scholarly journals Resin Infiltration in Dental Fluorosis Treatment—1-Year Follow-Up

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 22
Author(s):  
Francesca Zotti ◽  
Luca Albertini ◽  
Nicolò Tomizioli ◽  
Giorgia Capocasale ◽  
Massimo Albanese
Keyword(s):  
Statistical Analysis ◽  
Dental Fluorosis ◽  
Statistical Significance ◽  
Tooth Surface ◽  
Duration Of Treatment ◽  
Resin Infiltration ◽  
Dental Hard Tissues ◽  
Sensitive Teeth ◽  
The Stability

Background and objective: Dental fluorosis is a disease affecting dental hard tissues featured with white or yellowish lesions. Several treatments are proposed in the literature, some even invasive. This clinical study aimed to evaluate the effectiveness of resin infiltration in terms of lesions resolution, trend of sensitive teeth and satisfaction of patients over time. Methods and material: 200 fluorosis lesions were treated using ICON infiltrating resin (DMG, Hamburg, Germany). Parameters related to patients were collected by a questionnaire and analyzed aesthetic dissatisfaction about lesions, Shiff Air Index Sensitive Scale, sensitive teeth after treatment, the satisfaction of duration of treatment. The same operator measured dimensions of lesions Tooth Surface Index of Fluorosis (TSIF) and numbers of etching cycles needed for treating lesions. Statistical analysis was performed. The follow-up was of 1-year a measurement were performed at baseline (t0), immediately after the treatment (t1) and every three months during the observation period. Results: All lesions disappeared after one treatment. Pain or sensitive teeth were reported inside the 72 h and they disappeared after. Statistical analysis showed highly statistically correlation between etching cycles and the dimension of lesions and TSIF at the time-points evaluated as well as for pain during treatment, whereas a statistical significance was not noticed where etching cycles were correlated to sensitive teeth after 72 h. Overall, the treatment was found to be statistically significantly associated with differences in answers of aesthetic dissatisfaction between t0 and t1 and those collected between t1 and t2. Between t2 and t3 and between t3 and t4 no statistical differences were found in answers of patients about dissatisfaction, indicating the stability of the results. Conclusions: The ICON resin infiltration technique was found to be effective in lesions resolution with steady results.

scholarly journals Spectrophotometric Evaluation of Enamel Color Variation Using Infiltration Resin Treatment of White Spot Lesions at One Year Follow-Up

2020 ◽  
Vol 8 (2) ◽  
pp. 35 ◽  
Author(s):  
Roberto Lo Giudice ◽  
Frank Lipari ◽  
Francesco Puleio ◽  
Angela Alibrandi ◽  
Fabrizio Lo Giudice ◽  
...  
Keyword(s):  
Color Change ◽  
Statistical Significance ◽  
Color Variation ◽  
White Spot ◽  
White Spot Lesions ◽  
Color Changes ◽  
The Difference ◽  
One Year ◽  
The Stability

The aim of this study is to evaluate the color changes and the stability at a 1-year follow-up of white spot lesions (WSLs) treated with an infiltrating technique by using etching and TEGDMA resin. The color of 22 white spot lesions and the sound adjacent enamel (SAE) were assessed with a spectrophotometer at T0 (baseline), T1 (after treatment), and T2 (1 year after). The color change ΔE (WSLs-SAE) at T0 vs. T1 were compared to evaluate the camouflage effect efficiency, and at T1 vs. T2 to assess the stability of outcomes. To evaluate the effect on the treatment outcome of gender, the presence or not of previous orthodontic treatment, WSLs onset more/less than 10 years, the age of the patient, and the ΔE WSL (T0 vs. T1) was analyzed. The difference between ΔE (WSLs-SAE) at T0 and T1 resulted in statistical significance (p < 0.01). No statistical difference was found between ΔE (WSLs-SAE) at T1 vs. T2. The variables considered showed no statistical differences in treatment outcomes. The results of our investigation show that the technique used is immediately effective and the camouflage effect keeps up and steady one year after treatment. Such results do not appear to be influenced by analyzed clinical variables.

