scholarly journals How Sure Can We Be about ML Methods-Based Evaluation of Compound Activity: Incorporation of Information about Prediction Uncertainty Using Deep Learning Techniques

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1452
Author(s):  
Igor Sieradzki ◽  
Damian Leśniak ◽  
Sabina Podlewska
Keyword(s):  
Machine Learning ◽  
Training Set ◽  
Activity Prediction ◽  
Prediction Uncertainty ◽  
Screening Experiments ◽  
Learning Techniques ◽  
Model Training ◽  
Short Time ◽  
Selection Of

A great variety of computational approaches support drug design processes, helping in selection of new potentially active compounds, and optimization of their physicochemical and ADMET properties. Machine learning is a group of methods that are able to evaluate in relatively short time enormous amounts of data. However, the quality of machine-learning-based prediction depends on the data supplied for model training. In this study, we used deep neural networks for the task of compound activity prediction and developed dropout-based approaches for estimating prediction uncertainty. Several types of analyses were performed: the relationships between the prediction error, similarity to the training set, prediction uncertainty, number and standard deviation of activity values were examined. It was tested whether incorporation of information about prediction uncertainty influences compounds ranking based on predicted activity and prediction uncertainty was used to search for the potential errors in the ChEMBL database. The obtained outcome indicates that incorporation of information about uncertainty of compound activity prediction can be of great help during virtual screening experiments.

A Literature Review Study of Software Defect Prediction using Machine Learning Techniques

2018 ◽  
Vol 6 (6) ◽  
pp. 300 ◽  
Author(s):  
Feidu Akmel ◽  
Ermiyas Birihanu ◽  
Bahir Siraj
Keyword(s):  
Machine Learning ◽  
Software Metrics ◽  
Quality Standard ◽  
Machine Learning Techniques ◽  
Software Systems ◽  
Health Care Insurance ◽  
Software Defect ◽  
Learning Techniques ◽  
Software Product

Software systems are any software product or applications that support business domains such as Manufacturing,Aviation, Health care, insurance and so on.Software quality is a means of measuring how software is designed and how well the software conforms to that design. Some of the variables that we are looking for software quality are Correctness, Product quality, Scalability, Completeness and Absence of bugs, However the quality standard that was used from one organization is different from other for this reason it is better to apply the software metrics to measure the quality of software. Attributes that we gathered from source code through software metrics can be an input for software defect predictor. Software defect are an error that are introduced by software developer and stakeholders. Finally, in this study we discovered the application of machine learning on software defect that we gathered from the previous research works.

Machine learning techniques based on security management in smart cities using robots

Work ◽  
2021 ◽  
pp. 1-12
Author(s):  
Zhang Mengqi ◽  
Wang Xi ◽  
V.E. Sathishkumar ◽  
V. Sivakumar
Keyword(s):  
Machine Learning ◽  
Information And Communication Technologies ◽  
Smart City ◽  
Smart Cities ◽  
Security Management ◽  
Machine Learning Techniques ◽  
Quality Of Services ◽  
Learning Techniques ◽  
Learning Concept

BACKGROUND: Nowadays, the growth of smart cities is enhanced gradually, which collects a lot of information and communication technologies that are used to maximize the quality of services. Even though the intelligent city concept provides a lot of valuable services, security management is still one of the major issues due to shared threats and activities. For overcoming the above problems, smart cities’ security factors should be analyzed continuously to eliminate the unwanted activities that used to enhance the quality of the services. OBJECTIVES: To address the discussed problem, active machine learning techniques are used to predict the quality of services in the smart city manages security-related issues. In this work, a deep reinforcement learning concept is used to learn the features of smart cities; the learning concept understands the entire activities of the smart city. During this energetic city, information is gathered with the help of security robots called cobalt robots. The smart cities related to new incoming features are examined through the use of a modular neural network. RESULTS: The system successfully predicts the unwanted activity in intelligent cities by dividing the collected data into a smaller subset, which reduces the complexity and improves the overall security management process. The efficiency of the system is evaluated using experimental analysis. CONCLUSION: This exploratory study is conducted on the 200 obstacles are placed in the smart city, and the introduced DRL with MDNN approach attains maximum results on security maintains.

