scholarly journals An Optical Acoustic Detection System Based on Fabry Pérot Etalon Stability Structure

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1564
Author(s):  
Liyun Wu ◽  
Yongqiu Zheng ◽  
Chenyang Xue ◽  
Jiandong Bai ◽  
Jiamin Chen
Keyword(s):  
Acoustic Waves ◽  
Detection System ◽  
Signal To Noise Ratio ◽  
Audio Signal ◽  
High Sensitivity ◽  
Acoustic Detection ◽  
Detection Technology ◽  
Fabry Perot ◽  
Stability Model ◽  
Stability Structure

The optical acoustic detection system based on the Fabry Pérot Etalon (FPE) with high quality–factor (High Q) and stability structure is described and tested. The FPE contains two high–reflectivity Plano–Concave lenses, achieving high fineness and stability. The protective structure of the confocal stabilized FPE is composed of an invar tube, copper sheath, Bakelite sheath and aluminum housing to protect the sensor from the effects of ambient temperature and vibration. The audio signal is injected into the cavity through the sound hole located in the center of the cavity. Acoustic waves induce the vibration of the medium in the cavity, which leads to a simultaneous change in the FPE optical path and a shift of the interference spectrum. The acoustic detection system is built, and the frequency of the laser is locked on the resonant frequency points of the FPE by using phase modulation technology, so as to detect acoustic signals of different frequencies and amplitudes. In addition, the sensitivity of the proposed sensor exceeds 34.49 mV/Pa in the range of 20 Hz–20 kHz. A Signal-to-Noise Ratio (SNR) of 37 dB can be achieved at 20 Hz. Acoustic signal detection technology based on the FPE stability model is used to test the theoretical feasibility of the future high sensitivity Fabry Pérot Interferometric (FPI) acoustic sensors.

scholarly journals Scanning single-molecule counting system for Eprobe with highly simple and effective approach

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243319
Author(s):  
Takeshi Hanami ◽  
Tetsuya Tanabe ◽  
Takuya Hanashi ◽  
Mitsushiro Yamaguchi ◽  
Hidetaka Nakata ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Single Molecule ◽  
Detection System ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
Nucleic Acid Detection ◽  
Digital Measurement ◽  
Excitation Light ◽  
Target Nucleic Acid ◽  
Fluorescent Molecules

Here, we report a rapid and ultra-sensitive detection technique for fluorescent molecules called scanning single molecular counting (SSMC). The method uses a fluorescence-based digital measurement system to count single molecules in a solution. In this technique, noise is reduced by conforming the signal shape to the intensity distribution of the excitation light via a circular scan of the confocal region. This simple technique allows the fluorescent molecules to freely diffuse into the solution through the confocal region and be counted one by one and does not require statistical analysis. Using this technique, 28 to 62 aM fluorescent dye was detected through measurement for 600 s. Furthermore, we achieved a good signal-to-noise ratio (S/N = 2326) under the condition of 100 pM target nucleic acid by only mixing a hybridization-sensitive fluorescent probe, called Eprobe, into the target oligonucleotide solution. Combination of SSMC and Eprobe provides a simple, rapid, amplification-free, and high-sensitive target nucleic acid detection system. This method is promising for future applications to detect particularly difficult to design primers for amplification as miRNAs and other short oligo nucleotide biomarkers by only hybridization with high sensitivity.

Acoustic Detection Technology Based on Fiber Bragg Grating Fabry-Perot Interferometer in Liquid Medium

2013 ◽  
Vol 33 (9) ◽  
pp. 0906001 ◽  
Author(s):  
张伟超 Zhang Weichao ◽  
赵洪 Zhao Hong ◽  
刘通 Liu Tong ◽  
王国利 Wang Guoli ◽  
李锐海 Li Ruihai
Keyword(s):  
Liquid Medium ◽  
Fiber Bragg Grating ◽  
Bragg Grating ◽  
Acoustic Detection ◽  
Detection Technology ◽  
Fabry Perot

scholarly journals Homodyne Spectroscopy with Broadband Terahertz Power Detector Based on 90-nm Silicon CMOS Transistor

2021 ◽  
Vol 11 (1) ◽  
pp. 412
Author(s):  
Kęstutis Ikamas ◽  
Dmytro B. But ◽  
Alvydas Lisauskas
Keyword(s):  
Continuous Wave ◽  
Detection System ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
Complementary Metal Oxide Semiconductor ◽  
Oxide Semiconductor ◽  
Integration Time ◽  
Thz Spectroscopy ◽  
Homodyne Detection ◽  
Cmos Transistor

