Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial

Sex differences in cerebrovascular disease rates indicate a possible role for ovarian sex steroid hormones in cerebrovascular function. To synthesise and identify knowledge gaps, a systematic review and meta-analysis was conducted to assess how ovarian sex steroid hormone changes across the lifespan affect cerebrovascular function in women. Three databases (EMBASE, MEDLINE and Web of Science) were systematically searched for studies on adult cerebrovascular function and ovarian sex steroid hormones. Forty-five studies met pre-defined inclusion criteria. Studied hormone groups included hormone replacement therapy (HRT; n = 17), pregnancy (n = 12), menstrual cycle (n = 7), menopause (n = 5), oral contraception (n = 2), and ovarian hyperstimulation (n = 2). Outcome measures included pulsatility index (PI), cerebral blood flow/velocity (CBF), resistance index (RI), cerebral autoregulation, and cerebrovascular reactivity. Meta-analysis was carried out on HRT studies. PI significantly decreased [−0.05, 95% CI: (−0.10, −0.01); p = 0.01] in post-menopausal women undergoing HRT compared to post-menopausal women who were not, though there was considerable heterogeneity (I2 = 96.8%). No effects of HRT were seen in CBF (p = 0.24) or RI (p = 0.77). This review indicates that HRT improves PI in post-menopausal women. However, there remains insufficient evidence to determine how changing ovarian sex steroid hormone levels affects cerebrovascular function in women during other hormonal phases (e.g., pregnancy, oral contraception).

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Memory Decline in Peri- and Post-menopausal Women: The Potential of Mind–Body Medicine to Improve Cognitive Performance

Integrative Medicine Insights ◽

10.4137/imi.s15682 ◽

2014 ◽

Vol 9 ◽

pp. IMI.S15682 ◽

Cited By ~ 10

Author(s):

Jim R. Sliwinski ◽

Aimee K. Johnson ◽

Gary R. Elkins

Keyword(s):

Cognitive Decline ◽

Cognitive Performance ◽

Hot Flashes ◽

Integrative Approach ◽

Future Research ◽

Memory Decline ◽

Estrogen Production ◽

Menopausal Women ◽

Mind Body Medicine ◽

Post Menopausal

Cognitive decline is a frequent complaint during the menopause transition and among post-menopausal women. Changes in memory correspond with diminished estrogen production. Further, many peri- and post-menopausal women report sleep concerns, depression, and hot flashes, and these factors may contribute to cognitive decline. Hormone therapy can increase estrogen but is contraindicated for many women. Mind–body medicine has been shown to have beneficial effects on sleep, mood, and hot flashes, among post-menopausal women. Further, mind–body medicine holds potential in addressing symptoms of cognitive decline post-menopause. This study proposes an initial framework for how mind–body interventions may improve cognitive performance and inform future research seeking to identify the common and specific factors associated with mind–body medicine for addressing memory decline in peri- and post-menopausal women. It is our hope that this article will eventually lead to a more holistic and integrative approach to the treatment of cognitive deficits in peri- and post-menopausal women.

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The Mediating Role of SES on the Relationship between Pregnancy History and Later Life Cognition

10.1101/2021.09.29.21264303 ◽

2021 ◽

Author(s):

Averi J. Giudicessi ◽

Ursula G. Saelzler ◽

Aladdin H. Shadyab ◽

Alexander Ivan B. Posis ◽

Erin Sundermann ◽

...

Keyword(s):

Cognitive Performance ◽

Large Population ◽

Later Life ◽

Learning Task ◽

Education Level ◽

Digit Symbol Substitution Test ◽

Menopausal Women ◽

Post Menopausal ◽

The Relationship

ABSTRACTObjectiveThe association of pregnancy with later life cognition is not well understood. Few studies address the potential confounding role of socioeconomic factors on this relationship. We examined whether pregnancy was associated with cognitive function in a large, population-based sample of post-menopausal women and the potential mediating effects of education level and federal income-to-poverty ratio (PIR) on this relationship.MethodsParticipants were 1,016 post-menopausal women from the National Health and Nutrition Examination Survey (NHANES). We utilized data from two study waves between years 2011-2014. Cognitive functioning was evaluated by: Digit Symbol Substitution Test (DSST), Animal Fluency (AF), Consortium to Establish a Registry for Alzheimer’s Disease CERAD word learning task (CERAD-WL) and CERAD delayed recall (CERAD-DR). Lifetime education level and federal income-to-poverty ratio (PIR) were examined as mediating factors. Regression models were used to examine the relationship between number of term pregnancies and incomplete pregnancies and cognitive performance.ResultsA greater number of term pregnancies was related to worse performance on the DSST (p < .001), CERAD-DR (p < .007), and AF (p < .03). Conversely, greater incomplete pregnancies related to better CERAD-DR performance (p < .03). Significant associations between term pregnancies and cognitive scores were mediated by PIR but not education level.ConclusionsHigher number of term pregnancies was associated with worse cognitive performance, whereas higher number of incomplete pregnancies was associated with better cognitive performance. Results indicate the necessity to consider SES factors when studying the relationship between pregnancy and cognition.

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Counteracting sarcopenia in post-menopausal women: do hormones and strength training accomplish the task?

Clinical Science ◽

10.1042/cs20010123 ◽

2001 ◽

Vol 101 (2) ◽

pp. 171 ◽

Cited By ~ 2

Author(s):

MICHAEL KJÆR

Keyword(s):

Strength Training ◽

Menopausal Women ◽

Post Menopausal

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Pituitary dysfunction in recently post-menopausal women

Clinical Endocrinology ◽

10.1046/j.1365-2265.1998.0429c.x ◽

1998 ◽

Vol 48 (1) ◽

pp. 124-124

Author(s):

Henry G. Burger

Keyword(s):

Pituitary Dysfunction ◽

Menopausal Women ◽

Post Menopausal

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Low cardiovascular event rate in post-menopausal women with increased cardiovascular risk; Two year blinded summary from the ongoing Libigel (testosterone gel) cardiovascular safety study

PsycEXTRA Dataset ◽

10.1037/e512622013-014 ◽

2011 ◽

Author(s):

Michael C. Snabes ◽

Joanne Zborowski

Keyword(s):

Cardiovascular Risk ◽

Cardiovascular Event ◽

Event Rate ◽

Cardiovascular Safety ◽

Safety Study ◽

Menopausal Women ◽

Testosterone Gel ◽

Post Menopausal

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The Effects of Therapy with Oestriol Succinate and Ethinyl Oestradiol on the Haemostatic Mechanism in Post-Menopausal Women

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647935 ◽

1976 ◽

Vol 35 (02) ◽

pp. 403-414 ◽

Cited By ~ 19

Author(s):

Terence Davies ◽

Gillian Fieldhouse ◽

George P. McNicol

Keyword(s):

Coagulation Factors ◽

Factor Vii ◽

Oestrogen Therapy ◽

Qualitative And Quantitative ◽

Lysis Activity ◽

Menopausal Women ◽

Increased Sensitivity ◽

Post Menopausal ◽

Incremental Increase ◽

Ethinyl Oestradiol

SummaryThe effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 μg/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

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