An Unexpected Reaction of Isodehydracetic Acid with Amines in the Presence of 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride Yields a New Type of β-Enaminones
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New Type
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The reaction of isodehydracetic acid with amines was serendipitously found to afford β-enaminones in the presence of the coupling agent 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). Under the optimal reaction condition, 23 examples of α-aminomethylene glutaconic anhydride were obtained at approximately 30−80% yields. This is a concise, operationally simple method to expediently synthesize a new type of β-enaminone-containing compound.
2012 ◽
Vol 450-451
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pp. 223-227
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2019 ◽
Vol 8
(1)
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pp. 846-855
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2011 ◽
Vol 287-290
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pp. 1360-1364
2009 ◽
Vol 2009
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pp. 1-7
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1988 ◽
Vol 25
(4)
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pp. 422-423
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2012 ◽
Vol 209-211
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pp. 1774-1777
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