scholarly journals Comparative Evaluation of the Radiopacity of Bone Graft Materials used in Dentistry

2017 ◽  
Vol 7 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Emine S Kursun-Çakmak ◽  
Nihat Akbulut ◽  
Dogan D Öztas
Keyword(s):  
Statistical Analysis ◽  
Bone Graft ◽  
Bone Tissue ◽  
Optical Density ◽  
Comparative Evaluation ◽  
Statistical Significance ◽  
Radiographic Images ◽  
X Ray ◽  
Materials Used

ABSTRACT Introduction Ample radiopacity in order to distinguish from the surrounding tissues is a desirable property of dental graft materials. A total of 15 bone graft materials’ (BGMs) opacities were analyzed in this study. Materials and methods Graft materials were placed in the implant cavity (5 × 10 mm) in cadaver's mandible respectively. Cavity was exposed by using periapical film and a dental X-ray machine at 70 kVp and 8 mA. The optical density of the radiographic images was measured with a transmission densitometer. One-way analysis of variance (ANOVA) was conducted for statistical analysis. Results Among the materials tested, the most radiolucent bone grafts were Grafton and Allogenix with a statistical significance of p ≥ 0.05. 4Bone and Bego Oss exhibited the highest radiopacity with a statistical significance of p ≥ 0.05. Inadequate radiopacity of the dental graft materials may lead to confusion among clinicians in the radiographical follow-up. Among 15 BGMs tested, only three had higher density than bone tissue. Conclusion The radiopacity of the BGM was found to be higher than bone at only three of them. How to cite this article Kursun-Çakmak ES, Akbulut N, Öztas DD. Comparative Evaluation of the Radiopacity of Bone Graft Materials used in Dentistry. J Contemp Dent 2017;7(3):150-155.

scholarly journals Balloon expandable Stent utility for early Secondary Prevention of new Cerebral Ischemic events Caused by Intracranial Atherosclerotic Stenosis. Technical Nuances

2022 ◽  
Vol 11 (1) ◽  
pp. 01-10
Author(s):  
Orlando Villarreal-Barrera ◽  
Gustavo Melo-Guzman ◽  
Juan Isidro Ramirez-Rodriguez ◽  
Jonathan Ortiz-Rafael ◽  
Emma Del Carmen Macias-Cortes ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Secondary Prevention ◽  
Cerebral Artery ◽  
Statistical Significance ◽  
Categorical Variables ◽  
Intracranial Atherosclerotic Disease ◽  
Atherosclerotic Stenosis ◽  
Cerebral Ischemic ◽  
Ischemic Events

Objective: Recurrent cerebral ischemic events are estimated to appear in between 12-15% of symptomatic intracranial atherosclerotic disease (ICAD), regardless of the use of leading pharmacological therapies. Balloon expandable stent (balloon mounted coronary stent) could represent a feasible alternative in this disease’s treatment. This study pretends to report the balloon-expandable placement experience in our center. Materials and Methods: A unicentric retrospective study dated between September 2009 and March 2018 was conducted. Patients previously diagnosed with ICAD and symptomatic stenosis treated with balloon-expandable stent were included. Clinical features, morbidity, mortality, short and long-term evolution, and pre-and post-treatment angiographic features were analyzed, as well as a mean 8 years-period follow-up. Data are presented as means, frequencies, and percentages for categorical variables, and ranks for continuous variables. Statistical analysis was carried by IBM SPSS Statistics Base V22.0 (IBM Corporation, Mexico). A Wilcoxon Signed-rank test statistical analysis was performed. Statistical significance was considered when a p-value lesser than 0.05 was measured for every result. Results: A total of 6 patients with 7 affected vessels were treated, with an average age of 62.7 years. Affected and treated vessels were located in the Internal Carotid Artery (ICA) segment in 42.9%, Vertebral Artery (VA) V4 segment in 14.3%, Middle Cerebral Artery (MCA) M1 segment in 28.5%, and Posterior Cerebral Artery (PCA) P1 segment in 14.3%. The incidence of peri-operatory thrombotic events was 0%. Intracranial hemorrhage presented in 0% of cases. Recurrent ischemic or thrombotic events were not reported in a 97-months mean follow-up. 71.4% of patients scored ≤2 in the modified Rankin Score (mRS) pre-treatment, in a 90 day and 12-month follow-up. 100% presented a favorable evolution with mRS ≤2. Restenosis cases were not reported in radiologic control and retreatment was not needed in a 97-month mean follow-up. Conclusions: This study suggests that balloon-expandable stent therapy with some technical endovascular variants for its navigation and placement could be a safe and effective alternative in the treatment of ICAD as a means of cerebral ischemic event early secondary prevention. We propose to consider not to limit endovascular treatment exclusively to those symptomatic ICAD patients refractory to medical-exclusive treatment, as a means to reduce the risk of presenting a new neurological deficit. Further expanded clinical trials are needed to confirm these findings and the advantage of this kind of stents against other kinds reported in the literature.

