scholarly journals Microfluidic Viscometer Using a Suspending Micromembrane for Measurement of Biosamples

Micromachines ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 934
Author(s):  
Lelin Liu ◽  
Dinglong Hu ◽  
Raymond Lam
Keyword(s):  
Time Use ◽  
Biomedical Applications ◽  
Small Volume ◽  
Low Cost ◽  
Polymeric Materials ◽  
Disease Diagnosis ◽  
Analytical Relation ◽  
Liquid Volume ◽  
Liquid Sample ◽  
Membrane Displacement

The viscosity of biofluids such as blood and saliva can reflect an individual’s health conditions, and viscosity measurements are therefore considered in health monitoring and disease diagnosis. However, conventional viscometers can only handle a larger liquid volume beyond the quantity that can be extracted from a person. Though very effective, micro-sensors based on electrokinetic, ultrasonic, or other principles often have strict requirements for the supporting equipment and complicated procedures and signal processing. Sample contamination is always an important issue. In this paper, we report a microfluidic viscometer requiring a small volume of biosamples (<50 µL) and straightforward operation procedures. It is fabricated with low-cost and biocompatible polymeric materials as one-time-use devices, such that contamination is no longer the concern. It contains a suspending micromembrane located along a microchannel. Under a steady driving pressure, the membrane displacement is a function of viscosity of the liquid sample being tested. We derived a simple analytical relation and perform a simulation for converting the membrane displacement to the sample viscosity. We conducted experiments with liquids (water and mineral oil) with defined properties to verify such a relation. We further applied the micro-viscometer to measure bovine blood samples with different hematocrit levels. It can be concluded that the microfluidic viscometer has a high compatibility with a broad range of biomedical applications.

scholarly journals Recent Developments in Artificial Super-Wettable Surfaces Based on Bioinspired Polymeric Materials for Biomedical Applications

Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 238
Author(s):  
Ansar Abbas ◽  
Chen Zhang ◽  
Muhammad Asad ◽  
Ahsan Waqas ◽  
Asma Khatoon ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Polymeric Materials ◽  
Disease Diagnosis ◽  
Water Separation ◽  
Diverse Range ◽  
Significant Research ◽  
Recent Developments ◽  
Oil Water Separation ◽  
Oil Water ◽  
Self Cleaning

Inspired by nature, significant research efforts have been made to discover the diverse range of biomaterials for various biomedical applications such as drug development, disease diagnosis, biomedical testing, therapy, etc. Polymers as bioinspired materials with extreme wettable properties, such as superhydrophilic and superhydrophobic surfaces, have received considerable interest in the past due to their multiple applications in anti-fogging, anti-icing, self-cleaning, oil–water separation, biosensing, and effective transportation of water. Apart from the numerous technological applications for extreme wetting and self-cleaning products, recently, super-wettable surfaces based on polymeric materials have also emerged as excellent candidates in studying biological processes. In this review, we systematically illustrate the designing and processing of artificial, super-wettable surfaces by using different polymeric materials for a variety of biomedical applications including tissue engineering, drug/gene delivery, molecular recognition, and diagnosis. Special attention has been paid to applications concerning the identification, control, and analysis of exceedingly small molecular amounts and applications permitting high cell and biomaterial cell screening. Current outlook and future prospects are also provided.

Surface Modification of Poly(Vinylchloride) for Manufacturing Advanced Catheters

2020 ◽  
Vol 27 (10) ◽  
pp. 1616-1633 ◽  
Author(s):  
Oana Cristina Duta ◽  
Aurel Mihail Ţîţu ◽  
Alexandru Marin ◽  
Anton Ficai ◽  
Denisa Ficai ◽  
...  
Keyword(s):  
Surface Modification ◽  
Chemical Modification ◽  
Medical Devices ◽  
Low Cost ◽  
Physical And Mechanical Properties ◽  
Polymeric Materials ◽  
Modern Medicine ◽  
Structural Failure ◽  
Chemical Grafting ◽  
One Step

