Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is characterized by the presence of β-amyloid plaques and neurofibrillary tangles, while Lewy body dementia (LBD) is characterized by α-synuclein (α-syn) inclusions. Some authors examine α-syn protein in the neurodegeneration process of AD and propose to consider cerebrospinal fluid (CSF) α-syn as a possible additional biomarker to the so-called “core” of AD. Objective: To determine whether there is a correlation between α-syn levels and “core” AD biomarkers in patients with mild cognitive impairment (MCI). Materials and methods: In total, 81 patients in the early stages of MCI were selected from the outpatient dementia consultation in Alicante General Hospital. Using a cross-sectional case–control design, patients were analyzed in four groups: stable MCI (MCIs; n = 25), MCI due to AD (MCI-AD; n = 32), MCI due to LBD (MCI-LBD; n = 24) and a control group of patients with acute or chronic headache (Ctrl; n = 18). Correlation between CSF protein levels in the different groups was assessed by the Rho Spearman test. Results: We found positive correlations between T-tau protein and α-syn (ρ = 0.418; p value < 0.05) and p-tau181p and α-syn (ρ = 0.571; p value < 0.05) exclusively in the MCI-AD group. Conclusion: The correlation found between α-syn and tau proteins in the first stages of AD support the involvement of α-syn in the pathogenesis of AD. This result may have clinical and diagnostic implications, as well as help to apply the new concept of “precision medicine” in patients with MCI.

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Cerebrospinal Fluid Levels of sAPPαand sAPPβin Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates

International Journal of Alzheimer s Disease ◽

10.4061/2011/495025 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Ezra Mulugeta ◽

Elisabet Londos ◽

Oskar Hansson ◽

Clive Ballard ◽

Ragnhild Skogseth ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cerebrospinal Fluid ◽

Lewy Body ◽

Group Analysis ◽

Lewy Body Dementia ◽

Csf Biomarkers ◽

Commercial Kits ◽

Neurochemical Correlates ◽

Fluid Levels

We measured cerebrospinal fluid (CSF) levels of the soluble isoforms of amyloid precursor protein (APP; sAPPαsAPPβ) and other CSF biomarkers in 107 patients with Alzheimer's disease (AD), dementia with Lewy body dementia (DLB), Parkinson's disease dementia (PDD), and normal controls (NC) using commercial kits. DLB and PDD were combined in a Lewy body dementia group (LBD). No differences were observed in sAPPαand sAPPβlevels between the groups. Significant correlations were observed between sAPPαand sAPPβand between sAPPβand Mini-Mental State Examination scores in the total group analysis as well as when LBD and AD groups were analyzed separately. sAPPαand sAPPβlevels correlated with Aβ38, Aβ40, Aβ42, and Tau in the LBD group. In AD, sAPPαcorrelated with p-Tau and sAPPβwith Aβ40. The differential association between sAPPαand sAPPβwith Aβand Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD and AD.

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Relation between alpha‐synuclein and core CSF biomarkers in Alzheimer's disease

Alzheimer s & Dementia ◽

10.1002/alz.041147 ◽

2020 ◽

Vol 16 (S4) ◽

Author(s):

José Antonio Monge‐Argilés ◽

María‐Salud García‐Ayllón ◽

Victoria Monge García ◽

Francisco Navarrete Rueda ◽

Jorge Manzanares Robles ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Alpha Synuclein ◽

Csf Biomarkers

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Prevalence of Comorbidities in Individuals Diagnosed and Undiagnosed with Alzheimer’s Disease in León, Spain and a Proposal for Contingency Procedures to Follow in the Case of Emergencies Involving People with Alzheimer’s Disease

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17103398 ◽

2020 ◽

Vol 17 (10) ◽

pp. 3398

Author(s):

Macrina Tortajada-Soler ◽

Leticia Sánchez-Valdeón ◽

Marta Blanco-Nistal ◽

José Alberto Benítez-Andrades ◽

Cristina Liébana-Presa ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Disorders ◽

Cross Sectional Study ◽

Control Group ◽

Cross Sectional ◽

Emergency Procedures ◽

And Control ◽

Similar Incidence

Background: Alzheimer’s disease (AD) which is the most common type of dementia is characterized by mental or cognitive disorders. People suffering with this condition find it inherently difficult to communicate and describe symptoms. As a consequence, both detection and treatment of comorbidities associated with Alzheimer’s disease are substantially impaired. Equally, action protocols in the case of emergencies must be clearly formulated and stated. Methods: We performed a bibliography search followed by an observational and cross-sectional study involving a thorough review of medical records. A group of AD patients was compared with a control group. Each group consisted of 100 people and were all León residents aged ≥65 years. Results: The following comorbidities were found to be associated with AD: cataracts, urinary incontinence, osteoarthritis, hearing loss, osteoporosis, and personality disorders. The most frequent comorbidities in the control group were the following: eye strain, stroke, vertigo, as well as circulatory and respiratory disorders. Comorbidities with a similar incidence in both groups included type 2 diabetes mellitus, glaucoma, depression, obesity, arthritis, and anxiety. We also reviewed emergency procedures employed in the case of an emergency involving an AD patient. Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.