Anatomical Distribution of First VTE Event and Risk of VTE Recurrence: Long Term Follow-up and Retrospective Analysis of 346 Patients. Experience From a Single Center

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1224-1224
Author(s):  
Emmanouil Papadakis ◽  
Dionysia Theocharidou ◽  
Anastasia Mpanti ◽  
Anastasia Spyrou ◽  
Konstantinos Loukidis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Statistical Analysis ◽  
High Risk ◽  
Conflicts Of Interest ◽  
Statistical Significance ◽  
Recurrence Risk ◽  
Published Data ◽  
Anatomical Distribution ◽  
Independent Risk Factors

Abstract Abstract 1224 Venous thromboembolism (VTE) is a chronic disease with recurrence risk that persists over the years. Predicting the chance of recurrence on an individual basis is of paramount importance for the appropriate tailoring of anticoagulant therapy. Recurrence risk is affected by thrombophilia and is lower in patients with provoked VTE than in patients with unprovoked thrombosis. Up to date there are no studies focused on the recurrence risk according to the anatomical distribution of the 1st VTE event. In order to evaluate the risk factors of VTE recurrence, after a review of relevant literature we set specific laboratory and clinical variables, which could be associated with VTE recurrence. Moreover, we evaluated retrospectively 346 patients of the Haemostasis Unit, who had already had an episode of VTE concerning the risk of VTE recurrence. Data statistical analysis was done with SPSS package 15.0. At first a monovariable statistical model was used with significance levels set at p= 0.05. For the multivariable statistical analysis model we used all variables with p< 0.1 from the previous model and those mentioned at recent medical literature as significantly related with VTE recurrence. The 346 patients enrolled had already suffered a first episode of VTE and are being followed up regarding VTE recurrence. The study population, 169 (48.7%) male and 178 (51.3%) female, had a mean age at first VTE of 41.54 years. The exclusion criteria of our study were: high risk patients for VTE recurrence who received indefinite anticoagulation (n=72), patients who have suffered VTE and had a follow up period after discontinuation of anticoagulation shorter than 2 years (n=73) and patients who were lost at follow up (n=15). Among 194 patients who were enrolled 108 (55.7%) were women and 86 (44.3%) men, with a mean age at 1st VTE of 40.10 years. 114 patients had only one VTE episode, 59 suffered two, 16 patients had tree episodes and 5 patients had >= 4 episodes. Based on previously published data we tried to define whether the following variables are high risk factors for VTE recurrence in our population: gender, age of diagnosis, thrombophilic factors (FVLeiden, FII, HCY, VIII, AT, PrC, PrS, PAI1, Lp(a), XII), the presence of unprovoked VTE episode and VTE location (DVT, PE, CNS Thrombosis). Male gender p=0,038, FVLeiden homozygous p=0.036, the presence of unprovoked VTE p=0.029, and VTE location p= 0.05 reached statistical significance on a monovariable analysis. Based on the previous analysis and on previously published data we applied gender, age at the time of diagnosis, presence of unprovoked VTE episode and VTE location on a multiple regression analysis in order to define independent risk factors concerning VTE recurrence (Table 1).Table 1Independent Risk factors concerning VTE recurrenceRisk FactorORCI 95%FVLeiden9.7931.07–89.62Unprovoked VTE9.7571.404–5.414Pulmonary embolism11.5321.419–93.746Deep Venus Thrombosis (DVT)17.7932.232–141.841 Concerning VTE location, CNS thrombosis has the lowest risk for VTE recurrence and Pulmonary embolism and DVT are independent risk factors compared to the first one. Among VTE events CNS thrombosis and DVT/PE share similarities regarding the transient risk factors and the presence of predisposing thrombophilias. As far as the recurrence risk after a first VTE our study demonstrates ( in agreement with current literature) that CNS thrombosis carries recurrence risk statistically lesser than PE and the highest recurrence risk carry the patients after a first DVT event. Our study is the first observational study regarding recurrence risk after VTE coming from Greece. Disclosures: No relevant conflicts of interest to declare.