Polymeric materials, due to their excellent physicochemical properties and versatility found applicability in multiples areas, including biomaterials used in tissue regeneration, prosthetics (hip, artificial valves), medical devices, controlled drug delivery systems, etc. Medical devices and their applications are very important in modern medicine and the need to develop new materials with improved properties or to improve the existent materials is increasing every day. Numerous reasearches are activated in this domain in order to obtain materials/surfaces that does not have drawbacks such as structural failure, calcifications, infections or thrombosis. One of the most used material is poly(vinylchloride) (PVC) due to its unique properties, availability and low cost. The most common method used for obtaining tubular devices that meet the requirements of medical use is the surface modification of polymers without changing their physical and mechanical properties, in bulk. PVC is a hydrophobic polymer and therefore many research studies were conducted in order to increase the hydrophilicity of the surface by chemical modification in order to improve biocompatibility, to enhance wettability, reduce friction or to make lubricious or antimicrobial coatings. Surface modification of PVC can be achieved by several strategies, in only one step or, in some cases, in two or more steps by applying several techniques consecutively to obtain the desired modification / performances. The most common processes used for modifying the surface of PVC devices are: plasma treatment, corona discharge, chemical grafting, electric discharge, vapour deposition of metals, flame treatment, direct chemical modification (oxidation, hydrolysis, etc.) or even some physical modification of the roughness of the surface.

scholarly journals CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 924
Author(s):  
Alexander B. Shcherbakov ◽  
Vladimir V. Reukov ◽  
Alexander V. Yakimansky ◽  
Elena L. Krasnopeeva ◽  
Olga S. Ivanova ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Metal Oxide Nanoparticles ◽  
Polymeric Materials ◽  
Negative Effects ◽  
New Horizons ◽  
Beneficial Effects ◽  
Advanced Composite ◽  
Unique Material ◽  
Biomedical Polymers ◽  
Biomedical Potential

The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

scholarly journals Bacterial Nanocellulose in Dentistry: Perspectives and Challenges

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 49
Author(s):  
Hélida Gomes de Oliveira Barud ◽  
Robson Rosa da Silva ◽  
Marco Antonio Costa Borges ◽  
Guillermo Raul Castro ◽  
Sidney José Lima Ribeiro ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Biomedical Applications ◽  
Low Cost ◽  
Pulp Tissue ◽  
Bacterial Nanocellulose ◽  
Artificial Blood ◽  
Current Trends ◽  
Artificial Blood Vessels ◽  
Near Future ◽  
Dressing Materials

Bacterial cellulose (BC) is a natural polymer that has fascinating attributes, such as biocompatibility, low cost, and ease of processing, being considered a very interesting biomaterial due to its options for moldability and combination. Thus, BC-based compounds (for example, BC/collagen, BC/gelatin, BC/fibroin, BC/chitosan, etc.) have improved properties and/or functionality, allowing for various biomedical applications, such as artificial blood vessels and microvessels, artificial skin, and wounds dressing among others. Despite the wide applicability in biomedicine and tissue engineering, there is a lack of updated scientific reports on applications related to dentistry, since BC has great potential for this. It has been used mainly in the regeneration of periodontal tissue, surgical dressings, intraoral wounds, and also in the regeneration of pulp tissue. This review describes the properties and advantages of some BC studies focused on dental and oral applications, including the design of implants, scaffolds, and wound-dressing materials, as well as carriers for drug delivery in dentistry. Aligned to the current trends and biotechnology evolutions, BC-based nanocomposites offer a great field to be explored and other novel features can be expected in relation to oral and bone tissue repair in the near future.

Materials Selection for Sandwich Pipes Under the Combined Effect of Pressure, Bending and Temperature

2007 ◽  
Author(s):  
Allan R. de Souza ◽  
Theodoro A. Netto ◽  
Ilson P. Pasqualino
Keyword(s):  
Structural Strength ◽  
Material Selection ◽  
Low Cost ◽  
Polymeric Materials ◽  
External Pressure ◽  
Core Material ◽  
Annular Layer ◽  
Oil And Natural Gas ◽  
Longitudinal Bending ◽  
Logic Approach

