scholarly journals The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 211
Author(s):  
Bogdan Doroftei ◽  
Ovidiu-Dumitru Ilie ◽  
Theodora Armeanu ◽  
Emil Anton ◽  
Ioana Scripcariu ◽  
...  
Keyword(s):  
High Efficiency ◽  
Ureaplasma Urealyticum ◽  
Age Groups ◽  
Intrauterine Infection ◽  
Mycoplasma Hominis ◽  
Drug Susceptibility ◽  
Transient Stage ◽  
Intermediate Response ◽  
Infertile Patients ◽  
Dual Infections

Background and objectives: Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) are two commensal microorganisms that form the urogenital microbiota. Under a state of dysbiosis, both bacteria cause intrauterine infection. Material and methods: Therefore, the purpose of the present study was to analyze the prevalence of UU and MH among four hundred and eleven infertile women. Results: Women between thirty and thirty-five years old were the most affected group, followed by those that were 25 and 30 years old, respectively. Cumulatively, the prevalence of single UU and MH, and coinfection, was 28.46% (n = 117), (n = 2) 0.48%, and 2.91% (n = 12), respectively, with an overall detection rate of 31.87% (n = 131). To assess the associated drug susceptibility, endocervical samples were unequally sent to Regina Maria (n = 281) and Synevo (n = 130) laboratories for further analyses. Pristinamycin (100% vs. 100%) and Josamycin (100% vs. 98.00%) were the most efficient antibiotics in eradicating UU and MH, several others also displaying a high efficiency, among which can be mentioned Doxycycline (98.23%), Minocycline (96.00%), Tetracycline (96.48% vs. 68.00%), and Erythromycin (70.17% vs. 92.00%). Based on antibiograms, Clarithromycin (88.00%), Roxithromycin (88.00%), Levofloxacin (82.00%), and Azithromycin (78.94%) can be further used in treating such infections. On the other hand, Clindamycin (4.00%) and Ciprofloxacin (12.27% vs. 2.00%) are no longer viable because both UU and MH display an intermediate response towards gained resistance. Interestingly, the efficiency of Ofloxacin (22.79% vs. 60.00%) was conflicting, this possibly suggesting a transient stage to a gradual adaptability of these microorganisms to Ofloxacin. Conclusions: The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.

scholarly journals The health of children born to mothers who have had a threat of abortion

2019 ◽  
Vol 64 (5) ◽  
pp. 27-32
Author(s):  
A. V. Smirnova ◽  
N. Yu. Borzova ◽  
N. Yu. Sotnikova ◽  
A. I. Malyshkina ◽  
N. V. Kharlamova
Keyword(s):  
At Risk ◽  
Blood Serum ◽  
Premature Birth ◽  
Preterm Labor ◽  
Ureaplasma Urealyticum ◽  
Venous Blood ◽  
Intrauterine Infection ◽  
Mycoplasma Hominis ◽  
Control Group ◽  
Premature Labor

The risk of preterm labor is one of the leading complications of gestation which determines the high level of perinatal morbidity and mortality. Receptor for advanced glycation end product RAGE is considered to be an important participant of congenital and adaptive immunity and it can regulate the production of pro-inflammatory cytokines and chemokines. TNFa is a leading pro-inflammatory cytokine, it is produced in response to endotoxin. TGFß1 is the main mediator providing anti-inflammatory effect.Purpose. To identify the features of the health status of newborns after the threat of termination of pregnancy in 22–27 weeks, the content of sRAGE and cytokines in women at risk of preterm labor depending on perinatal pathology in children.Materials and methods. We examined 120 pregnant women at 22–27 weeks of gestation, they were divided into 2 groups: the main group (80 women at risk of preterm labor) and the control group (40 women with uncomplicated pregnancy). We determined the content of sRAGE, TGFβ1 и TNFα cytokines, and antibodies to Chlamydia trachomatis, Mycoplasma hominis и Ureaplasma urealyticum, simple herpes virus, cytomegalovirus, the virus of Epstein–Barr in the venous blood serum by ELISA.Results. The threat of preterm labor at 22–27 weeks increases the risk of perinatal hypoxic lesions of the CNS in newborn 1,5 times (relative risk (RR) 1.43; 95% confidence interval – CI 1.14–1.78). A premature birth, after the threat of preterm labor at 22–27 weeks, increases the risk of perinatal damage to the CNS more than five times (RR 5.13; 95% CI 2.47–10,69), and the risk of intrauterine infection is increased four times (RR 4.08; 95% CI 2.54–6.54). Low content of sRAGE in patients with threat of premature labor at 22–27 weeks is a predictor of development of perinatal hypoxic lesions of the CNS.Conclusion. Low content of sRAGE in the blood serum of patients at risk of premature labor at 22–27 weeks is a predictor of development of perinatal hypoxic lesions of the CNS. A decreased concentration of TGFβ1 cytokine in the blood of women at risk of premature birth is associated with intrauterine infection in newborns.