Analysis Of Transfusion Dependence Development and Disease Evolution In Patients With MDS and Del(5q) and Without Transfusion Needs At Diagnosis

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1542-1542
Author(s):  
Silvia M Rojas ◽  
María Díez-Campelo ◽  
Elisa Luño ◽  
Teresa Bernal ◽  
Monica Cabrero ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Statistical Analysis ◽  
Cumulative Incidence ◽  
Research Funding ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Disease Evolution ◽  
Free Survival ◽  
Kaplan Meier

Abstract Myelodysplastic syndrome with 5q- (MDS 5q-) is the only cytogenetically defined MDS category recognized by the world Health Organization (WHO) in 2001 and 2008 and is defined as a MDS with isolated deletion on the long arm of chromosome 5 and less than 5% of blast cells in bone marrow (BM). It is well known that for patients with MDS 5q- and transfusion dependence (TD), Lenalidomide is the first choice treatment. However, as far as we know there are no data regarding factors that may impact on the development of TD in these patients or the disease evolution in patients diagnosed without TD. In the present study a retrospective multicenter analysis on patients with low-int 1 MDS 5q- without TD at diagnosis has been performed in order to answer these questions. Patients and methods Data from eighty-four low-Int 1 risk MDS 5q- patients diagnosed between 1980 and 2012 were retrospectively analyzed. Ninety percent of patients had a single 5q deletion and according to IPSS-R 99% were in low and very low risk. Statistical analysis The event of TD was defined as the development of TD according to the IWG criteria (2006) and/or the beginning of a treatment which could modify disease course (Lenalidomide or ESA). Patients follow up was updated on March 30, 2013, and all follow up data were censored at that point. Transfusion free survival (TFS), Overall survival (OS) and AML were analyzed using the Kaplan – Meier method. TFS, OS, and Leukemia free survival (LFS) were measured from diagnosis to TD or to last follow up if transfusion free (TFS), death from any cause or last follow up (OS) and evolution to AML or last follow up (LFS). Multivariate analysis was performed using Cox’s proportional hazards regression model. Incidence of progression to AML was analyzed with cumulative incidence competing risk method. For comparison of Kaplan Meier curves the long rank test was used, with statistical significance with p<0.05 statistical analysis was performed using SPSS 15.0 and NCSS V.8, 2010. Results During the study 61 (73%) became TD at a median of 1.7 years from diagnosis. The unique factor associated with poorer TFS was Hb level <9 g/dl (p=0.007) and this impact retained statistical significance in the multivariate analysis (table.1) Among the 61 TD patients, 49 received treatment: 19 lenalidomide, 24 ESA and 6 other treatments. Fifteen patients were treated (7 with lenalidomide and 8 with ESA) previous to TD development. In order to know the evolution of this very good prognostic subgroup of patients, OS and LFS analysis were performed. Median follow up was 48 months, 46% of patients are alive at the time of the last follow up and 31% developed secondary AML (sAML). Estimated OS at 2 and 5 y was 92% and 50% respectively. Regarding Univariate analysis, platelet <100.000 x109/L, and IPSS-R intermediate risk group were associated with poorer OS (p=0.001 and 0.019 respectively). On the contrary, patients who had received treatment showed better OS. This benefit is more evident among patients receiving Lenalidomide (p=0.015). In the multivariate analysis platelets <100.000 x109/L and Lenalidomide treatment retained the statistical significant impact on OS (table1). When LFS was analyzed the cumulative incidence of progression into AML was 4,4% after 2 y. and 12,7% after 5 y from diagnosis with median time to sAML of 8.16 years (CI 95%: 6.05-10.27). LFS at 2 and 5 y was 86% and 73% respectively. When univariate analysis was performed variables with impact on sAML were platelet <100.000 x109/L (p=<0,001), and to have received treatment (p=0,02). In the multivariate analysis only thrombocytopenia retained statistical significance (table1).In summary, the present analysis shows that Hb is the only parameter that conditions the TD development in MDS-5q- patients. In this very good prognostic subgroup beginning treatment with lenalidomide improves survival. Disclosures: Díez-Campelo: Novartis: Honoraria, Research Funding; Celgene: Honoraria, Research Funding; Janssen-Cilag: Research Funding. Off Label Use: In the present study we describe Lenalidomide treatment among patients with MDS and del(5q-) receiving this drug, not approval for this use in Europe, patients with anemia and transfusional requirements. Solé:Celgene: Consultancy, Honoraria; Celgene: Consultancy. Consuelo:Celgene Jansen-Cilag Arry Novartis: Membership on an entity’s Board of Directors or advisory committees, Research Funding.

