scholarly journals Synthesis and Insecticidal Evaluation of Chiral Neonicotinoids Analogs: The Laurel Wilt Case

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4225
Author(s):  
Saúl A. Luna-Hernández ◽  
Israel Bonilla-Landa ◽  
Alfonso Reyes-Luna ◽  
Alfredo Rodríguez-Hernández ◽  
Ulises Cuapio-Muñoz ◽  
...  
Keyword(s):  
United States ◽  
Experimental Data ◽  
Drug Resistance ◽  
Insecticidal Activity ◽  
The United States ◽  
The Novel ◽  
Laurel Wilt ◽  
Open Chain ◽  
Chain Compounds ◽  
Cyclic Compounds

Xyleborus sp beetles are types of ambrosia beetles invasive to the United States and recently also to Mexico. The beetle can carry a fungus responsible for the Laurel Wilt, a vascular lethal disease that can host over 300 tree species, including redbay and avocado. This problem has a great economic and environmental impact. Indeed, synthetic chemists have recently attempted to develop new neonicotinoids. This is also due to severe drug resistance to “classic” insecticides. In this research, a series of neonicotinoids analogs were synthesized, characterized, and evaluated against Xyleborus sp. Most of the target compounds showed good to excellent insecticidal activity. Generally, the cyclic compounds also showed better activity in comparison with open-chain compounds. Compounds R-13, 23, S-29, and 43 showed a mortality percent of up to 73% after 12 h of exposure. These results highlight the enantioenriched compounds with absolute R configuration. The docking results correlated with experimental data which showed both cation-π interactions in relation to the aromatic ring and hydrogen bonds between the search cavity 3C79 and the novel molecules. The results suggest that these sorts of interactions are responsible for high insecticidal activity.

Breaking Free

2017 ◽  
Author(s):  
Deirdre David
Keyword(s):  
United States ◽  
The United States ◽  
The Novel ◽  
Male Homosexuality ◽  
Domestic Life ◽  
The Family

In the mid- to late 1950s, Pamela emerged as a critically acclaimed novelist, particularly after the family returned to London. In perhaps her best-known novel, The Unspeakable Skipton, she explores the life of a paranoid writer who sponges on English visitors to Bruges. The novel was hailed for its wit and sensitive depiction of the life of a writer. She also published a fine study of a London vicar martyred in marriage to a vain and selfish wife: The Humbler Creation is remarkable for its incisive and empathetic depiction of male despair. The Last Resort sealed her distinction as a brilliant novelist of domestic life in its frank depiction of male homosexuality. While continuing to publish fiction, Pamela maintained her reputation as a deft reviewer. In 1954, she and Charles travelled to the United States—the first of many trips that were to follow.

scholarly journals Laurel Wilt: Current and Potential Impacts and Possibilities for Prevention and Management

Forests ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 181
Author(s):  
Rabiu O. Olatinwo ◽  
Stephen W. Fraedrich ◽  
Albert E. Mayfield
Keyword(s):  
United States ◽  
Tree Mortality ◽  
The United States ◽  
Persea Americana ◽  
Laurel Wilt ◽  
Important Species ◽  
Invasive Insects ◽  
Raffaelea Lauricola ◽  
Redbay Ambrosia Beetle ◽  
The Impact

In recent years, outbreaks of nonnative invasive insects and pathogens have caused significant levels of tree mortality and disturbance in various forest ecosystems throughout the United States. Laurel wilt, caused by the pathogen Raffaelea lauricola (T.C. Harr., Fraedrich and Aghayeva) and the primary vector, the redbay ambrosia beetle (Xyleborus glabratus Eichhoff), is a nonnative pest-disease complex first reported in the southeastern United States in 2002. Since then, it has spread across eleven southeastern states to date, killing hundreds of millions of trees in the plant family Lauraceae. Here, we examine the impacts of laurel wilt on selected vulnerable Lauraceae in the United States and discuss management methods for limiting geographic expansion and reducing impact. Although about 13 species belonging to the Lauraceae are indigenous to the United States, the highly susceptible members of the family to laurel wilt are the large tree species including redbay (Persea borbonia (L.) Spreng) and sassafras (Sassafras albidum (Nutt.) Nees), with a significant economic impact on the commercial production of avocado (Persea americana Mill.), an important species native to Central America grown in the United States. Preventing new introductions and mitigating the impact of previously introduced nonnative species are critically important to decelerate losses of forest habitat, genetic diversity, and overall ecosystem value.

