scholarly journals In Vitro Dissolution of Na-Ca-P-Oxynitrides

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7425
Author(s):  
Natalia Anna Wójcik ◽  
Polina Sinitsyna ◽  
Sharafat Ali ◽  
Leena Hupa ◽  
Bo Jonson
Keyword(s):  
Nitrogen Content ◽  
Body Fluid ◽  
Glass Matrix ◽  
Glass Ceramics ◽  
In Vitro Dissolution ◽  
Nitrogen Incorporation ◽  
Sodium Calcium ◽  
The Mean ◽  
Static Conditions

Sodium-calcium-phosphate based oxynitride glasses and glass-ceramics doped with Mg, Si, and Nb were studied in vitro in simulated body fluid (SBF) under static conditions. The release of ions and pH changes up to 7 days of immersion were investigated. The nitrogen incorporation into phosphate glass matrix was found to notably influence in vitro dissolution only of homogenous glasses. Increasing the nitrogen content in the samples decreased the mean mass loss, while the niobate incorporation increased it. The correlation between the nitrogen content and increase in pH of SBF was also observed. The presence of phosphates crystallites was found to support the dissolution process at the beginning step (up to 3 days).

scholarly journals Characterisation of the surface structure and bioactivity of glass and glass ceramics using surface topography

2012 ◽  
Vol 10 (6) ◽  
pp. 1890-1898 ◽  
Author(s):  
Gabriela Lutišanová ◽  
Martin Palou ◽  
Milan Mikula ◽  
Jana Kozánková
Keyword(s):  
Surface Structure ◽  
Surface Topography ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Apatite Layer ◽  
In Vitro Bioactivity ◽  
Ceramic Samples ◽  
Melting Technique ◽  
The Relationship

AbstractThe present paper reports the results of the relationship between the surface topography, microstructure and the in vitro bioactivity of samples with and without fluorapatite content in simulated body fluid. Glasses and glass ceramics belonging to the Li2O-SiO2-CaO-P2O5-CaF2 system were prepared by using conventional melting technique following by heat treatment to obtain glass ceramics. This current study demonstrates the benefits of combining two microscopic methods for better investigation of the surface structure. The formation of apatite layer on the surface and the increase in surface roughness proved that the glasses and glass ceramics with bioactive fluorapatite content could satisfy to the requirements for biomaterial applications. The results also showed that the roughness of apatite layer formed after immersion in body fluid on the surface of glasses with fluorapatite was more pronounced than that of equivalent glass ceramic samples cured under the same conditions.

Glass-Ceramics of the Wollastonite - Tricalcium Phosphate-Silica System

2009 ◽  
Vol 1243 ◽  
Author(s):  
Jorge López-Cuevas ◽  
Martín I. Pech-Canul ◽  
Juan C. Rendón-Angeles ◽  
José L. Rodríguez-Galicia ◽  
Carlos A. Gutiérrez-Chavarría
Keyword(s):  
Surface Layer ◽  
Binary System ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Glass Melting ◽  
Glass Ceramics ◽  
Cooling Rates ◽  
Synthesized Materials

ABSTRACTGlass-ceramics based on hypo-eutectic (GC1) and hyper-eutectic (GC2) compositions of the Wollastonite (W, CaSiO3) - Tricalcium Phosphate [TCP, Ca3(PO4)2] binary system, which are saturated with SiO2 during the glass melting stage, are synthesized by the petrurgic method, using cooling rates of 0.5, 1 or 2°C/h. All synthesized materials are subjected to in vitro bioactivity tests using Kokubo's Simulated Body Fluid (SBF). Primary a-Cristobalite is formed in all cases. Metastable Apatite [Ap, Ca10(PO4)6O] and W phases are additionally formed, in general, in the GC1 glass-ceramics, as well as in the GC2 material obtained at a cooling rate of 0.5°C/h. However, at faster cooling rates, TCP is formed instead of Ap phase in the latter composition. During the bioactivity tests, a hydroxyapatite [HAp, Ca10(PO4)6(OH)2]-like surface layer is formed in all materials. It is proposed that GC2 glass-ceramics cooled at a rate of 1°C/h have the potential to show good in vivo osseointegration properties.