Growth of Hyperkinetic Children Taking Methylphenidate, Dextroamphetamine, or Imipramine/Desipramine

PEDIATRICS ◽  
1976 ◽  
Vol 58 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Mortimer D. Gross
Keyword(s):  
Statistical Significance ◽  
Dosage Level ◽  
Significant Degree ◽  
Brain Dysfunction ◽  
Iowa City ◽  
Minimal Brain Dysfunction ◽  
Duration Of Treatment ◽  
Hyperkinetic Syndrome

One hundred children with the hyperkinetic syndrome or minimal brain dysfunction syndrome were treated with medication: 60 with methylphenidate (Ritalin), 24 with dextroamphetamine (Dexedrine), and 16 with either imipramine or desipramine. The duration of treatment was for a minimum of two years, and averaged five years, with an average follow-up of six years from the onset of treatment. Their weight and height had been measured prior to treatment, and these and subsequent measurements were converted to percentiles, using the tables of norms of the Iowa City study. Initially there was a diminution in expected weight, but not height, but after a few years the growth in weight and height was found to be greater than predicted from the norms to a statistically significant degree. Gains in weight and height were greater for those whose medication had been stopped prior to the final measurements than for those still taking medication; but these differences did not reach statistical significance. No correlations were found between dosage level and changes in weight and height percentiles. It is concluded that there is no stunting of growth from the long-term use of methylphenidate, dextroamphetamine, or imipramine/desipramine in children. Any slowing of growth when treatment is first started is compensated for later on, both while the patient is still taking the medication, and after discontinuing it.

scholarly journals Minimally invasive esthetic management of dental fluorosis: a case report

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096753
Author(s):  
Qingqing Wang ◽  
Qingfei Meng ◽  
Jian Meng
Keyword(s):  
Minimally Invasive ◽  
Dental Fluorosis ◽  
Treatment Plan ◽  
Tooth Surface ◽  
Invasive Technique ◽  
Clinical Report ◽  
Resin Infiltration ◽  
Self Confidence ◽  
Excessive Intake ◽  
At Home

Dental fluorosis is a dental condition caused by excessive intake of fluoride during enamel formation, which can lead to color abnormalities or defects on the tooth surface. The resultant abnormal appearance ranges in severity from mildly white and opaque to dark brown, which substantially affects patients’ esthetic characteristics and self-confidence. Treatment methods include tooth whitening or restoration. This clinical report describes the use of a minimally invasive esthetic technique in a 22-year-old woman with moderate dental fluorosis. The treatment plan included enamel microabrasion, at-home bleaching for 2 weeks, and subsequent resin infiltration for each tooth under a rubber dam. After 2 years of follow-up, evaluation of the patient’s esthetic appearance revealed that teeth affected by dental fluorosis could be successfully treated with a minimally invasive technique involving microabrasion, at-home bleaching, and resin infiltration.