Afghanistan Meets the Amazon: Reading The Kite Runner in America

PMLA ◽  
2009 ◽  
Vol 124 (1) ◽  
pp. 25-43 ◽  
Author(s):  
Timothy Aubry
Keyword(s):  
United States ◽  
Military Intervention ◽  
The United States ◽  
The Novel ◽  
United States Military ◽  
War On Terrorism ◽  
Global War On Terrorism ◽  
Customer Reviews ◽  
Global War ◽  
Fictional Representations

This essay considers the American reception of Khaled Hosseini's The Kite Runner in the context of the Bush administration's global war on terrorism by examining the customer reviews of the novel posted on Amazon. As many of the responses indicate, identification serves as a paradoxical means of negotiating with fictional representations of foreignness. The intense and painful empathy inspired by The Kite Runner serves a valorizing function for American readers, strengthening their sense of their own humanity—an effect that resists strict political categorization. Hosseini's ambivalent conception of what it means to be human, I argue, supports a diversity of competing attitudes toward the United States' military intervention in the Middle East and central Asia, while simultaneously catering to fantasies of escape from ideological and cultural divisions altogether.

An Irishman in America: Irishness and Belonging in Roddy Doyle’s Oh, Play That Thing

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Genoveffa Giambona ◽  
Keyword(s):  
United States ◽  
Identity Construction ◽  
Historical Fiction ◽  
Minority Groups ◽  
The United States ◽  
The Novel

The purpose of this article is to analyse Roddy Doyle’s representations of Irishness and Ireland in Oh, Play That Thing (2004). The novel is the second instalment in Doyle’s The Last Roundup Trilogy, a historical fiction describing the making of the Irish nation through the adventures and misadventures of Henry Smart, its protagonist. In the novel, constructions of Irishness are projected onto the outside world through Henry’s picaresque travels in the United States. The article examines how Irishness is constructed in the book and how it becomes intertwined with identity construction in other minority groups.

scholarly journals The pCS20 PCR assay for Ehrlichia ruminantium does not cross-react with the novel deer ehrlichial agent found in white-tailed deer in the United States of America

2004 ◽  
Vol 71 (2) ◽  
Author(s):  
S.M. Mahan ◽  
B.H. Simbi ◽  
M.J. Burridge
Keyword(s):  
United States ◽  
High Specificity ◽  
Pcr Primers ◽  
The United States ◽  
Rrna Gene ◽  
The Novel ◽  
Pcr Assay ◽  
Ehrlichia Ruminantium ◽  
Cowdria Ruminantium ◽  
Specificity And Sensitivity

White-tailed deer are susceptible to heartwater (Ehrlichia [Cowdria] ruminantium infection) and are likely to suffer high mortality if the disease spreads to the United States. It is vital, therefore, to validate a highly specific and sensitive detection method for E. ruminantium infection that can be reliably used in testing white-tailed deer, which are reservoirs of antigenically or genetically related agents such as Ehrlichia chaffeensis, Anaplasma (Ehrlichia) phagocytophilum (HGE agent) and Ehrlichia ewingii. Recently, a novel but as yet unnamed ehrlichial species, the white-tailed deer ehrlichia (WTDE), has been discovered in deer populations in the United States. Although the significance of WTDE as a pathogen is unknown at present, it can be distinguished from other Ehrlichia spp. based on 16S rRNA gene sequence analysis. In this study it was differentiated from E. ruminantium by the use of the pCS20 PCR assay which has high specificity and sensitivity for the detection of E. ruminantium. This assay did not amplify DNA from the WTDE DNA samples isolated from deer resident in Florida, Georgia and Missouri, but amplified the specific 279 bp fragment from E. ruminantium DNA. The specificity of the pCS20 PCR assay for E. ruminantium was confirmed by Southern hybridization. Similarly, the 16S PCR primers (nested) that amplify a specific 405-412 bp fragment from the WTDE DNA samples, did not amplify any product from E. ruminantium DNA. This result demonstrates that it would be possible to differentiate between E. ruminantium and the novel WTDE agent found in white tailed deer by applying the two respective PCR assays followed by Southern hybridizations. Since the pCS20 PCR assay also does not amplify any DNA products from E. chaffeensis or Ehrlichia canis DNA, it is therefore the method of choice for the detection of E. ruminantium in these deer and other animal hosts.

