scholarly journals Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 993
Author(s):  
Megan A Catterton ◽  
Alexander G Ball ◽  
Rebecca R Pompano
Keyword(s):  
3D Printing ◽  
Ex Vivo ◽  
Local Delivery ◽  
Tissue Slices ◽  
Digital Light Processing ◽  
Rapid Fabrication ◽  
Wide Range ◽  
Scale Levels ◽  
Range Of Functions

SlipChips are two-part microfluidic devices that can be reconfigured to change fluidic pathways for a wide range of functions, including tissue stimulation. Currently, fabrication of these devices at the prototype stage requires a skilled microfluidic technician, e.g., for wet etching or alignment steps. In most cases, SlipChip functionality requires an optically clear, smooth, and flat surface that is fluorophilic and hydrophobic. Here, we tested digital light processing (DLP) 3D printing, which is rapid, reproducible, and easily shared, as a solution for fabrication of SlipChips at the prototype stage. As a case study, we sought to fabricate a SlipChip intended for local delivery to live tissue slices through a movable microfluidic port. The device was comprised of two multi-layer components: an enclosed channel with a delivery port and a culture chamber for tissue slices with a permeable support. Once the design was optimized, we demonstrated its function by locally delivering a chemical probe to slices of hydrogel and to living tissue with up to 120 µm spatial resolution. By establishing the design principles for 3D printing of SlipChip devices, this work will enhance the ability to rapidly prototype such devices at mid-scale levels of production.

scholarly journals Rapid fabrication of MOF-based mixed matrix membranes through digital light processing

2021 ◽  
Author(s):  
Alexey Pustovarenko ◽  
Beatriz Seoane ◽  
Edy Abou-Hamad ◽  
Helen E King ◽  
Bert Weckhuysen ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Processing Speed ◽  
Mixed Matrix Membranes ◽  
Scientific Interest ◽  
Mixed Matrix ◽  
Digital Light Processing ◽  
Additive Manufacturing Technology ◽  
Rapid Fabrication ◽  
Manufacturing Methods

3D printing, also known as additive manufacturing technology, has greatly expanded across multiple sectors of technology replacing classical manufacturing methods by combining processing speed and high precision. The scientific interest...

scholarly journals Comparative Studies on Polyurethane Composites Filled with Polyaniline and Graphene for DLP-Type 3D Printing

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 67 ◽  
Author(s):  
Hyeonseo Joo ◽  
Sunghun Cho
Keyword(s):  
3D Printing ◽  
Comparative Studies ◽  
Solution Process ◽  
Sem Images ◽  
Digital Light Processing ◽  
Wide Range ◽  
Light Curing ◽  
Ft Ir ◽  
Polyurethane Composites ◽  
Ft Ir Spectroscopy

Digital light processing (DLP)-type 3D printing ensures several advantages, such as an easy solution process, a short printing time, high-quality printing, and selective light curing. Furthermore, polyurethane (PU) is among the promising candidates for 3D printing because of its wide range of applications. This work reports comparative studies on the fabrication and optimization of PU composites using a polyaniline (PANI) nanomaterial and a graphene sheet (GS) for DLP-type 3D printing. The morphologies and dispersion of the printed PU composites were studied by field emission scanning electron microscope (FE-SEM) images. Bonding structures in the PU composites were investigated by Fourier-transform infrared (FT-IR) spectroscopy. As-prepared PU/PANI and PU/GS composites with different filler contents were successfully printed into sculptures with different sizes and shapes. The PU/PANI and PU/GS composites exhibit the improved sheet resistance, which is up to 8.57 × 104 times (1.19 × 106 ohm/sq) lower and 1.27 × 105 times (8.05 × 105 ohm/sq) lower, respectively, than the pristine PU (1.02 × 1011 ohm/sq). Moreover, the PU/PANI and PU/GS composites demonstrate 1.41 times (44.5 MPa) higher and 2.19 times (69.3 MPa) higher tensile strengths compared with the pristine PU (31.6 MPa). This work suggests the potential uses of highly conductive PU composites for DLP-type 3D printing.

Usability digitaler Lesemedien

2021 ◽  
Author(s):  
Sibylle Kunz
Keyword(s):  
Print Media ◽  
Reference Model ◽  
Digital Reading ◽  
Wide Range ◽  
Range Of Functions ◽  
Multiple Case ◽  
International University ◽  
Usability Requirements ◽  
Conducting Research

Focusing on the reader’s benefit: Digital reading media offer a wide range of functions compared to print media: search functions, bookmarking, annotations, social reading, etc. However, they often fail to meet basic usability requirements, hindering reception and driving readers back to print media. This dissertation designs a reference model and derives a set of suitable methods from it with which to measure and improve the usability of digital reading media, including heuristic evaluation, user observation and eye-tracking, which it empirically tests on professional journal apps in a multiple case study. Sibylle Kunz is a professor of media computer science at IUBH International University, conducting research on digital reading media and their usability.

scholarly journals The semantics of Moroccan Arabic dar ‘do’ in typological perspective

2012 ◽  
Vol 65 (4) ◽  
Author(s):  
Eva Schultze-Berndt ◽  
Dina El Zarka
Keyword(s):  
High Frequency ◽  
Spoken Language ◽  
Loan Words ◽  
Moroccan Arabic ◽  
Wide Range ◽  
Range Of Functions ◽  
Interesting Object ◽  
Object Of Study ◽  
Action Verbs

