scholarly journals Printing a Pacinian Corpuscle: Modeling and Performance

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 574
Author(s):  
Kieran Barrett-Snyder ◽  
Susan Lane ◽  
Nathan Lazarus ◽  
W. C. Kirkpatrick Alberts ◽  
Brendan Hanrahan
Keyword(s):  
Pacinian Corpuscle ◽  
Biological Cell ◽  
Vibration Sensors ◽  
Highly Sensitive ◽  
Fluid Layers ◽  
3D Printers ◽  
Band Pass ◽  
And Performance ◽  
Elastic Layers ◽  
Unique Band

The Pacinian corpuscle is a highly sensitive mammalian sensor cell that exhibits a unique band-pass sensitivity to vibrations. The cell achieves this band-pass response through the use of 20 to 70 elastic layers entrapping layers of viscous fluid. This paper develops and explores a scalable mechanical model of the Pacinian corpuscle and uses the model to predict the response of synthetic corpuscles, which could be the basis for future vibration sensors. The −3dB point of the biological cell is accurately mimicked using the geometries and materials available with off-the-shelf 3D printers. The artificial corpuscles here are constructed using uncured photoresist within structures printed in a commercial stereolithography (SLA) 3D printer, allowing the creation of trapped fluid layers analogous to the biological cell. Multi-layer artificial Pacinian corpuscles are vibration tested over the range of 20–3000 Hz and the response is in good agreement with the model.

Bio-Inspired Cell Concentration and Deformability Monitoring Chips

2007 ◽  
Vol 7 (11) ◽  
pp. 4214-4219 ◽  
Author(s):  
Young-Ho Cho ◽  
Sechan Youn ◽  
Dong Woo Lee
Keyword(s):  
Experimental Study ◽  
Control Mechanism ◽  
Cell Concentration ◽  
Biological Cell ◽  
High Integrability ◽  
Digital Signals ◽  
Cell Deformability ◽  
Destruction Mechanism ◽  
Biomedical Systems ◽  
And Performance

The paper presents a couple of biofluidic devices, whose functions are inspired from biological cell concentration and deformability monitoring functions. The cell concentration monitoring chip is inspired from RBC control mechanism in kidney, performing cell concentration monitoring functions. The cell deformability chip, inspired from selective RBC destruction mechanism in spleen, performs mechanical cell deformability monitoring functions. The structures and principles of the bio-inspired chips are presented and compared with those of the biological organs. The unique features and performance characteristics of the bio-inspired chips are analyzed and verified from experimental study. The bio-inspired cell concentration monitoring chips perform flow-rate insensitive concentration measurement, while the bio-inspired cell deformability monitoring chips achieve size-independent cell deformability measurement. Common advantages of the bio-inspired chips include simple structures, digital signals and high integrability, thus making them suitable for use in integrated digital biomedical systems.

X-ray monochromator combining high resolution with high intensity

2002 ◽  
Vol 35 (1) ◽  
pp. 41-48 ◽  
Author(s):  
M. Servidori
Keyword(s):  
High Resolution ◽  
High Intensity ◽  
Asymmetry Factor ◽  
Photon Flux ◽  
Wavelength Band ◽  
Germanium Crystal ◽  
X Ray ◽  
Band Pass ◽  
And Performance ◽  
Exit Beam

A two-germanium-crystal four-220-reflection (+ - - \,+) monochromator, combining high intensity with high resolution, is proposed in this work. The main characteristic is that only the first reflection is asymmetric. The asymmetry factor was chosen so as to allow mixing of asymmetric and symmetric reflections in a monolithic channel-cut crystal without the need for rotation of the two monolith components to correct for the different refraction-induced angular shifts of the reflection pair. It is demonstrated that the exit-beam divergence in the diffraction plane and the fractional wavelength band-pass are smaller by 40% than those of the widely used germanium 220 Bartels monochromator, while the photon flux collected from the source is larger by a factor of five. The optical features and performance of the monochromator are discussed and compared with those of other (+ - - \,+) monochromators reported in the literature.

scholarly journals Highly Sensitive High Performance Liquid Chromatography-Laser Induced Fluorescence for Proteomics Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ajeetkumar Patil ◽  
K. S. Choudhari ◽  
Vijendra Prabhu ◽  
V. K. Unnikrishnan ◽  
Sujatha Bhat ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Serum Proteins ◽  
Sensitivity Study ◽  
Laser Induced Fluorescence ◽  
Laser Induced Fluorescence Detection ◽  
Highly Sensitive ◽  
Sds Page ◽  
And Performance

