scholarly journals The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009–2019

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 449
Author(s):  
Jianwei Chen ◽  
Panqiao Zhang ◽  
Xinyi Ye ◽  
Bin Wei ◽  
Mahmoud Emam ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Microorganisms ◽  
Future Prospects ◽  
Marine Microbes ◽  
Cultivation Strategy ◽  
Culture Strategy ◽  
Bioactive Natural Product

Marine microorganisms have drawn great attention as novel bioactive natural product sources, particularly in the drug discovery area. Using different strategies, marine microbes have the ability to produce a wide variety of molecules. One of these strategies is the co-culturing of marine microbes; if two or more microorganisms are aseptically cultured together in a solid or liquid medium in a certain environment, their competition or synergetic relationship can activate the silent biosynthetic genes to produce cryptic natural products which do not exist in monocultures of the partner microbes. In recent years, the co-cultivation strategy of marine microbes has made more novel natural products with various biological activities. This review focuses on the significant and excellent examples covering sources, types, structures and bioactivities of secondary metabolites based on co-cultures of marine-derived microorganisms from 2009 to 2019. A detailed discussion on future prospects and current challenges in the field of co-culture is also provided on behalf of the authors’ own views of development tendencies.

Thiazole: A Privileged Motif in Marine Natural Products

2018 ◽  
Vol 16 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Sunil Kumar ◽  
Ranjana Aggarwal
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Secondary Metabolites ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Thiazole Ring ◽  
Cytotoxic Activities ◽  
Marine Microorganisms ◽  
Thiazole Derivatives ◽  
Drug Leads

Marine natural products have proven to be a rich source of drugs and drug leads. These natural products are secondary metabolites and show biological activity against bacteria, fungi and viruses. Natural products containing thiazole ring occur often in marine sources. They exhibit diverse and remarkable biological activities, including antitumor, antibacterial, anti-inflammatory and cytotoxic activities, to name a few. This review surveys the natural thiazole derivatives that have been isolated from marine microorganisms, with emphasis on biological implications in last three decades.

Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review

2020 ◽  
Vol 20 (19) ◽  
pp. 1966-2010
Author(s):  
Bin Zhang ◽  
Ting Zhang ◽  
Jianzhou Xu ◽  
Jian Lu ◽  
Panpan Qiu ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Sponge ◽  
Biological Activities ◽  
Structural Diversity ◽  
Bioactive Natural Products ◽  
Future Potential ◽  
New Compounds ◽  
Bioactive Natural Product ◽  
Structural Classes

Marine sponge-associated fungi are promising sources of structurally interesting and bioactive secondary metabolites. Great plenty of natural products have been discovered from spongeassociated fungi in recent years. Here reviewed are 571 new compounds isolated from marine fungi associated with sponges in 2010-2018. These molecules comprised eight different structural classes, including alkaloids, polyketides, terpenoids, meroterpenoids, etc. Moreover, most of these compounds demonstrated profoundly biological activities, such as antimicrobial, antiviral, cytotoxic, etc. This review systematically summarized the structural diversity, biological function, and future potential of these novel bioactive natural products for drug discovery.

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1898
Author(s):  
Fauzia Izzati ◽  
Mega Ferdina Warsito ◽  
Asep Bayu ◽  
Anggia Prasetyoputri ◽  
Akhirta Atikana ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Natural Products ◽  
Biological Function ◽  
Marine Invertebrates ◽  
Biological Activities ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Soft Corals ◽  
High Chemical

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

scholarly journals Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3830
Author(s):  
Hong Le ◽  
Quynh Do ◽  
Mai Doan ◽  
Quyen Vu ◽  
Mai Nguyen ◽  
...  
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Secondary Metabolites ◽  
Inhibitory Concentration ◽  
Biological Activities ◽  
2D Nmr ◽  
Inhibitory Effect ◽  
Marine Microorganisms ◽  
Penicillium Species ◽  
E Coli ◽  
Strong Inhibitory Effect

Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (1), 3-indolecarbaldehyde (2), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3), 2-[(2R-hydroxypropanoyl)amino]benzamide (4), 4-hydroxybenzandehyde (5), chrysogine (6), 3-acetyl-4-hydroxycinnoline (7), acid 1H-indole-3-acetic (8), cyclo (Tyr-Trp) (9), and 2’,3’-dihydrosorbicillin (10). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3) showed a strong inhibitory effect against Enterococcus faecalis with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2R-hydroxypropanoyl)amino]benzamide (4) and 4-hydroxybenzandehyde (5) selectively inhibited E. coli with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (10) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).

scholarly journals A Preliminary Study of the Microbial Resources and Their Biological Activities of the East China Sea

