scholarly journals Movement Disorders Related to Gluten Sensitivity: A Systematic Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1034 ◽  
Author(s):  
Ana Vinagre-Aragón ◽  
Panagiotis Zis ◽  
Richard Grunewald ◽  
Marios Hadjivassiliou
Keyword(s):  
Movement Disorders ◽  
Medical Literature ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Pubmed Database ◽  
Gluten Sensitive Enteropathy ◽  
The Subject

Gluten related disorders (GRD) represent a wide spectrum of clinical manifestations that are triggered by the ingestion of gluten. Coeliac disease (CD) or gluten sensitive enteropathy is the most widely recognised, but extra-intestinal manifestations have also been increasingly identified and reported. Such manifestations may exist in the absence of enteropathy. Gluten sensitivity (GS) is another term that has been used to include all GRD, including those where there is serological positivity for GS related antibodies in the absence of an enteropathy. Gluten ataxia (GA) is the commonest extraintestinal neurological manifestation and it has been the subject of many publications. Other movement disorders (MDs) have also been reported in the context of GS. The aim of this review was to assess the current available medical literature concerning MDs and GS with and without enteropathy. A systematic search was performed while using PubMed database. A total of 48 articles met the inclusion criteria and were included in the present review. This review highlights that the phenomenology of gluten related MDs is broader than GA and demonstrates that gluten-free diet (GFD) is beneficial in a great percentage of such cases.

scholarly journals Upper respiratory tract and otolaryngological manifestations of coronavirus disease 2019 (COVID-19): A systemic review

2021 ◽  
Vol 9 ◽  
pp. 205031212110169
Author(s):  
Jamil N Al-Swiahb ◽  
Mohammed A Motiwala
Keyword(s):  
Sore Throat ◽  
Clinical Presentation ◽  
Wide Spectrum ◽  
Research Question ◽  
Clinical Manifestations ◽  
Systemic Review ◽  
Cochrane Library ◽  
Lower Airway ◽  
Upper Respiratory Tract ◽  
Pubmed Database

To detect, analyze, and discuss the different ear nose throat manifestations, those were reported in coronavirus disease-positive patients in the published and reviewed literature. Coronavirus disease has been reported to present with several symptoms. Common symptoms include new onset of fever, cough, fatigue, and myalgia. Other symptoms like sputum production, dyspnea, rhinorrhea, anosmia, nasal stuffiness, headache, and sore throat are less frequently reported, but the clinical presentation is highly variable among individuals. We review the otolaryngologic manifestations of coronavirus disease reported in the published literature to assess its importance in the early diagnosis of coronavirus disease. We searched PubMed database, MEDLINE, Web of Science, LILACS, SciELO, and Cochrane Library to find out relevant articles, using the following keywords: COVID-19, clinical features, characteristics, symptoms, clinical, manifestations, throat, cough, rhinorrhea, COVID-19 anosmia, headache, nasal, coronavirus, and coronavirus otolaryngologic. Article selection was based on their relevance to the research question. Totally, 14 articles and 2971 patients were recruited for our study. A wide variety of upper and lower airway manifestations were reported. Fever (34%–96.5%), cough (17.9%–83%), myalgia or fatigue (10%–31%), expectoration (20%–32.7%), dyspnea (7.6%–7.5%), rhinorrhea (1%–6.8%), sore throat (4%–61%), nasal congestion (3%–4.8%), and headache (3%–16.2%) were the most common symptoms reported. Our findings confirm that coronavirus disease infection presents with a wide spectrum of clinical presentation. The ear nose throat manifestations for coronavirus disease are not uncommon, but more attention should also be paid to patients with otolaryngologic symptoms which can appear early, as this could encourage an earlier diagnosis and treatment, which limits spread of the disease.

scholarly journals A gluténérzékenység extraintestinalis spektruma

2019 ◽  
Vol 160 (34) ◽  
pp. 1327-1334
Author(s):  
István Fedor ◽  
Éva Zöld ◽  
Zsolt Barta
Keyword(s):  
Gastrointestinal Disease ◽  
Wide Spectrum ◽  
Gastrointestinal Symptoms ◽  
Autoimmune Disorder ◽  
Gluten Sensitivity ◽  
Age Group ◽  
Extraintestinal Manifestations ◽  
Gluten Sensitive Enteropathy ◽  
Paediatric Age ◽  
Delayed Recognition