scholarly journals Nano-sized Droplets of Self-Emulsifying System for Enhancing Oral Bioavailability of Chemotherapeutic Agent VP-16 in Rats: A Nano Lipid Carrier for BCS Class IV Drugs

2018 ◽  
Vol 21 ◽  
pp. 398-408 ◽  
Author(s):  
Nayab Khalid ◽  
Muhammad Sarfraz ◽  
Mosab Arafat ◽  
Muhammad Akhtar ◽  
Raimar Löbenberg ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Chemotherapeutic Agent ◽  
Ternary Phase Diagram ◽  
In Vitro Dissolution ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetic Data ◽  
The Mean ◽  
Class Iv

PURPOSE: The purpose of this study was to investigate the ability of a self-nano-emulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of a BCS class IV drug, etoposide (VP-16). METHOD: A series of SNEDDS formulations with VP-16 were prepared consisting of medium chain triglycerides, polysorbate 80, diethylene glycol monoethyl ether and propylene glycol monolaurate type-1.  Based on an obtained ternary phase diagram, an optimum formulation was selected and characterized in terms of size, zeta potential, loading, morphology and in vitro drug release. The pharmacokinetic parameters and oral bioavailability of VP-16 suspension and VP-16 in SNEDDS was assessed using 30 Male Sprague–Dawley rats and compared with the commercial product (VePesid®). RESULTS: Pharmacokinetic data showed that the mean values for AUC0-t of VP-16 in SNEDDS was 6.4 fold higher compared to a drug suspension and 2.4-folds higher than VePesid®. Similarly, the mean value for Cmax of VP-16 in SNEDDS (1.13± 0.07 µg/ml µg.h/mL) was higher than VePesid® (0.62± 0.09 µg/mL) and drug suspension (0.13± 0.07 µg/mL). CONCLUSION: The SNEDDS formulation was able to enhance the oral bioavailability of the BCS Class IV chemotherapeutic agent VP-16 by increasing the dissolution and absorption of the drug. A good in vitro in vivo correlation was found between the in vitro dissolution and in vivo absorption data of VP-16 SNEDDS preparation. Therefore, SNEDDS formulations might be a very promising approach for BCS Class IV drugs.

IN-VITRO BIOACTIVITY EVALUATION OF K2O-SUBSTITUTED Na2O-CaO-P2O5-SiO2 GLASS BIOCERAMICS

2018 ◽  
Vol 25 (05) ◽  
pp. 1850104
Author(s):  
REHANA ZIA ◽  
MADEEHA RIAZ ◽  
AYESHA ASGHAR ◽  
TOUSIF HUSSAIN
Keyword(s):  
Body Fluid ◽  
Glass Ceramics ◽  
Proper Function ◽  
Processing Temperature ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
Solid State Method ◽  
X Ray ◽  
Ceramic Samples

In the present work, the effect of K2O/Na2O substitution on the bioactivity of Na2O-CaO-P2O5-SiO2 ceramics prepared by solid-state method was studied. Ceramics-based bioactive implants are economical; they require low processing temperature and are more bioactive when compared with glasses, glass ceramics and composites. K2O is known to control proper function of cells and stimulate bone formation process. The hydroxyapatite layer developed on the surface of samples after soaking in stimulated body fluid solution was studied by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy and atomic absorption spectroscopy. The results showed an increase in the bioactivity of the samples as Na2O was partially replaced with K2O. The addition of K2O enhanced the apatite-forming ability of the ceramic samples and makes it suitable for filling defects and fracture in bones.

