The Association between Coffee Consumption and Risk of Colorectal Cancer in a Korean Population

This study was performed to investigate the association between coffee consumption and risk of colorectal cancer in a Korean population and examine whether the association can be altered by adjustment for intake of coffee additives. We conducted a case-control study involving 923 colorectal cancer cases and 1846 controls matched by sex and age (within 5 years). A semi-quantitative food frequency questionnaire was used to assess coffee intakes. High coffee consumption was associated with lower odds of developing colorectal cancer (≥3 cups/day vs. no drinks, OR = 0.68; 95% CI: 0.49–0.96). When we additionally controlled for consumption of coffee additives including sugar and cream, the inverse association became stronger (≥3 cups/day vs. no drinks, OR = 0.22; 95% CI: 0.14–0.33), and a significant inverse linear trend was shown (Ptrend < 0.0001). The inverse associations were observed for proximal (Ptrend = 0.0001) and distal (Ptrend = 0.0003) colon cancer, and rectal cancer (Ptrend < 0.0001) in the stratified analysis by anatomical sub-sites. Regarding sex, inverse associations between coffee consumption and colorectal cancer were found for men (Ptrend < 0.0001) and women (Ptrend = 0.0021). In the stratified analysis by obese status of subjects, inverse linear trends were observed in both non-obese and obese people (Ptrend < 0.0001). High coffee consumption may be associated with a lower risk of colorectal cancer in the Korean population and the degree of decrease in the odds of developing colorectal cancer changes by adjustment for intake of coffee additives.

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Interaction between physical activity, PITX1 rs647161 genetic polymorphism and colorectal cancer risk in a Korean population: a case-control study

Oncotarget ◽

10.18632/oncotarget.24136 ◽

2018 ◽

Vol 9 (7) ◽

pp. 7590-7603 ◽

Cited By ~ 4

Author(s):

Madhawa Neranjan Gunathilake ◽

Jeonghee Lee ◽

Young Ae Cho ◽

Jae Hwan Oh ◽

Hee Jin Chang ◽

...

Keyword(s):

Physical Activity ◽

Colorectal Cancer ◽

Genetic Polymorphism ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

Colorectal Cancer Risk ◽

Korean Population ◽

Control Study

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Drinking Water Source, Chlorinated Water, and Colorectal Cancer: A Matched Case-Control Study in Ethiopia

Environmental Health Insights ◽

10.1177/11786302211064432 ◽

2022 ◽

Vol 16 ◽

pp. 117863022110644

Author(s):

Nebiyou Tafesse ◽

Massimiliano Porcelli ◽

Sirak Robele Gari ◽

Argaw Ambelu

Keyword(s):

Colorectal Cancer ◽

Drinking Water ◽

Case Control Study ◽

Tap Water ◽

Addis Ababa ◽

Case Control ◽

Matched Case ◽

Stratified Analysis ◽

Matched Case Control Study ◽

Control Study

Background: There is no study conducted on the association between disinfection byproducts (DBPs) in chlorinated drinking water and colorectal cancer (CRC) in Ethiopia. Therefore, this study aimed to determine the relation between chlorine based DBPs in drinking water and CRC in Addis Ababa, Ethiopia. Methods: A facility based matched case control study was conducted involving 224 cases and 448 population controls from June 2020 to May 2021. Cases were defined as histologically confirmed CRC cases. Cases were matched with controls by residence, age, and sex using frequency and individual matching. Geocoding of cases, health facility, and georeferencing of controls were carried out. Data was collected using a pretested structured questionnaire. Pearson Chi square and Fisher’s exact tests were employed to assess associations. Stratified analysis was used to detect confounding factors and effect modification. A multivariable conditional logistic regression was used to identify risk factors of CRC. Results: Of 214 CRC cases, 148 (69.2%) used chlorinated water whereas out of 428 controls 161 (37.6%) used chlorinated water. In the final regression model, drinking chlorinated surface water (adjusted matched odds ratio [adjusted mOR] = 2.6; 95% CI 1.7-4.0), history of swimming (adjusted mOR = 2.4; 95% CI 1.4-4.1), years at the place of current residence (adjusted mOR = 1.5; 95% CI 1.1-2.2), hot tap water use for showering (adjusted mOR; 3.8 = 95% CI 2.5-5.9) were significantly associated with CRC. The stratified analysis confirmed that smoking and meat ingestion were not effect modifiers and confounders. Conclusion: Drinking chlorinated water for extended years is a significant risk factor for CRC in Addis Ababa, Ethiopia. In addition, hot tap water use for showering, and swimming history are risk factors for CRC. This information is essential to design integrated interventions that consider chlorination by-products and exposure routes toward the prevention and control of CRC in Ethiopia. Initiating alternative methods to chlorine disinfection of drinking water is also essential.

