scholarly journals Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 65
Author(s):  
Mengna Huang ◽  
Rachel S. Kelly ◽  
Su H. Chu ◽  
Priyadarshini Kachroo ◽  
Gözde Gürdeniz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Health ◽  
P Value ◽  
Third Trimester ◽  
Logistic Regression Models ◽  
Asthma Risk ◽  
Child Asthma ◽  
In Utero Environment ◽  
Recurrent Wheeze ◽  
In Pregnancy

The in utero environment during pregnancy has important implications for the developing health of the child. We aim to examine the potential impact of maternal metabolome at two different timepoints in pregnancy on offspring respiratory health in early life. In 685 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, we assessed the prospective associations between maternal metabolites at both baseline (10–18 weeks gestation) and third trimester (32–38 weeks gestation) and the risk of child asthma or recurrent wheeze by age three using logistic regression models accounting for confounding factors. Subgroup analyses were performed by child sex. Among 632 metabolites, 19 (3.0%) and 62 (9.8%) from baseline and third trimester, respectively, were associated with the outcome (p-value < 0.05). Coffee-related metabolites in the maternal metabolome appeared to be of particular importance. Caffeine, theophylline, trigonelline, quinate, and 3-hydroxypyridine sulfate were inversely associated with asthma risk at a minimum of one timepoint. Additional observations also highlight the roles of steroid and sphingolipid metabolites. Overall, there was a stronger relationship between the metabolome in later pregnancy and offspring asthma risk. Our results suggest that alterations in prenatal metabolites may act as drivers of the development of offspring asthma.

scholarly journals Vitamin D Status in Pregnancy: Fetomaternal Outcome and Correlation with Cord Blood Vitamin D

2017 ◽  
Vol 21 (1) ◽  
pp. 42-48
Author(s):  
Sanjay Jain ◽  
Arijit Debnath ◽  
Somosri Ray
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
P Value ◽  
Strong Positive Correlation ◽  
Vitamin D Status ◽  
The Mean ◽  
In Pregnancy

ABSTRACT Introduction Hypovitaminosis D in pregnancy has been reported to cause various maternal effects, i.e., hypocalcemia, subclinical myopathy, increased risk of preeclampsia (PE), gestational diabetes mellitus (GDM), cesarean sections, and fetal effects, i.e., neonatal tetany, hyperbilirubinemia congenital rickets, infantile rickets, etc. Only few Indian studies are available in this regard. Objective To estimate serum vitamin D levels in pregnant women, cord blood, and study fetomaternal outcomes. Materials and methods A prospective observational study was conducted on 54 consecutive pregnant women and their newborn babies. Serum 25-hydroxy vitamin D [25(OH)D] level was estimated in all women at the time of admission in labor ward. They were followed up to delivery and 48 hours postpartum. Vitamin D was also estimated in cord blood collected during delivery. All results were recorded and analyzed statistically. Results The mean 25(OH)D level in pregnancy was 6.81 ± 7.38 ng/mL. The mean 25(OH)D level in their babies (cord blood) was 6.34 ± 7.05 ng/mL. There was very strong positive correlation between maternal and fetal serum 25(OH)D levels (p-value 0.001, r-value 0.9). Vitamin D deficiency was strongly associated with obesity, PE, and GDM (p-value 0.001). Neonatal jaundice and tetany were also significantly associated with severe vitamin D deficiency. Conclusion Low levels of vitamin D have been observed in pregnant women and their newborn babies. Hypovitaminosis D has been associated with adverse fetomaternal outcomes. As there is a strong correlation of maternal and neonatal levels, supplementing vitamin D in a pregnant women might improve these adverse pregnancy outcomes. How to cite this article Gupta M, Debnath A, Jain S, Saini V, Ray S. Vitamin D Status in Pregnancy: Fetomaternal Outcome and Correlation with Cord Blood Vitamin D. Indian J Med Biochem 2017;21(1):42-48.

scholarly journals 382Association between nutrient supplementation and depressive symptom in Pregnancy: a multicenter prospective cohort study

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Yunli Chen ◽  
Yu Jiang
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Folic Acid ◽  
Depressive Symptom ◽  
Pregnant Women ◽  
Dietary Fiber ◽  
Prospective Cohort ◽  
Third Trimester ◽  
Nutrient Supplementation ◽  
In Pregnancy

