Effect of Heavy Ion 12C6+ Radiation on Lipid Constitution in the Rat Brain

Heavy ions refer to charged particles with a mass greater than four (i.e., alpha particles). The heavy ion irradiation used in radiotherapy or that astronauts suffer in space flight missions induces toxicity in normal tissue and leads to short-term and long-term damage in both the structure and function of the brain. However, the underlying molecular alterations caused by heavy ion radiation have yet to be completely elucidated. Herein, untargeted and targeted lipidomic profiling of the whole brain tissue and blood plasma 7 days after the administration of the 15 Gy (260 MeV, low linear energy (LET) = 13.9 KeV/μm) plateau irradiation of disposable 12C6+ heavy ions on the whole heads of rats was explored to study the lipid damage induced by heavy ion radiation in the rat brain using ultra performance liquid chromatography-mass spectrometry (UPLC–MS) technology. Combined with multivariate variables and univariate data analysis methods, our results indicated that an orthogonal partial least squares discriminant analysis (OPLS–DA) could clearly distinguish lipid metabolites between the irradiated and control groups. Through the combination of variable weight value (VIP), variation multiple (FC), and differential (p) analyses, the significant differential lipids diacylglycerols (DAGs) were screened out. Further quantitative targeted lipidomic analyses of these DAGs in the rat brain tissue and plasma supported the notion that DAG 47:1 could be used as a potential biomarker to study brain injury induced by heavy ion irradiation.

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NADPH Oxidase Activation Contributes to Heavy Ion Irradiation–Induced Cell Death

Dose-Response ◽

10.1177/1559325817699697 ◽

2017 ◽

Vol 15 (1) ◽

pp. 155932581769969 ◽

Cited By ~ 5

Author(s):

Yupei Wang ◽

Qing Liu ◽

Weiping Zhao ◽

Xin Zhou ◽

Guoying Miao ◽

...

Keyword(s):

Cell Death ◽

Nadph Oxidase ◽

Ion Irradiation ◽

Heavy Ion ◽

Ros Generation ◽

Heavy Ion Irradiation ◽

Radiation Induced ◽

Heavy Ion Radiation ◽

Nox Family ◽

Nadph Oxidase Activation

Increased oxidative stress plays an important role in heavy ion radiation–induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated. Here we show that NADPH oxidase activation is closely related to heavy ion radiation–induced cell death via excessive ROS generation. Cell death and cellular ROS can be greatly reduced in irradiated cancer cells with the preincubation of diphenyleneiodium, an inhibitor of NADPH oxidase. Most of the NADPH oxidase (NOX) family proteins (NOX1, NOX2, NOX3, NOX4, and NOX5) showed increased expression after heavy ion irradiation. Meanwhile, the cytoplasmic subunit p47phox was translocated to the cell membrane and localized with NOX2 to form reactive NADPH oxidase. Our data suggest for the first time that ROS generation, as mediated by NADPH oxidase activation, could be an important contributor to heavy ion irradiation–induced cell death.

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Effect of Cascade Remnants on Freely Migrating Defects in Cu -1 % Au Alloys

MRS Proceedings ◽

10.1557/proc-396-179 ◽

1995 ◽

Vol 396 ◽

Author(s):

A. Iwase ◽

L. E. Rehn ◽

P. M. Baldo ◽

L. Funk

Keyword(s):

Heavy Ions ◽

Ion Irradiation ◽

Ion Beam ◽

Heavy Ion ◽

The Other ◽

Inert Gas ◽

Heavy Ion Irradiation ◽

Simultaneous Irradiation ◽

Radiation Induced ◽

Cu Ions

AbstractThe effects of cascade remnants on Freely Migrating Defects (FMD) were studied by measuring Radiation-Induced Segregation (RIS) in Cu-l%Au at 400°C during simultaneous irradiation with 1.5-MeV He and (400-800)-keV heavy ions (Ne, Ar or Cu). The large RIS observed during 1.5-MeV He-only irradiation was dramatically suppressed under simultaneous heavy ion irradiation. For Cu simultaneous irradiation, the suppression disappeared immediately after the Cu irradiation ceased, while for simultaneous inert gas (Ne or Ar) irradiation, the suppression persisted after the ion beam was turned off. These results demonstrate that the displacement cascades created by heavy ions introduce additional annihilation sites, which reduce the steady-state FMD concentrations. As the cascade remnants produced by Cu ions are thermally unstable at 400°C, the RIS suppression occurs only during simultaneous irradiation. On the other hand, the inert gas atoms which accumulate in the specimen apparently stabilize the cascade remnants, allowing the suppression to persist.

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A poly(vinylidene fluoride-co-hexafluoro propylene) nanohybrid membrane using swift heavy ion irradiation for fuel cell applications

Journal of Materials Chemistry A ◽

10.1039/c5ta01398d ◽

2015 ◽

Vol 3 (19) ◽

pp. 10413-10424 ◽

Cited By ~ 17

Author(s):

Karun Kumar Jana ◽

Amit K. Thakur ◽

Vinod K. Shahi ◽

Devesh K. Avasthi ◽

Dipak Rana ◽

...

Keyword(s):

Heavy Ions ◽

Vinylidene Fluoride ◽

Ion Irradiation ◽

Heavy Ion ◽

High Energy ◽

Heavy Ion Irradiation ◽

Swift Heavy Ion ◽

Thin Polymer ◽

Poly Vinylidene Fluoride ◽

Amorphous Zone

Through channels in thin polymer/nanohybrid films have been made by irradiating with high energy swift heavy ions (SHI) followed by selective chemical etching of the amorphous zone in the latent track created by SHI during the bombardment.

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Ion Irradiation Smoothing and Film Bonding for Laser Mirrors

MRS Proceedings ◽

10.1557/proc-27-559 ◽

1983 ◽

Vol 27 ◽

Cited By ~ 5

Author(s):

P. P. Pronko ◽

A. W. Mccormick ◽

D. C. Ingram ◽

A. K. Rai ◽

J. A. Woollam ◽

...

Keyword(s):

Heavy Ions ◽

Ion Irradiation ◽

Surface Damage ◽

Heavy Ion ◽

High Energy ◽

Metallic Surfaces ◽

Heavy Ion Irradiation ◽

Structural Bonding ◽

Microstructure Of The Material

ABSTRACTIrradiation with high energy heavy ion beams has been investigated as a technique for improving the quality of highly reflecting metallic surfaces to be used as laser mirrors. Properties such as reflectivity, corrosion resistance, film bonding, and threshold to laser surface damage have been examined. Modifications of composition and microstructure of the material associated with the heavy ion irradiation have been measured with RBS, TEM, SEM, Auger, and ESCA. Reflectivity and extinction coefficient measurements were made using ellipsometry techniques. Observations indicate that keV heavy ion irradiations in the fluence range of 1015 to 1016 cm−2 produce significant surface smoothing. Additionally, MeV implants of heavy ions into films of Cu, Ag, Au and Al deposited on molybdenum substrates resulted in improvements to both tarnish resistance and structural bonding integrity.

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