Over the last two decades, photomixer-based continuous wave systems developed into versatile and practical tools for terahertz (THz) spectroscopy. The high responsivity to the THz field amplitude of photomixer-based systems is predetermined by the homodyne detection principle that allows the system to have high sensitivity. Here, we show that the advantages of homodyne detection can be exploited with broadband power detectors combined with two photomixer sources. For this, we employ a THz detector based on a complementary metal-oxide-semiconductor field-effect transistor and a broadband bow-tie antenna (TeraFET). At 500 GHz and an effective noise bandwidth of 1 Hz, the response from one photomixer-based THz source resulted in an about 43 dB signal-to-noise ratio (SNR). We demonstrate that by employing a homodyne detection system by overlaying the radiation from two photomixers, the SNR can reach up to 70 dB at the same frequency with an integration time 100 ms. The improvement in SNR and the spectroscopic evidence for water vapor lines demonstrated up to 2.2 THz allow us to conclude that these detectors can be successfully used in practical continuous wave THz spectrometry systems.

scholarly journals Detection Spectrum Optimization of Stealth Aircraft Targets From a Space-based Infrared Platform

2021 ◽  
Author(s):  
Xinyue Ni ◽  
Shutian Yu ◽  
Xiaofeng Su ◽  
Fansheng Chen
Keyword(s):  
Detection System ◽  
Signal To Noise Ratio ◽  
Signal To Noise ◽  
Central Wavelength ◽  
Detection Techniques ◽  
Detection Systems ◽  
Spectrum Detection ◽  
Detection Technology ◽  
Spectrum Optimization ◽  
Noise Ratio

Abstract Advances in infrared detection techniques require novel spectrum dynamic-modification strategies capable of sensing unprecedentedly low target radiant intensities. A conventional fixed-spectrum detection system cannot satisfy the effective detection of stealth aircraft targets due to complex Earth background clutter and atmospheric attenuation. Therefore, a detection method that can highlight aircraft targets is urgently needed to enhance stealth aircraft detectability. In this research, a spectrum set consisting of different bandwidths associated with a central wavelength is established. Furthermore, a signal-to-noise ratio of the stealth aircraft is computed using the established spectrum set. Finally, the optimal spectrum is selected according to the maximal signal-to-noise ratio from the spectrum set. Our numerical experiments and simulations further demonstrate that the proposed methodology can substantially strengthen the detection performance of stealth aircraft compared with traditional fixed-spectrum detection systems. This work on detection spectrum optimization paves the way to stealth aircraft detection and opens new vistas in the field of target detection technology.

scholarly journals Ultrahigh-speed point scanning two-photon microscopy using high dynamic range silicon photomultipliers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vincent D. Ching-Roa ◽  
Eben M. Olson ◽  
Sherrif F. Ibrahim ◽  
Richard Torres ◽  
Michael G. Giacomelli
Keyword(s):  
High Speed ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Photomultiplier Tubes ◽  
Silicon Photomultipliers ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Detection Technology

AbstractConventional two-photon microscopes use photomultiplier tubes, which enable high sensitivity but can detect relatively few photons per second, forcing longer pixel integration times and limiting maximum imaging rates. We introduce novel detection electronics using silicon photomultipliers that greatly extend dynamic range, enabling more than an order of magnitude increased photon detection rate as compared to state-of-the-art photomultiplier tubes. We demonstrate that this capability can dramatically improve both imaging rates and signal-to-noise ratio (SNR) in two-photon microscopy using human surgical specimens. Finally, to enable wider use of more advanced detection technology, we have formed the OpenSiPM project, which aims to provide open source detector designs for high-speed two-photon and confocal microscopy.