AbstractThis paper is a case study in the exploration of the semantic range of single a high-frequency lexical item on the basis of a corpus of spoken language, in this case Moroccan Arabic. Generalised action verbs (‘do’ verbs) are an interesting object of study because cross-linguistically, they can exhibit a wide range of functions including that of causative verb, verb of creation, verb in agentive collocations, verbaliser with loan words and mimetic expressions, quotative verb, and even a copula-like use with property predicates (Schultze-Berndt 2008). Against this typological background, the range of functions of Moroccan Arabic

scholarly journals Best practices for design and fabrication of biomicrofluidic devices by resin 3D printing

2021 ◽  
Author(s):  
Hannah B. Musgrove ◽  
Megan A. Catterton ◽  
Rebecca R. Pompano
Keyword(s):  
3D Printing ◽  
Best Practices ◽  
Mechanical Stability ◽  
Fabrication Method ◽  
Clinical Tests ◽  
Digital Light Processing ◽  
Integrated Devices ◽  
Rapid Fabrication ◽  
3D Printed ◽  
Printing Techniques

Stereolithographic (SL) 3D printing, especially digital light processing (DLP) printing, is a promising rapid fabrication method for bio-microfluidic applications such as clinical tests, lab-on-a-chip devices, and sensor integrated devices. The benefits of 3D printing lead many to believe this fabrication method will accelerate the use of bioanalytical microfluidics, but there are major obstacles to overcome to fully utilize this technology. For commercially available printing materials, this includes challenges in producing prints with the print resolution and mechanical stability required for a particular design, along with cytotoxic components within many SL resins and low optical compatibility for imaging experiments. Potential solutions to these problems are scattered throughout the literature and rarely available in head-to-head comparisons. Therefore, we present here principles for navigation of 3D printing techniques and systematic tests to inform resin selection and optimization of the design and fabrication of SL 3D printed bio-microfluidic devices.

scholarly journals HAR1: an insight into lncRNA genetic evolution

Epigenomics ◽  
2021 ◽  
Author(s):  
Ella Waters ◽  
Perla Pucci ◽  
Mark Hirst ◽  
Simon Chapman ◽  
Yuzhuo Wang ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Expression Patterns ◽  
Noncoding Rnas ◽  
Current State ◽  
Evolutionary Changes ◽  
Wide Range ◽  
Range Of Functions ◽  
Health And Disease ◽  
Insight Into

Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.

Site specific agricultural soil management with the use of new technologies

2013 ◽  
Vol 16 (1) ◽  
pp. 59-67
Keyword(s):  
New Technologies ◽  
Digital Interface ◽  
Appropriate Treatment ◽  
Wide Range ◽  
Soil Variation ◽  
Soil Information ◽  
Remote Sensing Techniques ◽  
Agricultural Areas

<p>The Soil Science Institute of Thessaloniki produces new digitized Soil Maps that provide a useful electronic database for the spatial representation of the soil variation within a region, based on in situ soil sampling, laboratory analyses, GIS techniques and plant nutrition mathematical models, coupled with the local land cadastre. The novelty of these studies is that local agronomists have immediate access to a wide range of soil information by clicking on a field parcel shown in this digital interface and, therefore, can suggest an appropriate treatment (e.g. liming, manure incorporation, desalination, application of proper type and quantity of fertilizer) depending on the field conditions and cultivated crops. A specific case study is presented in the current work with regards to the construction of the digitized Soil Map of the regional unit of Kastoria. The potential of this map can easily be realized by the fact that the mapping of the physicochemical properties of the soils in this region provided delineation zones for differential fertilization management. An experiment was also conducted using remote sensing techniques for the enhancement of the fertilization advisory software database, which is a component of the digitized map, and the optimization of nitrogen management in agricultural areas.</p>

Structure, Function and Interactions of Tau: Particular Focus on Potential Drug Targets for the Treatment of Tauopathies

2018 ◽  
Vol 17 (5) ◽  
pp. 325-337 ◽  
Author(s):  
Hojjat Borna ◽  
Kasim Assadoulahei ◽  
Gholamhossein Riazi ◽  
Asghar Beigi Harchegani ◽  
Alireza Shahriary
Keyword(s):  
Tau Protein ◽  
Drug Targets ◽  
Brain Injuries ◽  
Potential Drug ◽  
Microtubule Network ◽  
Wide Range ◽  
Potential Risk Factors ◽  
Range Of Functions ◽  
Potential Drug Targets

Background & Objective: Neurodegenrative diseases are among the most widespread lifethreatening disorders around the world in elderly ages. The common feature of a group of neurodegenerative disorders, called tauopathies, is an accumulation of microtubule associated protein tau inside the neurons. The exact mechanism underlying tauopathies is not well-understood but several factors such as traumatic brain injuries and genetics are considered as potential risk factors. Although tau protein is well-known for its key role in stabilizing and organization of axonal microtubule network, it bears a broad range of functions including DNA protection and participation in signaling pathways. Moreover, the flexible unfolded structure of tau facilitates modification of tau by a wide range of intracellular enzymes which in turn broadens tau function and interaction spectrum. The distinctive properties of tau protein concomitant with the crucial role of tau interaction partners in the progression of neurodegeneration suggest tau and its binding partners as potential drug targets for the treatment of neurodegenerative diseases. Conclusion: This review aims to give a detailed description of structure, functions and interactions of tau protein in order to provide insight into potential therapeutic targets for treatment of tauopathies.

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