Abstract: Although celiac disease (gluten-sensitive enteropathy) is a relatively well known malady, yet is surrounded by several misconceptions. It is in fact, a multi-systemic autoimmune disorder with a wide spectrum of possible presentations, though most clinicians regard it as a solely gastrointestinal disease. Another misconception that it is a disease of paediatric age group. Thus, the diagnosis of adult or elderly patients is often delayed. Recognition of the disease in the adults can be challenging, as there are less pronounced gastrointestinal symptoms, and patients present with other manifestations (i.e., neurologic, cardiovascular, hepatobiliary, or hematologic involvement are common). As these extraintestinal manifestations are less well known among practicing physicians, here we propose a brief overview of these. We aimed to summarize the available literature on the extraintestinal manifestations associated with gluten sensitivity. Orv Hetil. 2019; 160(34): 1327–1334.

scholarly journals Gluten Sensitivity Presenting as a Neuropsychiatric Disorder

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Stephen J. Genuis ◽  
Rebecca A. Lobo
Keyword(s):  
Scientific Literature ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Sole Source ◽  
Medical Community ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Neuropsychiatric Manifestations ◽  
History Of ◽  
Pathophysiologic Mechanisms

There has been increasing recognition in the medical community and the general public of the widespread prevalence of gluten sensitivity. Celiac disease (CD) was initially believed to be the sole source of this phenomenon. Signs and symptoms indicative of nonceliac gluten sensitivity (NCGS), in which classical serum and intestinal findings of CD may be absent, have been frequently reported of late. Clinical manifestations in patients with NCGS are characteristically triggered by gluten and are ameliorated or resolved within days to weeks of commencing a gluten-free diet. Emerging scientific literature contains several reports linking gluten sensitivity states with neuropsychiatric manifestations including autism, schizophrenia, and ataxia. A clinical review of gluten sensitivity is presented alongside a case illustrating the life-changing difference achieved by gluten elimination in a patient with a longstanding history of auditory and visual hallucinations. Physicians in clinical practice should routinely consider sensitivity issues as an etiological determinant of otherwise inexplicable symptoms. Pathophysiologic mechanisms to explain the multisystem symptomatology with gluten sensitivity are considered.

scholarly journals The principles of management of patients with liver cirrhosis complicated by ascites

2017 ◽  
Vol 95 (9) ◽  
pp. 789-796 ◽  
Author(s):  
Dmitry V. Garbuzenko
Keyword(s):  
Liver Cirrhosis ◽  
Search Strategy ◽  
Clinical Manifestations ◽  
Refractory Ascites ◽  
Inclusion Criteria ◽  
Unfavourable Outcome ◽  
Pubmed Database ◽  
Key Words Liver Cirrhosis ◽  
Minimally Invasive Methods

This review deals with modern principles of management of patients with liver cirrhosis complicated by ascites depending on its clinical manifestations. The search strategy included the use of the PubMed database, the Google Scholar system, Cochrane systematic reviews, and reference lists of individual articles that cover relevant publications for 1986-2016 and match the following key words: liver cirrhosis, portal hypertension, ascites, pathogenesis, diagnostics, treatment. Inclusion criteria were confined to uncomplicated or refractory ascites in patients with liver cirrhosis. The analysis of literature data revealed poor prognosis of this condition and high mortality rate despite progress in its management. A major prerequisite for the successful treatment is stratification of risks of unfavourable outcome and the choice of adequate personalized therapy. The pathogenetically sound prescription of pharmacotherapy and further optimization of minimally invasive methods make it possible to improve the quality of life and survivorship of the patients.

scholarly journals The rise and fall of gluten!

