scholarly journals Biomaterials for Drug Delivery: Sources, Classification, Synthesis, Processing, and Applications

2020 ◽  
Author(s):  
Samson O. Adeosun ◽  
Margaret O. Ilomuanya ◽  
Oluwashina P. Gbenebor ◽  
Modupeola O. Dada ◽  
Cletus C. Odili
Keyword(s):  
Drug Delivery ◽  
Target Cell ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Rehabilitation Process ◽  
Essential Components ◽  
Suitable Target ◽  
Health Related ◽  
Health Rehabilitation ◽  
And Performance

A way to avoid or minimize the side effect that could result in drug delivery to cells with increased efficiency and performance in the health rehabilitation process is to use biocompatible and biodegradable drug carriers. These are essentially biomaterials that are metallic, ceramic, or polymeric in nature. The sources of these materials must be biological in its entire ramification. The classification, synthesis, processing, and the applications to which these materials are put are the essential components of having suitable target cell drug carriers. This chapter will be devoted to discussing biomaterials suitable as drug carrier for use in the health-related matters of rehabilitation.

Mieleltään haavoittuneet

Kuntoutus ◽  
2021 ◽  
Vol 44 (3) ◽  
pp. 36-48
Author(s):  
Johanna Vilppola ◽  
Markku Vanttaja
Keyword(s):  
Mental Health ◽  
Life Stories ◽  
Life Story ◽  
Rehabilitation Process ◽  
Societal Factors ◽  
Health Related ◽  
Health Rehabilitation ◽  
Mental Health Rehabilitation ◽  
Intentions To Participate ◽  
Education Work

Mielenterveyssyistä johtuvat sairauspoissaolot ja työkyvyttömyyseläkkeet ovat lisääntyneet Suomessa viime vuosikymmeninä. Sen vuoksi on tarpeen tutkia mielenterveyskuntoutujien yksilöllisiä elämäntilanteita sekä heidän kuntoutumistaan ja kiinnittymistään yhteiskuntaan. Tässä artikkelissa tarkastellaan mielenterveyskuntoutujien kuntoutusprosessia erityisesti koulutus- ja työtoimijuuden näkökulmasta. Tutkimusaineistona käytetään aikuisten mielenterveyskuntoutujien kirjoittamia elämänkerrontoja (n = 42). Elämänkerrontojen teema-analyysin ja tyypittelyn perusteella kirjoittajat jaettiin kolmeen erilaiseen ryhmään, jotka nimettiin toimijoiksi (9), taistelijoiksi (18) ja tipahtaneiksi (15). Toimijat olivat aktiivisia oman kuntoutumisensa, koulutuksensa, työnsä sekä kokonaiselämänsä suhteen. Heillä oli vahva pyrkimys hakeutua koulutukseen, palata takaisin työelämään tai ylläpitää nykyinen koulutus- ja työtilanteensa. Taistelijat olivat puolestaan omassa kuntoutusprosessissaan matkalaisia, jotka halusivat olla yhteiskunnan tarpeellisia jäseniä. Myös heillä oli koulutukseen ja työhön liittyviä haaveita, mutta keinot oman elämän hallitsemiseksi olivat toisten ihmisten tuen varassa. Tipahtaneet olivat luovuttaneet sekä oman kuntoutumisensa että koulutus- ja työtoimijuutensa suhteen. Heillä ei ollut enää koulutukseen tai työhön liittyviä tavoitteita. Abstract Mentally wounded. Research of Education and Work Agency of Mental Health Rehabilitees Mental health related sick leaves and early pensions have increased enormously in our society in the last decades. That is why it is important to study the life narratives of mental health rehabilitees, especially focusing on individual and societal factors connected to rehabilitation, education and work agency. The data of this research consisted of 42 self-written life stories of adult mental health rehabilitees. Based on theme analysis and typification, life stories were divided into three groups: agentic actors (9), warriors (18) and dropouts (15). Agentic actors were described as active agents of their own rehabilitation, education, work and life. They had strong intentions to participate in education and work. Warriors seemed to be more like passengers in their own rehabilitation process, yet they had intentions to be a necessary part of society. They had hopes and dreams towards education and work, but they seemed to be lacking concrete means to lead their independent lives.  The dropouts had given up on their agency in rehabilitation, education and work. They had no more goals or intentions concerning education and work. Keywords: mental health rehabilitation, life story, education, work, agency

Multifunctional drug carrier on the basis of 3d–4f Fe/La-MOFs for drug delivery and dual-mode imaging

