◽  
Seyed Ahmad Mohajeri ◽  
Fariba Ganji ◽  
Gholamhossein Zohuri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Sustained Drug Delivery ◽  
In Situ Forming

Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

2013 ◽  
Vol 6 (3) ◽  
pp. 2113-2124
Author(s):  
Prashant Malik ◽  
Neha Gulati ◽  
Raj Kaur Malik ◽  
Upendra Nagaich
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Atomic Scale ◽  
Sustained Drug Delivery ◽  
Pharmaceutical Nanotechnology ◽  
Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.    

Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy

2015 ◽  
Vol 49 ◽  
pp. 262-268 ◽  
Author(s):  
Yanbo Zhang ◽  
Jianxun Ding ◽  
Diankui Sun ◽  
Hai Sun ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Drug Delivery

scholarly journals Effects of calcium phosphates incorporation on structural, thermal and drug-delivery properties of collagen:chitosan scaffolds

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Mirella Romanelli Vicente Bertolo ◽  
Virginia Conceição Amaro Martins ◽  
Ana Maria De Guzzi Plepis
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Great Influence ◽  
Collagen Gel ◽  
Dry Mass ◽  
Ex Situ ◽  
Porous Scaffolds ◽  
Drug Delivery Vehicles

In this study, we evaluated how different procedures of calcium phosphate synthesis and its incorporation in collagen:chitosan scaffolds could affect their structural and thermal properties, aiming the obtention of homogeneous scaffolds which can act as drug delivery vehicles in bone tissue engineering. Therefore, three different scaffold preparation procedures were developed, changing the order of addition of the components: in CC-CNPM1 and CC-CNPM2, calcium phosphate synthesis was performed in situ in the chitosan gel (1%, w/w) followed by mixture with collagen (1%, w/w), with changes in the reagents used for calcium phosphate formation; in CC-CNPM3 procedure, calcium phosphate was synthesized ex situ and then incorporated into the collagen gel, in which chitosan in powder was mixed. In all procedures, 5% (in dry mass) of ciprofloxacin was incorporated. FTIR analysis confirmed the presence of calcium phosphate in all scaffolds. DSC curves showed that collagen denaturation temperature (Td) increased with calcium incorporation. SEM photomicrographs of scaffolds cross-section revealed porous scaffolds with calcium phosphate grains internally distributed in the polymeric matrix. XRD diffractograms indicated that the calcium phosphates obtained are hydroxyapatite. The pore size distribution was more homogeneous for CC-CNPM3, which also stood out for its smaller porosity and lower absorption in PBS. These results indicate that the in situ or ex situ phosphate incorporation in the scaffolds had a great influence on its structural properties, which also had consequences for ciprofloxacin release. CC-CNPM3 released a smaller amount of antibiotic (30%), but its release profile was better described by all the tested models.

Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release

2012 ◽  
Vol 32 (11) ◽  
pp. 2679-2690 ◽  
Author(s):  
Hiva Baradari ◽  
Chantal Damia ◽  
Maggy Dutreih-Colas ◽  
Etienne Laborde ◽  
Nathalie Pécout ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

scholarly journals DEVELOPMENT, EVALUATION AND CHARACTERISTICS OF OPHTHALMIC IN SITU GEL SYSTEM: A REVIEW

2019 ◽  
pp. 47-53 ◽  
Author(s):  
MRINMOY DEKA ◽  
ABDUL BAQUEE AHMED ◽  
JASHOBIR CHAKRABORTY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Temperature Modulation ◽  
Duration Of Action ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Sensitive Organ ◽  
Ophthalmic Drug

Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to achieve the desired therapeutic concentration. There are various novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. In situ gelling systems are liquid upon instillation and undergo a phase transition to form gel due to some stimuli responses such as temperature modulation, change in pH and presence of ions. Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards an incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review based on ocular in situ gels, characteristization, techniques and evaluation of in situ ophthalmic drug delivery systems,

scholarly journals Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 187 ◽  
Author(s):  
Alessandra Adrover ◽  
Patrizia Paolicelli ◽  
Stefania Petralito ◽  
Laura Di Muzio ◽  
Jordan Trilli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitamin B12 ◽  
Drug Delivery Systems ◽  
Moving Boundary ◽  
Delivery Systems ◽  
Gellan Gum ◽  
Simulated Gastric Fluid ◽  
Sustained Drug Delivery ◽  
Porous Beads ◽  
Swelling Model

In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare polymeric beads. Rheological studies and preliminary experiments of beads preparation allowed to identify the GG and the CaCl2 concentrations suitable for obtaining stable and spherical particles. GG beads were formed, through ionotropic gelation technique, with and without the presence of the synthetic clay laponite. The resultant beads were analyzed for dimensions (before and after freeze-drying), morphological aspects and ability to swell in different media miming biological fluids, namely SGF (Simulated Gastric Fluid, HCl 0.1 M) and SIF (Simulated Intestinal Fluid, phosphate buffer, 0.044 M, pH 7.4). The swelling degree was lower in SGF than in SIF and further reduced in the presence of laponite. The GG and GG-layered silicate composite beads were loaded with two model drugs having different molecular weight, namely theophylline and cyanocobalamin (vitamin B12) and subjected to in-vitro release studies in SGF and SIF. The presence of laponite in the bead formulation increased the drug entrapment efficiency and slowed-down the release kinetics of both drugs in the gastric environment. A moving-boundary swelling model with “diffuse” glassy-rubbery interface was proposed in order to describe the swelling behavior of porous freeze-dried beads. Consistently with the swelling model adopted, two moving-boundary drug release models were developed to interpret release data from highly porous beads of different drugs: drug molecules, e.g., theophylline, that exhibit a typical Fickian behavior of release curves and drugs, such as vitamin B12, whose release curves are affected by the physical/chemical interaction of the drug with the polymer/clay complex. Theoretical results support the experimental observations, thus confirming that laponite may be an effective additive for fabricating sustained drug delivery systems.

Macroporous Calcium Phosphate Bioceramics as Drug Release Agents: A Kinetics Study of Ampicillin Release

2008 ◽  
Vol 396-398 ◽  
pp. 675-678
Author(s):  
J.S.V. Albuquerque ◽  
I.W.L. Franca ◽  
G.F. Silva ◽  
A.L.O. Ferreira ◽  
R.E.F.Q. Nogueira
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Antibacterial Agents ◽  
Human Medicine ◽  
Kinetics Study ◽  
Important Class ◽  
Mineral Component ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics

Semi-synthetic beta-lactam antibiotics are the most important class of antibacterial agents. Their use in veterinary and human medicine is in continuous expansion. Calcium phosphate bioceramics have been used in medicine and dentistry for nearly 30 years. Calcium phosphate ceramics (CPC) are nowadays being widely used as drug delivery systems because of their desirable properties such as biocompatibility, bioresorbability, controlled release etc. In recent years In this work, kinetic models to describe ampicillin adsorption from CPC were investigated. Calcium phosphate bioceramic are analogous to the mineral component of bones, its properties make it suitable for implant materials and delivery agents of drugs

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