scholarly journals PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1124
Author(s):  
Alejandro Valdés-Jiménez ◽  
Carlos Peña-Varas ◽  
Paola Borrego-Muñoz ◽  
Lily Arrue ◽  
Melissa Alegría-Arcos ◽  
...  
Keyword(s):  
Natural Products ◽  
Structural Information ◽  
Biological Activities ◽  
Structural Diversity ◽  
Secondary Compounds ◽  
Quantitative Structure Activity Relationship ◽  
Information Classification ◽  
3D Database ◽  
Plant Metabolite ◽  
Pharmaceutical Properties

Plants synthesize a large number of natural products, many of which are bioactive and have practical values as well as commercial potential. To explore this vast structural diversity, we present PSC-db, a unique plant metabolite database aimed to categorize the diverse phytochemical space by providing 3D-structural information along with physicochemical and pharmaceutical properties of the most relevant natural products. PSC-db may be utilized, for example, in qualitative estimation of biological activities (Quantitative Structure-Activity Relationship, QSAR) or massive docking campaigns to identify new bioactive compounds, as well as potential binding sites in target proteins. PSC-db has been implemented using the open-source PostgreSQL database platform where all compounds with their complementary and calculated information (classification, redundant names, unique IDs, physicochemical properties, etc.) were hierarchically organized. The source organism for each compound, as well as its biological activities against protein targets, cell lines and different organism were also included. PSC-db is freely available for public use and is hosted at the Universidad de Talca.

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1898
Author(s):  
Fauzia Izzati ◽  
Mega Ferdina Warsito ◽  
Asep Bayu ◽  
Anggia Prasetyoputri ◽  
Akhirta Atikana ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Natural Products ◽  
Biological Function ◽  
Marine Invertebrates ◽  
Biological Activities ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Soft Corals ◽  
High Chemical

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

scholarly journals Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 115 ◽  
Author(s):  
Amr El-Demerdash ◽  
Atanas G. Atanasov ◽  
Olaf K. Horbanczuk ◽  
Mohamed A. Tammam ◽  
Mamdouh Abdel-Mogib ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Sponges ◽  
Chemical Diversity ◽  
Molecular Scaffolds ◽  
Pharmacological Activities ◽  
Chemotaxonomic Markers ◽  
Novel Drug

Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998–2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

scholarly journals Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and its Complications

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Jian Chen ◽  
Sven Mangelinckx ◽  
An Adams ◽  
Zheng-tao Wang ◽  
Wei-lin Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Natural Products ◽  
Diabetic Complications ◽  
Biological Activities ◽  
Human Subjects ◽  
Structural Diversity ◽  
Diabetic Animal ◽  
Biomedical Sciences ◽  
Potential Benefits

Diabetes mellitus, together with its various complications, is becoming a serious threat to human health. Natural products are secondary metabolites widely distributed in plants, having a broad range of biological activities. The development of antidiabetic medication from natural products, especially those originating from plants with a traceable folk-usage history in treating diabetes, is receiving more attention. Many studies highlighted not only the benefits of natural flavonoids with hypoglycemic effects, but also their importance in the management of diabetic complications. This review describes selected natural flavonoids that have been validated for their hypoglycemic properties, together with their mechanisms of action. Also discussed are their activities in the treatment of diabetic complications demonstrated via laboratory diabetic animal models, in vitro and clinical trials using human subjects. Published papers from 2000 to date on flavonoids and diabetes were covered through accessing Web of Science and multiple databases for biomedical sciences. The major potential benefits of natural flavonoids discussed in this review clearly suggest that these substances are lead compounds with sufficient structural diversity of great importance in the antidiabetic drug developing process.

scholarly journals A New Monoterpenoid Glucoindole Alkaloid From Dipsacus asper

2020 ◽  
Vol 15 (4) ◽  
pp. 1934578X2091729
Author(s):  
Feng Li ◽  
Yuto Nishidono ◽  
Ken Tanaka ◽  
Shiro Watanabe ◽  
Yasuhiro Tezuka
Keyword(s):  
Nitric Oxide ◽  
Natural Products ◽  
Large Class ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Biological Activities ◽  
Structural Diversity ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Dipsacus Asper

