scholarly journals Novel Approach to Dental Biofilm Management through Guided Biofilm Therapy (GBT): A Review

2021 ◽  
Vol 9 (9) ◽  
pp. 1966
Author(s):  
Deepti Shrivastava ◽  
Valentino Natoli ◽  
Kumar Chandan Srivastava ◽  
Ibrahim A Alzoubi ◽  
Ahmed Ismail Nagy ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Gold Standard ◽  
Crucial Role ◽  
Scaling And Root Planing ◽  
Dental Biofilm ◽  
The Past ◽  
Vector Systems ◽  
Novel Approach ◽  
Biofilm Removal ◽  
Implant Therapy

Dental biofilm plays a very crucial role in the etiopathogenesis of periodontal andperi-implant diseases. Over the past decade, tremendous research has been carried outto know the structure of biofilm and the mechanism by which it causes the destruction of supporting tissues of tooth or implant. Periodontal or peri-implant therapy usually begins with primarily removing thebiofilm and is considered as non-surgical mechanical debridement. Although scaling and root planing (SRP) is regarded as a gold standard for mechanical plaque debridement, various other means of biofilm removal have constantly been evolving. These may vary from different scaling systems such as vector systems to decontamination of pockets with LASER therapy. Nowadays, a new concept has emerged known as “guided biofilm therapy” (GBT). It is beneficial in removing the biofilm around the tooth and implant structures, resulting in better or comparable clinical outcomes than SRP. These results were substantiated with the reduction in the microbial load as well as the reduction in the inflammatory cytokines. This review will highlight the various aspects of GBT used in periodontal and peri-implant disease.

Sending out Biased Signals: an Appropriate Proposition for Pain?

2019 ◽  
Vol 32 (2) ◽  
pp. 108-110 ◽  
Author(s):  
E. Besserer-Offroy ◽  
P. Sarret
Keyword(s):  
Side Effects ◽  
Acute Pain ◽  
Gold Standard ◽  
Pain Treatment ◽  
Opioid Analgesics ◽  
Mu Opioid Receptor ◽  
Clinical Development ◽  
Mu Opioid ◽  
Development Stages ◽  
The Past

In the past few years, several biased ligands acting at the mu-opioid receptor were reported in the literature. These agonists are aimed at reducing pain while having fewer side effects than morphine, the gold standard of opioid analgesics. In this mini-review, we describe and discuss the recent advances in mu-biased ligands actually in preclinical and clinical development stages, including the latest U.S. Food and Drug Administration review of oliceridine, a biased mu-agonist for moderate to severe acute pain treatment developed by the company Trevena.

Nucleosides and Nucleoside Analogues as Emerging Antiviral Drugs

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamed Ibrahim Elzagheid
Keyword(s):  
Significant Role ◽  
Mode Of Action ◽  
Crucial Role ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Nucleoside Analogues ◽  
The Past ◽  
Nucleoside Drugs

: Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play. Given that a significant amount of research and literature has been documented regarding nucleoside analogues, this review article mainly focuses the discussion on nucleosides and nucleoside analogous that have proven to play significant role or be emerging in the treatment of known viral infections. This covers the names, structures, applications, toxicity, and mode of action of relevant nucleoside analogues.

Extraordinary circumstances: Covid-19 – Italian Serie A scenario

2021 ◽  
pp. 175433712110192
Author(s):  
Milan Radojicic ◽  
Aleksandar Djokovic ◽  
Nikola Cvetkovic
Keyword(s):  
Cluster Analysis ◽  
Hierarchical Cluster Analysis ◽  
Hierarchical Cluster ◽  
Round Robin ◽  
The Past ◽  
Novel Approach ◽  
Round Robin Tournaments

Unpredictable and uncontrollable situations have happened throughout history. Inevitably, such situations have an impact on various spheres of life. The coronavirus disease 2019 has affected many of them, including sports. The ban on social gatherings has caused the cancellation of many sports competitions. This paper proposes a methodology based on hierarchical cluster analysis (HCA) that can be applied when a need occurs to end an interrupted tournament and the conditions for playing the remaining matches are far from ideal. The proposed methodology is based on how to conclude the season for Serie A, a top-division football league in Italy. The analysis showed that it is reasonable to play 14 instead of the 124 remaining matches of the 2019–2020 season to conclude the championship. The proposed methodology was tested on the past 10 seasons of the Serie A, and its effectiveness was confirmed. This novel approach can be used in any other sport where round-robin tournaments exist.

scholarly journals A palace fit for the future: Desirability in temporal work

2021 ◽  
pp. 147612702110120
Author(s):  
Siavash Alimadadi ◽  
Andrew Davies ◽  
Fredrik Tell
Keyword(s):  
Real Time ◽  
Crucial Role ◽  
The Past ◽  
Renewal Program ◽  
The Future ◽  
Depth Study ◽  
Future Events ◽  
Future Outcomes ◽  
Pluralistic Contexts

Research on the strategic organization of time often assumes that collective efforts are motivated by and oriented toward achieving desirable, although not necessarily well-defined, future states. In situations surrounded by uncertainty where work has to proceed urgently to avoid an impending disaster, however, temporal work is guided by engaging with both desirable and undesirable future outcomes. Drawing on a real-time, in-depth study of the inception of the Restoration and Renewal program of the Palace of Westminster, we investigate how organizational actors develop a strategy for an uncertain and highly contested future while safeguarding ongoing operations in the present and preserving the heritage of the past. Anticipation of undesirable future events played a crucial role in mobilizing collective efforts to move forward. We develop a model of future desirability in temporal work to identify how actors construct, link, and navigate interpretations of desirable and undesirable futures in their attempts to create a viable path of action. By conceptualizing temporal work based on the phenomenological quality of the future, we advance understanding of the strategic organization of time in pluralistic contexts characterized by uncertainty and urgency.