2015 ◽  
Vol 74 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Imran Aziz ◽  
Federica Branchi ◽  
David S. Sanders
Keyword(s):  
Coeliac Disease ◽  
Agricultural Production ◽  
Clinical Symptoms ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Western Asia ◽  
Fertile Crescent ◽  
Gluten Sensitive Enteropathy ◽  
The Relationship

Mankind has existed for 2·5 million years but only in the last 10 000 years have we been exposed to wheat. Wheat was first cultivated in the Fertile Crescent (South Western Asia) with a farming expansion that lasted from about 9000BC to 4000BC. Thus it could be considered that wheat (and gluten) is a novel introduction to man's diet! Prior to 1939 the rationing system had already been devised. This led to an imperative to try to increase agricultural production. Thus it was agreed in 1941 that there was a need to establish a Nutrition Society. The very roots of the society were geared towards necessarily increasing the production of wheat. This goal was achieved and by the end of the 20th century, global wheat output had expanded 5-fold. Perhaps as a result the epidemiology of coeliac disease (CD) or gluten sensitive enteropathy has changed. CD is a state of heightened immunological responsiveness to ingested gluten in genetically susceptible individuals. CD now affects 1 % or more of all adults, for which the treatment is a strict lifelong gluten-free diet. However, there is a growing body of evidence to show that a far greater proportion of individuals without coeliac disease are taking a gluten-free diet of their own volition. This clinical entity has been termed non-coeliac gluten sensitivity (NCGS), although the condition is fraught with complexities due to overlap with other gluten-based constituents that can also trigger similar clinical symptoms. This review will explore the relationship between gluten, the rising prevalence of modern coeliac disease, and the new entity of NCGS along with its associated uncertainties.

scholarly journals Post-Thalamic Stroke Movement Disorders: A Systematic Review

2018 ◽  
Vol 79 (5-6) ◽  
pp. 303-314 ◽  
Author(s):  
Navnika Gupta ◽  
Sanjay Pandey
Keyword(s):  
Systematic Review ◽  
Movement Disorder ◽  
Movement Disorders ◽  
Acute Onset ◽  
Research Articles ◽  
Inclusion Criteria ◽  
Search Terms ◽  
Thalamic Stroke ◽  
Pubmed Database ◽  
The Brain

Background: After a stroke, movement disorders are rare manifestations mainly affecting the deep structures of the brain like the basal ganglia (44%) and thalamus (37%), although there have been case studies of movement disorders in strokes affecting the cerebral cortex also. Summary: This review aims to delineate the various movement disorders seen in association with thalamic strokes and tries to identify the location of the nuclei affected in each of the described movement disorders. Cases were identified through a search of PubMed database using different search terms related to post-thalamic stroke movement disorders and a secondary search of references of identified articles. We reviewed 2,520 research articles and only 86 papers met the inclusion criteria. Cases were included if they met criteria for post-thalamic stroke movement disorders. Case-cohort studies were also reviewed and will be discussed further. Key Messages: The most common post-stroke abnormal movement disorder reported in our review was dystonia followed by hemiataxia. There was a higher association between ischaemic stroke and movement disorder. Acute onset movement disorders were more common than delayed. The posterolateral thalamus was most commonly involved in post-thalamic stroke movement disorders.

scholarly journals Sepse neonatal, avaliação do impacto: uma revisão integrativa

Bionorte ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 47-58
Author(s):  
Zandonaidy Matheus Alves dos Santos ◽  
Ana Paula Fernandes de Oliveira ◽  
Tallisson Matheus Oliveira Sales
Keyword(s):  
Risk Factors ◽  
Early Diagnosis ◽  
Antibiotic Therapy ◽  
Neonatal Sepsis ◽  
Treatment Process ◽  
Clinical Manifestations ◽  
Integrative Review ◽  
Inclusion Criteria ◽  
Final Sample ◽  
Pubmed Database

The objective is to analyze from the literature the main risk factors for neonatal sepsis, the main clinical manifestations and the most prevalent antibiotic therapy. The integrative review methodology was followed by criteria, including preterm infants who had sepsis. The independent reviewers performed an extraction and synthesis of the data obtained through the chosen database. The present integrative review had as a final sample eleven scientific articles, which met the inclusion criteria previously established. The articles were selected and analyzed in the PubMed database. From the selected articles, categories were constructed according to the problem raised for this study, the following categories are: Risk factors for neonatal sepsis in an ICU; Most common clinical manifestations; Sepsis treatment process: medications used (antibiotics). Therefore, it is concluded that the identification of risk factors, clinical manifestations and the process of treatment and early diagnosis of sepsis, may contribute more effectively to the reduction of cases of sepsis that evolve to death, from this analysis you can perform the necessary interventions, with that, the expansion of data on this theme is necessary.