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Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian Population

Balkan Journal of Medical Genetics ◽

10.2478/v10034-008-0028-7 ◽

2008 ◽

Vol 11 (2) ◽

pp. 17-24 ◽

Cited By ~ 1

Author(s):

N Matevska ◽

T Josifovski ◽

A Kapedanovska ◽

Z Sterjev ◽

Z Serafimoska ◽

...

Keyword(s):

Colorectal Cancer ◽

Methylenetetrahydrofolate Reductase ◽

Case Control Study ◽

Age Of Onset ◽

Case Control ◽

Mthfr Gene ◽

Inverse Association ◽

C677t Polymorphism ◽

677T Allele ◽

Control Study

Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk of Colorectal Cancer in the Macedonian PopulationMethylenetetrahydrofolate reductase (MTHFR) regulates the flow of folate groups between DNA synthesis and DNA methylation. A common C677T substitution (Ala222Val) in exon 4 of the MTHFR gene has been linked with the risk of colorectal cancer (CRC). To assess this risk in the Macedonian population, we conducted a case-control study of 413 randomly selected CRC patients and 185 controls without a clinical diagnosis of CRC. We found a statistically significant inverse association between the MTHFR T allele (35.35% for the patients and 41.35% for the controls) and the CRC risk [odds ratio (OR) 0.776; 95% confidence interval (95% CI) 0.603-0.997;p= 0.047). The prevalence of the MTHFR T allele is lower in patients with advanced CRC (Duke' s stage C and D) and with microsatellite instable tumors (MSI+), indicating the inverse association with the CRC aggressiveness and MSI status. This effect seems to be independent of gender, age of onset and localization. We concluded that the MTHFR 677T allele is more likely to have a protective effect on CRC development and progression in the Macedonian population.

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Correction: Interaction between physical activity, PITX1 rs647161 genetic polymorphism and colorectal cancer risk in a Korean population: a case-control study

Oncotarget ◽

10.18632/oncotarget.26227 ◽

2018 ◽

Vol 9 (79) ◽

pp. 35027-35027

Author(s):

Madhawa Neranjan Gunathilake ◽

Jeonghee Lee ◽

Young Ae Cho ◽

Jae Hwan Oh ◽

Hee Jin Chang ◽

...

Keyword(s):

Physical Activity ◽

Colorectal Cancer ◽

Genetic Polymorphism ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

Colorectal Cancer Risk ◽

Korean Population ◽

Control Study

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Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Frontiers in Nutrition ◽

10.3389/fnut.2021.688897 ◽

2021 ◽

Vol 8 ◽

Author(s):

Yang Liu ◽

Simin Li ◽

Liqing Jiang ◽

Yuchong Zhang ◽

Zhi Li ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Northeast China ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Dietary Factors ◽

Colorectal Cancer Risk ◽

Inverse Association ◽

Control Study

Background: Dietary factors are regarded as an essential influence in changing colorectal cancer (CRC) risk. However, there is no clear conclusion of the relationship between solanaceous vegetables and colorectal cancer at present. The study aimed to evaluate the intake of solanaceous vegetables in relation to colorectal cancer risk among the Northeast Chinese population.Methods: We carried out a hospital-based case-control study in three hospitals in Northeast China from 2009 to 2011. The study finally included 833 patients with CRC and 833 controls matched separately according to age, gender, and city of residence. We applied a structural questionnaire to collect demographic characteristics and dietary information by face-to-face interview and adopted conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by sex and subsites.Results: There was no obvious correlation between total intake of solanaceous plants and CRC risk. The adjusted OR for the highest quartile and the lowest quartile was 1 (95% CI: 0.68–1.5). Certain types of solanaceous vegetables were negatively associated with the risk of CRC, such as eggplant (OR = 0.42; 95% CI:0.29–0.62) and sweet pepper (OR = 0.48; 95%CI: 0.33–0.7). Potato was found to have a positive correlation with CRC (OR = 1.76; 95% CI: 1.26–2.47). In the stratified analyses by gender, total solanaceous vegetables intake was inversely associated with CRC risk only in men. In the stratified analyses of cancer subsites, no significant association between total solanaceous vegetables intake and CRC risk was found.Conclusion: No findings showed that the intake of total solanaceous vegetables was related to the reduction of CRC risk. However, specific types of solanaceous vegetables indicated an inverse association with CRC risk.

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Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study

European Journal of Nutrition ◽

10.1007/s00394-019-02046-w ◽

2019 ◽

Vol 59 (5) ◽

pp. 1963-1974 ◽

Cited By ~ 1

Author(s):

Jimi Kim ◽

Jeonghee Lee ◽

Jae Hwan Oh ◽

Hee Jin Chang ◽

Dae Kyung Sohn ◽

...