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Plasma neurofilament light and cerebrospinal fluid biomarkers are associated with white matter damage in Alzheimer's disease

10.21203/rs.3.rs-115308/v1 ◽

2020 ◽

Author(s):

Fardin Nabizadeh ◽

Mohammad Balabandian ◽

Mohammad Reza Rostami ◽

Samuel Berchi Kankam

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

White Matter ◽

Diffusion Tensor ◽

Brain Regions ◽

Csf Biomarkers ◽

Cross Sectional ◽

Neurofilament Light ◽

Microstructural Changes ◽

Cerebrospinal Fluid Biomarkers

Abstract The most replicated blood biomarker for monitoring Alzheimer’s disease is neurofilament light (NFL). Recent evidence revealed that the plasma level of the NFL has a strong predictive value in cognitive decline and is elevated in AD patients. The Diffusion Tensor Imaging (DTI) is understood to reflect white matter disruption, neurodegeneration largely, and synaptic damage in AD. However, there is no investigation of the association between plasma NFL and white matter microstructure integrity. we have investigated the cross-sectional associations of plasma NFL, CSF tau, p tau, and Aβ with white matter microstructural changes as measured by DTI in 92 mild cognitive impairment (MCI) participants. We investigated potential correlations of the DTI values of each region of the MNI atlas, with plasma NFL, CSF total tau, CSF p tau, and as well as CSF Aβ, separately using a partial correlation model controlled for the effect of age, sex and APOE ε4 genotype. Our findings revealed a significant correlation between plasma and CSF biomarkers with altered white matter microstructural changes in widespread brain regions. Plasma NFL has a negative correlation with FA and positive correlation with RD, AD, and MD values in different regions. Plasma NFL promises to be an early biomarker of microstructural changes in MCI and for MCI progression to AD.

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Adequacy of food consumption in elderly Alzheimer’s disease in a community of Southern Brazil: a Cross-sectional study

F1000Research ◽

10.12688/f1000research.13835.1 ◽

2018 ◽

Vol 7 ◽

pp. 671

Author(s):

Glaucia Renee Hilgemberg ◽

Aline Jacoski de Oliveira Krüger da Silva ◽

Bárbara Luisa Fermino ◽

Camila Diedrich ◽

Simone Carla Benincá ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Nutritional Status ◽

Neuronal Loss ◽

Great Difficulty ◽

Amyloid Peptide ◽

Control Group ◽

Food Record ◽

Cross Sectional ◽

Significant Difference

Background: Alzheimer's disease (AD) is the most common cause of dementia, with a multifactorial etiology, in which the person has great difficulty identifying feelings of hunger, satiety, and feeding, which may affect their nutritional status. Pathologically, it is associated with neurodegeneration of synapses followed by neuronal loss, accompanied by glial proliferation surrounded by neurofibrillary tangles, beta-amyloid peptide (Aβ) deposition, inflammation and cerebrovascular injury hindering the ability to perform activities of daily living. This study aimed to analyze quantitatively the differences between an elderly group with AD and a control group, in terms of macro and micronutrient consumption evaluation. Methods: the study involved 69 participants who were assessed via collection of anthropometric measurements (weight, height and body mass index) with nutritional status being assessed by 24-hour food recall and three-day food record. Cognitive assessments were performed using the Mini-Mental State Examination (MMSE) and Clinical Dementia Ranting (CDR). Results: The intake of lipids in patients with severe dementia, was lower (p <0.05). The consumption of proteins showed a decrease with demential advance. For vitamins, there was a significant difference (p <0.05) in the amount of thiamine, niacin, vitamin D, E and K and calcium, chromium and iodine minerals, which were significantly reduced in AD patients (p <0.05). Conclusions: Decreases in macronutrient and micronutrient consumption may result in a consequent impairment of nutritional status, dementia progression, and decreased quality and life expectancy of elderly patients with AD.