Machine Learning for Neurodegenerative Disorder Diagnosis — Survey of Practices and Launch of Benchmark Dataset

2018 ◽  
Vol 27 (03) ◽  
pp. 1850011 ◽  
Author(s):  
Athanasios Tagaris ◽  
Dimitrios Kollias ◽  
Andreas Stafylopatis ◽  
Georgios Tagaris ◽  
Stefanos Kollias
Keyword(s):  
Machine Learning ◽  
Neurodegenerative Disorder ◽  
Developed Countries ◽  
Machine Learning Techniques ◽  
Network Architectures ◽  
Imaging Data ◽  
Learning Techniques ◽  
Medical Examinations

Neurodegenerative disorders, such as Alzheimer’s and Parkinson’s, constitute a major factor in long-term disability and are becoming more and more a serious concern in developed countries. As there are, at present, no effective therapies, early diagnosis along with avoidance of misdiagnosis seem to be critical in ensuring a good quality of life for patients. In this sense, the adoption of computer-aided-diagnosis tools can offer significant assistance to clinicians. In the present paper, we provide in the first place a comprehensive recording of medical examinations relevant to those disorders. Then, a review is conducted concerning the use of Machine Learning techniques in supporting diagnosis of neurodegenerative diseases, with reference to at times used medical datasets. Special attention has been given to the field of Deep Learning. In addition to that, we communicate the launch of a newly created dataset for Parkinson’s disease, containing epidemiological, clinical and imaging data, which will be publicly available to researchers for benchmarking purposes. To assess the potential of the new dataset, an experimental study in Parkinson’s diagnosis is carried out, based on state-of-the-art Deep Neural Network architectures and yielding very promising accuracy results.

scholarly journals Human In Command Machine Learning

2021 ◽  
Author(s):  
◽  
Lars Holmberg
Keyword(s):  
Machine Learning ◽  
Human Life ◽  
Design Guidelines ◽  
Significant Other ◽  
Target Domain ◽  
Extraterrestrial Life ◽  
Human Capabilities ◽  
Domain Experts ◽  
Model Training ◽  
Selection Of

Machine Learning (ML) and Artificial Intelligence (AI) impact many aspects of human life, from recommending a significant other to assist the search for extraterrestrial life. The area develops rapidly and exiting unexplored design spaces are constantly laid bare. The focus in this work is one of these areas; ML systems where decisions concerning ML model training, usage and selection of target domain lay in the hands of domain experts. This work is then on ML systems that function as a tool that augments and/or enhance human capabilities. The approach presented is denoted Human In Command ML (HIC-ML) systems. To enquire into this research domain design experiments of varying fidelity were used. Two of these experiments focus on augmenting human capabilities and targets the domains commuting and sorting batteries. One experiment focuses on enhancing human capabilities by identifying similar hand-painted plates. The experiments are used as illustrative examples to explore settings where domain experts potentially can: independently train an ML model and in an iterative fashion, interact with it and interpret and understand its decisions. HIC-ML should be seen as a governance principle that focuses on adding value and meaning to users. In this work, concrete application areas are presented and discussed. To open up for designing ML-based products for the area an abstract model for HIC-ML is constructed and design guidelines are proposed. In addition, terminology and abstractions useful when designing for explicability are presented by imposing structure and rigidity derived from scientific explanations. Together, this opens up for a contextual shift in ML and makes new application areas probable, areas that naturally couples the usage of AI technology to human virtues and potentially, as a consequence, can result in a democratisation of the usage and knowledge concerning this powerful technology.

scholarly journals Framework for the Classification of Emotions in People With Visual Disabilities Through Brain Signals

2021 ◽  
Vol 15 ◽  
Author(s):  
Jesús Leonardo López-Hernández ◽  
Israel González-Carrasco ◽  
José Luis López-Cuadrado ◽  
Belén Ruiz-Mezcua
Keyword(s):  
Machine Learning ◽  
Positive Emotions ◽  
Machine Learning Techniques ◽  
Visual Disabilities ◽  
Brain Signals ◽  
Learning Techniques ◽  
Sensory Disabilities ◽  
Recognition Of Emotions

Nowadays, the recognition of emotions in people with sensory disabilities still represents a challenge due to the difficulty of generalizing and modeling the set of brain signals. In recent years, the technology that has been used to study a person’s behavior and emotions based on brain signals is the brain–computer interface (BCI). Although previous works have already proposed the classification of emotions in people with sensory disabilities using machine learning techniques, a model of recognition of emotions in people with visual disabilities has not yet been evaluated. Consequently, in this work, the authors present a twofold framework focused on people with visual disabilities. Firstly, auditory stimuli have been used, and a component of acquisition and extraction of brain signals has been defined. Secondly, analysis techniques for the modeling of emotions have been developed, and machine learning models for the classification of emotions have been defined. Based on the results, the algorithm with the best performance in the validation is random forest (RF), with an accuracy of 85 and 88% in the classification for negative and positive emotions, respectively. According to the results, the framework is able to classify positive and negative emotions, but the experimentation performed also shows that the framework performance depends on the number of features in the dataset and the quality of the Electroencephalogram (EEG) signals is a determining factor.