Preparation and Characterization of Bioactive and Magnetic Biphasic Thermo-Seeds Material

2013 ◽  
Vol 834-836 ◽  
pp. 301-304
Author(s):  
Jian An Liu ◽  
Xue Na Yang ◽  
Mei Mei Zhang
Keyword(s):  
Magnetic Property ◽  
Phase Composition ◽  
Glass Ceramic ◽  
Body Fluid ◽  
Glass Ceramics ◽  
Magnetic Behavior ◽  
In Vitro Bioactivity ◽  
Magnetic Glass

A novel biphasic material has been synthesized from a melt-derived bioactive glass (45S5) and a glass-ceramic obtained from a melt-derived magnetic glass-ceramics for hyperthermia application. The biphasic material obtained from a mixture 1:1 of these components. The phase composition was investigated by XRD. The magnetic property was measured by VSM. The in vitro bioactivity was investigated by simulated body fluid (SBF) soaking experiment. The glass-ceramic shows magnetic behavior and bioactive, useful for hyperthermia.

In vitro dissolution of calcium phosphate-mullite composite in simulated body fluid

2010 ◽  
Vol 21 (6) ◽  
pp. 1817-1828 ◽  
Author(s):  
Ashok Priya ◽  
Shekhar Nath ◽  
Krishanu Biswas ◽  
Bikramjit Basu
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
In Vitro Dissolution

scholarly journals Characterization andIn VivoBiological Performance of Biosilicate

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Claudia M. Renno ◽  
Paulo Sérgio Bossini ◽  
Murilo C. Crovace ◽  
Ana Candida M. Rodrigues ◽  
Edgar Dutra Zanotto ◽  
...  
Keyword(s):  
Body Fluid ◽  
Glass Ceramics ◽  
Osteoblastic Cells ◽  
Tissue Formation ◽  
Osteogenic Cell ◽  
Bioactive Properties ◽  
Sbf Solution ◽  
45S5 Bioglass

After an introduction showing the growing interest in glasses and glass-ceramics as biomaterials used for bone healing, we describe a new biomaterial named Biosilicate. Biosilicate is the designation of a group of fully crystallized glass-ceramics of the Na2O-CaO-SiO2-P2O5system. Severalin vitrotests have shown that Biosilicate is a very active biomaterial and that the HCA layer is formed in less than 24 hours of exposure to “simulated body fluid” (SBF) solution. Also,in vitrostudies with osteoblastic cells have shown that Biosilicate disks supported significantly larger areas of calcified matrix compared to 45S5 Bioglass, indicating that this bioactive glass-ceramic may promote enhancement ofin vitrobone-like tissue formation in osteogenic cell cultures. Finally, due to its special characteristics, Biosilicate has also been successfully tested in severalin vivostudies. These studies revealed that the material is biocompatible, presents excellent bioactive properties, and is effective to stimulate the deposition of newly formed bone in animal models. All these data highlight the huge potential of Biosilicate to be used in bone regeneration applications.

scholarly journals Combination of Na-Ca-phosphate and fluorapatite in wollastonite-diopside glass-ceramic: degradation and biocompatibility

2021 ◽  
Author(s):  
Ebrahim A. Mahdy ◽  
Hanaa Y. Ahmed ◽  
Mohammad Farag
Keyword(s):  
Calcium Phosphate ◽  
Cell Viability ◽  
Glass Ceramic ◽  
Glass Ceramics ◽  
Ceramic Materials ◽  
Vero Cells ◽  
Crystalline Phases ◽  
Sodium Calcium ◽  
Glass Ceramic Materials