scholarly journals Presence ofChlamydia, Mycoplasma, Ureaplasma,and Other Bacteria in the Upper and Lower Genital Tracts of Fertile and Infertile Populations

1993 ◽  
Vol 1 (2) ◽  
pp. 85-90
Author(s):  
Mark G. Martens ◽  
Ronald L. Young ◽  
Marco Uribe ◽  
V. C. Buttram ◽  
Sebastian Faro
Keyword(s):  
Genital Tract ◽  
Ureaplasma Urealyticum ◽  
Anaerobic Bacteria ◽  
Mycoplasma Hominis ◽  
First Trimester ◽  
Infertile Group ◽  
Work Up ◽  
Aerobic And Anaerobic ◽  
Infertile Patients ◽  
Fertile Women

Objective:The genital mycoplasmas (Mycoplasma hominisandUreaplasma urealyticum) andChlamydia trachomatishave been implicated as possible etiologic factors in infertility. Their role in patients with infertility needs to be further defined.Methods:Seventy-nine infertile patients underwent laparoscopy with cultures obtained for aerobic and anaerobic bacteria,Chlamydia, Mycoplasma,andUreaplasmafrom the peritoneal fluid, fallopian tube, endometrium, and endocervix. Cultures for similar organisms were taken from the endocervix of 80 fertile women in their first trimester. Culture results were also compared according to ovulatory status and laparoscopic findings in the infertile group.Results:There were no differences in the recovery ofUreaplasma(29% vs. 28%) orChlamydia(4% vs. 0%) positive cervical cultures in the fertile and infertile groups, respectively. However, a significantly higher number ofMycoplasmapositive cervical cultures (14% vs. 5%,P= 0.05) were found in the fertile group. Only two upper genital tract cultures were found to be positive (Ureaplasma).Conclusions:Therefore, if these organisms play a role in infertility, they are present and eradicated prior to infertility work-up and thus do not supports the use of a routine trial of antibiotics prior to laparoscopy.

scholarly journals Awareness of aerosol-related transmission of COVID-19 among the dentists of Nepal

BDJ Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nashib Pandey ◽  
Buddha Bahadur Basnet ◽  
Sushmit Koju ◽  
Anju Khapung ◽  
Alka Gupta
Keyword(s):  
Social Sciences ◽  
Particle Size ◽  
High Efficiency ◽  
Emergency Services ◽  
Uv Light ◽  
Ventilation System ◽  
Age Groups ◽  
Air Filtration ◽  
Online Questionnaire ◽  
Dental Practitioners