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoling Lu ◽  
Xiaoyu Liu ◽  
Cong Long ◽  
Guoxiang Wang ◽  
Yun Gao ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
East China Sea ◽  
Large Scale ◽  
Biological Activities ◽  
Structure Type ◽  
East China ◽  
Marine Microorganisms ◽  
The East China Sea ◽  
China Sea

East China Sea is one of the four sea areas in China, which possesses peculiar ecological environment and many kinds of living creatures, especially the microorganisms. We established the East China Sea microorganism library (during 2006–2010) for the first time, which stored about 30000 strains that covered most kinds of the species. In this paper, 395 pure strains of East China Sea microorganism library which belong to 33 different genera were mainly introduced.Sulfitobacter,Halomonas,Bacillus,Pseudoalteromonas, andIdiomarinawere the most dominant species. On the large-scale biological activity screening of the 395 strains, 100 strains possess different biological activities based on different screening models, of which 11.4% strains have antibacterial activities, 15.9% have cytotoxicity activities, and 6.1% have antioxidation activities. Besides, the secondary metabolites of 6 strains with strong biological activities were studied systematically; diketopiperazines and macrocyclic lactones are the active secondary metabolites. The species and the biological activity of microorganisms diversity, the abundant structure type of the secondary metabolites, and their bioactivities all indicate that East China Sea is a potent marine microorganisms-derived developing resource for drug discovery.

scholarly journals ANTIMICROBIAL, CYTOTOXIC AND HEMOLYTIC ACTIVITIES OF MARINE ALGAE-ASSOCIATED FUNGAL ISOLATES IN VIETNAM

2019 ◽  
Vol 18 (4) ◽  
pp. 406-412
Author(s):  
Hoang Kim Chi ◽  
Tran Thi Hong Ha ◽  
Le Huu Cuong ◽  
Tran Thi Nhu Hang ◽  
Nguyen Dinh Tuan ◽  
...  
Keyword(s):  
Natural Products ◽  
Human Cancer ◽  
Biological Activities ◽  
Breast Adenocarcinoma ◽  
Cytotoxic Activities ◽  
Marine Microorganisms ◽  
Fungal Strains ◽  
Fungal Isolates ◽  
Fungal Extracts

In the context of sources for natural products discovery are going scarcer, exploiting biotechnologically potential compounds from marine microbial symbionts is considered a relatively new trend. In our study a total of fifteen fungal strains were isolated from marine algal samples belonging to species Kappaphycus cottonii, K. striatus, Gracilaria eucheumatoides and Betaphycus gelatinus collected in Nha Trang in 2017. The in vitro biological activities, including antimicrobial, cytotoxic and hemolytic activities of ethyl acetate extracts of the fungal strains were determined. From fifteen fungal extracts, six displayed antimicrobial activity against at least one test strain. At 20 μg.ml-1, four fungal extracts were found to express cytotoxic activity on two human cancer cell lines hepatocellular carcinoma (Hep-G2) and breast adenocarcinoma (MCF-7), with G. eucheumatoides being the source of the highest number of producer strains. Hemolytic activity was observed in rabbit erythrocytes under almost all fungal extracts’ effect. No apparent relationship was observed between the biological activities of fungal isolates. The biological assessments uncovered several fungal candidates, such as Bge-1.1, Kco-2.1 and Geu-1.1 with relatively potent antimicrobial and cytotoxic activities while expressing less hemolytic effect at concentrations from 20 μg.ml-1 to 200 μg.ml-1. The results evidenced the potential of exploiting natural products from associated marine microorganisms, especially those for the purpose of pharmaceutical applications.

scholarly journals Insights into the Diversity of Secondary Metabolites of Planktothrix Using a Biphasic Approach Combining Global Genomics and Metabolomics

2019 ◽  
Author(s):  
Sanrda Kim Tiam ◽  
Muriel Gugger ◽  
Justine Demay ◽  
Severine Le Manach ◽  
Charlotte Duval ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Chemical Structures ◽  
Metabolite Profiles ◽  
Ancient Lineage ◽  
Major Bottleneck ◽  
Different Strains ◽  
Slow Growing