Abstract In this study, we investigated the effect of introducing sodium calcium phosphate (NCP), fluorapatite (FA), or the combination of both phases in the wollastonite-diopside (WD) bioactive glass-ceramic system on the crystalline phases formed, microstructure, degradation, and biocompatibility of those materials. The prepared materials were characterized by DTA, XRD, and SEM/EDX. Moreover, the density was measured via Archimede’s method, and the mechanical properties were measured by Vicker’s microhardness indenter. The in vitro bioactivity test was carried out in the simulated body fluid (SBF), and the cell viability test was evaluated using the Vero cells. The results showed that the formed crystalline phases were close to the starting proposed phases. Moreover, NCP-containing WD glass-ceramic was showed the lowest density value due to its low densification, and accordingly, it showed the lowest Vicker`s microhardness value due to the same reason. Furthermore, combining sodium calcium phosphate in WD glass-ceramic was increased cell viability better than that included fluorapatite, whereas, the combination of both crystalline phases in WD glass-ceramic led to an increase in the cytotoxicity to the highest value. In conclusion, different properties of wollastonite-diopside glass-ceramics can be tailored by the combination of NCP or FA, and hence, these glass-ceramic materials can be modified effectively according to the purpose for which it is intended to be applied. The obtained results indicated that different properties of WD glass-ceramic materials can be tailored by the combination of NCP and/or FA. Hence, these glass-ceramics are expected to be useful materials in promising biomedical applications, such as orthopedics and dentistry.

scholarly journals In Vitro Evaluation of Some Types of Ferrimagnetic Glass Ceramics

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
S. A. M. Abdel-Hameed ◽  
M. A. Marzouk ◽  
R. L. Elwan
Keyword(s):  
Simulated Body Fluid ◽  
Metal Oxides ◽  
Body Fluid ◽  
Simulated Body Fluid Solution ◽  
Glass Ceramics ◽  
Ion Extraction ◽  
Prepared Glass ◽  
Different Types ◽  
Icp Analysis

The present study aimed at studying the acceleration of the bioactive layer on the surface of ferrimagnetic glass ceramic with a basic composition 40Fe2O3–15P2O5–20SiO2–5TiO2through the addition of 20% of different types of metal oxides like MgO or CaO or MnO or CuO or ZnO or CeO2. SEM, EDAX, and ICP were applied to present the results of the study. SEM and EDAX measurements indicated the presence of apatite layer formed on the surface of the prepared glass ceramics after immersion in SBF within 7 to 30 days. The investigation of the results clarified that the addition of CaO or ZnO accelerated the formation of apatite on the surfaces of the samples in the simulated body fluid faster than other metal oxides. Inductive coupled plasma (ICP) analysis shows the evolution of ion extraction by the simulated body fluid solution (SBF) with time in relation to the elemental composition.

In Vitro Dissolution Behavior of Gel-Derived Bioactive Glasses in the SiO2-CaO-P2O5-MgO System

2005 ◽  
Vol 288-289 ◽  
pp. 541-544
Author(s):  
Yurong Cai ◽  
Lian Zhou ◽  
Jian Hua Wei ◽  
Zhen Tao Yu ◽  
Jin Long Niu
Keyword(s):  
Calcium Phosphate ◽  
Ph Value ◽  
Sol Gel ◽  
Glass Ceramics ◽  
Surface Characteristic ◽  
In Vitro Dissolution ◽  
Dissolution Behavior ◽  
Carbonate Apatite ◽  
High Concentration

Bioactive glass-ceramics of the SiO2-CaO-P2O5-MgO system were fabricated by sol-gel-self propagating method. Two Gel-derived materials discs， 5S and 3S， were prepared by compression of powders. The materials obtained were examined in vitro with regard to the dissolution behavior and the formation ability of calcium phosphate layer on the surfaces of samples in simulated body fluid (SBF). Concentration of ions and pH value in SBF were determined by ICP-AES and micro acidity meter after 3S and 5S were immerged in SBF for intervals from 6h to 15 days and the surface characteristic of 3S and 5S soaked were determined by SEM. Experiment results showed that the formation ability of calcium phosphate on the surface of gel-derived materials depended on the speed of dissolution of samples, which related to original chemical composition and size of crystal on the surface of materials. With decreasing of Si content and increasing of Ca content, smaller crystal could be formed on the surface of 3S, which tended to dissolve more quickly in SBF. Solubility product of calcium phosphate can be reached more easily in the solution with high concentration of Ca and P and bone-like carbonate apatite formed easily on the surface of 3S.

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