Abstract Objective To access the awareness of dental practitioners of Nepal towards COVID-19 transmission through aerosols. Materials and methods The study involved 384 dentists from all over Nepal and was conducted for a period of 3 months. A self-reported online questionnaire was developed using Google forms and the link was shared. It emphasized the awareness related to the aerosol and ventilation system in their daily practices was prepared. The data were analyzed in Statistical Package for Social Sciences version 20.0 software. Results The majority of participants were female 52.9% (n = 203) and within the age groups of <30 years 57% (n = 219). Participants from Bagmati Province were 60.4% (n = 232), with least from Sudurpaschim Province 0.5% (n = 2). 60% of participants provided only emergency services during the COVID-19 pandemic and few (7%) provided consultations via telephone. The current ventilation system used was a well-ventilated room with open windows 65.4% (n = 251). However, 52.8% (n = 203) preferred specialized operatory incorporating high-efficiency particulate air (HEPA) filters and ultraviolet (UV) light. More than 60% of respondents were unaware of the particle size of the aerosol. Conclusions The obtained results signify the need for the proper ventilation system with appropriate air filtration systems in dental clinical setups.

scholarly journals Chlamydia trachomatis and urogenital mycoplasms in nonconococcal urethirits in men

2010 ◽  
Vol 63 (1-2) ◽  
pp. 47-50
Author(s):  
Sonja Vesic ◽  
Jelica Vukicevic ◽  
Eleonora Gvozdenovic ◽  
Dusan Skiljevic ◽  
Slobodanka Janosevic ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Ureaplasma Urealyticum ◽  
Mycoplasma Hominis ◽  
Sexually Active ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Nongonococcal Urethritis ◽  
Etiological Agents ◽  
The One

Introduction. Nongonococcal urethritis is the most common sexually transmitted infection in men, with vast majority of the etiological agents such as Chlamydia trachomatis, followed by urogenital mycoplasmas. The aim of this study was to determine the prevalence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis in nongonococcal urethritis in men, and to examine infections associated with these agents. Material and methods. 299 sexually active, heterosexual men with nongonococcal urethritis were included into the study. Urethral samples were taken with a dacron swab placed into the urethra up to 2-3 cm. The Direct immunojluorescence tehnique was performed for identification of Chlamydia trachomatis. Ureaplasma urealyticum and Mycoplasma hominis were detected with Mycoplasma 1ST assay. Results. Chlamydia trachomatis was detected in 22.75%, Uraeplasma urealyticum in 21.08% and Mycoplasma hominis in 8.02% cases. We found no significant differences in prevalence between Chlamydia trachomatis and Ureaplasma urealyticym (p>0.05). Monoinjections were found in 51.85% with significantly higher rate (p<0.01) than associated infections (11.70%). Among associated infections, coinfection of Chlamydia trahomatis and Ureaplasma urealyticum was predominant. Association of Chlamydia trachomatis with urogenital mycoplasmas was significantly higher (p<0.05) than the one between Ureaplasma urealyticum and Mycoplasma hominis. In 36.45% patients no patogenic microorganisms were detected. Conclusion. These results confirmed the etiological role of Chlamydia trachomatis and urogenital mycoplasmas in nongonococcal urethritis with prevalence of 51.85% in monoinfections and 11.70% in associated infections. In 36.45% of cases the etiology of urethritis was not elucidated. These results suggest that more sensitive diagnostic tool should be applied when searching for the detailed etiology of nongonococcal urethritis.

Vaginal Colonization with Mycoplasma hominis and Ureaplasma urealyticum

1986 ◽  
Vol 13 (2) ◽  
pp. 67-70 ◽  
Author(s):  
WILLIAM M. MCCORMACK ◽  
BERNARD ROSNER ◽  
SUSAN ALPERT ◽  
JOHN R. EVRARD ◽  
VICKI ANN CROCKETT ◽  
...  
Keyword(s):  
Ureaplasma Urealyticum ◽  
Mycoplasma Hominis ◽  
Vaginal Colonization

Association of Genital Mycoplasmas with Exudative Vaginitis in a 10 Year Old: A Case of Misdiagnosis

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 250-252
Author(s):  
K. B. Waites ◽  
M. B. Brown ◽  
S. Stagno ◽  
J. Schachter ◽  
S. Greenberg ◽  
...  
Keyword(s):  
Ureaplasma Urealyticum ◽  
Bacterial Pathogen ◽  
Mycoplasma Hominis ◽  
University Of Alabama ◽  
Large Numbers ◽  
Lower Genital Tract ◽  
History Of ◽  
The University ◽  
Urology Clinic ◽  
Multiple Antibiotics