Machine Learning Techniques and Risk Management

2021 ◽  
pp. 185-200
Author(s):  
Christos Floros ◽  
Panagiotis Ballas
Keyword(s):  
Machine Learning ◽  
Financial Institutions ◽  
Business Practice ◽  
Machine Learning Techniques ◽  
Accounting Disclosure ◽  
Future Performance ◽  
Learning Techniques ◽  
The World ◽  
Unstable Environment

Crises around the world reveal a generally unstable environment in the last decades within which banks and financial institutions operate. Risk is an inherent characteristic of financial institutions and is a multifaceted phenomenon. Everyday business practice involves decisions, which requires the use of information regarding various types of threats involved together with an evaluation of their impact on future performance, concluding to combinations of types of risks and projected returns for decision makers to choose from. Moreover, financial institutions process a massive amount of data, collected either internally or externally, in an effort to continuously analyse trends of the economy they operate in and decode global economic conditions. Even though research has been performed in the field of accounting and finance, the authors explore the application of machine learning techniques to facilitate decision making by top management of contemporary financial institutions improving the quality of their accounting disclosure.

scholarly journals Modeling of Aboveground Biomass with Landsat 8 OLI and Machine Learning in Temperate Forests

Forests ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Pablito M. López-Serrano ◽  
José Luis Cárdenas Domínguez ◽  
José Javier Corral-Rivas ◽  
Enrique Jiménez ◽  
Carlos A. López-Sánchez ◽  
...  
Keyword(s):  
Machine Learning ◽  
Aboveground Biomass ◽  
Goodness Of Fit ◽  
Accurate Estimation ◽  
Support Vector ◽  
Landsat 8 ◽  
Sensing Applications ◽  
Learning Techniques ◽  
Physical Variables ◽  
Selection Of

An accurate estimation of forests’ aboveground biomass (AGB) is required because of its relevance to the carbon cycle, and because of its economic and ecological importance. The selection of appropriate variables from satellite information and physical variables is important for precise AGB prediction mapping. Because of the complex relationships for AGB prediction, non-parametric machine-learning techniques represent potentially useful techniques for AGB estimation, but their use and comparison in forest remote-sensing applications is still relatively limited. The objective of the present study was to evaluate the performance of automatic learning techniques, support vector regression (SVR) and random forest (RF), to predict the observed AGB (from 318 permanent sampling plots) from the Landsat 8 Landsat 8 Operational Land Imager (OLI) sensor, spectral indexes, texture indexes and physical variables the Sierra Madre Occidental in Mexico. The result showed that the best SVR model explained 80% of the total variance (root mean square error (RMSE) = 8.20 Mg ha−1). The variables that best predicted AGB, in order of importance, were the bands that belong to the region of red and near and middle infrared, and the average temperature. The results show that the SVR technique has a good potential for the estimation of the AGB and that the selection of the model hyperparameters has important implications for optimizing the goodness of fit.

Quality of Experience Models for Multimedia Streaming

2010 ◽  
Vol 2 (4) ◽  
pp. 1-20 ◽  
Author(s):  
Vlado Menkovski ◽  
Georgios Exarchakos ◽  
Antonio Liotta ◽  
Antonio Cuadra Sánchez
Keyword(s):  
Machine Learning ◽  
Quality Of Experience ◽  
Prediction Models ◽  
Multimedia Streaming ◽  
Accurate Estimation ◽  
Management Service ◽  
Subjective Data ◽  
Efficient Management ◽  
Learning Techniques

Understanding how quality is perceived by viewers of multimedia streaming services is essential for efficient management of those services. Quality of Experience (QoE) is a subjective metric that quantifies the perceived quality, which is crucial in the process of optimizing tradeoff between quality and resources. However, accurate estimation of QoE often entails cumbersome studies that are long and expensive to execute. In this regard, the authors present a QoE estimation methodology for developing Machine Learning prediction models based on initial restricted-size subjective tests. Experimental results on subjective data from streaming multimedia tests show that the Machine Learning models outperform other statistical methods achieving accuracy greater than 90%. These models are suitable for real-time use due to their small computational complexity. Even though they have high accuracy, these models are static and cannot adapt to environmental change. To maintain the accuracy of the prediction models, the authors have adopted Online Learning techniques that update the models on data from subjective viewer feedback. This method provides accurate and adaptive QoE prediction models that are an indispensible component of a QoE-aware management service.

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