Cyanobacteria are an ancient lineage of slow-growing photosynthetic bacteria and a prolific source of natural products with diverse chemical structures and potent biological activities and toxicities. The chemical identification of these compounds remains a major bottleneck. Strategies that can prioritize the most prolific strains and novel compounds are of great interest. Here, we combine chemical analysis and genomics to investigate the chemodiversity of secondary metabolites based on their pattern of distribution within some cyanobacteria. Planktothrix being a cyanobacterial genus known to form blooms worldwide and to produce a broad spectrum of toxins and other bioactive compounds, we applied this combined approach on four closely related strains of Planktothrix. The chemical diversity of the metabolites produced by the four strains was evaluated using an untargeted metabolomics strategy with high-resolution LC-MS. Metabolite profiles were correlated with the potential of metabolite production identified by genomics for the different strains. Although, the Planktothrix strains present a global similarity in term biosynthetic cluster gene for microcystin, aeruginosin and prenylagaramide for example, we found remarkable strain-specific chemo-diversity. Only few of the chemical features were common to the four studied strains. Additionally, the MS/MS data were analyzed using Global Natural Products Social Molecular Networking (GNPS) to identify molecular families of the same biosynthetic origin. In conclusion, we present an efficient integrative strategy for elucidating the chemical diversity of a given genus and link the data obtained from analytical chemistry to biosynthetic genes of cyanobacteria.

Secondary metabolites, their structural diversity, bioactivity, and ecological functions: An overview

2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Berhanu M. Abegaz ◽  
Henok H. Kinfe
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Structural Diversity ◽  
Building Blocks ◽  
Narrative Texts ◽  
Ecological Functions ◽  
Acetyl Coenzyme A ◽  
Primary Metabolites ◽  
Geranyl Diphosphate ◽  
Aromatic Polyketides

Abstract Natural products are also called secondary metabolites to distinguish them from the primary metabolites, i.e. those natural compounds like glucose, amino acids, etc. that are present in every living cell and are used and required in the essential life processes of cells. Natural products are classified according to their metabolic building blocks into alkaloids, fatty acids, polyketides, phenyl propanoids and aromatic polyketides, and terpenoids. The structural diversity of natural products is explored using the scaffold approach focusing on the characteristic carbon frameworks.  Aside from discussing specific alkaloids that are either pharmacologically (e.g. boldine, berberine, galantamine, etc.) or historically (caffeine, atropine, lobeline, etc.) important alkaloids, a single chart is presented which shows the typical scaffolds of the most important subclasses of alkaloids.  How certain classes of natural products are formed in nature from simple biochemical ‘building blocks’ are shown using graphical schemes. This has been done for a typical tetra-ketide (6-methylsalicylic acid) from acetyl coenzyme A, or in general to all the major subclasses of terpenes.   An important aspect of understanding the structural diversity of natural products is to recognize how some compounds can be visualized as key intermediates for enzyme mediated transformation to several other related structures.  This is seen in the case of how arachidonic acid can transform into prostaglandins, or geranyl diphosphate to various monoterpenes, or squalene epoxide to various pentacyclic triterpenes, or cholesterol transforming to sex hormones, bile acids and the cardioactive cardenolides and bufadienolides. These are presented in carefully designed schemes and charts that are appropriately placed in the relevant sections of the narrative texts.  The ecological functions and pharmacological properties of natural products are also presented showing wherever possible how the chemical scaffolds have led to developing drugs as well as commercial products like sweeteners.

Marine Natural Products as A Source of Drug Leads against Respiratory Viruses: Structural and Bioactive Diversity

2020 ◽  
Vol 27 ◽  
Author(s):  
Tian-Tian Sun ◽  
Hua-Jie Zhu ◽  
Fei Cao
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Respiratory Viruses ◽  
Antiviral Activities ◽  
Syncytial Virus ◽  
Effective Drugs ◽  
Drug Leads ◽  
Novel Structures

: Respiratory viruses, including influenza virus, respiratory syncytial virus, coronavirus, et al., have seriously threatened the human health. For example, the outbreak of severe acute respiratory syndrome coronavirus, SARS, affected a large number of countries around the world. Marine organisms, which could produce secondary metabolites with novel structures and abundant biological activities, are an important source for seeking effective drugs against respiratory viruses. This report reviews marine natural products with activities against respiratory viruses, the emphasis of which was put on structures and antiviral activities of these natural products. This review has described 167 marine-derived secondary metabolites with activities against respiratory viruses published during 1981 to 2019. Altogether 102 references are cited in this review article.

scholarly journals Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 115 ◽  
Author(s):  
Amr El-Demerdash ◽  
Atanas G. Atanasov ◽  
Olaf K. Horbanczuk ◽  
Mohamed A. Tammam ◽  
Mamdouh Abdel-Mogib ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Structural Diversity ◽  
Marine Sponges ◽  
Chemical Diversity ◽  
Molecular Scaffolds ◽  
Pharmacological Activities ◽  
Chemotaxonomic Markers ◽  
Novel Drug

Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998–2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

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