A 10-year-old girl with a 1-year history of lower genitourinary tract symptoms suggestive of bacterial infection but with numerous negative urine cultures was referred to the University of Alabama urology clinic after empirical treatment with multiple antibiotics failed to resolve her symptoms. An extensive urologic evaluation revealed no structural or physiologic abnormalities, but an exudative vaginitis was noted and large numbers of Ureaplasma urealyticum and Mycoplasma hominis were isolated from the lower genital tract. Cultures for Chlamydia, viruses, and routine bacterial pathogens were negative. After initiation of tetracycline therapy, symptoms resolved and subsequent cultures for mycoplasmas were negative. In addition, a seroconversion was noted for M hominis but not for U urealyticum. Chlamydia serology was negative. It was later learned that the patient had been sexually molested just prior to the onset of symptoms. This case illustrates the necessity of early consideration of a mycoplasmal etiology in the patient with persistent genitourinary symptoms and no obvious bacterial pathogen, or in the patient whose condition is refractory to routine antibiotic therapy.

scholarly journals Prevalence and significance of Mycoplasma hominis and Ureaplasma urealyticum in the urines of a non-venereal disease population

1987 ◽  
Vol 98 (3) ◽  
pp. 353-359 ◽  
Author(s):  
Patricia M. Furr ◽  
D. Taylor-Robinson
Keyword(s):  
Healthy Volunteers ◽  
Genital Tract ◽  
Ureaplasma Urealyticum ◽  
Venereal Disease ◽  
Mycoplasma Hominis ◽  
Tract Disease

SUMMARYUreaplasma urealyticum organisms (ureaplasmas) and Mycoplasma hominis organisms (mycoplasmas) were sought in mid-stream urines collected from 200 men and 200 women attending hospital with conditions of a non-venereal nature. In addition, the urines from 100 male and 100 female healthy volunteers were examined. Overall, ureaplasmas were isolated four times more often than mycoplasmas. In individuals less than 50 years of age, the organisms were found in about 20 % of men and about 40 % of women. In individuals 50 years or older, they were found about one-third to one-half as frequently. Centrifugation of urine and examination of the resuspended deposit did not increase the isolation rates. In men, the numbers of organisms in the urine were usually small (< 103 c.c.u./ml) with less than tenfold more in the urine of women. The occurrence of 51– > 1000 leucocytes per mm3 in some of the urines was not associated with either the presence or an increased number of ureaplasmas/mycoplasmas, whereas they were associated with the presence of 105 or more bacteria/ml. The significance of these findings in the context of defining the role of ureaplasmas/mycoplasmas in genital-tract disease is discussed.

Epidemiology ofMycoplasmaacquisition in male HIV-1 infected patients: a multistage cross-sectional survey in Jiangsu, China

2015 ◽  
Vol 143 (15) ◽  
pp. 3327-3334 ◽  
Author(s):  
L.-S. CHEN ◽  
J.-R. WU ◽  
B. WANG ◽  
T. YANG ◽  
R. YUAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Highly Active Antiretroviral Therapy ◽  
Protective Factor ◽  
Ureaplasma Urealyticum ◽  
Venous Blood ◽  
Mycoplasma Hominis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Highly Active ◽  
Hiv Aids

SUMMARYMycoplasmainfections are most frequently associated with disease in the urogenital or respiratory tracts and, in most cases, mycoplasmas infect the host persistently. In HIV-infected individuals the prevalence and role of genital mycoplasmas has not been well studied. To investigate the six species ofMycoplasmaand the risk factors for infection in Jiangsu province, first-void urine and venous blood samples were collected and epidemiological questionnaires were administered after informed consent. A total of 1541 HIV/AIDS patients were recruited in this study. The overall infection rates of sixMycoplasmaspecies were:Ureaplasma urealyticum(26·7%),Mycoplasma hominis(25·3%),M. fermentans(5·1%),M. genitalium(20·1%),M. penetrans(1·6%) andM. pirum(15·4%). TheMycoplasmainfection rate in the unmarried group was lower than that of the married, divorced and widowed groups [adjusted odds ratio (aOR) 1·432, 95% confidence interval (CI) 1·077–1·904,P< 0·05]. The patients who refused highly active antiretroviral therapy (HAART) had a much higher risk ofMucoplasmainfection (aOR 1·357, 95% CI 1·097–1·679,P< 0·05). Otherwise, a high CD4+T cell count was a protective factor againstMycoplasmainfection (aOR 0·576, 95% CI 0·460–0·719,P< 0·05). Further research will be required to confirm a causal relationship and to identify risk factors forMycoplasmainfection in HIV/AIDS populations.

