scholarly journals Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 869
Author(s):  
Weixuan Chen ◽  
Yanli Pang
Keyword(s):  
Polycystic Ovary ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Endocrine Diseases ◽  
Daily Diet ◽  
The Relationship ◽  
Underlying Pathogenesis ◽  
Prevention And Therapy

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.

The Relationship Between Thyroid Disorders and Polycystic Ovary Syndrome

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
SZainab Shnewer Mehdi ◽  
Batool Abdul Wahid Hashim ◽  
Baneen Chasib Jabal
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Function ◽  
Teaching Hospital ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Thyroid Disorders ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
The Relationship

This study was conducted at the Fertility Center at Al-Sadr Teaching Hospital in Najaf Governorate from 16/10/2016 to 10/3/2017 to determine the relationship between thyroid disorders and polycystic ovary syndrome in women of reproductive age. There was no significant difference in body mass and age for thyroid function. The study as well showed not significant difference in T3 and T4 levels when comparing the two groups, but there was a significant difference (P less than 0.05) in the TSH level, which is higher in the patients. It is concluded that there is a relationship between thyroid disorders and PCOS due to increased TSH in women with the syndrome.

scholarly journals Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

2013 ◽  
Vol 50 (2) ◽  
pp. R21-R37 ◽  
Author(s):  
Xinwang Chen ◽  
Xiao Jia ◽  
Jie Qiao ◽  
Youfei Guan ◽  
Jihong Kang
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Underlying Mechanisms ◽  
Insight Into

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

The role of anti-Müllerian hormone in the diagnostics of polycystic ovary syndrome in adolescence (review)

2016 ◽  
Vol 62 (4) ◽  
pp. 56-59
Author(s):  
Elena L. Soboleva ◽  
Elena S. Vlasova ◽  
Irina E. Zazerskaya
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Adolescent Girls ◽  
Polycystic Ovary ◽  
Diagnostic Value ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Criteria For Diagnosis ◽  
Time Diagnosis

Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism in women. The criteria for diagnosis in women of reproductive age at present are subject to dispute. At the same time, diagnosis in adolescent girls is associated with even greater challenges, since many of the manifestations of the disease are a manifestation of normal puberty. In the absence of clear criteria for diagnosis in adolescence, more attention is paid to the search for new markers PCOS, one of which may be anti-Müllerian hormone. However, data on its diagnostic value is currently controversial, which calls for more extensive research in order to develop specific criteria for the diagnosis PCOS in teenagers.

Disorders of steroid metabolism in women of reproductive age with polycystic ovary syndrome

2021 ◽  
Author(s):  
Olga Glavnova ◽  
Ludmila Velikanova ◽  
Natalia Vorokhobina ◽  
raviliy Galakhova ◽  
Ekaterina Malevanania ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Steroid Metabolism ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome

scholarly journals Pharmacological Treatment of Obesity in Patients with Polycystic Ovary Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Hassan Kahal ◽  
Stephen L. Atkin ◽  
Thozhukat Sathyapalan
Keyword(s):  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Weight Reduction ◽  
Pharmacological Treatment ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Prevalence Of Obesity ◽  
Treatment Of Obesity

Polycystic ovary syndrome (PCOS) is a common disorder affecting women of reproductive age and it is associated with increased cardiovascular risk. Obesity plays an important role in the pathogenesis of PCOS, and the majority of patients with PCOS are obese. Over the last 20 years, the prevalence of obesity has dramatically increased, with probable associated increase in PCOS. Weight reduction plays an integral part in the management of women with PCOS. In this paper, current available weight reduction therapies in the management of PCOS are discussed.

Polycystic ovary syndrome: reproductive aspects

2011 ◽  
pp. 1229-1234
Author(s):  
Sophie Catteau-Jonard ◽  
Cécile Gallo ◽  
Didier Didier
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Therapeutic Approaches ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Common Cause ◽  
The Metabolic Syndrome

The polycystic ovary syndrome (PCOS) is the most common cause of anovulation and hyperandrogenism in women, affecting between 5 and 10% of women of reproductive age worldwide (1). Although this difficult topic in endocrine gynaecology is under extensive research, controversies still remain about the pathophysiology, diagnosis, and therapy of PCOS. The PCOS phenotype can be structured in three components: manifestations of anovulation, hyperandrogenism, and the metabolic syndrome (of which hyperinsulinaemia secondary to insulin resistance is the central abnormality). The latter two are addressed in other chapters. Our knowledge about the mechanism of disturbed folliculogenesis in PCOS that is responsible for its reproductive aspects has much increased these last years, thus opening new avenues for the diagnostic and therapeutic approaches.

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