Abstract Background There are few researches about the association between nutrient supplementation and depressive symptom in pregnancy in large prospective cohort studies. Methods In Chinese Pregnant Women Cohort Study (CPWCS), twenty-four hospitals distributed in 15 provinces in China were selected as centre sites. Related information were collected in the first, second and third trimester respectively. Nutrient supplements include folic acid, vitamin D, calcium, iron, docosahexaenoic acid (DHA), dietary fiber, and probiotics. Edinburgh postnatal depression scale (EPDS) was used to assess the mood of depression. Univariable and multivariable Generalized Estimating Equation were applied to analyze the association of nutrient supplementation and depressive symptom in pregnancy. Results A total of 5759 pregnant women were included in our study. Results showed that 93.3%(5374/5759), 92.8%(5189/5591) and 94.2%(4056/4307) women supplemented one or more nutrients in the first, second and third trimester separately. The detection rates of antenatal depression was 30.77%(1772/5759), 28.13%(1573/5591) and 28.44%(1225/4307) separately. Multivariable analyses suggested that supplementing one or more nutrients was significantly associated with depression (OR = 0.812, p = 0.013). When analyzed separately, depression was negatively related to vitamin D (OR = 0.850, p = 0.001), calcium (OR = 0.880, p = 0.006), and DHA (OR = 0.903, p = 0.040), but not associated with supplement of folic acid, dietary fiber, iron, or probiotics. Conclusions Depressive symptom is highly prevalent among Chinese pregnant women, and supplement of vitamin D, calcium, and DHA are preventive factors of depressive symptom in pregnancy. Key message About a third of Chinese pregnant women have depressive symptom, and supplement of vitamin D, calcium, and DHA are preventive factors of depressive symptom in pregnancy.

scholarly journals Pelaksanaan Antenatal Care Berhubungan dengan Anemia pada Kehamilan Trimester III di Puskesmas Sedayu I Yogyakarta

2016 ◽  
Vol 3 (3) ◽  
pp. 134
Author(s):  
Fatimah Fatimah ◽  
Susi Ernawati
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Significant Relationship ◽  
Sampling Technique ◽  
P Value ◽  
Third Trimester ◽  
Chi Square ◽  
The Third ◽  
Independent Variable ◽  
In Pregnancy

<p>Anemia is one of the problems in Indonesia that important to examine, especially for pregnant women. This research used quantitative with explanatory design. Population were 44 pregnant women in 3 trimester selected by the total sampling technique. The independent variable were implementation of the antenatal care by midwives and dependent variable is anemia in 3 trimester of pregnancy at Puskesmas Sedayu I Yogyakarta. Data was collected using questionnaire. The analysis used was chi-square. The results of study showed that there was 33 (75%) of antenatal care in good category, with no anemia were 32 (72.7%) respondents, and there was a significant relationship between antenatal care and anemia in the third trimester of pregnancy with p-value=0.004. In conclusion, there was a significant relationship between antenatal care and anemia in the third trimester of pregnancy. Suggestions were needed to maintain and improve the care of midwives in antenatal care to improve the health of pregnant women, especially anemia in pregnancy.</p>

Calcium in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Bone Growth ◽  
Calcium Absorption ◽  
The Body ◽  
Calcium Stores ◽  
Third Trimester ◽  
Pregnant Adolescents ◽  
The Third ◽  
In Pregnancy

Most calcium in the body is present in the skeleton, where it serves a structural role and also as a reservoir for use in other tissues. During pregnancy, calcium is accumulated in the fetal skeleton, mostly during the third trimester when bone growth is at its peak. Although this increases the demand on maternal bone stores, the calcium transfer to the fetus is balanced by increased intestinal calcium absorption in the mother, mediated by compensatory changes in vitamin D synthesis and endogenous hormone levels. Bone loss is minimized if calcium intake is maintained at 1,000#amp;#x2013;1,200 mg/day during pregnancy. This intake level builds up calcium stores in early pregnancy for increased fetal transfer in the third trimester. Additional dietary calcium is usually not required if pre-pregnancy intake is adequate, although pregnant adolescents and women carrying multiple fetuses may require supplementation.

scholarly journals ANALISIS PENGARUH STATUS GIZI DAN TABLET TAMBAH DARAH TERHADAP ANEMIA DALAM KEHAMILAN

2020 ◽  
Vol 11 (2) ◽  
pp. 59-66
Author(s):  
Sumiyati
Keyword(s):  
Nutritional Status ◽  
Pregnant Women ◽  
Statistical Test ◽  
P Value ◽  
Cluster Sampling ◽  
Third Trimester ◽  
Chi Square ◽  
Design Data ◽  
Anemia In Pregnancy ◽  
In Pregnancy

Anemia is a decrease in levels of red blood cells (erythrocytes), namely hemoglobin levels less than 11 gr / dl in third trimester pregnant women. This study aims to determine the effect of nutritional status and distance of pregnancy on the occurrence of anemia in pregnancy. This study uses a cross sectional study design. Data collection was carried out by trained researchers and field officers including nutritional status, hemoglobin levels, consumption of Fe tablets for pregnant women. Subjects in this study were third trimester pregnant women with a total sample of 80 people taken using cluster sampling techniques and inclusion criteria. Data were analyzed using the chi-square statistical test. The results showed that there was one variable that significantly influenced the occurrence of anemia in pregnancy and there was one variable that did not significantly influence the occurrence of anemia in pregnancy. Statistical test results using the Chi-Square test obtained nutritional status (p-value = 0.929) and consumption of Fe tablets (p-value = 0.036)

ACOG: No Routine Vitamin D Screen in Pregnancy

Ob Gyn News ◽  
2011 ◽  
Vol 46 (7) ◽  
pp. 7
Author(s):  
HEIDI SPLETE
Keyword(s):  
Vitamin D ◽  
In Pregnancy
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