scholarly journals The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 278
Author(s):  
Asher Shafrir ◽  
Michal Shauly-Aharonov ◽  
Lior H. Katz ◽  
Ora Paltiel ◽  
Yishai Pickman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Helicobacter Pylori ◽  
Health Maintenance Organization ◽  
Serum Vitamin ◽  
Population Based ◽  
Health Maintenance ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Antigen Tests ◽  
H Pylori

Background: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. Methods: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. Results: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels <20 ng/mL, compared with those with levels ≥20 ng/mL (OR 1.31, 99% CI 1.22–1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). Conclusions: Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication.

scholarly journals Response of Helicobacter Pylori Eradication Treatment in Patients With Normal and Below-Normal Serum Vitamin D Levels

Cureus ◽  
2021 ◽  
Author(s):  
Irshad Magsi ◽  
Shakir Hussain keerio ◽  
Chandar Kumar ◽  
Abdul Subhan Talpur ◽  
Fnu Shahzeen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Helicobacter Pylori ◽  
Serum Vitamin ◽  
Normal Serum ◽  
Helicobacter Pylori Eradication ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Helicobacter Pylori interacts with Serum Vitamin D to influence Hypertension

2020 ◽  
Vol 13 ◽  
Author(s):  
Elie Salem-Sokhn ◽  
Ali Salami ◽  
Mirna Fawaz ◽  
Ali H Eid ◽  
Said El Shamieh
Keyword(s):  
Vitamin D ◽  
Helicobacter Pylori ◽  
Logistic Regression ◽  
Regression Model ◽  
Logistic Regression Model ◽  
Serum Vitamin ◽  
The Other ◽  
Serum Vitamin D ◽  
Other Hand ◽  
H Pylori

Background and objective: Hypertension is a multifactorial disease where numerous constitutive, genetic and environmental factors interplay. Among the constitutive factors, age is a major determent continuously reported to be associated with a significant increase in the prevalence of hypertension. In addition to age, Helicobacter pylori (H. pylori) infection was also shown to be associated. On the other hand, Vitamin D (Vit D) plays an important role against the development of hypertension. In the current study, we investigated whether H. pylori interacts with Vit D levels to influence hypertension. Methods: This cross-sectional study was conducted on seven hundred eighty-two “a priori” healthy individuals equally divided according to hypertension status. To study the association between Vit D, H. pylori and hypertension, a multivariate logistic regression model was used while correcting for different confounding factors. Power analysis was also performed. Results: Approximately half of the participants were hypertensive and had Vit D insufficiency, they were also matched for age. Using a multiple logistic regression model, our results showed an inversely proportionate association between H. pylori infection and the risk of hypertension (OR=0.37, P<0.001). On the other hand, a proportionate association between Vit D deficiency and hypertension was observed (OR=2.76, P=0.004). Furthermore, Vit D and H. pylori status interacted to affect the risk of hypertension (OR=0.973, P=0.004). Stratification according to Vit D status showed that 59.1% of Vit D deficient participants were infected with H. pylori organisms (P<0.001). When taking hypertension, Vit D, and H. pylori statuses into account, we found that the prevalence of hypertension was doubled when the participants were negative for H. pylori infection but had Vit D deficiency (P<0.001). Conclusion: H. pylori infection and Vit D deficiency could predict hypertension. The odds of hypertension development were double when the participants were negative for H. pylori infection and had vitamin D deficiency.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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