scholarly journals FEATURES OF MANUFACTURE OF ADVANCED PROVISIONAL BRIDGE-BASED PROSTHESES

2021 ◽  
pp. 33-37
Author(s):  
А. В. Kostyshyn
Keyword(s):  
High Efficiency ◽  
Age Groups ◽  
Masticatory Muscles ◽  
Pathological Process ◽  
Muscle Group ◽  
Control Group ◽  
Masticatory Muscle ◽  
Orthopedic Treatment ◽  
Group 2 ◽  
Reinforcement Model

Abstract. The relevance of the topic is related to the need to improve methods of preparation of dentitions for orthopedic treatment, taking into account the defects of dentitions in patients with reduced occlusion height, taking into account the condition of the masticatory muscles and temporary use of plastic dentures, which provide gradual lifting of occlusion to normalize the masticatory group muscles and reorganization of myostatic reflexes. The aim of the research. Improving the effectiveness of preparation for orthopedic treatment of patients with partial tooth loss, with reduced occlusion height, by improving the design of a temporary bridge-based prosthesis. Materials and methods of research. We examined, treated and conducted clinical observation of 93 patients, who were divided into three groups according to the height of the reduction in occlusion, to achieve this goal and solve problems during the dissertation. Group 1 consisted of 32 patients with included dentition defects with reduced occlusion height up to 2 mm (n=32), group 2 - patients with included dentition defects with reduced occlusion height up to 2-4 mm (n=31), group 3 - these are patients with included dentition defects with reduced occlusion height up to 4-6 mm (n=30). All patients of the main groups belonged to the second and third age groups according to the WHO, aged 35-55 years. The control group (n=30) are young people who belonged to the 1st age group according to the WHO with intact dentition, without concomitant somatic and dental pathology, were admitted in one visit. Also, 123 fiberglass-reinforced plastic prostheses were made. Research results. When drawing up a plan for orthopedic treatment of patients with reduced occlusion height, we took into account possible complications, which are characterized by chipping of the facing material, pathological changes in the temporomandibular joint and masticatory muscle group. We have improved the method of manufacturing non-removable temporary plastic orthopedic constructions by reinforcing with fiberglass tapes and beams, to prevent them and gradually raise the bite. Expanded data on the dynamics of changes in myostatic reflexes and the effectiveness of the use of fixed orthopedic constructions, depending on the pathological process, the timing of adaptation of the masticatory muscle group to orthopedic constructions, according to the degree of reduction in occlusion height. The absence of complaints of breakage and other technical defects of the proposed temporary orthopedic constructions in 100% of cases, successfully allows to use it in the clinic of orthopedic dentistry. A new method of preparing patients for permanent orthopedic treatment by combined reinforcement of temporary non-removable bridge constructions with fiberglass tapes and beams is proposed, which differ in that after preliminary modeling of the frame of the bridge constructions, the technology of double reinforcement, model two support platforms with a step-like transition between them, in which fiberglass tapes and beams are fitted with dental tweezers, after which they are polymerized by the generally accepted method with a photopolymer lamp. Complete the modeling of the constructions and polymerize the prosthesis in the pneumopolymerizer with subsequent grinding and polymerize the prosthesis. Conclusion. The results of the research revealed the high efficiency of the improved method of manufacturing non-removable makeshift plastic of orthopedic constructions.

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