This paper describes the sensitivity study and performance evaluation of high-performance liquid chromatography-laser-induced fluorescence detection (HPLC-LIF) system assembled in our laboratory for proteomics applications. The limits of Detection (LOD) of several serum proteins have been estimated with this instrument and are found to be much lower compared to other commonly used proteomics techniques like SELDI, MALDI, 2-D-SDS-PAGE, and so forth. Techniques for improving the LOD still further with similar setup are briefly discussed. Using the system, protein profiles of serum in normal, malignant, and premalignant conditions were recorded for different malignancy situations.

scholarly journals Hedge Fund Flows and Performance Streaks: How Investors Weigh Information

2021 ◽  
Author(s):  
Guillermo Baquero ◽  
Marno Verbeek
Keyword(s):  
Hedge Funds ◽  
Hedge Fund ◽  
Cash Flows ◽  
Fund Flows ◽  
Hot Hand ◽  
Highly Sensitive ◽  
Wide Range ◽  
Processing Abilities ◽  
And Performance ◽  
Types Of Information

Cash flows to hedge funds are highly sensitive to performance streaks, a streak being defined as subsequent quarters during which a fund performs above or below a benchmark, even after controlling for a wide range of common performance measures. At the same time, streaks have limited predictive power regarding future fund performance. This suggests investors weigh information suboptimally, and their decisions are driven too strongly by a belief in continuation of good performance, consistent with the “hot hand fallacy.” The hedge funds that investors choose to invest in do not perform significantly better than those they divest from. These findings are consistent with overreaction to certain types of information and do not support the notion that sophisticated investors have superior information or superior information processing abilities. This paper was accepted by David Simchi-Levi, finance.

Bio-Inspired Cell Concentration and Deformability Monitoring Chips

2007 ◽  
Vol 7 (11) ◽  
pp. 4214-4219
Author(s):  
Young-Ho Cho ◽  
Sechan Youn ◽  
Dong Woo Lee
Keyword(s):  
Experimental Study ◽  
Control Mechanism ◽  
Cell Concentration ◽  
Biological Cell ◽  
High Integrability ◽  
Digital Signals ◽  
Cell Deformability ◽  
Destruction Mechanism ◽  
Biomedical Systems ◽  
And Performance

The paper presents a couple of biofluidic devices, whose functions are inspired from biological cell concentration and deformability monitoring functions. The cell concentration monitoring chip is inspired from RBC control mechanism in kidney, performing cell concentration monitoring functions. The cell deformability chip, inspired from selective RBC destruction mechanism in spleen, performs mechanical cell deformability monitoring functions. The structures and principles of the bio-inspired chips are presented and compared with those of the biological organs. The unique features and performance characteristics of the bio-inspired chips are analyzed and verified from experimental study. The bio-inspired cell concentration monitoring chips perform flow-rate insensitive concentration measurement, while the bio-inspired cell deformability monitoring chips achieve size-independent cell deformability measurement. Common advantages of the bio-inspired chips include simple structures, digital signals and high integrability, thus making them suitable for use in integrated digital biomedical systems.

Integration of Functional Circuits into FDM Parts

2014 ◽  
Vol 1038 ◽  
pp. 29-33 ◽  
Author(s):  
Alissa Wild
Keyword(s):  
Electrically Conductive ◽  
Ground Vehicle ◽  
Electronic Circuitry ◽  
Ink Jet ◽  
3D Printers ◽  
3D Printed ◽  
And Performance ◽  
Plastic Parts ◽  
Thermoplastic Resins ◽  
Design Freedom

The incorporation of electronic circuitry into additively manufactured thermoplastic parts is a highly desirable innovation enabler. Applications include embedding signal traces into custom air or ground vehicle components, creation of complex interconnect devices exploiting the design freedom of 3D printers, or as a way to create various grounding, shielding, sensing or antenna patterns on custom structures. Stratasys has explored multiple approaches for creating selective metallization on 3D printed plastic parts. Earlier publications [1] described evaluations of metal-based ink deposition methods such as ink jet and aerosol jet. More recently we have explored the use of Laser Direct Structuring, (LDS) thermoplastic resins in our 3D printers. With LDS technology, parts are selectively metallized after 3D part build through a laser imaging and electroless plating process. Finally, some early feasibility work has been attempted using inherently electrically conductive materials. In this paper, the various methods evaluated for integration of metal traces with 3D parts will be discussed, along with part examples and performance comparisons.

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