scholarly journals Three New 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originated from Gyrinops salicifolia

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 576 ◽  
Author(s):  
Wen-Hua Dong ◽  
Hao Wang ◽  
Feng-Juan Guo ◽  
Wen-Li Mei ◽  
Hui-Qin Chen ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Inhibitory Activity ◽  
Leukemia Cell ◽  
2D Nmr ◽  
Leukemia Cell Line ◽  
Chromone Derivatives ◽  
Ache Inhibitory Activity ◽  
2D Nmr Spectra ◽  
Derivatives Of

Two new 2-(2-phenylethyl)chromone derivatives (1–2), comprising 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and benzylacetone moieties, together with one new 2-(2-phenylethenyl)chromone (3) were isolated from the ethyl acetate extraction of agarwood originated from Gyrinops salicifolia Ridl. All structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. All isolated compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxic activity against human myeloid leukemia cell line (K562). However, none of the compounds displayed AChE inhibitory activity at a concentration of 50 µg mL−1 or cytotoxic activity against K562 cell line.

scholarly journals Cytotoxic Activity of Compounds from Styrax obassia

2017 ◽  
Vol 12 (2) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Thao Quyen Cao ◽  
Bo Mi Lee ◽  
Yeon Woo Jung ◽  
Van Thu Nguyen ◽  
Jeong Ah Kim ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Leukemia Cell ◽  
Cancer Cell Line ◽  
Stem Bark ◽  
Leukemia Cell Line ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Mcf 7

Cancer is a major public health burden in both developed and developing countries. Plant-derived compounds have played an important role in the development of useful anti-cancer agents. The current study was designed to evaluate the cytotoxic activity of chemical compounds from the stem bark of Styrax obassia. Seven known compounds (1–7) were isolated and identified. Compound 2 exhibited cytotoxic activity against the breast cancer cell line MCF-7 with an IC50 of 27.9 μM, followed by the human cervical cancer cell line Hela with an IC50 of 23.3 μM, and the human promyelocytic leukemia cell line HL-60 with an IC50 of 47.8 μM. Compound 7 exhibited cytotoxicity against Hela cells with an IC50 of 16.8 μM, followed by MCF-7 cells with an IC50 of 53.5 μM. This is the first study to investigate the significant anti-tumor properties of isolated compounds from the stem bark of S. obassia.

Antiproliferative Effects of a Series of Cyclic Imides on Primary Endothelial Cells and a Leukemia Cell Line

2008 ◽  
Vol 63 (9-10) ◽  
pp. 675-680 ◽  
Author(s):  
José A. Yunes ◽  
Angelo A. Cardoso ◽  
Rosendo A. Yunes ◽  
Rogério Corrêa ◽  
Fátima de Campos-Buzzi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Umbilical Vein ◽  
Leukemia Cell ◽  
Leukemic Cell ◽  
Leukemic Cells ◽  
Leukemia Cell Line ◽  
Cyclic Imides ◽  
Umbilical Vein Endothelial Cells

The present study describes the cytotoxic properties of a series of 15 cyclic imides observed against different endothelial cells and K562 leukemic cells. Initially, eight structurally unrelated compounds were evaluated against cultured bone marrow endothelial cells (BMEC) and human umbilical vein endothelial cells (HUVEC). Only two imides showed cytotoxic activity at 10 μm. In continuation of our screening, eight compounds, structurally related to the compound with the higher cytotoxic activity, were assayed against endothelial cells and the K562 leukemic cell line. All of these new compounds except two exhibited cytotoxic and antiproliferative activities at concentrations below 10 μm against BMEC and HUVEC, respectively. The K562 leukemia cell line was only affected by concentrations of 100 μm. Preliminary SAR analysis indicated that the cytotoxic activity of these compounds was related to the presence of a planar imide ring directly bound to an aromatic ring.

scholarly journals Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Edward Davis Oldham ◽  
Larissa M Nunes ◽  
Armando Varela-Ramirez ◽  
Stephen E Rankin ◽  
Barbara L Knutson ◽  
...  
Keyword(s):  
T Cell ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Human T Cell

Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers

2020 ◽  
Vol 49 (20) ◽  
pp. 6842-6853 ◽  
Author(s):  
Daniel Baecker ◽  
Benjamin N. Ma ◽  
Jessica Sagasser ◽  
Lukas Schultz ◽  
Carina Hörschläger ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Line ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Leukemia Cell Line ◽  
Derivatives Of ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) were synthesized and characterized as necroptosis and ferroptosis inducers using the acute myeloid leukemia cell line HL-60.

scholarly journals Pembuatan, Karakterisasi dan Uji In Vitro Nanopartikel Emas Berbasis Konjugat Gom Arab-Vinkristin

2018 ◽  
Vol 16 (1) ◽  
pp. 6
Author(s):  
Ratih Dyah Pertiwi ◽  
Joshita Djajadisastra ◽  
ABDUL MUTALIB ◽  
Anung Pujiyanto
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Leukemia Cell ◽  
Gum Arabic ◽  
Size Exclusion ◽  
Leukemia Cell Line ◽  
Tetrazolium Salt

Gold nanoparticles (AuNP) are potentially developed as nanomedicine because AuNP is easily synthesized, functionalized, and biocompatible. With gum arabic as a stabilizer, vincristine was conjugated with gold nanoparticles. As a reducing agent, it used 0.02 M Natrium Boro Hidrat (NaBH4)  solution. Gold nanoparticles (AuNP) coated with conjugated gum Arabic (GA) and vincristine (VCR) were successfully synthesized and characterized. The conjugation of GA-VCR and AuNP displayed a narrow hydrodynamic particle size distribution with average size < 100 nm by TEM and  PSA (particle size analyzer). We investigated the cytotoxic activity of conjugated vincristine-gum arabic-gold nanoparticle by tetrazolium salt assay (MTT) using cancer cell line CCR-CEM. Cytotoxic activity of conjugated VCR-GA-AuNP before and after purification by Size Exclusion Chromatography (SEC), against leukemia cell line CCRF-CEM, was described by IC50 value. All formulation had a cytotoxic of activity with IC50 <20 μg/ml. The IC50 of samples against CCRF cell line were 1,026 μg/mL and  2,607 ug/mL, respectively.

scholarly journals Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line

2014 ◽  
Vol 27 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Daniel Zaluski ◽  
Helena Danuta Smolarz ◽  
Anna Bogucka-Kocka
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Morphological Changes ◽  
Leukemia Cell ◽  
Ethanol Extract ◽  
Leukemia Cell Line ◽  
Lymphoid Leukemia ◽  
Ethanolic Extracts ◽  
Ic50 Values

Abstract The Eleutherococcus species including 40 species native to Asia are medicinal plants widely used in traditional medicine. Some of these species are cultivated at the botanical gardens in Europe. On the basis on our earlier studies it was concluded that the extracts of analyzed species act as antioxidants, inhibitors of MMPs, and cytotoxic against Jurkat 45 leukemia cell line. In this study, the anti-leukemic potential of roots and leaves from six Eleutherococcus species cultivated in Poland was determined. The in vitro cytotoxic activity towards human promyelotic leukemia cell line HL60 using trypan blue assay was evaluated. The induction of apoptosis in stimulated leukemia cells was determined by AnnexinV method. Morphological changes in treated cells were observed by microscopic investigations. The results showed that ethanolic extracts from the roots and the leaves of E. senticosus, E. setchuensis, E. sessiliflorus, E.gracilistylus, E. henryi and E. divaricatus exhibit cytotoxic effect towards leukemic HL60 cells. The received IC50 values for roots ranged from 49- 208 μg/mL and for the leaves from 116-518 μg/mL. The ethanol extract from the roots of E. divaricatus showed the highest cytotoxic and proapoptotic effect on HL60 human lymphoid leukemia cell line.

scholarly journals A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Diana M Castañeda ◽  
Luis Miguel Pombo ◽  
Claudia Patricia Urueña ◽  
John Fredy Hernandez ◽  
Susana Fiorentino
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Leukemia Cell ◽  
Leukemia Cell Line
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