scholarly journals Other People’s Cabins: German Inversions of Onkel Tom’s Hutte

Lateral ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Kristin Moriah
Keyword(s):  
United States ◽  
20Th Century ◽  
The United States ◽  
Early 20Th Century ◽  
The Novel ◽  
Housing Projects ◽  
Uncle Tom's Cabin ◽  
The Us ◽  
Archival Work

Kristin Moriah’s essay is rooted in extensive archival work in the US and Germany, examining the transatlantic circulation of Uncle Tom’s Cabin through markets of performance and literature in and between Germany and the United States. The essay follows the performative tropes of Uncle Tom’s Cabin from its originary political resonances to the present-day restaurants, train-stops, and housing projects named for the novel. Moriah reveals how the figurations of blackness arising from these texts are foundational to the construction of Germanness and American-German relations in the early 20th century and beyond.

scholarly journals Implications for Europe of high prevalence of HIV drug resistance in the United States

2002 ◽  
Vol 6 (2) ◽  
Author(s):  
D Pillay
Keyword(s):  
United States ◽  
Drug Resistance ◽  
Disease Progression ◽  
Successful Treatment ◽  
Virological Failure ◽  
The United States ◽  
Viral Rna ◽  
Viral Rebound ◽  
Drug Compliance ◽  
High Prevalence

Over 16 drugs are now available for use against HIV, broadly comprising three classes of agent. Their use, in combination, has had a dramatic impact in reducing disease progression. Successful treatment is increasingly defined as the maintenance of plasma viral RNA load at undetectable levels. Reasons for ‘virological failure’ (viral rebound) on treatment are many, but perhaps the single most important factor is suboptimal drug compliance.

scholarly journals Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against fleas in cats, under field conditions

Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 22 ◽  
Author(s):  
Eric Tielemans ◽  
Tomoko Otsuki ◽  
Tara Cheesman ◽  
Fiona Selmes ◽  
Anthony Pfefferkorn ◽  
...  
Keyword(s):  
United States ◽  
Field Studies ◽  
The United States ◽  
Positive Control ◽  
Control Group ◽  
The Novel ◽  
Domestic Cats ◽  
Label Dose ◽  
Treatment Tolerance ◽  
Significant Health

Esafoxolaner is a purified afoxolaner enantiomer with insecticidal and acaricidal properties. It is combined with eprinomectin and praziquantel, nematodicidal and cestodicidal compounds, in a novel topical endectoparasiticide formulation for cats. This novel formulation was tested in four field studies, in the United States, Europe, Japan and Australia. In all studies, naturally flea-infested domestic cats were treated with the novel formulation at the label dose and conditions of use. The main objective, identical in the four studies, was to assess efficacy on fleas, based on comparison of mean number of fleas found on infested cats before and one month after treatment. Tolerance to the product was also evaluated in the four studies. Otherwise, the studies had some differences in their design and secondary objectives, for example testing for a reduction in flea infestation-related cutaneous signs, testing of one treatment or of three monthly treatments, and use of a positive control group. In the four studies, a total of 307 cats were treated with the novel formulation. The reduction of fleas one month after treatment was 97.7%, 98.8%, 100% and 99.7% in the United States, Europe, Japan and Australia, respectively. There were no significant health abnormalities attributed to treatment in any of the studies.

On Fat Clothes: Unraveling Plus-Size Design Discourse

Design Issues ◽  
2022 ◽  
Vol 38 (1) ◽  
pp. 17-28
Author(s):  
Lauren Downing Peters
Keyword(s):  
United States ◽  
The United States ◽  
The Novel ◽  
Disability Theory ◽  
The World ◽  
Fashion Theory ◽  
History Of

Abstract This article considers the possibilities and limitations of plus-size clothing— a subcategory of ready-to-wear that is deeply embedded in the history of dieting, exercise, standardized sizing, and the industrialization of clothing manufacturing in the United States. In doing so, it draws on fashion theory and disability theory in exposing how plus-size clothing functions as a normalizing mechanism, thereby inhibiting innovation in this sector. The article concludes with a counterexploration of the possibilities of “fat clothes” and the novel w ays of seeing and existing in the world that they might enable.

Sign in / Sign up

Export Citation Format

Share Document