The Carpentier-Edwards Classic and Physio Mitral Annuloplasty Rings: A Randomized Trial

2006 ◽  
Vol 8 (5) ◽  
pp. 389 ◽  
Author(s):  
Ghada M. M. Shahin ◽  
Geert J. M. G. van der Heijden ◽  
Michiel L. Bots ◽  
Maarten-Jan Cramer ◽  
Wybren Jaarsma ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Absolute Risk ◽  
Statistical Significance ◽  
Nyha Class ◽  
Left Ventricular ◽  
Mitral Annuloplasty ◽  
Risk Of Death ◽  
Late Failure

<P>Objective: To evaluate clinical and echocardiographic outcomes for the semi-flexible Carpentier-Edwards Physio and the rigid Classic mitral annuloplasty ring. </P><P>Methods: Ninety-six patients were randomized for either a Classic (n = 53) or a Physio (n = 43) ring from October 1995 through July 1997. Mean follow-up was 5.1 years (range .1-6.6). We included standard patient characteristics at baseline and during follow-up. Analyses were adjusted for age and gender, and for factors that differed across groups at baseline. In 2002, echocardiography was performed in 74% of the survivors. </P><P>Results: We found a 16% difference in mortality: 14% in the Physio group (n = 6) and 30% in the Classic group (n = 16) (adjusted P = .41). Life table analysis shows that the absolute risk of death after 30 months is lower in the Physio group. Intra-operative repair failure occurred in 3 patients (6%) of the Classic group, and in 4 (9%) of the Physio group, resulting in mitral valve replacement. Late failure occurred in 1 patient (2%) in the Classic group, and in 4 (9%) in the Physio group. At follow-up, left ventricular function did not differ across groups (ejection fraction 45% and 48% (adjusted P = .65)). The combined NYHA class III-IV had improved for the Classic group in 42% and for the Physio group in 34%. </P><P>Conclusion: Although the 16% difference in mortality did not reach statistical significance, it is considered clinically important. No differences in morbidity, valve function, and left ventricular function were found. Further research to explain the difference in mortality is required.</P>

An impact of intima media thickness of carotids in cardio vascular profile

2020 ◽  
Vol 10 (2) ◽  
pp. 48-52
Author(s):  
Jeevitha M ◽  
Kalaichandar M ◽  
Kirubakaran K ◽  
Baskaran V ◽  
Kokila K ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Statistical Significance ◽  
Intima Media Thickness ◽  
Cardio Vascular ◽  
Intima Medial Thickness ◽  
The Stability ◽  
Carotid Intima Medial Thickness ◽  
Oral Sodium ◽  
Worse Prognosis

Low blood pressure truly includes a worse prognosis than the excessive blood strain. This mechanism,bills for the "reverse causation "seen within the haemodialysis’ patients, the company of conventional risk elements, such as high blood pressure, hyperlipidemia, and obesity, appear to be a worst diagnosis.Exogenous erythropoietic products can growth blood strain and requirement of antihypertensive tablets.30 Chronic ECFV overload secondary to activation of renin-angiotensin-aldosterone axisand disturbances inside the stability of vasoconstrictors and the vasodilators make a contribution to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation. LVH is related with reduced endurance of sufferers on hemo/peritoneal dialysis .Lower five year survival charge in ESRD patients with LVH have a 30% than people missing LVH. This have a look at produces the mean carotid artery intima-medial thickness turned into higher in sufferers with superior CKD although it did now not attain statistical significance, probable due to smaller sample size.It was also observed that carotid intima medial thickness had no correlation with dyslipidemia. Even though the patients had maintained significantly normal cholesterol and high HDL levels, there was an increase in CIMT. Therefore, CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.

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