The monoterpenoid glucoindole alkaloids comprise a large class of structurally complex natural products that have attracted widespread attention owing to their biological activities and structural diversity. In the present study, we investigated the constituents of a methanol extract of Dipsacus asper roots and obtained a new monoterpenoid glucoindole alkaloid, (3 R,5 S)-5-carboxyvincosidic acid 22-loganin ester (1), together with the known alkaloid (3 S,5 S)-5-carboxystrictosidic acid 22-loganin ester (dipsaperine) (2). We herein report our structural elucidation of 1 by spectroscopic analysis and its anti-inflammatory activity as revealed by its inhibition of nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.

scholarly journals Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry

2020 ◽  
Vol 7 (9) ◽  
pp. 4016-4021
Author(s):  
Abdulmutalib Alabeed Allaq ◽  
Norrizah Jaafar Sidik ◽  
Aziyah Abdul-Aziz ◽  
Idris Adewale Ahmed
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Relevant Literature ◽  
Chemical Compounds ◽  
Google Scholar ◽  
Annual Plant ◽  
Plant Leaves ◽  
Cuminum Cyminum ◽  
Immunomodulatory Properties ◽  
Pharmaceutical Properties

Introduction: Cumin (Cuminum cyminum L.) is an annual plant that is not only one of the most popular seed species but also one of the oldest and most cultivated aromatic and herbaceous natural products with numerous medicinal, nutraceutical, and pharmaceutical properties. It is widely used in the beverage, food, liquor, medicine, perfume, and toiletry industries. The objective of this work was to provide a precise and up-to-date review of the ethnopharmacology, phytochemistry, and biological activities of cumin. Methods: Information was gathered from the review of relevant literature obtained from various databases, such as Science Direct, Springer, PubMed, Google, and Google Scholar. Results: The various parts of the cumin plant (leaves, shoot, root, and flowers) contain similar and different chemical compounds. Conclusion: The medicinal and health potential of cumin is mainly attributed to its antioxidant, antibacterial, antifungal, anti-inflammatory, antidiabetic, insecticide, and immunomodulatory properties. More studies are, however, required to unravel novel components and applications of cumin.

scholarly journals Generation of Unusual Aromatic Polyketides by Incorporation of Phenylamine Analogues into a C-Ring-Cleaved Angucyclinone

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1959
Author(s):  
Hua Xiao ◽  
Guiyang Wang ◽  
Zhengdong Wang ◽  
Yi Kuang ◽  
Juan Song ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Structural Diversity ◽  
Related Factor ◽  
Nuclear Factor ◽  
Streptomyces Sp ◽  
Mild Conditions ◽  
Aromatic Polyketides ◽  
Marine Streptomyces ◽  
New Compounds

Angucyclinones are aromatic polyketides that possess impressive structural diversity and significant biological activities. The structural diversity of these natural products is attributed to various enzymatic or nonenzymatic modifications on their tetracyclic benz(a)anthracene skeleton. Previously, we discovered an unusual phenylamine-incorporated angucyclinone (1) from a marine Streptomyces sp. PKU-MA00218, and identified that it was produced from the nonenzymatic conversion of a C-ring-cleaved angucyclinone (2) with phenylamine. In this study, we tested the nonenzymatic conversion of 2 with more phenylamine analogues, to expand the utility of this feasible conversion in unusual angucyclinones generation. The (3-ethynyl)phenylamine and disubstituted analogues including (3,4-dimethyl)phenylamine, (3,4-methylenedioxy)phenylamine, and (4-bromo-3-methyl)phenylamine were used in the conversion of 2, which was isolated from the fermentation of Streptomyces sp. PKU-MA00218. All four phenylamine analogues were incorporated into 2 efficiently under mild conditions, generating new compounds 3–6. The activation of 3–6 on nuclear factor erythroid 2-related factor 2 (Nrf2) transcription were tested, which showed that 4 possessing a dimethyl-substitution gave most potent activity. These results evidenced that disubstitutions on phenylamine can be roughly tolerated in the nonenzymatic reactions with 2, suggesting extended applications of more disubstituted phenylamines incorporation to generate new bioactive angucyclinones in the future.

Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review

2020 ◽  
Vol 20 (19) ◽  
pp. 1966-2010
Author(s):  
Bin Zhang ◽  
Ting Zhang ◽  
Jianzhou Xu ◽  
Jian Lu ◽  
Panpan Qiu ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Sponge ◽  
Biological Activities ◽  
Structural Diversity ◽  
Bioactive Natural Products ◽  
Future Potential ◽  
New Compounds ◽  
Bioactive Natural Product ◽  
Structural Classes

Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

scholarly journals The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009–2019

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 449
Author(s):  
Jianwei Chen ◽  
Panqiao Zhang ◽  
Xinyi Ye ◽  
Bin Wei ◽  
Mahmoud Emam ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Microorganisms ◽  
Future Prospects ◽  
Marine Microbes ◽  
Cultivation Strategy ◽  
Culture Strategy ◽  
Bioactive Natural Product

Marine microorganisms have drawn great attention as novel bioactive natural product sources, particularly in the drug discovery area. Using different strategies, marine microbes have the ability to produce a wide variety of molecules. One of these strategies is the co-culturing of marine microbes; if two or more microorganisms are aseptically cultured together in a solid or liquid medium in a certain environment, their competition or synergetic relationship can activate the silent biosynthetic genes to produce cryptic natural products which do not exist in monocultures of the partner microbes. In recent years, the co-cultivation strategy of marine microbes has made more novel natural products with various biological activities. This review focuses on the significant and excellent examples covering sources, types, structures and bioactivities of secondary metabolites based on co-cultures of marine-derived microorganisms from 2009 to 2019. A detailed discussion on future prospects and current challenges in the field of co-culture is also provided on behalf of the authors’ own views of development tendencies.

Natural Products from the Poles: Structural Diversity and Biological Activities

2022 ◽  
Author(s):  
Gustavo Souza dos Santos ◽  
Thaiz Rodrigues Teixeira ◽  
Pio Colepicolo ◽  
Hosana Maria Debonsi
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Structural Diversity

scholarly journals Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 378 ◽  
Author(s):  
Jiho Lee ◽  
Hong Seok Yang ◽  
Hyogeun Jeong ◽  
Jung-Hwan Kim ◽  
Heejung Yang
Keyword(s):  
Natural Products ◽  
Hierarchical Clustering ◽  
Clustering Analysis ◽  
High Resolution Mass Spectrometry ◽  
Structural Information ◽  
Biological Activities ◽  
Hierarchical Clustering Analysis ◽  
Molecular Networking ◽  
Targeted Analysis ◽  
Analysis Mode

High-resolution-mass-spectrometry (HR-MS) methods rapidly provide extensive structural information for the isolation of metabolites in natural products. However, they may occasionally provide more information than required and interfere with the targeted analysis of natural products. In this study, we aimed to selectively isolate lignans from Trachelospermum asiaticum by applying the Global Natural Product Social Molecular Networking (GNPS) platform and hierarchical clustering analysis (HCA). T. asiaticum, which contains lignans, triterpenoids and flavonoids that possess various biological activities, was analyzed in a data-dependent acquisition (DDA) analysis mode using HR-MS. The preprocessed MS spectra were applied not only to GNPS for molecular networking but also to HCA based on similarity patterns between two nodes. The combination of these two methods reliably helped in the targeted isolation of lignan-type metabolites, which are expected to possess potent anti-cancer or anti-inflammatory activities.

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