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Case Control ◽

Korean Population ◽

Control Study

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Association between phytosterol intake and colorectal cancer risk: a case–control study

British Journal Of Nutrition ◽

10.1017/s0007114517000617 ◽

2017 ◽

Vol 117 (6) ◽

pp. 839-850 ◽

Cited By ~ 17

Author(s):

Jing Huang ◽

Ming Xu ◽

Yu-Jing Fang ◽

Min-Shan Lu ◽

Zhi-Zhong Pan ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Chinese Population ◽

Case Control Study ◽

Positive Association ◽

Case Control ◽

Colorectal Cancer Risk ◽

Inverse Association ◽

Increased Risk ◽

Control Study

AbstractA study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case–control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, Ptrend<0·01) for total phytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

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Cigarette smoking, coffee intake and alcohol consumption preceding Parkinson's disease: a case–control study

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2011.00593.x ◽

2012 ◽

Vol 24 (2) ◽

pp. 109-114 ◽

Cited By ~ 5

Author(s):

Sandra B. Sipetic ◽

Hristina D. Vlajinac ◽

Jadranka M. Maksimovic ◽

Jelena M. Marinkovic ◽

Eleonora D. Dzoljic ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Alcohol Consumption ◽

Case Control Study ◽

Coffee Consumption ◽

Case Control ◽

Inverse Association ◽

Daily Consumption ◽

Coffee Intake ◽

Control Study

Objective: A case–control study was performed in Belgrade in order to investigate the association between Parkinson's disease (PD) and smoking, coffee and alcohol consumption.Methods: During the period 2001–2005, 110 new PD cases and 220 hospital controls were interviewed. Cases and controls were matched by sex, age and place of residence (urban/rural). For the analysis of data conditional univariate and multivariate logistic regression methods were used.Results: With PD were associated, independently from each other, current smoking [odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.23–0.82], alcohol consumption (OR = 4.78; 95% CI = 2.67–8.55) and coffee consumption (OR = 2.54; 95% CI = 1.36–4.75). In ever smokers the risk for PD significantly decreased with the increasing number of cigarettes smoked and with increasing duration of smoking. The risk for PD significantly increased with the increasing quantity of alcohol consumption. PD risk was significantly higher in subjects whose average daily consumption of coffee was 1 and 2–3 cups, and it was lower (but not significantly) in those whose daily coffee consumption was 4+ cups. Cases and controls did not differ in duration of alcohol and coffee consumption. The results of multivariate analyses did not substantially change after adjustment on family history positive on PD.Conclusion: The findings of this study support the hypotheses of inverse association of smoking with PD, but an inverse association with coffee was not confirmed. PD was found to be positively associated with coffee and alcohol consumption.

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Case-Control Study of Diet, Cooking Methods and Colorectal Cancer In Viet Nam

Journal of Global Oncology ◽

10.1200/jgo.18.60900 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 22s-22s

Author(s):

N. Tuan ◽

L. Giang ◽

L. Ngoan

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Positive Association ◽

Case Control ◽

Cooking Methods ◽

Viet Nam ◽

Food Frequency ◽

Increased Risk ◽

Underlying Mechanisms ◽

Control Study

Background: Colorectal cancer is one of the most common cancers and the leading cause of death in the world and the third most common cancer in Viet Nam. Aim: To examine the association between diet, cooking methods and the risk of colorectal cancer by a case-control study in the Hanoi city, Viet Nam. Methods: A case-control study was designed. Case was newly incident colorectal cancer (125 cases). Control was hospital-based case without any cancer and matched to case by sex and +/− 5 years old admitted to the same Bach Mai hospital in Hanoi city. Case to control ratio was one. Data collection was performed by face to face interviewed by the trained interviewers in using the validated semiquantitative food frequency and demographic and lifestyle questionnaires. Food frequency intake inquired about a frequent intake per day, per week, per month or per year for 85 items of fruit, vegetables, fishes, meats, salted foods, bean and nuts; lightly browned, medium browned, high browned, well browned, and blackened/charred of cooking meat and fishes. Multivariable adjusted odds ratio and 95% confidence interval (OR, 95% CI) was estimated using STATA 10.0. Results: The significant increased risk of colorectal cancer was observed for a high frequent intake of fried meat (OR=2.63, 95% CI: 1.47-4.66); fried soya cheese (OR=2.00, 95% CI: 1.05-3.80); grilled food (OR=3.18, 95% CI: 1.84-5.48); roasted food (OR=3.56, 95% CI: 2.05-6.20); beef (OR=2.06, 95% CI: 1.17-3.83); eat salty food (OR=1.71, 95% CI: 1.03-2.82); instant noodle (OR=3.08, 95% CI: 1.61-5.91); salted vegetable (OR=1.63, 95% CI: 1.01-2.73); smoking (OR=5.5, 95% CI: 1.90-15.96). In contrast, a significant decreased risk of colorectal cancer was seen for a high frequent intake of soymilk (OR=0.45, 95% CI: 0.24-0.87); sweet leaf (OR=0.28, 95% CI: 0.13-0.60); guava (OR=0.55, 95% CI: 0.32-0.94); orange (OR=0.15, 95% CI: 0.07-0.36). Conclusion: We observed the positive association between cooking methods and the risk of colorectal cancer. Further study of the underlying mechanisms of cooked meat and fish is highly recommended in Viet Nam.

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