Light Side of Design: Professional Vector

2020 ◽  
pp. 23-33
Author(s):  
Elena A. Zaeva-Burdonskaya ◽  
Yuri V. Nazarov
Keyword(s):  
Professional Practice ◽  
Wide Spectrum ◽  
Scientific Basis ◽  
Design Culture ◽  
Interdisciplinary Nature ◽  
Educational Programmes ◽  
Design Activities ◽  
The Subject ◽  
Light Side

This article addresses one of the most actively developing types of design activities – light design. The article comprises quotes of the leading Russian and foreign light design specialists published over the previous five years, as well as the authors’ own conclusions. The thoughts quoted in the article are sometimes opposite to each other and reflect the wide spectrum of professional practice. They reflect the initial opinions of analysts and experts which are often diverging. All of the specialists point at the interdisciplinary nature of the new profession, which imposes additional load on a designer overloaded enough already by the scope and speed of the problems being solved nowadays. The discussion of the new profession of light designer initiated on the pages of professional publications is especially important in view of the development of professional standards and standards of design and architectural education, as well as creation of new educational programmes based on various approaches to the subject in technical and humanitarian institutions. The goal of this article is to introduce light design into the field of fully legitimate sections of design culture, to define the authentic scientific basis of the new creative profession, to initiate a foundation for self-determination of the new synthetic area, which materially affects the state of the profession as a whole and the life standards of a wide variety of consumers. In order to reach the set goal, a comparative and analytical method of study was selected, which allows studying the problem to a large extent and from all angles and finding the ways of overcoming the challenges emerging in the area of the new activity.

Pilot study on non-celiac gluten sensitivity: effects of Bifidobacterium longum ES1 co-administered with a gluten-free diet

2020 ◽  
Vol 66 (3) ◽  
Author(s):  
Francesco Di Pierro ◽  
Francesca Bergomas ◽  
Paolo Marraccini ◽  
Maria R. Ingenito ◽  
Lorena Ferrari ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bifidobacterium Longum ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free

scholarly journals Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain

2018 ◽  
Vol 73 (Suppl. 4) ◽  
pp. 39-46 ◽  
Author(s):  
Frank M. Ruemmele
Keyword(s):  
Abdominal Pain ◽  
Celiac Disease ◽  
Clinical Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Clear Cut ◽  
Clinical Presentations ◽  
New Findings ◽  
Three Phase ◽  
Gi Symptoms

Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis based on clinical tests and biological parameters, NCGS is a more difficult diagnosis, especially in children with functional gastrointestinal (GI) complaints. NCGS is considered a syndrome of intestinal but also extraintestinal symptoms occurring within hours, but sometimes even after several days of gluten ingestion. In children, the leading symptoms of NCGS are abdominal pain and diarrhea, while extraintestinal symptoms are rare, in contrast to adult patients. No precise diagnostic test nor specific biomarkers exist, except a rather cumbersome three-phase gluten-exposure, gluten-free diet, followed by a blinded placebo-controlled gluten challenge with crossover to provoke symptoms elicited by gluten in a reproducible manner that disappear on gluten-free alimentation. Recent data indicate that the peptide part of wheat proteins is not necessarily the sole trigger of clinical symptoms. Mono- or oligosaccharides, such as fructan and other constituents of wheat, were able to provoke GI symptoms in clinical trials. These new findings indicate that the term gluten sensitivity is probably too restrictive. The incidence of NCGS was reported in the range of 1–10% in the general population and to increase steadily; however, most data are based on patients’ self-reported gluten intolerance or avoidance without a medically confirmed diagnosis. Treatment consists of gluten avoidance for at least several weeks or months. Patients with NCGS require regular reassessment for gluten tolerance allowing with time the reintroduction of increasing amounts of gluten.

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