2019 ◽  
Vol 7 (42) ◽  
pp. 6612-6622 ◽  
Author(s):  
Caixue Lin ◽  
Bin Chi ◽  
Chen Xu ◽  
Cheng Zhang ◽  
Feng Tian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Dual Mode ◽  
Simultaneous Imaging

Multifunctional drug carriers for simultaneous imaging and drug delivery have emerged as an important new direction for the treatment of cancer.

scholarly journals Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1274 ◽  
Author(s):  
Wang ◽  
Zhao ◽  
Gao ◽  
Xu ◽  
Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Dual Mode ◽  
Metal Organic ◽  
Lanthanide Metal ◽  
Good Biocompatibility ◽  
Anti Stokes

Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF4@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal–organic frameworks (MOFs-Y:Eu3+) and anti-stokes luminescent NaYF4:Tm3+/Yb3+ nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF4@MOF-Ln nanocomposites.

scholarly journals Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 694 ◽  
Author(s):  
Liang Ding ◽  
Xinxia Cui ◽  
Rui Jiang ◽  
Keya Zhou ◽  
Yalei Wen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Scanning ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Laser Scanning Confocal Microscopy ◽  
Composite Hydrogel ◽  
Design Synthesis ◽  
Liposome Membrane ◽  
Scanning Confocal Microscopy ◽  
Drug Carrier System

Liposomes are extensively used in drug delivery, while alginates are widely used in tissue engineering. However, liposomes are usually thermally unstable and drug-leaking when in liquids, while the drug carriers made of alginates show low loading capacities when used for drug delivery. Herein, we developed a type of thermo-responsible liposome–alginate composite hydrogel (TSPMAH) by grafting thermo-responsive liposomes onto alginates by using Ca2+ mediated bonding between the phosphatidic serine (PS) in the liposome membrane and the alginate. The temperature-sensitivity of the liposomes was actualized by using phospholipids comprising dipalmitoylphosphatidylcholine (DPPC) and PS and the liposomes were prepared by a thin-film dispersion method. The TSPMAH was then successfully prepared by bridge-linking the microcapsules onto the alginate hydrogel via PS-Ca2+-Carboxyl-alginate interaction. Characterizations of the TSPMAH were carried out using scanning electron microscopy, transform infrared spectroscopy, and laser scanning confocal microscopy, respectively. Their rheological property was also characterized by using a rheometer. Cytotoxicity evaluations of the TSPMAH showed that the composite hydrogel was biocompatible, safe, and non-toxic. Further, loading and thermos-inducible release of model drugs encapsulated by the TSPMAH as a drug carrier system was also studied by making protamine–siRNA complex-carrying TSPMAH drug carriers. Our results indicated that the TSPMAH described herein has great potentials to be further developed into an intelligent drug delivery system.

scholarly journals Fabrication and performance of a spherical cellulose nanocrystal-based hydrophobic drug delivery vehicle using rubber wood

BioResources ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. 7763-7774
Author(s):  
Dingyuan Zheng ◽  
Yating Deng ◽  
Yue Xia ◽  
Yiman Nan ◽  
Meijiao Peng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Carrier ◽  
Raw Material ◽  
Release Mechanism ◽  
Ammonium Bromide ◽  
Hydrophobic Drug ◽  
Rubber Wood ◽  
Model Drug ◽  
And Performance

Cellulose nanocrystals (CNCs) were fabricated using rubber wood (RW) as the raw material via acid hydrolysis followed by ultrasonication. The CNCs samples were then grafted with succinic anhydride to obtain modified CNCs, hereafter called CS. The CS samples were subsequently coated with a cationic surfactant, cetyltrimethyl ammonium bromide, and the obtained samples were named as CC. The morphology, chemical structure, and thermal stability of the RW, CNCs, CS, and CC samples were characterized using transmission electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, respectively. Finally, the drug release performance was investigated using CC as the drug carrier and hesperidin, a hydrophobic drug, as the model drug. The drug release mechanism was also considered. The results of this study identified a new route for the high-value utilization of RW and also demonstrated that RW could be used as a novel substrate for the construction of cellulose-based hydrophobic drug delivery systems.

scholarly journals Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

2017 ◽  
pp. 459-485
Author(s):  
Prabhakar Singh ◽  
Sudhakar Singh ◽  
Rajesh Kumar Kesharwani
Keyword(s):  
Drug Delivery ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
The Body ◽  
Body Ideal

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting. Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs targeting specially for a longer period of time. This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits.

Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

2016 ◽  
pp. 340-366
Author(s):  
Prabhakar Singh ◽  
Sudhakar Singh ◽  
Rajesh Kumar Kesharwani
Keyword(s):  
Drug Delivery ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
The Body ◽  
Body Ideal

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting. Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs targeting specially for a longer period of time. This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits.

Formulation, Characterization and In vitro Drug Delivery of Vitexin Loaded Liposomes

2021 ◽  
Vol 14 (2) ◽  
pp. 5364-5371
Author(s):  
Dr.S.Bhagavathy Sivathanu ◽  
Shivapriya G ◽  
Shivapriya G
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Egg Yolk ◽  
Drug Carriers ◽  
Good Choice ◽  
Target Site ◽  
Carrier System ◽  
Liposome Preparation ◽  
Drug Carrier System ◽  
Novel Drug

Liposome is a spherical vesicle which contains atleast one lipid bilayer. Liposomes are used as a novel drug carriers because of its hydrophobic and hydrophilic nature, it has many advantages in the field of medical sciences. There are some other drug carriers like dendrimers, micelles, niosomes. Out of all, liposomes are considered to be the most promising agent for drug delivery. The uniqueness of liposome is when it is used as a pharmaceutical drug, it acts as a natural receptor. Thus it acts as an antigen and binds with the antibody (cancer cell) without causing any damage to the adjacent cells. For the synthesis of liposomes, a phospholipid is required. The liposomes can be synthesized using egg yolk and chloroform. So the basic phospholipid is obtained from egg yolk. For more stability, the liposomes are prepared using popc. The present work  discuss about the effective preparation of drug loaded liposomes using popc (1- palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine). POPC is an important phospholipid for biophysical experiments. Additionally chloroform is used as the solvent for the liposome preparation. The drug chosen for liposome loading is vitexin (vxn), which is an effective therapeutic agent against inflammation and cancer. The vesicular size, shape, drug entrapment efficacy, stability, electrochemical property and drug releasing property of the formulated liposomes were characterized. The results showed that the formulated liposomes are considered as the better drug carrier system and good choice for biotransformation within the cell to reach the target site such as cancer cells. Even though available treatments like chemotherapy and radiation therapy, causes damage to the surrounding cells, the alternative drug transferring system such as liposomal mediated drug transfer within the cell is considered as good choice of treatment to avoid such complications. The aim of liposome mediated  drug carrier system is to develop a method to reach the drug to the target site. After drug delivery at the target site, the liposomes are fused within the surface of the body. This is because of the pH of liposomes, which is at 7.4 and temperature is maintained at 37 oC. So, the vxn loaded liposomes are considered as the novel drug carriers for the successful targetted drug delivery.

scholarly journals NIOSOMES: A PROMISING DRUG DELIVERY CARRIER

2021 ◽  
Vol 6 (6) ◽  
pp. 15-27
Author(s):  
Patil Abhishek S. ◽  
Shaikh Bilal J. ◽  
Bhosale Ankush S. ◽  
Raut Indrayani D. ◽  
Nitalikar Manojkumar M.
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Ionic Surfactant ◽  
Medicinal Uses ◽  
Drug Delivery Carrier ◽  
Medication Side ◽  
Surface Active ◽  
Active Substances ◽  
Delivery Technology

Niosomes are non-ionic surfactant-based multilamellar or unilamellar vesicles in which an aqueous solute solution is completely encapsulated by a membrane formed by surfactant macromolecules organised as a bilayer. Because vesicles are made up of a bilayer of non-ionic surface-active substances, the term "Niosomes" was coined (non-ionic surfactants). Niosomes are an unique drug delivery technology that encapsulates the medication in a vesicle. Ionic drug carriers are hazardous and inappropriate, whereas niosomal drug carriers are less dangerous. Niosomes do not require any specific handling or storage conditions.Niosomes have shown to be a promising drug carrier, with the potential to minimise medication side effects and improve therapeutic efficacy in a variety of disorders. Drug insolubility, instability, limited bioavailability, and fast degradation are all issues that niosomes address. The benefits, preparations, assessment, and medicinal uses of niosomes are discussed in this review article.

Tailoring Nano-copolymer/CNTs Composite and Its Application in Drug Delivery

2021 ◽  
Author(s):  
M. K. Darwish ◽  
M. S. Said ◽  
A. A. El-Sayed ◽  
R. A. Sobh ◽  
A. A. Abdel Khalek
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Entrapment Efficiency ◽  
Drug Carriers ◽  
Feed Composition ◽  
Particle Size Analyzer ◽  
Monomer Feed ◽  
Novel Drug ◽  
Mcf 7

Abstract This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these ground-breaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.

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