Recent researches point to the great potential of the sandwich pipe conception for ultra deepwater exploitation and production of oil and natural gas. Its configuration is very simple and comprises two concentric metallic pipes with a core material, polymeric or ceramic, in the annulus. The main functions of the annular layer are: to provide satisfactory thermal insulation so as to avoid the formation of wax and hydrates along the pipeline during production shutdown; to improve the overall structural strength of the system. Polypropylene and cement have been recently proposed for these applications. The reason for the choice of these materials was the low cost and the extensive availability in industry. Here a systematic material selection approach is employed in order to assess the applicability of other polymeric materials. The attributes of materials needed to meet the design specification are thoroughly studied. The list of possible materials was enlarged and the modified digital logic approach is used with the purpose to define a top group of materials for further numerical comparative study. Finite element analyses are carried out to assess the structural strength of the sandwich pipe under pure external pressure or longitudinal bending and combined external pressure and bending. Additionally, the effect of thermal gradient is included to the numerical analyses to evaluate each pre-selected material of the top group. Results indicate that other potential materials such as PEEK and polycarbonate can improve the structural performance of the sandwich pipe conception and yet meet other several design criteria.

Carbon Dioxide as a Carbon Resource – Recent Trends and Perspectives

2012 ◽  
Vol 67 (10) ◽  
pp. 961-975 ◽  
Author(s):  
Markus Hölscher ◽  
Christoph Gürtler ◽  
Wilhelm Keim ◽  
Thomas E. Müller ◽  
Martina Peters ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Raw Materials ◽  
Low Cost ◽  
Polymeric Materials ◽  
Short Review ◽  
Chemical Research ◽  
Bond Forming ◽  
Bulk Chemicals ◽  
High Thermodynamic Stability ◽  
Recent Trends

With the growing perception of industrialized societies that fossil raw materials are limited resources, academic chemical research and chemical industry have started to introduce novel catalytic technologies which aim at the development of economically competitive processes relying much more strongly on the use of alternative carbon feedstocks. Great interest is given world-wide to carbon dioxide (CO2) as it is part of the global carbon cycle, nontoxic, easily available in sufficient quantities anywhere in the industrialized world, and can be managed technically with ease, and at low cost. In principle carbon dioxide can be used to generate a large variety of synthetic products ranging from bulk chemicals like methanol and formic acid, through polymeric materials, to fine chemicals like aromatic acids useful in the pharmaceutical industry. Owing to the high thermodynamic stability of CO2, the energy constraints of chemical reactions have to be carefully analyzed to select promising processes. Furthermore, the high kinetic barriers for incorporation of CO2 into C-H or C-C bond forming reactions require that any novel transformation of CO2 must inevitably be associated with a novel catalytic technology. This short review comprises a selection of the most recent academic and industrial research developments mainly with regard to innovations in CO2 chemistry in the field of homogeneous catalysis and processes.

scholarly journals Influence of kaolin filler on the mechanical properties of Luffa cylindrica/ polyester composite

2021 ◽  
Author(s):  
Aliyu Yaro ◽  
Laminu Kuburi ◽  
Musa Abiodun Moshood
Keyword(s):  
Mechanical Properties ◽  
Polyester Resin ◽  
Unsaturated Polyester ◽  
Low Cost ◽  
Microstructural Analysis ◽  
Polymeric Materials ◽  
Weight Fraction ◽  
Industrial Applications ◽  
Luffa Cylindrica ◽  
Polyester Composite

Abstract Polymeric materials are used in different industrial applications because they retain good environmental properties, low-cost, and easy to produce compared to conventional materials. This study investigated the effect of adding kaolin micro-filler (KF) on the mechanical properties of Luffa Fiber (LCF) reinforced polyester resin. Luffa cylindrica fiber treated with 5% NaOH, varied in weight fraction (5, 10, and 15%wt) was used to reinforce unsaturated polyester resin using hand lay-up method, whereas for the hybrid composite kaolin filler were kept constant at 6wt% fraction while the fibers varied as in the mono-reinforced composite. The samples were machined for mechanical and microstructural analysis. Analysis of the result revealed that the addition of kaolin has enhanced greatly the mechanical properties of Luffa-fibre based composites. The result reveal of the microstructure analysis, shows that there is an improvement in fiber-matrix adhesion.

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