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Selenium concentrations in elderly people with Alzheimer’s disease: a cross-sectional study with control group

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2020-0984 ◽

2021 ◽

Vol 74 (suppl 2) ◽

Author(s):

Carlos Queiroz do Nascimento ◽

João Araújo Barros-Neto ◽

Nathalia Fidelis Lins Vieira ◽

José Antonio Menezes-Filho ◽

Sabrina Joanny Felizardo Neves ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Plasma Concentrations ◽

Atomic Absorption Spectrophotometry ◽

Cross Sectional Study ◽

Elderly Group ◽

Control Group ◽

Sectional Study ◽

Disease Group ◽

Cross Sectional

ABSTRACT Objective: To investigate possible differences in plasma and erythrocyte concentrations of selenium among elderly with and without a diagnosis of Alzheimer’s disease (AD). Methods: Cross-sectional study, performed with an elderly group with Alzheimer’s disease, diagnosed by a geriatric doctor, and compared to an elderly group without the disease, equaling gender, education, and age. Atomic absorption spectrophotometry determined plasma and erythrocyte concentrations of total selenium (Set). Results: The mean age was 74.41±7.1 years in the Alzheimer’s disease group and 71.46±5.1 years among the control group. The Alzheimer’s disease group presented lower plasma concentrations (mean of 45.29±14.51 µg/dL vs. 55.14±14.01 µg/dL; p=0.004), and erythrocyte Set (median of 56.36 µg/L vs. 76.96 µg/L; p<0.001). The logistic regression model indicated an association between erythrocyte Set concentrations and diagnosis of Alzheimer’s disease (p=0.028). Conclusion: Elderly with Alzheimer’s disease present lower selenium concentrations in the evaluated organic compartments.

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MRI findings suggestive of alzheimer’s disease in patients with primary open angle glaucoma – a single sequence analysis using rapid 3D T1 spoiled gradient echo

British Journal of Radiology ◽

10.1259/bjr.20210857 ◽

2022 ◽

Author(s):

Mohammad Hanafiah ◽

Bushra Johari ◽

Nazimah Ab Mumin ◽

Azlan Azha Musa ◽

Hazlenah Hanafiah

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Primary Open Angle Glaucoma ◽

Parietal Lobe ◽

Open Angle Glaucoma ◽

Control Group ◽

P Value ◽

Open Angle ◽

Scoring Method ◽

Healthy Control

Objective: Primary open-angle glaucoma (POAG) is a degenerative optic neuropathy disease which has somewhat similar pathophysiology to Alzheimer’s disease (AD). This study aims to determine the presence of medial temporal atrophy and parietal lobe atrophy in patients with POAG compared to normal controls using MTA scoring and PCA scoring system on T1-MPRAGE. Methods: 50 POAG patients and 50 normal subjects were recruited and an MRI brain with T1-MPRAGE was performed. Medial temporal lobe and parietal lobe atrophy were by MTA and PCA/Koedam scoring. The score of the PCA and MTA were compared between the POAG group and the controls. Results: There was a significant statistical difference between PCA score in POAG and the healthy control group (p-value = 0.026). There is no statistical difference between MTA score in POAG compared to the healthy control group (p-value = 0.58). Conclusion: This study suggests a correlation between POAG and PCA score. Potential application of this scoring method in clinical diagnosis and monitoring of POAG patients. Advances in knowledge: The scoring method used in Alzheimer’s disease may also be applied in the diagnosis and monitoring of POAG MRI brain, specifically rapid volumetric T1spoiled gradient echo sequence, may be applied in primary open-angle glaucoma assessment

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Plasma neurofilament light is associated with white matter damage in Alzheimer's disease

10.21203/rs.3.rs-115308/v2 ◽

2020 ◽

Author(s):

Fardin Nabizadeh ◽

Mohammad Balabandian ◽

Mohammad Reza Rostami ◽

Samuel Berchi Kankam ◽

Fetemeh Ranjbaran ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

White Matter ◽

Diffusion Tensor ◽

Amyloid Β ◽

Brain Regions ◽

Csf Biomarkers ◽

Cross Sectional ◽

Neurofilament Light ◽

Microstructural Changes

Abstract The most replicated blood biomarker for monitoring Alzheimer’s disease is neurofilament light (NFL). Recent evidence revealed that the plasma level of the NFL has a strong predictive value in cognitive decline and is elevated in AD patients. The Diffusion Tensor Imaging (DTI) is understood to reflect white matter disruption, neurodegeneration, and synaptic damage in AD. However, few investigations have been carried out on the association between plasma NFL and white matter microstructure integrity. We have investigated the cross-sectional associations of plasma NFL, CSF total tau, phosphorylated tau, and Amyloid β with white matter microstructural changes as measured by DTI in 92 mild cognitive impairment (MCI) participants. We investigated potential correlations of the DTI values of each region of the MNI atlas, with plasma NFL, separately using a partial correlation model controlled for the effect of age, sex, and APOE ε4 genotype. Our findings revealed a significant correlation between plasma and CSF biomarkers with altered white matter microstructural changes in widespread brain regions. Plasma NFL negatively correlates with FA and the positive correlation with RD, DA, and MD values in different regions. Our findings showed that plasma NFL is associated with white matter changes and AD-related features, including atrophy and hypometabolism. Plasma NFL promises to be an early biomarker of microstructural changes in MCI and MCI progression to AD.

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