INEXPENSIVE CHEMICAL DEFENSE NETWORK FOR A FIXED SITE

2008 ◽  
Vol 18 (03) ◽  
pp. 593-600
Author(s):  
JULIETTE A. SEELEY ◽  
MATTHEW ANGEL ◽  
ROSHAN L. AGGARWAL ◽  
THOMAS H. JEYS ◽  
ANTONIO SANCHEZ-RUBIO ◽  
...  
Keyword(s):  
Detection System ◽  
Signal To Noise Ratio ◽  
Chemical Vapor ◽  
High Sensitivity ◽  
Characteristic Change ◽  
Chemical Agent ◽  
Ir Absorption ◽  
Long Wave ◽  
Chemical Threats ◽  
Hot Filament

The Inexpensive Chemical Agent Detection System (ICADS) consists of a network of affordable line-of-sight sensors, each designed to detect chemical threats passing between two points with high sensitivity and a low false-alarm rate. Each leg of the ICADS system is composed of two devices, a broadband IR transmitter, and a receiver containing a long-wave-IR spectrometer. The spectrometer continually measures the spectrum of the radiation emitted by the transmitter, which is separated from the receiver by up to several hundred meters, forming a line of protection. A chemical vapor or aerosol plume with sufficient long-wave-IR absorption causes a characteristic change in the spectrum of light collected by the receiver as the plume crosses the protected line, signaling a threat. Background measurements were conducted to determine background-limited performance. Additionally, a sensor composed of a long-wave-IR fixed-grating spectrometer and a hot-filament transmitter was designed and built. Measurements of the signal-to-noise ratio (SNR) and resolution agree with our analytical model and meet sensor requirements.

scholarly journals Non-Contact Ultrasonic Inspection by Gas-Coupled Laser Acoustic Detection (GCLAD)

2021 ◽  
Author(s):  
Michelangelo-Santo Gulino ◽  
Mara Bruzzi ◽  
James Caron ◽  
Dario Vangi
Keyword(s):  
Laser Beam ◽  
Acoustic Waves ◽  
Detection System ◽  
Surface Acoustic Waves ◽  
Ultrasonic Inspection ◽  
Two Dimensions ◽  
Probe Laser ◽  
Acoustic Detection ◽  
Probe Laser Beam ◽  
Subsurface Defects

Abstract Gas-Coupled Laser Acoustic Detection (GCLAD) is an ultrasonic, non-contact detection technique that has been recently proven to be applicable to the inspection of mechanical components. GCLAD response raises as the intersection length between the probe laser beam and the acoustic wavefront propagating in the air increases; such feature differentiates the GCLAD device from other optical detection instruments, making it a line detection system rather than a point detector. During the inspection of structures mainly extending in two dimensions, the capability to evidence presence of defects in whichever point over a line would enable moving the emitter and the detector along a single direction: this translates in the possibility to decrease the overall required time for interrogation of components compared to point detectors, as well as generating simpler automated monitoring layouts. Based on this assumption, the present study highlights the possibility of employing the GCLAD device as a line inspection tool. To this end, preliminary concepts are provided allowing maximization of the GCLAD response for the non-destructive testing of components which predominantly extend in two dimensions. Afterwards, the GCLAD device is employed in pulse-echo mode for the detection of artificial defects machined on a 12 mm-thick steel plate: the GCLAD probe laser beam is inclined to be perpendicular to the propagation direction of the airborne ultrasound, generated by surface acoustic waves (SAWs) in the solid which are first reflected by the defect flanks and subsequently refracted in the air. Numerical results are provided highlighting the SAW reflection patterns, originated by 3 mm deep surface and subsurface defects, that the GCLAD should interpret. The subsequent experimental campaign highlights that the GCLAD device can identify echoes associated with surface and subsurface defects, located in eight different positions on the plate. B-scan of the component ultimately demonstrates the GCLAD performance in accomplishing the inspection task.

scholarly journals Non-contact ultrasonic inspection by Gas-Coupled Laser Acoustic Detection (GCLAD)

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Michelangelo-Santo Gulino ◽  
Mara Bruzzi ◽  
James Norbert Caron ◽  
Dario Vangi
Keyword(s):  
Laser Beam ◽  
Acoustic Waves ◽  
Detection System ◽  
Surface Acoustic Waves ◽  
Ultrasonic Inspection ◽  
Two Dimensions ◽  
Probe Laser ◽  
Acoustic Detection ◽  
Probe Laser Beam ◽  
Subsurface Defects