Real Bills, The Gold Standard, and Central Bank Policy

1976 ◽  
Vol 50 (4) ◽  
pp. 503-513 ◽  
Author(s):  
Robert Craig West
Keyword(s):  
Central Bank ◽  
Discount Rate ◽  
Real World ◽  
Federal Reserve ◽  
Economic Activity ◽  
Gold Standard ◽  
Government Regulation ◽  
International Exchange ◽  
The Real ◽  
The Past

Students of the origins and accomplishments of government regulation of economic activity have open suspected that the laws on which regulation is based were addressed to problems and conditions of the past that no longer prevailed, or — what is worse — assumptions about the “real world” that are highly unrealistic. This is Professor West's main conclusion about the Federal Reserve Act of 1913, especially as regards its discount rate and international exchange policies.

Adventism, Apocalyptic, and the Cause of Liberty

1994 ◽  
Vol 63 (2) ◽  
pp. 235-249
Author(s):  
Douglas Morgan
Keyword(s):  
Nineteenth Century ◽  
Crucial Role ◽  
Driving Force ◽  
Late Nineteenth Century ◽  
The Past ◽  
Conservative Protestantism ◽  
Late Nineteenth

“I have felt like working three times as hard as ever since I came to understand that my Lord was coming back again,” reported revivalist Dwight L. Moody, the most prominent of nineteenth-century premillennialists. Moody's testimony to the motivating power of premillennialism points to the crucial role of that eschatology in conservative Protestantism since the late nineteenth century—a role delineated by several studies within the past twenty-five years. As a comprehensive interpretation of history which gives meaning and pattern to past, present, and future, and a role for the believer in the outworking of the divine program, premillennialism has been a driving force in the fundamentalistand evangelical movements.

ROOT END FILLING MATERIALS – A REVIEW

2021 ◽  
pp. 5-9
Author(s):  
Bynagari Chandra Shekar ◽  
Veerendra Uppin ◽  
Madhu Pujar
Keyword(s):  
Root Canal ◽  
Gold Standard ◽  
The Past ◽  
Filling Materials ◽  
Restorative Materials ◽  
The Creation ◽  
Almost All

The aim of a root end lling is to prevent irritants from the root canal from leaking into the periapical region and to improve the apical seal created by nonsurgical endodontic care. Various restorative materials that have been used for coronal restorations have been tried and tested as root end lling materials, as well as the creation of restorative materials designed specically for root end lling. In the past, amalgam was the preferred material for root end lling. MTA, a recently established material that meets almost all of the criteria for an ideal root end lling material, has become the gold standard against which newer materials are measured. This article examines traditional endodontic root end materials and provides an overview of recent advancements in root end lling

scholarly journals Bacteria in Cancer Therapy: Renaissance of an Old Concept

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Sebastian Felgner ◽  
Dino Kocijancic ◽  
Michael Frahm ◽  
Siegfried Weiss
Keyword(s):  
Treatment Options ◽  
Tumor Therapy ◽  
The Past ◽  
Novel Treatment ◽  
Vector Systems ◽  
Rising Incidence ◽  
Solid Foundation ◽  
Ancient Times ◽  
Therapeutic Compounds ◽  
The 19Th Century

The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.

scholarly journals The Clinical Concept of Fibromyalgia as a Changing Paradigm in the Past 20 Years

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mary-Ann Fitzcharles ◽  
Muhammad B. Yunus
Keyword(s):  
Gold Standard ◽  
Standard Treatment ◽  
Good Health ◽  
Pain Processing ◽  
Predictors Of Outcome ◽  
Rational Treatment ◽  
The Past ◽  
Active Patient ◽  
Pharmacologic Treatments ◽  
Clinical Concept

Fibromyalgia (FMS) is a valid clinical condition that affects 2%–4% of the population with a pivot symptom of widespread body pain. The cause and cure of FMS are as yet unknown. The concept of FMS has evolved over the past two decades to incorporate symptoms beyond pain as contributing to the global spectrum of suffering. FMS is now recognized to be grounded in the neurological domain with evidence of dysregulation of pain processing. Appreciation of the neurophysiologic mechanisms operative in FMS has contributed to rational treatment recommendations, although a “gold standard treatment” does not currently exist. Ideal treatments for FMS patients should be individualized with emphasis on active patient participation, good health practices, and multimodal intervention, incorporating nonpharmacologic and pharmacologic treatments. Predictors of outcome, which is favourable in over 50% of patients, are unknown, but those with better outcome do more physical activity and use fewer medications.

scholarly journals Gallbladder volvulus: a case report

2019 ◽  
pp. 1-2
Author(s):  
Tomas Urbonas
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Case Report ◽  
Computer Tomography ◽  
Small Proportion ◽  
Gold Standard ◽  
Crucial Role ◽  
Standard Treatment ◽  
Rare Condition ◽  
Computer Tomography Scan ◽  
Tomography Scan

The gallbladder volvulus is a rare condition. There have been around 500 cases described worldwide. It is virtually impossible to diagnose it clinically as symptoms are analogous to those of acute cholecystitis. Small proportion of gallbladder volvulus cases get accurately diagnosed preoperatively according to available literature. The imaging such as computer tomography plays a crucial role in diagnosing this condition. Laparoscopic cholecystectomy is considered to be a gold standard treatment for this condition. In our report we present a case of gallbladder volvulus which was successfully diagnosed by means of computer tomography scan

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