AbstractGas-Coupled Laser Acoustic Detection (GCLAD) is an ultrasonic, non-contact detection technique that has been recently proven to be applicable to the inspection of mechanical components. GCLAD response raises as the intersection length between the probe laser beam and the acoustic wavefront propagating in the air increases; such feature differentiates the GCLAD device from other optical detection instruments, making it a line detection system rather than a point detector. During the inspection of structures mainly extending in two dimensions, the capability to evidence presence of defects in whichever point over a line would enable moving the emitter and the detector along a single direction: this translates in the possibility to decrease the overall required time for interrogation of components compared to point detectors, as well as generating simpler automated monitoring layouts. Based on this assumption, the present study highlights the possibility of employing the GCLAD device as a line inspection tool. To this end, preliminary concepts are provided allowing maximization of the GCLAD response for the non-destructive testing of components which predominantly extend in two dimensions. Afterwards, the GCLAD device is employed in pulse-echo mode for the detection of artificial defects machined on a 12 mm-thick steel plate: the GCLAD probe laser beam is inclined to be perpendicular to the propagation direction of the airborne ultrasound, generated by surface acoustic waves (SAWs) in the solid which are first reflected by the defect flanks and subsequently refracted in the air. Numerical results are provided highlighting the SAW reflection patterns, originated by 3 mm deep surface and subsurface defects, that the GCLAD should interpret. The subsequent experimental campaign highlights that the GCLAD device can identify echoes associated with surface and subsurface defects, located in eight different positions on the plate. B-scan of the component ultimately demonstrates the GCLAD performance in accomplishing the inspection task.

scholarly journals The Double Face of Ketamine—The Possibility of Its Identification in Blood and Beverages

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 813
Author(s):  
Magdalena Świądro ◽  
Paweł Stelmaszczyk ◽  
Irena Lenart ◽  
Renata Wietecha-Posłuszny
Keyword(s):  
Date Rape ◽  
Signal To Noise Ratio ◽  
High Sensitivity ◽  
Heroin Addiction ◽  
Assisted Extraction ◽  
Low Concentrations ◽  
High Concentrations ◽  
Rosé Wine ◽  
Tof Ms

The purpose of this study was to develop and validate a high-sensitivity methodology for identifying one of the most used drugs—ketamine. Ketamine is used medicinally to treat depression, alcoholism, and heroin addiction. Moreover, ketamine is the main ingredient used in so-called “date-rape” pills (DRP). This study presents a novel methodology for the simultaneous determination of ketamine based on the Dried Blood Spot (DBS) method, in combination with capillary electrophoresis coupled with a mass spectrometer (CE-TOF-MS). Then, 6-mm circles were punched out from DBS collected on Whatman DMPK-C paper and extracted using microwave-assisted extraction (MAE). The assay was linear in the range of 25–300 ng/mL. Values of limits of detection (LOD = 6.0 ng/mL) and quantification (LOQ = 19.8 ng/mL) were determined based on the signal to noise ratio. Intra-day precision at each determined concentration level was in the range of 6.1–11.1%, and inter-day between 7.9–13.1%. The obtained precision was under 15.0% (for medium and high concentrations) and lower than 20.0% (for low concentrations), which are in accordance with acceptance criteria. Therefore, the DBS/MAE/CE-TOF-MS method was successfully checked for analysis of ketamine in matrices other than blood, i.e., rose wine and orange juice. Moreover, it is possible to identify ketamine in the presence of flunitrazepam, which is the other most popular ingredient used in DRP. Based on this information, the selectivity of the proposed methodology for identifying ketamine in the presence of other components of rape pills was checked.

scholarly journals Nanopore Technology for the Application of Protein Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1942
Author(s):  
Xiaoqing Zeng ◽  
Yang Xiang ◽  
Qianshan Liu ◽  
Liang Wang ◽  
Qianyun Ma ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Detection ◽  
High Sensitivity ◽  
Single Molecule Detection ◽  
Sequence Detection ◽  
Fast Detection ◽  
Material Basis ◽  
Sensing Technology ◽  
Detection Technology ◽  
Structure Recognition

Protein is an important component of all the cells and tissues of the human body and is the material basis of life. Its content, sequence, and spatial structure have a great impact on proteomics and human biology. It can reflect the important information of normal or pathophysiological processes and promote the development of new diagnoses and treatment methods. However, the current techniques of proteomics for protein analysis are limited by chemical modifications, large sample sizes, or cumbersome operations. Solving this problem requires overcoming huge challenges. Nanopore single molecule detection technology overcomes this shortcoming. As a new sensing technology, it has the advantages of no labeling, high sensitivity, fast detection speed, real-time monitoring, and simple operation. It is widely used in gene sequencing, detection of peptides and proteins, markers and microorganisms, and other biomolecules and metal ions. Therefore, based on the advantages of novel nanopore single-molecule detection technology, its application to protein sequence detection and structure recognition has also been proposed and developed. In this paper, the application of nanopore single-molecule detection technology in protein detection in recent years is reviewed, and its development prospect is investigated.

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